Ntuj tebchaw yog nyob rau hauv kev thov nyob rau hauv niaj hnub kev tshawb fawb thiab tshuaj industries. 7,8-Dihydroxyflavone (7,8-Dihydroxyflavone), uas yog ib qho tseem ceeb ntawm cov nroj tsuag tau txais los ntawm cov nroj tsuag, tau nyiam cov neeg tuaj saib thoob plaws vim nws txoj haujlwm tseem ceeb hauv kev lom neeg. Rau cov kws tshawb fawb tshawb fawb thiab kev lag luam, nws yog ib qho tseem ceeb kom nrhiav tau cov neeg muag khoom txhim khu kev qha ntawm 7,8-Dihydroxyflavone Powder. Lub 7,8-Dihydroxyflavone Powder muab los ntawm Suzhou Myland muajCAS tus naj npawb ntawm 38183-03-8 thiab purity txog li 98%, muab kev ntseeg siab rau koj.
7,8-Dihydroxyflavone hmoov(tseem hu ua 7,8-DHF los yog proflavonoid) yog ib txwm tshwm sim molecule uas belongs rau cov chav kawm flavonoid ntawm cov tebchaw. Pom nyob rau hauv nplooj ntawm Godmania aesculifolia, Tridax procumbens thiab primula.
7,8-DHF yog cov organic compound nrog cov mis molecular C15H10O4. Nws yog soluble hauv cov kuab tshuaj organic thiab muaj cov yam ntxwv xim, tsw thiab saj txuam nrog flavonoid tebchaw.
7,8-DHF tau tshwm sim los ua ib qho kev cog lus nootropic compound. Nws tau pom ntau yam ntawm cov teebmeem neuropharmacological hauv kev tshawb fawb preclinical, suav nrog kev txhim kho kev nco, txhawb nqa neurogenesis thiab tiv thaiv neurodegeneration.
Raws li lub zog thiab xaiv me me molecule agonist ntawm tropomyosin receptor kinase B (TrkB), proflavin tau ua kom pom kev ua tau zoo hauv cov qauv tsiaj tiv thaiv ntau yam kab mob, suav nrog Alzheimer's disease.
Flavonoids yog ib chav kawm ntawm polyphenolic compounds pom nyob rau hauv ntau yam txiv hmab txiv ntoo, zaub, thiab lwm yam nroj tsuag. Nyob rau hauv xyoo tas los no, lawv tau txais kev saib xyuas ntau heev vim lawv cov tshuaj tua kab mob antioxidant, tiv thaiv kab mob, thiab cov khoom tiv thaiv neuroprotective.
Cov tebchaw no tau pom tias muaj txiaj ntsig zoo rau lub hlwb, nrog rau kev txhim kho kev txawj ntse thiab tiv thaiv cov kab mob neurodegenerative. 7,8-DHF yog ib qho tseem ceeb tshaj plaws polyphenolic tebchaw uas tau txais kev saib xyuas raws li nootropic. Nws tau raug kawm txog nws cov txiaj ntsig zoo ntawm kev xav, nco, kev kawm, kev ntxhov siab, thiab lwm yam kev paub txog kev paub.
Cov teebmeem neurological ntawm 7,8-DHF tau xav tias yuav tsum tau kho los ntawm nws cov kev cuam tshuam nrog cov receptors tshwj xeeb. Nws tau raug pom tias yog TrkA, ib qho receptor koom nrog hauv cov paj hlwb kev loj hlob ntawm qhov taw qhia thiab tseem ceeb rau kev muaj sia nyob neuronal thiab plasticity.
7,8-DHF ua los ntawm kev tswj cov kev qhia ntawm ntau yam receptors, suav nrog glutamate receptor subunits thiab BDNF. Nws kuj cuam tshuam rau kev tsim synapse, lub zog metabolism, thiab tso tawm acetylcholine hauv qee qhov chaw hauv lub hlwb.
Kev tshawb fawb ntawm 7,8-dihydroxyflavone tau nthuav dav rau hauv nws cov teebmeem ntawm tib neeg kev noj qab haus huv, tshwj xeeb yog saib seb nws ua li cas ntawm lub hlwb-derived neurotrophic factor (BDNF), cov protein tseem ceeb rau kev muaj sia nyob thiab kev ua haujlwm. ntawm protein.
