NAD lub npe scientific yog nicotinamide adenine dinucleotide. NAD + muaj nyob rau hauv txhua lub cell ntawm peb lub cev. Nws yog ib qho tseem ceeb metabolite thiab coenzyme nyob rau hauv ntau yam metabolic txoj kev. Nws kho thiab koom nrog ntau yam txheej txheem lom neeg. Ntau tshaj 300 enzymes nyob ntawm NAD + Ua haujlwm. Txawm li cas los xij, cov ntsiab lus ntawm NAD + tsis zoo li qub. Raws li peb muaj hnub nyoog, cov ntsiab lus ntawm NAD + hauv hlwb yuav txo qis. Tshwj xeeb tshaj yog tom qab muaj hnub nyoog 30 xyoo, qib ntawm NAD + yuav poob qis, ua rau poob ntawm ntau lub zog thiab yog li qhia cov tsos mob ntawm kev laus. Nicotinamide riboside chloride yog ib daim ntawv ntawm vitamin B3. Nicotinamide riboside chloride tuaj yeem hloov mus rau hauv NAD + (nicotinamide adenine dinucleotide). Nws yog ib qho ntawm feem ntau kawm NAD + precursors. Nws yog yooj yim absorbed los ntawm lub cev thiab siv. Ntau cov kev tshawb fawb tau pom tias kev ntxiv NRC tuaj yeem nce qib NAD +, uas tuaj yeem ua rau muaj txiaj ntsig zoo rau cov kab mob metabolic, hlab plawv thiab lub paj hlwb. Nws feem ntau yog siv los ua kev noj zaub mov ntxiv los txhawb kev noj qab haus huv thiab kev noj qab haus huv.
Nicotinamide riboside chloride (NRC) yog ib tug derivative ntawm vitamin B3 thiab ib tug tshiab bioactive tshuaj. Nws yog tsim los ntawm cov piam thaj molecule ribose thiab vitamin B3 tivthaiv nicotinamide (tseem hu ua nicotinic acid lossis vitamin B3). Nws tuaj yeem noj tau los ntawm kev noj nqaij, ntses, zaub mov thiab lwm yam khoom noj lossis los ntawm NRC cov tshuaj ntxiv.
Nicotinamide ribose chloride tuaj yeem hloov mus rau hauv NAD + (nicotinamide adenine dinucleotide) thiab tawm dag zog hauv cov hlwb. NAD + yog ib qho tseem ceeb intracellular coenzyme uas koom nrog ntau yam cellular metabolic dab, nrog rau kev tsim hluav taws xob, kho DNA, cell proliferation, thiab lwm yam. Thaum lub sij hawm kev laus ntawm tib neeg lub cev, cov ntsiab lus ntawm NAD + maj mam txo. Nicotinamide riboside chloride supplementation tuaj yeem nce qib ntawm NAD +, uas yuav tsum ncua qhov tshwm sim ntawm cell aging thiab lwm yam kab mob.
Kev tshawb fawb ntawm nicotinamide riboside chloride tau qhia tias nws muaj ntau yam kev ua ub no, xws li:
Txhim kho cov metabolism hauv lub zog, txhim kho kev ua siab ntev thiab kev ua haujlwm;
Txhim kho neurological muaj nuj nqi thiab nco;
Txhim kho lub cev tiv thaiv kab mob ua haujlwm.
Zuag qhia tag nrho, nicotinamide riboside chloride yog ib qho kev cog lus nutraceutical zoo heev nrog rau kev siv dav dav.
Tsis tas li ntawd, nicotinamide ribose chloride kuj tau siv dav hauv kev tshawb fawb tshawb fawb. Raws li cov khoom siv ua ntej ntawm NAD +, nws tuaj yeem siv los kawm txog biosynthesis thiab metabolic txoj hauv kev ntawm NAD + thiab lwm yam teeb meem. Nyob rau tib lub sijhawm, nicotinamide riboside chloride kuj tseem siv los ua cov khoom siv kho mob thiab tshuaj pleev ib ce los txhawb kev noj qab haus huv ntawm tes thiab txo cov tawv nqaij laus.
