Glycerylphosphocholine tuaj yeem txhawb koj lub hlwb lub zog li cas?

Glycerylphosphocholine (GPC, tseem hu ua L-alpha-glycerylphosphorylcholine lossis alphacholine)yog ib qho tshwm sim ntawm choline pom nyob rau hauv ntau yam khoom noj (xws li mis niam) thiab nyob rau hauv tag nrho cov tib neeg lub hlwb muaj choline me me. GPC yog ib qho dej-soluble molecule uas tau pom tias yog qhov muaj zog tshaj ntawm kev kho mob choline dua li choline lossis phosphatidylcholine (PC) los ntawm kev noj zaub mov lossis tshuaj ntxiv.

GPC qhov ncauj tau zoo absorbed thiab yog cleaved nyob rau hauv enterocytes rau hauv glycerol-1-phosphate thiab choline. Tom qab noj GPC, qib choline hauv plasma tau nce sai thiab tseem siab rau 10 teev. Lub siab plasma concentration gradient ntawm choline txhawb nws txoj kev thauj mus los thoob plaws cov ntshav-hlwb teeb meem. Qhov no nce choline khw muag khoom nyob rau hauv neurons, qhov uas nws yog siv los ua ke PC thiab acetylcholine.

Raws li txoj cai, α-GPC yog choline compound ua ke rau glycerol molecule los ntawm pawg phosphate, thiab yog choline uas muaj phospholipid. Cov ntsiab lus ntawm choline yog siab heev, suav txog li 40%, uas txhais tau hais tias 1000 mg ntawm α-GPC tuaj yeem tsim txog 400 mg ntawm choline dawb.

Choline yog ib qho tseem ceeb cov khoom noj muaj nyob rau hauv cov khoom noj siv mis thiab qe uas pab cov cell tswj lawv daim nyias nyias. Choline nws tus kheej kuj yog tsim nyog los ua acetylcholine. Thaum alpha-GPC thiab lwm yam cholines xws li phosphatidylcholine thiab lecithin tuaj yeem txhawb kev tsim cov acetylcholine, alpha-GPC ua tau zoo dua vim tias cov lipids nws muab tau ua rau nws yooj yim rau cov hlwb nqus, Ntau tshaj 90% ntawm phosphatidylcholine yog absorbed los ntawm lymphatic hlab ntsha. , thaum α-GPC feem ntau absorbed los ntawm cov hlab ntsha portal, yog li qhov kev nqus tau zoo dua, yog li txhawb kev tsim cov acetylcholine zoo dua. Acetylcholine yog ib qho neurotransmitter uas ua lub luag haujlwm tseem ceeb hauv kev tswj lub hlwb ua haujlwm thiab tswj cov leeg. Txawm hais tias peb tuaj yeem haus choline los ntawm cov khoom noj, cov acetylcholine txo qis thaum muaj hnub nyoog.

Cov txiaj ntsig ntawm Kev Tshawb Fawb Raws GPC

Lub hlwb ua haujlwm

• Txhim kho kev nco, kev xav thiab lub sijhawm ua haujlwm ntawm cov neeg laus thiab cov hluas
• Txhawb kev tsim thiab tso tawm acetylcholine (ACh) los ntawm cov neurons thiab tej zaum lwm cov hlwb.
• Tej zaum yuav them rau qhov poob ntawm ACh los ntawm kev laus, estrogen deficiency (menopause, thiab tej zaum yuav siv tshuaj tiv thaiv qhov ncauj)
• Txhim kho EEG cov qauv
• Ua kom ntau lawm ntawm dopamine, serotonin thiab GABA18.
• Txhim kho mitochondrial muaj nuj nqi thaum lub sij hawm ischemia/oxidative stress
• Tiv thaiv cov hnub nyoog ntsig txog kev txo qis hauv hlwb hlwb thiab ACh receptor tus lej, cov leeg nqaij ua haujlwm thiab kev loj hlob hormone ntau lawm
• Txhawb kev loj hlob hormone secretion nyob rau hauv cov hluas thiab cov laus
• Ua kom muaj roj oxidation, cov leeg nqaij muaj zog thiab lub sijhawm ua haujlwm, tuaj yeem txhim kho kev sib npaug, tshwj xeeb tshaj yog cov laus.

