Deazaflavins, hluavtaws analogs ntawm riboflavin, dhau los ua cov neeg tseem ceeb hauv enzymatic catalysis thiab redox cov tshuaj tiv thaiv. Lawv cov qauv tshwj xeeb thiab cov khoom siv redox ua rau lawv zoo tagnrho cofactors rau ntau yam enzymes rau kev hloov hluav taws xob zoo thiab kev ua haujlwm catalytic. tuav cov lus cog tseg zoo hauv kev lag luam tshuaj. Nws lub peev xwm ua antioxidant thiab tswj hwm ntawm cellular metabolism qhib txoj hauv kev tshiab rau kev tshawb fawb thiab kev kho mob.
Deazaflavin, derivative ntawm riboflavin thiab ib qho tseem ceeb analogue ntawm ntuj flavin, muaj cov khoom tshwj xeeb uas tau nyiam cov neeg tshawb fawb hauv ntau yam kev tshawb fawb. Deazaflavin, tseem hu ua 7,8-dimethyl-8-hydroxy-5-deazariboflavin, muaj npe tom qab 7th nitrogen atom ntawm isoalloxazine nplhaib ntawm riboflavin yog hloov los ntawm cov pa roj carbon atom.
Qhov kev hloov pauv no txawv ntawm nws cov riboflavin counterpart thiab muab nws cov khoom siv tshuaj lom neeg tshwj xeeb. Nrog nws cov qauv tshwj xeeb, dezaflavin plays lub luag haujlwm tseem ceeb hauv ntau cov txheej txheem lom neeg.
Deazaflavin yog daj-txiv kab ntxwv compound nrog ib tug molecular mis ntawm C16H13N3O2, uas yog yus muaj los ntawm ib tug phenolic hydroxyl pab pawg neeg ntawm 8-txoj hauj lwm.
Ib qho ntawm cov haujlwm tseem ceeb ntawm deazaflavin yog koom nrog hauv biosynthesis ntawm cofactor F420, uas muaj nyob rau hauv qee cov kab mob, archaea thiab qis eukaryotes. Raws li ib qho tseem ceeb electron cab kuj, F420 plays lub luag hauj lwm nyob rau hauv redox cov tshuaj tiv thaiv thiab sai hloov electrons ntawm enzymes. Lub xub ntiag ntawm deazaflavin yog qhov tseem ceeb rau cov kauj ruam kawg ntawm F420 synthesis, hloov riboflavin mus rau F420 thiab ua rau nws ntau txoj haujlwm lom.
Cov txiaj ntsig zoo ntawm dezaflavin:
●tiv thaiv kab mob
●Boosts Cellular Energy Production
●Antioxidant thiab anti-inflammatory zog
●Txhawb nqa lub hlwb noj qab haus huv thiab muaj nuj nqi
●kev tiv thaiv kab mob
1. Anti-aging / anti-aging
5-Desaflavin hmoov yog cov khoom muaj zog tiv thaiv kev laus uas tau txais koob meej hauv kev noj qab haus huv thiab kev noj qab haus huv kev lag luam. Nws paub tias yuav txhawb lub cev tsim NAD +, acoenzymeuas plays lub luag haujlwm tseem ceeb hauv lub zog metabolism thiab kho cellular.
2. Tiv thaiv kab mob
Deazaflavins ua lub luag haujlwm tseem ceeb hauv cov txheej txheem ntawm erythropoiesis. Nws pab tswj kev tsim thiab ua haujlwm ntawm cov qe ntshav liab thiab tiv thaiv cov kab mob xws li ntshav liab.
