Alpha-ketoglutarate (AKG luv luv) yog ib qho tseem ceeb metabolic nruab nrab uas ua lub luag haujlwm tseem ceeb hauv tib neeg lub cev, tshwj xeeb tshaj yog nyob rau hauv lub zog metabolism, antioxidant teb, thiab kho cell.
Nyob rau hauv xyoo tas los no, AKG tau txais kev saib xyuas rau nws lub peev xwm los ncua kev laus thiab kho cov kab mob ntev. Nov yog cov txheej txheem tshwj xeeb ntawm kev ua ntawm AKG hauv cov txheej txheem no:
AKG ua si ntau lub luag haujlwm hauv kev kho DNA, pab tswj DNA kev ncaj ncees los ntawm cov hauv qab no:
Raws li cofactor rau hydroxylation cov tshuaj tiv thaiv: AKG yog ib cofactor rau ntau dioxygenases (xws li TET enzymes thiab PHDs enzymes).
Cov enzymes no koom nrog DNA demethylation thiab hloov kho histone, tswj kev ruaj ntseg ntawm genome thiab tswj cov noob qhia.
TET enzyme catalyzes demethylation ntawm 5-methylcytosine (5mC) thiab hloov mus rau 5-hydroxymethylcytosine (5hmC), yog li tswj cov noob qhia.
Los ntawm kev txhawb nqa cov haujlwm ntawm cov enzymes no, AKG pab kho DNA puas thiab tswj kev ncaj ncees ntawm genome.
Antioxidant nyhuv: AKG tuaj yeem txo cov DNA puas tsuaj los ntawm oxidative kev nyuaj siab los ntawm neutralizing dawb radicals thiab reactive oxygen hom (ROS).
Oxidative stress yog ib qho tseem ceeb uas ua rau DNA puas thiab cellular aging. Los ntawm kev txhim kho lub peev xwm antioxidant ntawm cov hlwb, AKG tuaj yeem pab tiv thaiv DNA puas cuam tshuam rau oxidative kev nyuaj siab.
Kho cov hlwb thiab cov ntaub so ntswg
AKG plays lub luag haujlwm tseem ceeb hauv kev kho cov cell thiab rov tsim cov ntaub so ntswg, feem ntau los ntawm txoj hauv kev hauv qab no:
Txhawb nqa qia cell muaj nuj nqi: AKG tuaj yeem txhim kho kev ua haujlwm thiab rov tsim muaj peev xwm ntawm cov qia hlwb. Kev tshawb fawb qhia tau hais tias AKG tuaj yeem txuas ntxiv lub neej ntawm cov qia hlwb, txhawb kev sib txawv thiab kev loj hlob, thiab yog li pab txhawb rau cov ntaub so ntswg rov tsim dua thiab kho.
Los ntawm kev tswj hwm cov haujlwm ntawm cov qia hlwb, AKG tuaj yeem ncua cov ntaub so ntswg laus thiab txhim kho lub cev muaj peev xwm rov tsim dua tshiab.
Txhim kho cell metabolism thiab autophagy: AKG koom rau hauv lub voj voog tricarboxylic acid (TCA voj voog) thiab yog ib qho tseem ceeb ntawm cov khoom nruab nrab ntawm cellular zog metabolism.
Los ntawm kev txhim kho qhov ua tau zoo ntawm TCA lub voj voog, AKG tuaj yeem nce qib cellular zog thiab txhawb kev kho ntawm tes thiab kev ua haujlwm.
Tsis tas li ntawd, AKG tau pom los txhawb cov txheej txheem autophagy, pab cov hlwb tshem tawm cov khoom puas thiab tswj kev noj qab haus huv ntawm tes.
Gene balance thiab kev tswj hwm ntawm epigenetic
AKG ua lub luag haujlwm tseem ceeb hauv kev sib npaug ntawm cov noob caj noob ces thiab kev tswj hwm epigenetic, pab tswj kev ua haujlwm zoo thiab kev noj qab haus huv ntawm cov hlwb:
Kev cuam tshuam rau kev tswj hwm epigenetic: AKG tswj cov qauv qhia cov noob caj noob ces los ntawm kev koom tes hauv kev hloov kho epigenetic, xws li demethylation ntawm DNA thiab histones.
Epigenetic regulation yog ib qho tseem ceeb ntawm kev tswj cov txheej txheem rau cov noob qhia thiab kev ua haujlwm ntawm tes. Lub luag haujlwm ntawm AKG tuaj yeem pab tswj cov kev qhia ntawm cov noob thiab tiv thaiv cov kab mob thiab kev laus los ntawm kev qhia cov noob txawv txawv.
Inhibit inflammatory teb: AKG tuaj yeem txo cov kab mob inflammatory uas cuam tshuam nrog kev laus los ntawm kev tswj cov noob qhia.
Cov kab mob rhiab heev ua rau muaj ntau yam kab mob ntsig txog kev laus, thiab cov teebmeem ntawm AKG tuaj yeem pab tiv thaiv thiab txo cov mob no.
ncua kev laus thiab kho cov kab mob ntev
AKG ntau yam ua rau nws muaj peev xwm ncua kev laus thiab kho cov kab mob ntev:
Ncua kev laus: Los ntawm kev txhawb nqa DNA kho, txhim kho lub peev xwm antioxidant, txhawb cov qia cell muaj nuj nqi, tswj cov noob qhia, thiab lwm yam, AKG tuaj yeem ncua kev laus ntawm cov hlwb thiab cov ntaub so ntswg.
Cov kev tshawb fawb tsiaj pom tau hais tias ntxiv nrog AKG tuaj yeem ua rau lub neej ntev thiab txhim kho kev noj qab haus huv hauv cov tsiaj laus.
Kev kho cov kab mob ntev: AKG cov teebmeem hauv kev txhim kho cov metabolism hauv kev ua haujlwm, tiv thaiv kab mob, thiab antioxidant ua rau nws muaj txiaj ntsig zoo hauv kev kho mob ntev.
Piv txwv li, AKG tej zaum yuav muaj kev tiv thaiv thiab kho cov teebmeem ntawm ntshav qab zib, kab mob plawv, kab mob neurodegenerative, thiab lwm yam.
Cov ntsiab lus
AKG ua lub luag haujlwm hauv kev ncua kev laus thiab kho cov kab mob ntev los ntawm kev kho DNA, txhawb kev kho cov cell thiab cov ntaub so ntswg, tswj cov noob sib npaug thiab tswj cov epigenetics.
Kev sib koom ua ke ntawm cov txheej txheem no ua rau AKG lub hom phiaj zoo rau kev tiv thaiv kev laus thiab kev tiv thaiv kab mob ntev.
Nyob rau yav tom ntej, kev tshawb fawb ntxiv yuav pab nthuav tawm ntau cov txiaj ntsig zoo ntawm AKG thiab nws cov ntawv thov tau.
Kev lees paub: Kab lus no yog rau cov ntaub ntawv dav dav nkaus xwb thiab yuav tsum tsis txhob raug txhais raws li cov lus qhia kho mob. Qee cov ntaub ntawv blog tshaj tawm los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, formatting thiab kho cov ntawv. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntau ntxiv tsis txhais tau hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Nco ntsoov sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Post lub sij hawm: Sep-05-2024