Kho lub hlwb thiab Alzheimer's / Dementia Support

• Txhim kho lub hlwb rov qab tom qab mob stroke, mob hlwb raug mob, thiab tshuaj loog (ua ntej thiab tom qab phais).
• Kho cov ntshav-hlwb barrier cov ntaub so ntswg puas los ntawm kev kub siab
• Txhim kho kev paub thiab kev coj tus cwj pwm hauv Alzheimer's disease, vascular/senile dementia, thiab Parkinson's disease.
• Txo cov hlwb pob txha zoo ib yam li Alzheimer's disease
• Tej zaum yuav muaj txiaj ntsig zoo rau cov kab mob uas xav tau kho myelin thiab Duchenne cov leeg nqaij dystrophy Choline ua haujlwm hauv tib neeg cov metabolism thiab GPC

Cov khoom tshwj xeeb raws li lub zog muaj zog ntawm choline, lub tsev thaiv ntawm acetylcholine thiab ib yam khoom uas txhawb nqa nws cov synthesis thiab secretion.

• Acetylcholine yog ib qho neurotransmitter nyob rau hauv lub hlwb thiab lub teeb liab transducer nyob rau lwm qhov ntawm lub cev, tseem ceeb heev rau cov leeg nqaij contraction, tawv nqaij laus, plab hnyuv motility, thiab lwm yam ntaub so ntswg functions. Tsis zoo li choline / PC muab los ntawm kev noj zaub mov lossis kev noj tshuaj ntxiv, GPC supplementation tau pom tias muaj kev cuam tshuam tseem ceeb ntawm kev sib txuas ntawm ACh thiab nws tso tawm los ntawm cholinergic hlwb.

Kev ntxiv ntawm GPC ua rau muaj kev txhim kho cholinergic signaling nyob rau hauv neurons thiab lwm lub hlwb uas yuav tsim acetylcholine. Qhov no yog qhov tshwj xeeb tshaj yog thaum tus lej thiab kev ua haujlwm zoo ntawm cholinergic neurons raug txo vim kev laus ib txwm muaj lossis ntau yam txheej txheem degenerative. Ntxiv nrog rau GPC muaj peev xwm los them ib feem rau cov kev tsis zoo no vim tias nws ua rau cov ntshav choline nce sai, uas ua rau muaj zog substrate cuam tshuam rau cov enzymes thiab thauj hauv cov kev no.

Lub tsev thaiv ntawm phosphatidylcholine (PC)

• PC belongs rau phospholipids thiab yog ib qho tseem ceeb ntawm cov cell membranes thiab mitochondrial membranes. Lub peev xwm ntawm GPC supplementation los pab kev mob stroke rov qab, nrog rau kev tiv thaiv lub hnub nyoog txog kev txo qis ntawm ACh receptors hauv paj hlwb lossis hlwb, yog cov pov thawj ntxiv ntawm nws txoj kev koom tes rau kev kho mob neuronal membrane los ntawm PC synthesis.

Kev tsim ntawm sphingomyelin

• Sphingomyelin yog ib feem ntawm myelin sheath uas npog thiab insulates neurons thiab paj hlwb. Yog li, GPC supplementation tej zaum yuav pab tau nyob rau hauv txhua yam mob uas muaj kev xav tau ntxiv rau myelin kho, xws li neuropathy, ntau yam sclerosis, thiab lwm yam mob uas muaj demyelination thiab autoimmunity ntawm paj hlwb. Kev thauj cov rog nyob rau hauv thiab sab nraud

• PC yog tsim nyog rau synthesis thiab tso tawm ntawm VLDL hais. Triglycerides tawm hauv daim siab nyob rau hauv VLDL hais, uas piav qhia vim li cas choline deficiency ua rau muaj kev pheej hmoo ntawm cov kab mob rog rog. PC tuaj yeem tau txais los ntawm cov khoom noj lossis tshuaj ntxiv; Txawm li cas los xij, PC rau phospholipids thiab lipoproteins tsis tau ncaj qha los ntawm kev noj los yog preformed PC. Nws yog synthesized los ntawm ntau yam choline precursors (xws li GPC), yog li ingesting PC tsis tas yog txoj kev zoo tshaj plaws kom lub cev lub PC pas dej ua ke.
Txhawb cov phev motility

