Hauv kev loj hlob ntawm kev noj qab haus huv thiab kev noj qab haus huv hauv ntiaj teb, oleoylethanolamide (OEA) tau dhau los ua cov khoom siv nrov tshaj plaws paub txog nws cov txiaj ntsig zoo hauv kev tswj qhov hnyav, kev noj qab haus huv, thiab kev noj qab haus huv tag nrho. Qhov kev thov rau hwm oleoylethanolamide hmoov cov khoom lag luam tau nce siab vim ntau thiab ntau tus neeg paub txog nws cov txiaj ntsig. Txawm li cas los xij, nrhiav kev ua haujlwm zoo OEA tuaj yeem ua haujlwm nyuaj vim muaj ntau yam kev xaiv muaj.
Los ntawm kev paub seb yuav nrhiav dab tsi thiab qhov twg yuav mus yuav khoom, koj tuaj yeem txiav txim siab paub meej uas haum rau koj cov hom phiaj kev noj qab haus huv. Thaum xaiv oleoylethanolamide, nco ntsoov ua ntej purity, zoo thiab meej. Tsuas yog nyob rau hauv txoj kev no koj tuaj yeem xaiv cov oleoylethanolamide hmoov cov khoom uas ua tau raws li koj xav tau.
Oleoylethanolamide (OEA),los yog oleoylethanolamide, yog ib txwm tshwm sim li lipid uas yog synthesized nyob rau hauv lub cev, feem ntau nyob rau hauv cov hnyuv me. Nws yog muab los ntawm cov tshuaj tiv thaiv enzymatic ntawm oleic acid (ib qho monounsaturated fatty acid pom nyob rau hauv ntau yam kev noj haus rog) thiab ethanolamine, uas yog ib tug thib ob amide compound uas muaj lipophilic oleic acid thiab hydrophilic ethanolamine.
OEA kuj yog ib qho lipid molecule tshwm sim nyob rau hauv lwm yam tsiaj thiab cov ntaub so ntswg. Nws yog dav nyob rau hauv cov tsiaj thiab cov ntaub so ntswg xws li cocoa hmoov, soybeans, thiab txiv ntseej, tab sis nws cov ntsiab lus tsis tshua muaj heev. Tsuas yog thaum ib puag ncig sab nraud hloov pauv lossis cov zaub mov raug txhawb nqa, lub cev cov ntaub so ntswg ntawm tes Cov tshuaj no yuav raug tsim tawm ntau dua, yog li OEA tuaj yeem siv los ua cov khoom noj ntxiv.
OEA yog ib qho amphiphilic molecule ib txwm siv los ua surfactant thiab xab npum hauv kev lag luam tshuaj. Txawm li cas los xij, kev tshawb fawb ntxiv tau pom tias OEA tuaj yeem ua lub luag haujlwm lipid signaling molecule nyob rau hauv lub plab-hlwb axis thiab tso tawm ntau cov haujlwm lom hauv lub cev, suav nrog: tswj kev qab los noj mov, txhim kho lipid metabolism, txhim kho kev nco thiab kev paub thiab lwm yam haujlwm. Ntawm lawv, OEA lub luag haujlwm ntawm kev tswj kev qab los noj mov thiab txhim kho lipid metabolism tau txais kev mloog zoo tshaj plaws.
Oleoylethanolamide (OEA) yog ib qho endogenous lipid signaling molecule thiab belongs rau ethanolamine chav kawm ntawm cov tebchaw. Nws tsuas yog ua lub luag haujlwm hauv lub cev los ntawm kev tswj cov txheej txheem xws li qab los noj mov, lub zog metabolism thiab fatty acid oxidation. OEA feem ntau yog synthesized nyob rau hauv cov hnyuv me thiab cuam tshuam rau lub paj hlwb thiab cov txheej txheem metabolic los ntawm kev khi rau cov receptors tshwj xeeb.
Oleylethanolamide ua haujlwm los ntawm ntau lub tshuab:
●PPAR-α ua kom muaj zog: OEA khi rau thiab ua kom PPAR-α, ib qho receptor nuclear koom nrog hauv lipid metabolism, pab txo qis kev noj zaub mov thiab nce kev siv zog.
