N-Methyl-DL-Aspartic Acid yog cov khoom sib xyaw ua ke ntawm cov amino acids. Paub feem ntau rau nws lub luag haujlwm hauv neurobiology, qhov sib xyaw no yog cov khoom siv hluavtaws ntawm aspartate uas ua rau N-Methyl-DL-Aspartic Acid receptors hauv lub hlwb. NMDA receptors ua lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem ntawm lub paj hlwb, suav nrog kev kawm, nco, thiab synaptic plasticity.
Yog tias koj xav paub tias N-Methyl-DL-Aspartic Acid yog dab tsi, cia peb nkag siab txog dab tsi yog ib qho amino acid? Amino acid yog qhov tseem ceeb ntawm cov protein, thiab cov protein yog cov khoom tseem ceeb ntawm ntau yam khoom siv roj ntsha hauv tib neeg lub hlwb, xws li enzymes, tshuaj tiv thaiv kab mob, cov leeg thiab cov ntaub so ntswg. Kev noj zaub mov kom zoo ntawm cov amino acids txaus tuaj yeem tswj kev noj qab haus huv protein synthesis thiab kho, thiab txhawb kev loj hlob thiab kho cov ntaub so ntswg hauv lub cev.
Amino acids yog qhov tseem ceeb rau kev ua haujlwm zoo ntawm ntau lub cev thiab kev ua haujlwm hauv lub cev. Tsim nyog thiab txaus noj ntawm ntau yam amino acids yog ib qho tseem ceeb rau kev noj qab haus huv.
N-Methyl-DL-Aspartic Acid yog methylated derivative ntawm aspartic acid (Astentic Acid) nrog ib pawg methyl.
Nws yog ib qho isomer ntawm aspartic acid nrog ib pawg methyl txuas nrog nitrogen atom. yog ib qho amino acid derivative uas ua raws li ib tug tshwj xeeb agonist ntawm NMDA receptors, mimicking qhov kev txiav txim ntawm glutamate, cov neurotransmitter uas ib txwm ua ntawm no receptor.
N-Methyl-DL-Aspartic Acid muaj nyob rau hauv ntau yam kab mob, nrog rau cov nroj tsuag thiab tsiaj txhu.
Nws muaj qee yam kev ua lom neeg hauv lub cev muaj sia thiab koom nrog ntau yam txheej txheem physiological, xws li kev sib txuas thiab tso tawm cov neurotransmitters, protein synthesis, thiab lwm yam.
Tsis tas li ntawd, nws kuj yog ib tug neuromodulator, N-Methyl-DL-Aspartic Acid muaj cov kev tswj xyuas hauv lub paj hlwb, thiab koom nrog cov paj hlwb xa mus thiab neuroprotection.
N-Methyl-DL-Aspartic Acid, ib qho kev sib xyaw ua ke tshwm sim hauv tib neeg lub hlwb, ua lub luag haujlwm tseem ceeb hauv synaptic plasticity, txheej txheem tseem ceeb hauv kev kawm thiab kev tsim kev nco. Synaptic plasticity yog hais txog lub peev xwm ntawm lub hlwb cov synapses kom ntxiv dag zog los yog tsis muaj zog thaum lub sij hawm, nyob ntawm qhov kev siv thiab zaus ntawm neural kev ua ub no. NMDAA tshwj xeeb cuam tshuam rau N-Methyl-DL-Aspartic (NMDA) receptors, uas koom nrog rau lub sijhawm ntev (LTP) - kev txhawb zog ntawm kev sib txuas synaptic.
Ib txoj hauv kev tseem ceeb uas N-Methyl-DL-Aspartic Acid tuaj yeem txhim kho kev nco yog los ntawm kev txhawb kev sib txuas lus ntawm hlwb hlwb. NMDA ua raws li cov tshuaj neurotransmitter uas khi rau cov receptors tshwj xeeb hauv lub hlwb, tshwj xeeb tshaj yog nyob rau hauv hippocampus, uas yog lub luag haujlwm rau tsim cov cim tshiab. Los ntawm kev khi rau cov receptors no, NMDA pab txhawb kev sib txuas ntawm cov neurons, ua kom yooj yim rau cov ntaub ntawv ua tiav thiab khaws cia zoo.