Kev laus yog lub ntsiab lus nyob mus ib txhis rau tib neeg. Raws li kev tshawb fawb los ntawm cov kws tshawb fawb, cell aging yog ze ze rau kev txo qis ntawm nicotinamide adenine dinucleotide (NAD) cov ntsiab lus. NAD yog qhov txuas tseem ceeb hauv cov metabolism thiab kho cell hauv tib neeg lub cev. Nws tuaj yeem tsis tsuas yog ncua kev laus, tab sis kuj tswj cov cell tseem ceeb thiab tswj lub cev thiab lub hlwb. tab sis. Raws li peb muaj hnub nyoog, qib NAD hauv peb lub cev poob qis dua thiab nrawm dua, thiab tej zaum yuav poob ntau dua li ib nrab ntawm cov hnub nyoog 40 thiab 80.
Muaj ib qho tseem ceeb heev enzyme nyob rau hauv peb lub cev, uas yog lub hauv paus ntsiab lus ntawm cellular zog metabolism. Nws tseem ceeb npaum li cas? Yuav luag tag nrho cov txheej txheem uas tswj kev ua haujlwm ntawm lub cev, xws li cov metabolism, kho, thiab kev tiv thaiv, yuav tsum muaj kev koom tes ntawm cov enzyme no. Thaum cov qib ntawm cov enzyme no poob qis, ntau cov tsos mob thiab cov kab mob cuam tshuam nrog kev laus tuaj yeem tshwm sim, xws li cov kab mob metabolic, lub cev tsis muaj zog, kev txawj ntse poob, thiab lwm yam. Cov enzyme tseem ceeb no muaj lub npe ntev: nicotinamide adenine dinucleotide, lossis NAD +.
Hauv luv luv, qhov txo qis ntawm NAD + hauv lub cev txhais tau tias kev laus. Yog li, peb puas tuaj yeem ntxiv NAD + rau lub cev kom ncua kev laus? Yog tias koj ncaj qha ntxiv NAD +, tib neeg lub cev yuav tsis tuaj yeem nqus tau nws, thiab nws yuav muaj kev phiv loj heev. Yog li ntawd, tib neeg tig lawv lub siab rau cov khoom ua ntej ntawm NAD +: nicotinamide ribose chloride (NRC).
Nicotinamide riboside chloride yog ib daim ntawv ntawm vitamin B3 thiab ib qho ntawm feem ntau kawm NAD + precursors. Nws yog yooj yim absorbed thiab siv los ntawm lub cev. Ntau cov kev tshawb fawb tau pom tias kev ntxiv NR tuaj yeem nce qib NAD +, uas tuaj yeem ua rau muaj txiaj ntsig zoo rau cov kab mob metabolic, hlab plawv thiab lub paj hlwb.
Lo lus "anti-aging" tau txais qhov phem rap. Nws zoo li peb tab tom sim txwv qee yam uas twb tau ua lawm, lossis peb tsis muaj peev xwm tuav tau ntawm peb tus kheej uas peb yuav tsum hlub. Tab sis qhov tseeb yog qhov hloov pauv metabolic tshwm sim hauv qab ntawm daim tawv nqaij ua ntej peb pom cov teebmeem ntawm kev laus. Kev xaiv los ua kom peb txoj kev noj qab haus huv los ntawm sab hauv tuaj yeem yog qhov peb xav tau los txhim kho txoj kev peb hnub nyoog.
Qhov tseeb, ib qho ntawm cov cim ntawm kev laus yog cov txheej txheem hu ua "mitochondrial dysfunction," ib lo lus uas hais txog kev poob ntawm lub zog thiab kev ua haujlwm ntawm peb lub hlwb thaum lub sijhawm. Qhov no tej zaum yuav yog ib qho laj thawj vim li cas peb muaj hnub nyoog. Yog tias mitochondria nyob hauv plawv ntawm peb cov laus, nws tsim nyog tshawb xyuas txhua txoj hauv kev kom lawv ua haujlwm ntev li ntev tau.
Kawm txog mitochondria.
Nyob rau hauv yuav luag txhua lub cell yog cov me me, oddly zoo li organelles hu ua mitochondria - "lub zog ntawm lub cell." Cov kabmob me me no yog lub luag haujlwm tsim 90% ntawm lub zog uas peb lub cev xav tau. Mitochondria yog vim li cas peb nyob niaj hnub no raws li cov tsiaj txhu nyuaj dua li cov kab mob.
Peb yeej tsis paub tias mitochondria tseem ceeb npaum li cas rau peb txoj kev noj qab haus huv. Ib txoj hauv kev tseem ceeb los ua kom koj cov mitochondria noj qab nyob zoo yog lub molecule hu ua NAD + (nicotinamide adenine dinucleotide). Peb cov hlwb ib txwm tsim NAD + thiab peb siv nws tsis tu ncua txhua hnub.