● Txhawb nqa lipid oxidation: Los ntawm kev ua kom PPAR-α, OEA tuaj yeem txhim kho qhov decomposition ntawm fatty acids hauv daim siab thiab txhawb kev siv zog.
● Kev tswj ntawm lub plab-hlwb axis: OEA cuam tshuam rau satiety signals los ntawm kev cuam tshuam rau cov hlab ntsha vagus, uas nqa cov lus ntawm lub plab thiab lub hlwb.
Lub ECS (Endocannabinoid System) yog ib lub xovtooj ntawm tes taw qhia uas muaj cov endocannabinoids (xws li cannabinoids), lawv cov receptors (CB1 thiab CB2), thiab lwm yam synthesis thiab degradation enzymes. ECS ua lub luag haujlwm tseem ceeb hauv kev tswj hwm ntau yam txheej txheem physiological, suav nrog kev qab los noj mov, mob kev xav, mus ob peb vas, nco, thiab kev tiv thaiv kab mob.
Lub tshuab uas ECS cuam tshuam rau kev ua haujlwm ntawm lub cev yog raws li hauv qab no:
Kev tswj hwm kev txhim kho neuronal thiab synaptic plasticity: ECS ua lub luag haujlwm tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm cov paj hlwb, nrog rau cov txheej txheem xws li neurogenesis, glia tsim, neuronal migration, synaptogenesis, thiab synaptic pruning. CB1R thiab AEA ua lub luag haujlwm tseem ceeb thaum tib neeg txoj kev loj hlob thiab cuam tshuam nrog kev sib txawv ntawm tes thiab axonal elongation nyob rau hauv nruab nrab paj hlwb.
Modulates qhov mob thiab nqi zog: Cannabinoids hloov kho qhov mob los ntawm kev ua ntawm ntau lub hom phiaj thiab tau pom tias yuav txo tau ntau hom mob. ECS tseem yog ib qho tseem ceeb rau cov txiaj ntsig zoo ntawm cov tshuaj muaj yees, cuam tshuam rau kev nyiam thiab kev coj tus cwj pwm rov qab rau ntau yam yeeb tshuaj.
Tswj kev xav thiab kev nco muaj nuj nqi: ECS koom nrog tswj kev ntxhov siab thiab cuam tshuam rau kev kawm, khaws cia, nco qab thiab paub cov txheej txheem ntawm ntau hom kev nco. CB1R plays lub luag haujlwm hauv kev ua haujlwm ntawm ntau lub hlwb hauv cheeb tsam thiab muaj peev xwm tswj kev cuam tshuam ntawm kev xav thiab kev nco.
Tswj lub cev tiv thaiv kab mob thiab lwm yam haujlwm: ECS muaj nyob rau hauv lub cev tiv thaiv kab mob thiab tuaj yeem cuam tshuam rau lawv txoj haujlwm. AEA tuaj yeem cuam tshuam kev tso tawm ntawm cov cytokines pro-inflammatory thiab tswj kev tiv thaiv kab mob. Tsis tas li ntawd, ECS tseem koom nrog hauv kev tswj hwm kev qab los noj mov, kev coj noj coj ua, thiab kev ua haujlwm ntawm lub cev ntawm ntau lub cev.
Kev sib raug zoo ntawm oleoylethanolamine thiab ECS feem ntau yog tshwm sim hauv cov hauv qab no:
Kev sib cuam tshuam: OEA tuaj yeem cuam tshuam qhov qab los noj mov thiab lub zog sib npaug los ntawm kev cuam tshuam nrog receptors hauv ECS. OEA xav tias yuav txo qis qab los noj mov thiab txhawb oxidation ntawm fatty acids.
Kev tswj hwm txoj cai: OEA tuaj yeem cuam tshuam rau kev ua haujlwm ntawm ECS los ntawm kev tswj cov synthesis thiab degradation ntawm endocannabinoids, yog li ua lub luag haujlwm hauv lub zog metabolism thiab tswj kev noj qab haus huv.
Lub luag haujlwm muaj peev xwm: Vim tias lawv lub luag haujlwm hauv kev tswj cov metabolism thiab qab los noj mov, cov kws tshawb fawb tau tshawb nrhiav lawv lub luag haujlwm hauv kev rog rog, metabolic syndrome, thiab lwm yam kab mob.