• GPC yog qhov tseem ceeb hauv kev txuas ntawm DHA (docosahexaenoic acid), ua rau PC-DHA. DHA-PC complex yog siv nyob rau hauv ntau yam cell hom xws li retinal lub teeb-sensing hlwb thiab phev hlwb. DHA-PC ua kom cov kua dej ntau ntxiv, uas yog qhov tseem ceeb rau kev noj qab haus huv cov phev. Cov phev muaj cov ntsiab lus siab ntawm GPC; Cov kab mob epididymal uas tsim cov phev hlwb raug rho tawm los ntawm GPC pas dej ua ke thiab ua ke PC-DHA. Qib qis ntawm GPC thiab PC-DHA hauv cov phev tuaj yeem ua rau muaj kev pheej hmoo ntawm kev txo cov phev motility.

Kev sib piv ntawm GPC thiab Acetyl-L-Carnitine (ALCAR)

• Hauv kev tshawb fawb ntawm cov neeg mob uas muaj tus kab mob Alzheimer's siab heev, GPC ua rau muaj kev txhim kho ntau dua hauv cov kab mob neuropsychological feem ntau piv nrog ALCAR. Thaum ob lub tebchaw txhawb nqa kev nce hauv acetylcholine, nws yog qhov pom tau tias yuav muaj kev sib koom ua ke ntawm kev ntxiv ob lub tebchaw, vim GPC muab choline thaum ALCAR muab cov acetyl tivthaiv rau kev sib txuas ntawm acetylcholine.

Muaj peev xwm sib koom ua ke ntawm GPC thiab tshuaj. GPC supplementation tsis xav tias yuav cuam tshuam tsis zoo rau cov tshuaj uas tsim los txhim kho lub hlwb. Qhov tseeb, vim nws cov txiaj ntsig ntawm txoj hauv kev cholinergic thiab txhim kho neuronal cell membrane muaj nuj nqi, nws tuaj yeem txhim kho lawv cov txiaj ntsig. GPC tuaj yeem txhim kho qhov cuam tshuam ntawm acetylcholinesterase AChE inhibitors vim tias nws tuaj yeem ua rau nce ACh hauv cov synaptic cleft, thaum cov tshuaj no qeeb nws cov degradation.

Tsis tas li ntawd, raws li kev tshawb fawb tsiaj, GPC tuaj yeem txhim kho kev tsim cov dopamine, serotonin, lossis GABA hauv lub hlwb, thiab GPC tuaj yeem txhim kho cov teebmeem ntawm reuptake inhibitors ntawm cov neurotransmitters.

Suzhou Myland Pharm & Nutrition Inc.is yog lub chaw tsim khoom lag luam FDA tso npe uas muab cov khoom zoo thiab siab dawb huv Alpha GPC hmoov.

Ntawm Suzhou Myland Pharm peb tau cog lus los muab cov khoom lag luam zoo tshaj plaws ntawm tus nqi zoo tshaj. Peb Alpha GPC hmoov yog nruj me ntsis soj ntsuam rau purity thiab potency, kom ntseeg tau tias koj tau txais cov khoom zoo uas koj tuaj yeem ntseeg tau. Txawm hais tias koj xav txhawb nqa kev noj qab haus huv ntawm tes, txhawb koj lub cev tiv thaiv kab mob lossis txhim kho kev noj qab haus huv tag nrho, peb Alpha GPC hmoov yog qhov kev xaiv zoo tshaj.

Nrog 30 xyoo ntawm kev paub thiab tsav los ntawm cov cuab yeej siv siab thiab cov tswv yim zoo R & D, Suzhou Myland Pharm tau tsim ntau yam khoom sib tw thiab dhau los ua lub neej tshiab kev tshawb fawb ntxiv, kev cai synthesis thiab kev tsim cov tuam txhab.

Tsis tas li ntawd, Suzhou Myland Pharm tseem yog FDA-sau npe chaw tsim khoom. Lub tuam txhab R&D cov peev txheej, cov chaw tsim khoom, thiab cov cuab yeej tshuaj ntsuam xyuas yog niaj hnub thiab muaj ntau yam, thiab tuaj yeem tsim cov tshuaj los ntawm milligrams mus rau tons hauv nplai, thiab ua raws li ISO 9001 cov qauv thiab cov khoom tshwj xeeb GMP.