Peb kuj paub tias peb cov khoom ntawm NAD + poob qis thaum peb muaj hnub nyoog. Thaum cov kws tshawb fawb pom tau tias NAD + tuaj yeem tuav tus yuam sij ua kom peb lub hlwb noj qab haus huv, lawv tau sib cav los nrhiav txoj hauv kev los ua kom tau zoo tshaj plaws.
Cov kws tshawb fawb twb paub lawm tias ob cov vitamins pib cov txheej txheem tshuaj ntawm NAD +: niacin thiab niacinamide. Cov no tau pom nyob rau xyoo 1930 los kho pellagra, qhov ua rau muaj vitamin B3 tsis txaus.
Niacin kuj tseem yuav dhau los ua kev kho mob rau cov roj cholesterol siab hauv xyoo 1950s. Txawm li cas los xij, nws tau pom tias kev noj ntau ntawm niacin tuaj yeem ua rau muaj kev cuam tshuam ntawm daim tawv nqaij uas ua rau khaus thiab tsis pom.
Niacinamide tsis ua rau cov tawv nqaij ua kom tawv nqaij thiab tuaj yeem muab ntau yam txiaj ntsig zoo ib yam, tab sis nws inhibits kev ua kom cov cell kho tseem ceeb-txhawb cov proteins hu ua sirtuins. Tsis yog niacinamide lossis niacin tsis zoo li cov kws tshawb fawb tau cia siab.
Txawm hais tias ob cov vitamins no yog NAD + precursors, lawv tsis yog ib qho kev daws teeb meem zoo tshaj plaws. Vim tias qhov tsis zoo ntawm niacin thiab cov txiaj ntsig zoo ntawm nicotinamide, cov kws tshawb fawb tseem tsis muaj cov tshuaj vitamin txaus kom nce qib NAD +.
Kev tshawb pom ntawm nicotinamide riboside.
Lwm daim ntawv ntawm vitamin B3 hu ua nicotinamide riboside tau pom nyob rau hauv cov poov xab hauv xyoo 1940. Tab sis nws tsis yog txog thaum xyoo 2000s uas cov kws tshawb fawb tau pib pom lub peev xwm ntawm cov vitamin thib peb, B3, tsis tsuas yog nce NAD + tab sis kuj txhim kho tib neeg kev noj qab haus huv. Hauv xyoo 2004, pab pawg tshawb fawb hauv Dartmouth College tau tshawb pom tias nicotinamide riboside, zoo li nws cov kwv tij vitamin B3, yog tus thawj coj rau NAD +.
Pab pawg tshawb fawb coj los ntawm Dr. Charles Brenner pom tias nicotinamide riboside nce NAD + hauv cov nas, thiab cov nas tau ntsib ntau yam txiaj ntsig kev noj qab haus huv raws li qhov tshwm sim.
Cov nas tau pom txhua yam los ntawm kev txhim kho cov ntshav qab zib thiab cov roj cholesterol kom txo cov hlab ntsha puas thiab tiv thaiv qhov hnyav nce. Dr. Charles Brenner pom cov txiaj ntsig zoo li no txhawb kom nws ua cov kauj ruam tom ntej kom nkag siab txog qhov cuam tshuam ntawm nicotinamide riboside rau tib neeg kev noj qab haus huv.
Xyoo 2014, Dr. Brenner tau los ua thawj tus neeg noj nicotinamide riboside ua ib qho ntxiv. Cov txiaj ntsig tau sib npaug txhawb nqa. Daim ntawv no kuj tsis paub txog ntawm vitamin B3 ua rau nws nce qib NAD + kom nyab xeeb, sai, thiab tsis muaj kev phiv tsis zoo.
Nicotinamide riboside siv txoj hauv kev tshwj xeeb los tsim NAD + uas tsis muaj lwm yam vitamin B3 siv.
Nicotinamide riboside kuj tseem tuaj yeem qhib lub cell kho-txhim kho cov proteins sirtuins. Raws li peb muaj hnub nyoog, cov sirtuins no ua haujlwm tshaj sijhawm los pab cov hlwb kom muaj zog.