Nyob rau hauv cov nqe lus ntawm nws siv, 7,8-DHF tau tshawb nrhiav rau cov ntaub ntawv muaj peev xwm hauv kev kho mob ntawm cov kab mob neurological vim nws muaj peev xwm nkag mus rau hauv cov hlab ntsha hauv hlwb.
7,8-Dihydroxyflavone tshwm sim nyob rau hauv ntau yam khoom noj cog, suav nrog:
● Txiv hmab txiv ntoo: txiv apples, berries, txiv hmab txiv ntoo thiab citrus txiv hmab txiv ntoo
● Zaub: dos, kale, broccoli thiab spinach
● Tshuaj ntsuab: Parsley, thyme thiab oregano
Ntxiv rau cov peev txheej ntuj no, 7,8-DHF kuj muaj nyob rau hauv daim ntawv ntxiv kom yooj yim thiab npaj noj.
Kawm paub txog flavonoids
Flavonoids yog cov tshuaj polyphenolic uas ua lub luag haujlwm tseem ceeb hauv cov nroj tsuag pigmentation, UV lim, thiab tiv thaiv kab mob. Lawv tau muab faib ua ntau pawg, suav nrog flavonols, flavones, isoflavones, flavanones, thiab anthocyanins. Txhua subclass muaj cov qauv tshuaj sib txawv thiab cov dej num lom neeg, ua rau muaj txiaj ntsig kev noj qab haus huv sib txawv.
7,8-dihydroxyflavone yog dab tsi?
7,8-Dihydroxyflavone yog ib hom tshwj xeeb ntawm flavonoid uas belongs rau flavonoid subclass. Nws cov qauv tshuaj muaj ob pawg hydroxyl ntawm txoj haujlwm 7 thiab 8 ntawm cov pob txha flavonoid, uas yog lub luag haujlwm rau nws cov khoom tshwj xeeb. Qhov kev sib xyaw no pom muaj feem ntau hauv cov nroj tsuag xws li dioscorea (yam) thiab tau kawm txog nws cov teebmeem neuroprotective, cov khoom tiv thaiv kab mob, thiab kev txawj ntse.
Qhov txawv ntawm 7,8-DHF thiab lwm yam Flavonoids
1. Cov qauv tshuaj
Qhov sib txawv tshaj plaws ntawm 7,8-DHF thiab lwm yam flavonoids yog nws cov qauv tshuaj. Txawm hais tias muaj ntau cov flavonoids sib koom ua ke, muaj cov pab pawg hydroxyl ntawm cov haujlwm tshwj xeeb tuaj yeem cuam tshuam rau lawv txoj haujlwm lom neeg. Piv txwv li, quercetin, ib tug paub zoo flavonol, muaj kev sib txawv ntawm hydroxyl pawg, uas cuam tshuam rau nws solubility thiab kev sib cuam tshuam nrog cov hom phiaj lom neeg.
2. Kev ua si lom neeg
7,8-DHF tau pom tias muaj cov haujlwm lom neeg tshwj xeeb piv rau lwm cov flavonoids. Kev tshawb fawb qhia tau hais tias nws ua rau lub hlwb-derived neurotrophic yam (BDNF) taw qhia txoj kev, uas yog ib qho tseem ceeb rau neuron ciaj sia taus, kev loj hlob thiab sib txawv. Cov txheej txheem no tseem ceeb tshwj xeeb hauv cov ntsiab lus ntawm cov kab mob neurodegenerative thiab kev txawj ntse poob.
Hauv qhov sib piv, lwm cov flavonoids xws li catechins (pom nyob rau hauv cov tshuaj yej ntsuab) thiab anthocyanins (pom nyob rau hauv berries) ua hauj lwm feem ntau los ntawm antioxidant kev ua si, tshem tawm dawb radicals thiab txo oxidative kev nyuaj siab. Txawm hais tias cov khoom no muaj txiaj ntsig zoo, lawv yuav tsis cuam tshuam ncaj qha rau cov teeb meem neurotrophic tib yam li 7,8-DHF ua.