Zuag qhia tag nrho, kev sib cuam tshuam ntawm oleoylethanolamine thiab endocannabinoid system yog ib qho chaw ua haujlwm ntawm kev tshawb fawb thiab tuaj yeem muab kev nkag siab tshiab rau kev nkag siab thiab kho cov kab mob ntsig txog cov metabolism.
1. Tswj kev qab los noj mov thiab poob phaus
OEA yog ib qho tseem ceeb noj zaub mov inhibitor, thiab nws lub luag haujlwm tseem ceeb yog los pab txo kev rog rog. Kev txhaj tshuaj Intraperitoneal ntawm OEA tuaj yeem txo cov khoom noj thiab qhov hnyav nce hauv nas. Kev tswj hwm qhov ncauj ntawm OEA tuaj yeem ua rau muaj txiaj ntsig zoo sib xws, tab sis kev txhaj tshuaj intracerebroventricular ntawm OEA tsis ua. Tsis cuam tshuam rau nas noj. Lub ntsiab yuag poob ntawm OEA yog tias nws tuaj yeem ua rau muaj kev xav ntawm satiety, yog li tswj kev noj zaub mov ntau dhau. Ntxiv qee qhov concentration ntawm OEA rau kev pub noj ntawm cov nas ib txwm muaj lossis rog tuaj yeem txo cov nas qab los noj mov thiab qhov hnyav.
OEA tsis tsuas yog inhibits plab hnyuv plab zom mov, tab sis kuj tseem ua kom cov beta oxidation ntawm fatty acids los ntawm kev txhawb nqa cov hydrolysis ntawm triglycerides hauv cov ntaub so ntswg peripheral (siab thiab rog), thaum kawg txo cov rog thiab ua tiav kev tswj qhov hnyav.
2. Txo cov ntshav lipids thiab tiv thaiv atherosclerosis
Peroxisome proliferator-activated receptor-α (PPAR-α) yog ib hom receptor ze ze rau cov haujlwm metabolic hauv lub cev. PPAR-α koom nrog hauv lipid metabolism los ntawm kev khi rau peroxisome proliferator teb cov ntsiab lus. Kev thauj mus los ntawm metabolic, kev tiv thaiv kab mob, tiv thaiv kab mob, tiv thaiv kev loj hlob thiab lwm yam txheej txheem ntxiv ua lub luag haujlwm hauv kev tswj cov ntshav lipids thiab tiv thaiv atherosclerosis.
OEA yog ib qho endocannabinoid analog uas yog tsim thaum lub cev nqaij daim tawv raug txhawb. Cov kev tshawb fawb tau pom tias OEA ua kom PPAR-M, txo cov kev tso tawm ntawm endothelin-1, inhibits vasoconstriction thiab du cov leeg cell proliferation, txhawb vasodilation, thiab nyob rau tib lub sij hawm nce lub synthesis ntawm endothelial nitric oxide synthase thiab induces zus tau tej cov nitric oxide ntau. synthase. nitrogen, yog li txo qhov tsim ntawm vascular cell adhesion molecules, ua tiav cov teebmeem los tiv thaiv, thiab ua kom cov teebmeem ntawm cov ntshav lipid txo qis thiab tiv thaiv atherosclerosis.
3. Tswj bulimia
Kev noj zaub mov tsis zoo (BED) yog qhov kev noj zaub mov ntau tshaj plaws, uas tshwm sim los ntawm kev tswj tsis tau, kev noj zaub mov ntau dhau, nrog rau kev xav tsis zoo ntawm kev tswj tsis tau, txaj muag, ua txhaum, qias neeg, thiab kev ntxhov siab.
Txawm hais tias cov xwm txheej uas ua rau kev noj zaub mov tsis zoo tseem tsis tau lees paub, muaj pov thawj tias kev noj zaub mov thiab kev ntxhov siab hauv lub neej yog qhov ua rau muaj kev noj zaub mov ntau. Lwm cov kev tshawb fawb tau pom tias cov txheej txheem neurobiological ntawm kev noj binge tsom rau kev ua kom lub cev mesocortical limbic dopamine (DA) thiab lub hlwb serotonin (5-HT) thiab norepinephrine (NA) signaling.