Kev noj qab haus huv thaum koj muaj hnub nyoog yuav tsis yooj yim li ib qho vitamin, txawm tias muaj ib qho kev cog lus zoo li nicotinamide riboside. Muaj ntau tshaj 100 qhov kev tshawb fawb tshawb xyuas nicotinamide riboside, ntau qhov qhia tau hais tias nce NAD + ntau ntau cuam tshuam nrog metabolic thiab nqaij mob hauv nas. Kev tshawb fawb ntxiv tau txuas ntxiv kom nkag siab txog lub luag haujlwm ntawm NAD + hauv kev txhawb nqa lwm yam kev noj qab haus huv uas muaj hnub nyoog, suav nrog kev ua haujlwm siab hauv siab, qhov hnyav nce, qib insulin thiab lub hlwb ua haujlwm hauv nas.
NAD yog dab tsi?
NAD + yog coenzyme I, uas yog coenzyme uas hloov cov protons (ntau dua, hydrogen ions) thiab koom nrog ntau yam kev ua ub no xws li cellular cov khoom metabolism, lub zog synthesis, thiab kho DNA. NAD + yog ib qho khoom noj tsim nyog rau kev ua haujlwm ntawm Sirtuin protein, uas yog hu ua "kev ua neej ntev" los ntawm cov kws tshawb fawb. Tshwj xeeb, nws tuaj yeem tswj tau qhov ntev ntawm cov telomeres tseem ceeb, ua kom cov txheej txheem kev laus thiab ua kom lub neej ntev.
NAD + tuaj yeem txhawb nqa kev kho noob thiab ncua kev laus ntawm tes. NAD + txhawb nqa cell rov tsim dua tshiab thiab tiv thaiv kab mob hauv lub cev. NAD + txhim kho chromosome stability thiab txo txoj kev pheej hmoo ntawm mob qog noj ntshav.
Lawv yog cov enzymes 'cov phooj ywg zoo tshaj plaws, pab roj "cov tshuab ntawm tes" uas tsim lub zog xav tau rau txhua txoj haujlwm tseem ceeb hauv koj lub cev ntawm qib cellular.
Vim li cas NAD + tseem ceeb?
Vim nws lub luag haujlwm tseem ceeb hauv kev tsim hluav taws xob ntawm tes, qhov tsis muaj NAD + hauv koj lub cev ua rau lub cev ua haujlwm tsis zoo. Yog tsis muaj NAD, koj lub ntsws yuav tsis tuaj yeem nqa oxygen, koj lub plawv yuav tsis tuaj yeem tso ntshav, thiab koj lub hlwb synapses yuav tsis tua.
NAD + kuj tseem pab txhawb DNA kho thiab tswj kev ua haujlwm ntawm tes los ntawm kev ua haujlwm nrog sirtuins thiab poly (ADP-ribose) polymerases (PARPs), uas yog qhov tseem ceeb hauv kev tswj cov cellular teb rau kev thuam xws li overeating, haus cawv, cuam tshuam kev pw tsaug zog, thiab sedentary qauv. Enzymes.
NAD + thiab kev laus
Kev tshawb fawb tau ua nyob rau hauv 2012 los ntawm ib pab neeg los ntawm Department of Pharmacology ntawm University of New South Wales qhia tias NAD metabolism yog txuam nrog hnub nyoog. Txoj kev tshawb no qhia tau hais tias NAD + qib hauv tib neeg daim tawv nqaij poob mus txog 50% ntawm cov hnub nyoog 40 thiab 60, thiab tias NAD + depletion tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev laus.
"Kev sib raug zoo tsis zoo tau pom ntawm NAD + qib thiab hnub nyoog ntawm ob tus txiv neej thiab poj niam," cov kws tshawb fawb tau hais hauv daim ntawv.
Tsis tas li ntawd, NAD koom nrog hauv kev ua pa ntawm tes, tshwj xeeb tshaj yog nyob rau hauv mitochondria, thiab pab txhawb rau tag nrho mitochondrial kev noj qab haus huv. Muaj kev txaus siab rau kev tshawb fawb hauv kev koom tes ntawm NAD hauv mitochondrial dysfunction, ib qho ntawm cov cim ntawm kev laus.
Hauv xyoo tas los no, kev tshawb fawb tau tsom mus rau kev nkag siab lub luag haujlwm ntawm NAD hauv kev hais txog cov hnub nyoog cuam tshuam txog kev ua haujlwm poob qis.
Nicotinamide Ribose Chloride nce NAD + qib.