3. Bioavailability
Bioavailability yog hais txog qhov twg thiab tus nqi uas muaj cov khoom xyaw nquag lossis cov moiety nquag nqus thiab ua rau muaj nyob rau ntawm qhov chaw ua haujlwm. 7,8-DHF tau qhia txog bioavailability zoo hauv kev tshawb fawb tsiaj, qhia tias nws muaj peev xwm hla cov ntshav-hlwb barrier, uas yog ib qho tseem ceeb rau nws cov teebmeem neuroprotective.
Hauv qhov sib piv, bioavailability ntawm lwm cov flavonoids tuaj yeem sib txawv. Piv txwv li, txawm hais tias quercetin tau siv dav, nws qhov nqus tau feem ntau txwv vim nws cov metabolism sai. Qhov sib txawv ntawm bioavailability no cuam tshuam rau kev ua tau zoo ntawm cov tebchaw hauv kev ua tiav cov txiaj ntsig kev noj qab haus huv xav tau.
7,8-DHF mechanism ntawm kev txiav txim: BDNF kev cai thiab Trkb receptor activation
Hais txog cov txheej txheem ntawm kev ua, 7,8-DHF paub los txhawb kev tsim cov BDNF (lub hlwb-derived neurotrophic yam) los ntawm kev khi rau thiab ua kom nws cov receptor TrkB. Tsis tau txais kev paub dhau los, qhov no ua rau muaj kev cuam tshuam ntawm cov kev ua haujlwm ntawm tes uas muaj txiaj ntsig zoo hauv kev tswj hwm kev ua haujlwm zoo neuronal thiab txhawb nqa neurogenesis.
7,8-DHF lub ntsiab hom kev ua:
(1) Brain-derived neurotrophic factor (BDNF) thiab nws lub luag haujlwm hauv neuroplasticity
Nrog rau kev tshawb pom tias lub paj hlwb-derived neurotrophic factor (BDNF) qhia tau txo qis hauv cov kab mob neurodegenerative, tshwj xeeb tshaj yog Alzheimer's disease (AD), nws qhov tseem ceeb hauv kev tswj hwm thiab txhim kho lub hlwb kev noj qab haus huv tau dhau los ua pom tseeb.
BDNF yog qhov tseem ceeb rau ntau yam kev ua haujlwm ntawm lub paj hlwb vim nws txhawb kev sib kis ntawm synaptic, synaptogenesis, thiab synaptic plasticity los ntawm kev taw qhia nrog TrkB receptors. Qhov no ua rau BDNF-TrkB taw qhia txoj hauv kev yog lub hom phiaj zoo rau kev txhim kho cov kev pabcuam kho mob txhawm rau tiv thaiv cov kab mob neurodegenerative.
(2) Tropomyosin receptor kinase B (Trkb) receptor signaling pathway
tropomyosin receptor kinase B (TrkB) receptor plays lub luag haujlwm tseem ceeb hauv kev kho cov teebmeem ntawm BDNF ntawm cov neurons. Raws li ib tug transmembrane tyrosine kinase receptor, TrkB yog thawj receptor rau BDNF thiab pib ib tug cascade ntawm intracellular signaling txheej xwm raws li khi rau neurotrophic yam.
BDNF ua kom TrkB ua rau muaj ntau txoj hauv kev tseem ceeb hauv lub cev, suav nrog phosphatidylinositol 3-kinase (PI3K)-Akt, mitogen-activated protein kinase (MAPK)-extracellular signal-regulated kinase (ERK), thiab phospholipase Cγ (PLCγ)-protein. PKC) txoj kev. Txhua txoj hauv kev no ua rau muaj qhov sib txawv ntawm kev ua haujlwm neuronal thiab kev noj qab haus huv.