Tsis tas li ntawd, cov kev tshawb fawb tau pom tias N-Methyl-DL-Aspartic Acid txhawb kev tso tawm ntawm lub hlwb-derived neurotrophic factor (BDNF), cov protein tseem ceeb rau kev loj hlob thiab ciaj sia ntawm cov neurons tshiab hauv lub hlwb. BDNF plays lub luag haujlwm tseem ceeb hauv neuroplasticity, lub hlwb lub peev xwm los hloov kho thiab kho cov kev sib txuas ntawm neural hauv kev teb rau kev kawm thiab kev paub dhau los. Los ntawm kev ua kom muaj BDNF, NMDA txhawb kev tsim cov txheej txheem neural tshiab, txhim kho kev nco thiab kev kawm muaj peev xwm.
Tau kawg, cov txiaj ntsig ntawm N-Methyl-DL-Aspartic Acid tsis txwv rau kev nco thiab kev kawm muaj peev xwm. Qee qhov kev tshawb fawb qhia tias nws tuaj yeem txhim kho kev paub txog kev ua tau zoo. NMDAAs tau pom tias muaj kev cuam tshuam rau lwm cov kab mob neurotransmitter, xws li dopaminergic thiab serotonergic txoj hauv kev, uas koom nrog kev tswj hwm kev xav, kev xav, thiab kev txhawb siab. Los ntawm kev hloov kho cov tshuab no, N-Methyl-DL-Aspartic Acid tuaj yeem pab txhim kho kev ua kom pom tseeb, ceeb toom, thiab pom meej ntawm kev xav, ntxiv dag zog rau kev txawj ntse.
Zuag qhia tag nrho, N-Methyl-DL-Aspartic Acid qhia tau hais tias muaj peev xwm txhim kho kev nco thiab kev kawm. Txhim kho kev txawj ntse tsim nyog rau kev kawm thiab kev ua haujlwm tau zoo los ntawm kev cuam tshuam synaptic plasticity thiab neuroprotective mechanisms. Tsis tas li ntawd, nws cov teebmeem ntawm lwm cov kab mob neurotransmitter tuaj yeem pab txhim kho kev txawj ntse tag nrho. Txawm hais tias tseem xav tau kev tshawb fawb ntxiv, NMDAA supplementation nthuav qhia txoj hauv kev zoo siab rau cov neeg nrhiav kev txhim kho lawv lub peev xwm thiab tswj lawv lub siab lub ntsws thoob plaws lub neej.
N-Methyl-DL-Aspartic Acid yog ib qho tshwm sim ntawm cov amino acid uas ua lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem physiological hauv lub cev. Nws feem ntau pom nyob rau hauv cov khoom noj muaj protein ntau xws li nqaij, ntses, qe, thiab cov khoom noj siv mis. Txawm li cas los xij, nws kuj muaj los ntawm cov tshuaj ntxiv. Tom ntej no, cia peb tshawb nrhiav qhov zoo sib xws thiab qhov sib txawv ntawm kev tau txais N-Methyl-DL-Aspartic Acid los ntawm cov khoom noj thiab noj nws ntxiv!
Ua ntej, kom tau txais N-Methyl-DL-Aspartic Acid ncaj qha los ntawm cov khoom noj, cov khoom noj muaj protein ntau muaj ntau qhov sib txawv ntawm cov amino acid no. Cov tib neeg tuaj yeem ua tau raws li lawv cov kev xav tau NMDAA los ntawm kev noj cov zaub mov uas muaj protein ntau. Ntxiv rau, tau txais N-Methyl-DL-Aspartic Acid los ntawm tag nrho cov khoom noj muaj txiaj ntsig ntxiv uas muaj lwm cov as-ham tseem ceeb uas koj xav tau rau kev noj qab haus huv tag nrho.