NR yog qhov ua ntej rau NAD, uas txhais tau tias nws yog "lub tsev thaiv" los ntawm NAD + molecules tau tsim. Nws tau pom nyob rau hauv 2004 raws li ib tug vitamin precursor rau NAD +, ua rau nws yog ib tug ntawm qhov tseeb breakthroughs nyob rau hauv NAD + kev tshawb fawb.
NR yog ib qho tshuaj vitamin uas tshwm sim thiab ib daim ntawv tshiab ntawm vitamin B3, tab sis nws siv los ua ib qho ntxiv tau cuam tshuam los ntawm "kev laus noj qab haus huv" cov vitamins. Nws muaj txiaj ntsig zoo ntawm kev nce NAD, ua rau nws yog ib qho kev pabcuam zoo siab tshaj plaws hauv kev noj qab haus huv kev laus.
NR tuaj yeem nce qib NAD + zoo. Ib qho kev sim tshuaj ntsuam luam tawm hauv Kev Tshaj Tawm Txog Kev Tshawb Fawb tau pom tias nws nce NAD + txog li 50% tom qab ob lub lis piam ntawm kev noj nws.
Txawm hais tias NR supplementation tau raug pov thawj hauv kev kho mob kom nce NAD + ntau ntau, NAD + supplementation raws li cov khoom muaj nyob ib leeg tsis zoo.
NAD + yog cov molecule loj heev thiab tsis tuaj yeem nkag mus rau cov hlwb ncaj qha. Hloov chaw, koj lub cev yuav tsum tau tawg mus rau hauv me me ua ntej nws tuaj yeem hla lub cell membrane. Cov khoom no yog reassembled hauv lub roj teeb.
Nicotinamide riboside (NR) thiab Nicotinamide riboside chloride (NRC) yog ob hom vitamin B3, tseem hu ua niacin. Vitamin B3 yog cov khoom noj tseem ceeb uas ua lub luag haujlwm tseem ceeb hauv ntau lub cev ua haujlwm, suav nrog kev tsim hluav taws xob, kho DNA, thiab cov metabolism hauv cell. Ob NR thiab NRC yog precursors ntawm nicotinamide adenine dinucleotide (NAD +), ib coenzyme koom nrog ntau yam kev lom neeg, xws li tswj cellular zog tsim thiab txhawb DNA kho.
Nicotinamide riboside (NR) yog ib daim ntawv ntawm vitamin B3 uas tau txais kev saib xyuas rau nws lub peev xwm los tiv thaiv kev laus thiab lub zog txhawb zog. Nws yog ib qho tshwm sim tshwm sim nyob rau hauv cov kab mob hauv qee cov khoom noj, tab sis nws kuj muaj nyob rau hauv kev noj haus ntxiv. NR paub txog nws lub peev xwm los nce NAD + qib hauv lub cev, uas tuaj yeem txhawb nqa kev ua haujlwm mitochondrial, txhim kho cellular zog, thiab tuaj yeem muab kev tiv thaiv kev poob qis ntawm lub hnub nyoog.
Nicotinamide riboside chloride (NRC), ntawm qhov tod tes, yog daim ntawv ntsev ntawm NR thiab feem ntau siv hauv kev noj zaub mov. Ntxiv cov tshuaj chloride rau NR ua rau NRC, uas ntseeg tau tias yuav txhim kho qhov sib xyaw kom ruaj khov thiab bioavailability. Qhov no txhais tau hais tias NRC yuav muaj kev nqus tau zoo dua thiab siv hauv lub cev dua li NR ib leeg thiab tuaj yeem ua rau muaj kev cuam tshuam ntau dua ntawm NAD + qib thiab kev ua haujlwm ntawm tes.
Ib qho ntawm qhov sib txawv tseem ceeb ntawm NR thiab NRC yog lawv cov qauv tshuaj. NR yog lub hauv paus daim ntawv ntawm no compound, thaum NRC yog ib tug hloov kho version nrog ntxiv chloride. Qhov kev hloov kho no yog npaj los ua kom cov compound solubility thiab bioavailability, ua rau nws yooj yim rau lub cev nqus thiab siv nws.