Oleylethanolamide (OEA) yog ib qho tshwm sim lipid metabolite uas ua lub luag haujlwm tseem ceeb hauv kev noj qab haus huv, tswj lub zog, thiab tswj qhov hnyav. Raws li ib qho tseem ceeb physiological regulator, OEA cuam tshuam nrog peroxisome proliferator-activated receptor α (PPAR-α) los txhawb satiety thiab txhawb cov roj oxidation. Cov kws tshawb fawb tau tshawb nrhiav cov peev txheej kho mob ntawm OEA, ua rau kev txhim kho cov tshuaj oleoylethanolamide tsim los txhawb cov haujlwm no.
Ua ntej yuav khoomOleylethanolamide (OEA) hmoov, xav txog cov hauv qab no:
1. Nkag siab txog OEA
Nws yog dab tsi: OEA yog fatty acid ethanolamide uas ua lub luag haujlwm hauv kev tswj kev qab los noj mov, metabolism, thiab lub zog homeostasis. Nws tuaj yeem pab tswj qhov hnyav, txhim kho lipid metabolism, thiab nce kev siv zog.
2. Zoo thiab Purity
Tau qhov twg los: Kev yuav khoom los ntawm cov neeg muag khoom muaj npe nrov uas muab kev kuaj thib peb rau kev coj dawb huv thiab zoo.
Daim ntawv pov thawj ntawm Kev Ntsuam Xyuas (CoA): Ua kom cov khoom muaj CoA lees paub nws qhov muaj pes tsawg leeg thiab tsis muaj cov khoom paug.
3. Kev siv tshuaj thiab kev siv
Pom zoo noj ntau npaum li cas: Kev tshawb fawb pom zoo ntau npaum li cas thiab sab laj tus kws kho mob rau cov lus pom zoo ntawm tus kheej.
Daim Ntawv Pom Zoo: OEA tuaj ntau hom (hmoov, tshuaj ntsiav). Xaiv ib yam khoom uas haum koj lub neej.
4. Tej yam tshwm sim tshwm sim
Cov Kev Phem Tseem Ceeb: Thaum feem ntau pom tias muaj kev nyab xeeb, qee cov neeg siv yuav muaj kev tsis xis nyob hauv plab lossis lwm yam kev mob tshwm sim me.
Nrog koj tus kws kho mob tham: Yog tias koj muaj mob ua ntej lossis tab tom noj tshuaj, nrog koj tus kws kho mob tham ua ntej siv.
5. Raws li txoj cai
Txoj Cai: Txheeb xyuas qhov xwm txheej raws li txoj cai ntawm OEA hauv koj lub tebchaws raws li cov cai yuav txawv.
6. Cia thiab txee lub neej
Cia Lub Sijhawm: Nco ntsoov tias koj nkag siab tias yuav khaws cov hmoov zoo li cas kom tswj tau nws cov txiaj ntsig zoo.
Hnub Kawg: Txheeb xyuas hnub tas sij hawm kom paub tseeb tias koj tab tom yuav khoom tshiab.
7. Tus nqi thiab tus nqi
Nqe Sib piv: Sib piv cov nqi los ntawm cov neeg muag khoom sib txawv, tab sis yuav tsum ceev faj txog tus nqi qis uas yuav qhia tau qis dua.
Yuav hauv ntau: Yog tias koj npaj yuav siv nws ntev, xav txog kev yuav hauv ntau vim nws tuaj yeem txuag nqi.
8. Ua ke nrog lwm cov tshuaj ntxiv
Synergistic Effects: Tshawb nrhiav yuav ua li cas OEA cuam tshuam nrog lwm cov tshuaj ntxiv lossis kev hloov pauv kev noj haus uas koj xav tau.
Los ntawm kev xav txog cov xwm txheej no, koj tuaj yeem txiav txim siab paub ntau ntxiv thaum yuav oleoylethanolamide hmoov. Ib txwm ua qhov tseem ceeb ntawm kev nyab xeeb thiab zoo thaum xaiv cov khoom ntxiv.
Ploj mus yog cov hnub thaum koj tsis paub qhov twg yuav oleylethanolamine hmoov. Niaj hnub no, muaj ntau qhov chaw uas koj tuaj yeem yuav magnesium acetyl taurate hmoov. Ua tsaug rau internet, koj tuaj yeem yuav txhua yam yam tsis tau tawm hauv koj lub tsev. Ua hauv online tsis tsuas yog ua rau koj txoj haujlwm yooj yim dua, nws tseem ua rau koj txoj kev yuav khoom yooj yim dua. Koj tseem muaj sijhawm los nyeem ntxiv txog qhov zoo kawg nkaus oleoylethanolamine ua ntej koj txiav txim siab yuav.