3. Boosts Cellular Energy Production
Ib qho ntawm cov txheej txheem tseem ceeb uas deazaflavin siv nws cov txiaj ntsig kev noj qab haus huv yog los ntawm kev txhim kho cellular zog. Zoo li riboflavin, deazaflavin ua ib qho tseem ceeb coenzyme hauv cellular metabolism. Los ntawm kev koom tes hauv cov saw hlau thauj khoom siv hluav taws xob thiab lwm cov tshuaj tiv thaiv enzymatic, deazaflavin txhawb kev tsim hluav taws xob zoo, ua kom pom kev ua haujlwm ntawm tes. Cov cuab yeej no tsis tsuas yog pab tiv thaiv kev qaug zog, tab sis kuj txhawb nqa tag nrho lub zog thiab kev noj qab haus huv.
4. Antioxidant thiab anti-inflammatory zog
Cov kev tshawb fawb tau pom tias deazaflavin muaj cov khoom muaj zog antioxidant uas ua lub luag haujlwm tseem ceeb hauv kev txo qis oxidative kev nyuaj siab thiab tiv thaiv cov teeb meem ntawm cov dawb radicals hauv lub cev. Oxidative kev nyuaj siab yog cuam tshuam nrog ntau yam kab mob, nrog rau cov kab mob plawv, kab mob neurodegenerative, thiab mob qog noj ntshav. Lub peev xwm dawb radical-scavenging ntawm deazaflavin tuaj yeem pab tiv thaiv lub cev los ntawm cov kab mob no thiab txhawb nqa tag nrho lub neej ntev.
Tsis tas li ntawd, kev tshawb fawb tshiab qhia tau tias Deazaflavin muaj cov tshuaj tiv thaiv kab mob. Kev mob ntev yog qhov ua rau muaj ntau yam teeb meem kev noj qab haus huv. Los ntawm kev hloov kho cov lus teb inflammatory, deazaflavin tuaj yeem pab kho thiab tiv thaiv kab mob xws li mob caj dab, mob hawb pob, thiab kab mob autoimmune.
5. Txhawb nqa lub hlwb noj qab haus huv thiab muaj nuj nqi
Cov txiaj ntsig neuroprotective ntawm deazaflavin kuj yog qhov txaus siab rau cov kws tshawb fawb kawm paub txog kev paub thiab kev noj qab haus huv ntawm lub hlwb. Cov kab mob neurodegenerative xws li Alzheimer's disease thiab Parkinson's disease tau dhau los ua teeb meem kev noj qab haus huv loj thoob ntiaj teb. Lub peev xwm ntawm deazaflavins los txhim kho cellular zog ntau lawm nrog rau cov tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob ua rau lawv cov neeg sib tw rau kev txo cov teebmeem ntawm cov kab mob no.
Tsis tas li ntawd, kev tshawb fawb ua ntej qhia tias Deazaflavin tuaj yeem txhawb kev nco thiab kev txawj ntse, ua rau nws muaj peev xwm ua phooj ywg hauv kev tawm tsam hnub nyoog txog kev paub txog kev poob qis thiab txhim kho tag nrho lub hlwb kev noj qab haus huv. Txawm li cas los xij, xav tau kev tshawb fawb ntau ntxiv kom nkag siab txog qhov cuam tshuam ntawm deazaflavin rau lub hlwb.
6. Kev them nyiaj yug lub cev tiv thaiv kab mob
Peb lub cev tiv thaiv kab mob yog peb lub cev tiv thaiv kab mob thiab kab mob. Lub luag haujlwm ntawm deazaflavin yog ib qho tseem ceeb coenzyme nyob rau hauv ntau yam enzymatic cov tshuaj tiv thaiv kuj txuas rau lub cev tsis muaj zog. Kev txhawb nqa lub cev tiv thaiv kab mob muaj zog yog qhov tseem ceeb rau kev saib xyuas kev noj qab haus huv thiab tiv thaiv kab mob. Los ntawm kev txhawb nqa kev tsim hluav taws xob thiab kev noj qab haus huv ntawm tes tag nrho, deazaflavins tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev txhawb kev tiv thaiv kab mob thiab ua kom peb lub cev muaj peev xwm tawm tsam cov kab mob.