Hais txog lawv cov txiaj ntsig kev noj qab haus huv, NR thiab NRC tau xav tias muaj kev cuam tshuam zoo sib xws vim lawv muaj peev xwm nce ntxivNAD+qib. Cov teebmeem no yuav suav nrog kev txhim kho mitochondrial, txhim kho cov metabolism hauv lub zog, thiab muaj peev xwm txhawb nqa kev noj qab haus huv ntawm cellular tag nrho. Txawm li cas los xij, kev siv NRC hauv ib qho ntxiv tuaj yeem ua rau muaj txiaj ntsig ntxiv ntawm kev nqus tau zoo dua thiab siv, uas ua rau muaj txiaj ntsig zoo dua piv rau kev siv NR ib leeg.
1. Txhim kho cellular zog ntau lawm
Ib qho ntawm cov txiaj ntsig tseem ceeb tshaj plaws ntawmnicotinamide riboside chloride yog nws lub luag haujlwm hauv kev txhim kho cellular zog ntau lawm. NR yog tus thawj coj ntawm nicotinamide adenine dinucleotide (NAD +), coenzyme uas ua lub luag haujlwm hauv kev tsim cov adenosine triphosphate (ATP), lub xov tooj ntawm lub zog tseem ceeb. lub luag haujlwm tseem ceeb. Raws li peb muaj hnub nyoog, NAD + qib txo qis, ua rau txo qis cellular zog. Los ntawm kev ntxiv nrog NR, nws ntseeg tau tias NAD + qib tuaj yeem rov ua dua, yog li txhawb nqa cov cellular zog metabolism.
2. Mitochondrial muaj nuj nqi thiab lifespan
Mitochondria yog lub zog ntawm lub cell, lub luag haujlwm tsim lub zog thiab tswj cov txheej txheem ntawm tes. Kev tshawb fawb qhia tau hais tias Nicotinamide Riboside Chloride tuaj yeem pab txhawb kev ua haujlwm mitochondrial los ntawm kev txhawb nqa biogenesis ntawm mitochondria tshiab thiab ua kom lawv cov txiaj ntsig zoo. Qhov no muaj feem cuam tshuam rau tag nrho lub neej thiab kev laus noj qab haus huv, raws li kev ua haujlwm zoo ntawm mitochondria yog qhov tseem ceeb rau kev tswj hwm cellular kev noj qab haus huv thiab kev ua haujlwm zoo.
3. Metabolic noj qab haus huv thiab tswj qhov hnyav
NAD + yog coenzyme, lossis cov khoom siv molecule, koom nrog ntau yam tshuaj lom neeg. Ib txoj kev tshawb fawb tsis ntev los no tau pom tias nicotinamide ribose supplementation tuaj yeem txhawb NAD + cov metabolism hauv cov neeg laus hnub nyoog nruab nrab thiab cov laus. Tsis tsuas yog NR cov tshuaj tau txais txiaj ntsig zoo los ntawm cov neeg koom, lawv tuaj yeem pab txo cov ntshav siab thiab cov hlab ntsha. NAD + tsis muaj peev xwm yog ib qho tseem ceeb ua rau kev laus thiab ntau yam kab mob, thiab kev tshawb fawb qhia tau hais tias kev kho cov qib NAD + muaj txiaj ntsig zoo heev thiab noj zaub mov zoo.
Los ntawm kev nce qib NAD +, nicotinamide ribose tau txais txiaj ntsig kev tswj hwm cov metabolism, lub zog cia, DNA synthesis, thiab lwm yam haujlwm hauv lub cev.
Tsis tas li ntawd, cov kev tshawb fawb tau pom tias NR supplementation tuaj yeem txhim kho insulin rhiab heev, txo qhov mob, thiab txhim kho metabolic yooj. Cov teebmeem no yuav muaj txiaj ntsig tshwj xeeb rau cov tib neeg uas xav tswj lawv qhov hnyav thiab txhawb nqa kev noj qab haus huv tag nrho.
4. Kev paub txog kev ua haujlwm thiab lub hlwb kev noj qab haus huv
Raws li ib tug precursor rau NAD +, nicotinamide ribose tiv thaiv hlwb hlwb los ntawm oxidative kev nyuaj siab, uas tuaj yeem ua rau muaj hnub nyoog txog kab mob hlwb. Hauv cov hlwb hlwb, NAD + pab tswj kev tsim cov PGC-1-alpha, cov protein uas zoo li pab tiv thaiv cov hlwb ntawm oxidative kev nyuaj siab thiab kev ua haujlwm tsis zoo ntawm mitochondrial.