Ntawm qhov tod tes, zaub mov ib leeg yuav tsis txaus kom ua tau raws li N-Methyl-DL-Aspartic Acid cov kev xav tau ntawm qee tus neeg. Cov neeg ncaws pob, cov kws tsim lub cev, lossis cov uas tau txais kev cob qhia lub cev hnyav yuav xav tau ntau dua ntawm NMDAAs los txhawb cov leeg nqaij thiab kev loj hlob. Hauv qhov no, N-Methyl-DL-Aspartic Acid supplementation yuav raug txiav txim siab.
Cov tshuaj N-Methyl-DL-Aspartic Acid tuaj ntau hom, nrog rau cov hmoov thiab cov tshuaj ntsiav, thiab muaj nyob rau hauv. Lawv feem ntau muaj purified los yog hluavtaws NMDAA, ua kom yooj yim rau kev tswj thiab ntsuas kev noj. Tsis tas li ntawd, cov tshuaj ntxiv muab ib txoj hauv kev yooj yim los xyuas kom muaj cov khoom txaus ntawm N-Methyl-DL-Aspartic Acid, tshwj xeeb tshaj yog rau cov neeg uas muaj kev txwv tsis pub noj zaub mov, ua xua, lossis nyuaj rau noj cov zaub mov muaj protein ntau txaus.
Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias cov tshuaj N-Methyl-DL-Aspartic Acid yuav tsum tau siv nrog ceev faj. Ua ntej muab cov tshuaj ntxiv tshiab rau hauv koj qhov niaj hnub, nws raug nquahu kom sab laj nrog kws kho mob lossis kws kho mob sau npe. Lawv tuaj yeem ntsuas koj cov kev xav tau tshwj xeeb thiab txiav txim siab qhov tsim nyog koob tshuaj N-Methyl-DL-Aspartic Acid rau koj qhov xwm txheej tshwj xeeb.
Thaum cov tshuaj ntxiv tuaj yeem muab cov hom phiaj thiab yooj yim ntxiv, lawv yuav tsum tsis txhob hloov cov khoom noj kom zoo. Tag nrho cov khoom noj tsis yog tsuas yog N-Methyl-DL-Aspartic Acid, tab sis kuj muaj ntau yam khoom noj khoom haus ntxiv thiab kev noj qab haus huv. Kev noj zaub mov kom sib luag thiab sib txawv yog qhov tseem ceeb los ua kom pom kev noj qab haus huv thiab kev noj qab haus huv.
Txhawm rau ua kom tiav, peb tuaj yeem tau txais N-Methyl-DL-Aspartic Acid los ntawm cov khoom noj lossis los ntawm cov tshuaj ntxiv. Thaum noj zaub mov sib npaug yuav tsum yog qhov tseem ceeb ntawm NMDAA, cov tshuaj ntxiv tuaj yeem muab cov kev daws teeb meem yooj yim rau cov tib neeg uas muaj kev xav tau tshwj xeeb lossis kev txwv kev noj haus. Txawm li cas los xij, nws yog ib qho tseem ceeb kom nrhiav tau cov lus qhia tshaj lij ua ntej muab cov khoom ntxiv tshiab rau hauv koj li niaj hnub. Thaum kawg, kev sib xyaw ua ke ntawm kev noj qab haus huv thiab kev noj tshuaj ntxiv (yog tias tsim nyog) tuaj yeem pab ua kom pom cov qib N-Methyl-DL-Aspartic Acid rau kev noj qab haus huv zoo.
Ua ntej siv NMA, peb yuav tsum nkag siab txog kev nyab xeeb thiab kev phiv ntawm NMA, yog li ntawd peb tuaj yeem ua haujlwm zoo tshaj plaws ntawm NMA yam tsis muaj kev puas tsuaj rau lub cev.
Hais txog kev nyab xeeb ua ntej, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias NMA feem ntau suav tias muaj kev nyab xeeb thaum noj cov tshuaj tsim nyog. Txawm li cas los xij, zoo li lwm yam sib xyaw, kev noj ntau dhau ntawm NMDA tuaj yeem ua rau muaj kev phom sij. Nws yog ib qho tseem ceeb uas yuav tau ua raws li cov lus qhia tau pom zoo thiab sab laj nrog kws kho mob ua ntej pib ua cov tshuaj ntxiv.