Suzhou Myland Pharm & Khoom noj khoom haus Inc. yog ib lub chaw tsim tshuaj paus FDA uas muab cov khoom zoo thiab siab dawb huv Oleoylethanolamide (OEA) hmoov.
Ntawm Suzhou Myland Pharm peb tau cog lus los muab cov khoom lag luam zoo tshaj plaws ntawm tus nqi zoo tshaj. Peb Oleoylethanolamide (OEA) hmoov yog nruj me ntsis soj ntsuam rau purity thiab potency, kom ntseeg tau tias koj tau txais cov khoom zoo uas koj tuaj yeem ntseeg tau. Txawm hais tias koj xav txhawb kev noj qab haus huv ntawm tes, txhawb koj lub cev tiv thaiv kab mob lossis txhim kho kev noj qab haus huv tag nrho, peb Oleoylethanolamide (OEA) hmoov yog qhov kev xaiv zoo tshaj.
Nrog 30 xyoo ntawm kev paub thiab tsav los ntawm cov cuab yeej siv siab thiab cov tswv yim zoo R & D, Suzhou Myland Pharm tau tsim ntau yam khoom sib tw thiab dhau los ua lub neej tshiab kev tshawb fawb ntxiv, kev cai synthesis thiab kev tsim cov tuam txhab.
Tsis tas li ntawd, Suzhou Myland Pharm kuj yog ib lub chaw tsim tshuaj paus FDA. Lub tuam txhab R&D cov peev txheej, cov chaw tsim khoom, thiab cov cuab yeej tshuaj ntsuam xyuas yog niaj hnub thiab muaj ntau yam, thiab tuaj yeem tsim cov tshuaj los ntawm milligrams mus rau tons hauv nplai, thiab ua raws li ISO 9001 cov qauv thiab cov khoom tshwj xeeb GMP.
Q: Dab tsi yog Oleoylethanolamide (OEA) thiab nws cov txiaj ntsig yog dab tsi?
A: Oleoylethanolamide (OEA) yog ib qho lipid tshwm sim uas ua lub luag haujlwm hauv kev tswj kev qab los noj mov, metabolism, thiab lub zog sib npaug. Nws feem ntau yog siv los ua kev noj zaub mov ntxiv rau kev tswj qhov hnyav, txhawb kev txaus siab, thiab txhim kho cov rog metabolism.
Q: Kuv yuav txiav txim tau qhov zoo ntawm Oleoylethanolamide hmoov li cas?
A: Txhawm rau txiav txim siab qhov zoo ntawm Oleoylethanolamide hmoov, nrhiav cov khoom uas muab Daim Ntawv Pov Thawj Kev Ntsuam Xyuas (COA) los ntawm lub chaw kuaj thib peb. Tsis tas li ntawd, xyuas cov neeg siv khoom tshuaj xyuas, cov khoom muaj pob tshab, thiab seb cov khoom puas yog dawb los ntawm cov kab mob thiab cov khoom ua kom huv.
Q: Kuv yuav tsum xav txog dab tsi thaum yuav Oleoylethanolamide hmoov?
A: Thaum muas Oleoylethanolamide hmoov, xav txog tej yam xws li qhov chaw ntawm cov khoom, qhov concentration ntawm OEA, muaj cov additives, lub koob npe nrov ntawm cov chaw tsim tshuaj paus, thiab cov neeg muas zaub tawm tswv yim. Nws tseem yog ib qho tseem ceeb uas yuav tau xyuas kom zoo khaws cia thiab tuav cov lus qhia.
Kev lees paub: Kab lus no yog rau cov ntaub ntawv dav dav nkaus xwb thiab yuav tsum tsis txhob raug txhais raws li cov lus qhia kho mob. Qee cov ntaub ntawv blog tshaj tawm los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, formatting thiab kho cov ntawv. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntau ntxiv tsis txhais tau hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Nco ntsoov sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Post lub sij hawm: Sep-27-2024