Cov kws tshawb fawb pom tias hauv cov nas, NAD + depletion plays lub luag haujlwm tseem ceeb hauv neuroinflamation, DNA puas, thiab neuronal degeneration hauv Alzheimer's disease. Tsis tas li nyob rau hauv kev tshawb fawb-tube, nicotinamide riboside txhawb nqa NAD + qib thiab txhim kho mitochondrial muaj nuj nqi hauv cov qia hlwb ntawm cov neeg mob Parkinson.
Cov kev tshawb fawb tshiab kuj tseem qhia txog cov txiaj ntsig zoo ntawm nicotinamide riboside chloride. NAD + koom nrog ntau yam txheej txheem ntsig txog kev noj qab haus huv ntawm lub hlwb, suav nrog kev qhia txog neuronal, kho DNA, thiab tshem tawm cov protein uas puas lawm. Los ntawm kev txhawb nqa NAD + qib, NR tuaj yeem pab tswj kev paub txog kev paub thiab tiv thaiv hnub nyoog txog kev paub txog kev poob qis.
5. Kev ua kis las ncaws pob thiab rov qab los
Ib txoj kev tshawb fawb 2019 luam tawm nyob rau hauv European Journal of Nutrient Impurities pom tias siv cov tshuaj nicotinamide ribose txhim kho lub cev kev txawj ntse thiab txo cov kev ntxhov siab oxidative hauv cov laus.
Cov kws tshawb fawb tau xaus lus tias NR supplementation muaj txiaj ntsig zoo rau cov neeg tsis muaj NAD +, piav qhia vim li cas nws thiaj li muaj txiaj ntsig zoo rau cov neeg laus dua li cov neeg laus.
Cov neeg ncaws pob thiab cov neeg nyiam kev tawm dag zog tuaj yeem xav paub tias nicotinamide riboside chloride tuaj yeem cuam tshuam rau kev ua kis las thiab rov zoo. NAD + ua lub luag haujlwm tseem ceeb hauv kev tswj cov txheej txheem cellular koom nrog hauv kev tsim hluav taws xob thiab cov leeg ua haujlwm. Los ntawm kev txhawb nqa NAD + qib, NR tuaj yeem txhim kho kev ua siab ntev, txhim kho cov leeg nqaij, thiab txhim kho kev ua kis las tag nrho.
Zoo thiab Purity
Thaum muas nicotinamide riboside chloride hmoov, zoo thiab purity yuav tsum yog koj qhov tseem ceeb. Saib rau cov khoom tsim los ntawm cov tuam txhab muaj koob npe thiab cov neeg thib peb tau sim rau purity thiab potency. Qhov zoo tshaj plaws, cov khoom lag luam yuav tsum tsis pub muaj cov kab mob sib kis thiab cov fillers kom ntseeg tau tias koj tau txais cov khoom zoo tshaj plaws uas muab cov txiaj ntsig xav tau.
Dosage thiab siv
Ua ntej koom nrog nicotinamide riboside chloride hmoov rau hauv koj lub neej txhua hnub, nws yog ib qho tseem ceeb kom nkag siab txog kev siv tshuaj thiab cov lus qhia siv. Nws yog ib qho tseem ceeb uas yuav tau pib nrog cov koob tshuaj qis dua thiab maj mam nce ntxiv raws li qhov xav tau, vim tias cov koob tshuaj ntau dua tsis tas yuav muaj qhov sib npaug zoo dua thiab tuaj yeem ua rau muaj kev cuam tshuam tsis zoo. Tsis tas li ntawd, thov xav txog kev sab laj nrog tus kws kho mob los txiav txim seb qhov ntau npaum li cas yog qhov zoo tshaj plaws rau koj cov hom phiaj kev noj qab haus huv tshwj xeeb thiab xav tau.
Cov txiaj ntsig muaj peev xwm thiab kev txiav txim siab
Nicotinamide Riboside Chloride Powder feem ntau touted rau nws cov txiaj ntsig zoo, suav nrog kev txhawb nqa qib zog, kev ua haujlwm mitochondrial, thiab kev noj qab haus huv ntawm tes. Kev tshawb fawb qhia tias nws kuj tseem muaj feem cuam tshuam rau kev laus thiab cov kab mob uas muaj hnub nyoog.