Deazaflavin yog ib qho khoom noj tseem ceeb uas ua lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem physiological. Cov hauv qab no yog qee qhov tshwm sim thiab cov tsos mob ntawm dezaflavin deficiency:
Teeb meem ntawm daim tawv nqaij thiab mucous membrane: Deazaflavin deficiency tuaj yeem ua rau kev txhim kho ntawm daim tawv nqaij mob xws li dermatitis, daim di ncauj qhuav los yog chapped, thiab mob caj pas. Qhov chaw ntawm daim tawv nqaij tej zaum yuav qhuav, scaly, los yog o.
Teeb meem qhov muag: Hauv cov xwm txheej hnyav, deazaflavin tsis txaus tuaj yeem ua rau muaj teeb meem ntawm qhov muag xws li photosensitivity thiab qhov muag tsis pom kev.
Ntshav Qab Zib: Deazaflavin yog qhov tseem ceeb rau kev tsim cov qe ntshav liab. Nws qhov tsis txaus tuaj yeem ua rau muaj ntshav tsis txaus, uas yog tus cwj pwm los ntawm cov qe ntshav liab tsawg thiab tsis muaj peev xwm nqa oxygen, ua rau qaug zog, tsis muaj zog thiab ua tsis taus pa.
Teeb meem ntawm qhov ncauj thiab qhov ncauj: Deazaflavins deficiency tuaj yeem ua rau muaj teeb meem kev noj qab haus huv ntawm qhov ncauj xws li glossitis (o ntawm tus nplaig), daim di ncauj tawg, thiab qhov ncauj qhov ncauj.
Cov tsos mob ntawm neurologic: Txawm hais tias tsis tshua muaj, qhov tsis txaus deazaflavin hnyav tuaj yeem cuam tshuam rau lub paj hlwb, ua rau cov tsos mob ntawm lub paj hlwb xws li kev paub tsis meej, tsis meej pem, thiab puas hlwb.
Deazaflavin yog ib hom tshuaj hloov kho ntawm riboflavin (tseem hu uavitamin B2). Nws yog siv los ua cofactor rau ntau yam enzymes hauv biotechnology thiab molecular biology daim ntaub ntawv. Nov yog qee cov lus qhia dav dav txog kev siv deazaflavin:
Xyuas kom tseeb tias koj muaj cov tshiab, cov khoom lag luam zoo tshaj plaws muaj ua ntej siv dezaflavin. Desaflavin feem ntau muaj nyob rau hauv cov hmoov los yog khoom, yog li koj yuav tsum tau yaj nws nyob rau hauv ib tug haum hnyav, xws li dej los yog ib tug buffered tov. Yog tias muaj, ua raws li cov chaw tsim khoom cov lus qhia rau kev kho dua tshiab.
Deazaflavins rhiab heev rau lub teeb, tshav kub thiab oxidation. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum khaws cov tshuaj nyob rau hauv ib qho chaw tsaus, txias thiab tiv thaiv nws los ntawm kev raug huab cua ntev. Xav txog aliquoting cov tshuaj hauv Tshuag rau hauv cov khoom me me pov tseg kom txo qis degradation.
Qhov tshwj xeeb ntawm dezaflavin xav tau yuav txawv nyob ntawm qhov enzyme lossis cov tshuaj tiv thaiv tau kawm. Nws raug nquahu kom sab laj cov ntaub ntawv lossis sab laj nrog tus kws tshaj lij hauv daim ntawv thov xav tau los txiav txim siab qhov sib txawv uas tsim nyog.
Deazaflavins feem ntau yog siv los ntawm kev ntxiv lawv rau cov tshuaj tiv thaiv sib xyaw lossis cov tshuaj enzymatic. Lub sij hawm incubation yuav txawv nyob ntawm seb cov txheej txheem kev sim tshwj xeeb. Ua raws li cov chaw tsim khoom cov lus qhia lossis sab laj nrog cov ntaub ntawv muaj feem xyuam rau lub sijhawm thiab cov xwm txheej zoo.