Ib qho kev mob tshwm sim ntawm NMAs yog excitotoxicity. Excitotoxicity tshwm sim thaum NMA receptors overactivated, ua rau calcium ion overload thiab tom qab kev puas tsuaj rau neurons. Cov mob no tau txuas nrog ntau yam kab mob neurodegenerative, xws li Alzheimer's thiab Parkinson's. Txawm li cas los xij, nws tsim nyog sau cia tias excitotoxicity feem ntau cuam tshuam nrog cov koob tshuaj ntau ntawm NMA, uas feem ntau tsis pom nyob rau hauv cov khoom noj los yog cov qauv tshuaj.
Lwm qhov kev mob tshwm sim ntawm NMA yog nws qhov muaj peev xwm cuam tshuam rau kev sib npaug hormonal. Qee qhov kev tshawb fawb qhia tias NMA ntau dhau tuaj yeem cuam tshuam rau kev tsim khoom thiab kev tswj hwm ntawm qee yam tshuaj hormones, xws li testosterone. Cov tshuaj hormonal tsis txaus no tuaj yeem ua rau muaj kev cuam tshuam tsis zoo rau kev yug menyuam thiab kev noj qab haus huv tag nrho. Txawm li cas los xij, xav tau kev tshawb fawb ntxiv kom nkag siab txog cov txheej txheem meej thiab cov txiaj ntsig ntev ntawm NMA ntawm cov tshuaj hormones.
Tsis tas li ntawd, cov tib neeg uas muaj mob ua ntej yuav tsum tau ceev faj thaum xav txog NMA supplementation. Piv txwv li, cov neeg mob qaug dab peg lossis keeb kwm ntawm kev mob vwm yuav tsum zam NMA ntxiv, vim nws tuaj yeem ua rau qaug dab peg vim nws cov teebmeem ntawm NMA receptors.
Rau Kev Xav Siv Thaum feem ntau xav tias muaj kev nyab xeeb thaum noj cov tshuaj tsim nyog, kev noj ntau dhau yuav ua rau muaj kev cuam tshuam tsis zoo xws li excitotoxicity thiab hormonal imbalances. Cov tib neeg uas muaj kev kho mob ua ntej (tshwj xeeb yog qaug dab peg thiab keeb kwm ntawm qaug dab peg) yuav tsum tau ceev faj thaum xav txog NMA supplementation. Raws li nrog rau ib qho ntxiv, nws yog ib qho tseem ceeb rau kev sab laj tus kws kho mob ua ntej muab NMAs rau hauv ib qho kev kho mob ntawm tus kheej.
Q: Nws siv sijhawm ntev npaum li casN-Methyl-DL-Asparticmus ua hauj lwm?
A: Cov teebmeem ntawm N-Methyl-DL-Aspartic acid tuaj yeem sib txawv nyob ntawm tus neeg, ntau npaum li cas, thiab txoj kev tswj hwm. Txawm li cas los xij, feem ntau, nws ntseeg tau tias N-Methyl-DL-Aspartic acid yuav siv sijhawm nyob qhov twg los ntawm ob peb feeb mus rau ob peb teev los pib ua haujlwm. Nws raug nquahu kom sab laj nrog tus kws kho mob lossis ua raws li cov lus qhia los ntawm cov chaw tsim khoom kom paub meej ntxiv txog yuav siv sijhawm ntev npaum li cas rau qhov sib xyaw no kom siv tau.
Kev lees paub: Kab lus no yog siv rau cov ntaub ntawv xov xwm nkaus xwb thiab yuav tsum tsis txhob suav hais tias yog cov lus qhia kho mob. Nco ntsoov sab laj nrog kws kho mob ua ntej siv cov tshuaj los yog hloov koj cov kev kho mob.
Lub sij hawm xa tuaj: Plaub Hlis-07-2023