Kev nyab xeeb thiab ceev faj
Raws li nrog rau ib qho ntxiv, nws yog ib qho tseem ceeb uas yuav tsum tau saib xyuas kev nyab xeeb thiab nkag siab txog kev ceev faj. Txawm hais tias nicotinamide riboside chloride feem ntau zam tau zoo, qee tus neeg yuav muaj kev phiv me me, xws li plab hnyuv. Tsis tas li ntawd, yog tias koj muaj mob hauv qab no lossis noj tshuaj, nco ntsoov sab laj nrog kws kho mob ua ntej siv cov tshuaj ntxiv no kom ntseeg tau tias nws muaj kev nyab xeeb thiab tsim nyog rau koj tus kheej qhov xwm txheej.
Xaiv tus neeg muag khoom muaj npe nrov
Thaum yuav Nicotinamide Riboside Chloride Powder, nws yog ib qho tseem ceeb uas yuav tau xaiv ib tus neeg muag khoom muaj npe nrov uas ua kom pom tseeb qhov zoo, pob tshab, thiab cov neeg siv khoom txaus siab. Nrhiav cov tuam txhab uas muab cov ntsiab lus hais txog lawv cov txheej txheem tsim khoom, kev tsim khoom, thiab kev sim thib peb. Tsis tas li ntawd, xav txog kev nyeem cov neeg siv khoom tshuaj xyuas thiab nrhiav cov lus pom zoo los ntawm cov chaw ntseeg siab kom ntseeg tau tias koj tab tom yuav khoom los ntawm tus neeg muag khoom ntseeg siab thiab ntseeg siab.
Suzhou Myland Pharm & Nutrition Inc. tau koom nrog kev lag luam khoom noj khoom haus ntxiv txij li xyoo 1992. Nws yog thawj lub tuam txhab hauv Suav teb los tsim thiab ua lag luam txiv hmab txiv ntoo extract.
Nrog 30 xyoo ntawm kev paub thiab tsav los ntawm cov cuab yeej siv siab thiab lub tswv yim zoo R & D, lub tuam txhab tau tsim ntau yam khoom sib tw thiab dhau los ua lub neej tshiab kev tshawb fawb ntxiv, kev cai synthesis thiab tsim cov tuam txhab.
Tsis tas li ntawd, Suzhou Myland Pharm & Nutrition Inc. kuj yog ib lub chaw tsim tshuaj paus FDA. Lub tuam txhab R&D cov peev txheej, cov chaw tsim khoom, thiab cov cuab yeej tshuaj ntsuam xyuas yog niaj hnub thiab muaj ntau yam thiab tuaj yeem tsim cov tshuaj los ntawm milligrams mus rau tons hauv nplai, thiab ua raws li ISO 9001 cov qauv thiab cov khoom siv tshwj xeeb GMP.
Q: Dab tsi yog nicotinamide riboside chloride hmoov?
A: Nicotinamide Riboside Chloride Powder yog ib daim ntawv ntawm cov vitamin B3 uas tau kawm txog nws lub peev xwm los txhawb kev tsim cov cellular zog thiab cov metabolism. Nws feem ntau yog siv los ua kev noj haus ntxiv los txhawb kev noj qab haus huv thiab kev noj qab haus huv.
Q: Dab tsi yog cov txiaj ntsig zoo ntawm nicotinamide riboside chloride hmoov?
A: Qee qhov txiaj ntsig zoo ntawm Nicotinamide Riboside Chloride Powder suav nrog kev txhawb nqa mitochondrial muaj nuj nqi, txhawb kev laus noj qab haus huv, thiab txhawb kev ua siab ntev thiab kev ua haujlwm ntawm lub cev. Nws kuj tseem tuaj yeem pab txhawb kev paub txog kev ua haujlwm thiab kev noj qab haus huv ntawm tes.
Q: Kuv tuaj yeem yuav nicotinamide riboside chloride hmoov nyob qhov twg?
A: Nicotinamide Riboside Chloride hmoov yog muaj los ntawm ntau lub khw muag khoom thiab khw hauv online. Thaum yuav cov khoom ntxiv no, nws yog ib qho tseem ceeb uas yuav tau xaiv qhov chaw muaj koob npe los xyuas kom zoo thiab kev nyab xeeb.
Kev lees paub: Kab lus no yog rau cov ntaub ntawv dav dav nkaus xwb thiab yuav tsum tsis txhob raug txhais raws li cov lus qhia kho mob. Qee cov ntaub ntawv blog tshaj tawm los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, formatting thiab kho cov ntawv. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntau ntxiv tsis txhais tau hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Nco ntsoov sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Post lub sij hawm: Aug-14-2024