Nws yog ib qho tseem ceeb kom suav nrog cov lus teb tsim nyog lossis tswj pawg tsis muaj dezaflavin hauv kev sim tsim. Cov kev tswj hwm no yuav pab koj sib txawv cov teebmeem tshwm sim los ntawm deazaflavin los ntawm lwm yam hauv koj lub cev.
Cov ntaub ntawv kev sim, kev soj ntsuam, thiab ua rau muaj cov ntaub ntawv zoo. Ua tib zoo tshuaj xyuas thiab txhais cov ntaub ntawv tau los ntawm kev sim, sib piv cov txiaj ntsig nrog kev tswj kom tsim nyog.
Nco ntsoov tias cov no yog cov lus qhia dav dav thiab kev siv tshwj xeeb thiab cov txheej txheem yuav txawv nyob ntawm seb koj qhov kev sim tshwj xeeb thiab daim ntawv thov npaj. Nco ntsoov sab laj cov ntaub ntawv uas cuam tshuam los yog nrhiav cov lus qhia ntawm tus kws tshaj lij hauv koj daim teb rau cov lus qhia tseeb tshaj plaws rau ib qho kev sim.
Kev nyab xeeb ntawm deazaflavin
Thaum txiav txim siab txog kev nyab xeeb ntawm deazaflavin, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias qhov sib xyaw ua ke tau dhau los ua qhov kev kuaj mob hnyav thiab kuaj tsiaj txhawm rau txiav txim siab nws cov tshuaj lom thiab muaj peev xwm cuam tshuam. Cov kev tshawb fawb no tau tshaj tawm tsis pom qhov mob hnyav lossis mob toxicity, qhia txog lub ntsiab lus ntawm kev nyab xeeb tag nrho. Txawm li cas los xij, nws yog ib qho tseem ceeb rau kev sim tshuaj ntsuam xyuas ntxiv los ntsuas nws txoj kev nyab xeeb hauv tib neeg.
Deazaflavin cov kev mob tshwm sim:
Thaum cov kev tshawb fawb preclinical tsis tau tshaj tawm cov kev mob tshwm sim tseem ceeb ntawm deazaflavin, nws yog ib qho tseem ceeb kom ceev faj txog kev siv. Raws li nrog txhua qhov sib xyaw, kev sim tshuaj ntxiv yog xav tau los ntsuas nws txoj kev nyab xeeb hauv tib neeg thiab txheeb xyuas cov kev mob tshwm sim lossis kev cuam tshuam ntawm cov tshuaj. Kev noj tshuaj kom raug, kev tswj hwm thiab kev saib xyuas tus neeg mob yuav yog qhov tseem ceeb kom ntseeg tau tias nws siv tau zoo.
Q: Nws siv sijhawm ntev npaum li cas rau dezaflavin ua haujlwm?
A: Cov teebmeem ntawm Calcium deazaflavin tuaj yeem sib txawv nyob ntawm tus neeg, ntau npaum li cas, thiab kev tswj hwm. Txawm li cas los xij, feem ntau, nws ntseeg tau tias deazaflavin yuav siv sijhawm nyob qhov twg los ntawm ob peb feeb mus rau ob peb teev los pib ua haujlwm. Nws raug nquahu kom sab laj nrog tus kws kho mob lossis ua raws li cov lus qhia los ntawm cov chaw tsim khoom kom paub meej ntxiv txog yuav siv sijhawm ntev npaum li cas rau qhov sib xyaw no kom siv tau.
Kev lees paub: Kab lus no yog siv rau cov ntaub ntawv xov xwm nkaus xwb thiab yuav tsum tsis txhob suav hais tias yog cov lus qhia kho mob. Nco ntsoov sab laj nrog kws kho mob ua ntej siv cov tshuaj los yog hloov koj cov kev kho mob.
Post lub sij hawm: Lub Xya hli ntuj-10-2023