Txoj hauv kev PI3K-Akt yog qhov tseem ceeb rau kev txhawb nqa kev muaj sia nyob ntawm neuronal thiab inhibiting apoptosis. BDNF-TrkB signaling ua rau txoj hauv kev no kom muaj sia nyob ntawm tes los ntawm inhibiting pro-apoptotic yam thiab stimulating anti-apoptotic yam, yog li ua kom muaj kev ruaj ntseg ntawm kev noj qab haus huv neurons.
Ntawm qhov tod tes, txoj hauv kev MAPK-ERK plays lub luag haujlwm tseem ceeb hauv kev sib txawv neuronal thiab kev loj hlob. BDNF-TrkB signaling txhawb kev ua haujlwm ntawm MAPK-ERK txoj hauv kev, uas nyob rau hauv lem txhawb neuronal maturation thiab sib txawv thiab lawv kev koom ua ke rau hauv cov network neuronal uas twb muaj lawm.
Txoj hauv kev PLCγ-PKC yog qhov tseem ceeb rau kev tswj cov khoom siv hluavtaws, cov txheej txheem tseem ceeb ntawm kev kawm thiab kev nco. BDNF-TrkB signaling modulates cov haujlwm ntawm txoj kev no, thaum kawg ua rau muaj kev hloov pauv hauv synaptic zog thiab kev sib txuas.
Qhov kev hloov pauv no txhawb kev hloov pauv thiab rov tsim kho ntawm neural circuits hauv kev teb rau cov kev paub tshiab thiab ib puag ncig stimuli.
Los ntawm kev ua raws li TrkB agonist, 7,8-DHF exerts nws cov teebmeem nootropic feem ntau los ntawm kev tswj BDNF-txog kev taw qhia txoj hauv kev, yog li txhawb nqa neurogenesis thiab txhim kho synaptic plasticity.
Los ntawm kev ua raws li cov teebmeem ntawm BDNF, 7,8-DHF pab tiv thaiv cov neurons los ntawm kev puas tsuaj, txhawb lawv txoj sia nyob, thiab txhawb kev loj hlob thiab kev saib xyuas ntawm kev sib txuas ntawm cov neurons tshiab. Qhov no muaj peev xwm los txhawb neuroplasticity, txhim kho kev paub txog kev ua haujlwm, thiab txo cov tsos mob ntawm cov kab mob neurological ua rau 7,8-DHF yog ib tus neeg sib tw rau kev txhim kho tshuaj thiab kev tshawb fawb ntxiv.
7,8-DHF Nootropic Cov txiaj ntsig: Kev Paub Txog Kev Txawj Ntse thiab Kev Tiv Thaiv Neuroprotection
Hais txog nws cov txiaj ntsig nootropic, 7,8-DHF ua haujlwm los ntawm 4 lub luag haujlwm tseem ceeb:
Nco kev sib koom ua ke thiab rov qab tau: ib txoj haujlwm hippocampus-dependent
7,8-DHF tau pom los txhim kho kev nco sib koom ua ke thiab rov qab tau ntau yam ntawm hippocampus-nyob ntawm kev kawm thiab kev nco ua haujlwm hauv cov qauv nas. Cov kev tshawb pom no qhia tias 7,8-DHF yuav yog ib qho kev cog lus nootropic, tuaj yeem siv los txhim kho kev nco ua haujlwm hauv cov tib neeg noj qab haus huv thiab cov neeg muaj kev nco tsis zoo.
Synaptic plasticity: lub sij hawm ntev potentiation thiab kev nyuaj siab
7,8-DHF tau pom tias tswj cov synaptic plasticity los ntawm kev txhawb LTP thiab txo LTD hauv hippocampus. Cov teebmeem no tau xav tias yuav tsum tau kho los ntawm nws lub peev xwm los qhib TrkB receptors thiab tom qab ntawd txhim kho BDNF txoj kev taw qhia. Qhov kev hloov pauv ntawm synaptic plasticity no ua rau muaj kev txhim kho hauv kev paub txog kev ua haujlwm raws li kev tswj hwm 7,8-DHF.
Antioxidant zog: ROS scavenging thiab lipid peroxidation
7,8-DHF muaj antioxidant zog raws li muaj pov thawj los ntawm nws lub peev xwm mus khawb reactive oxygen hom (ROS) thiab txo lipid peroxidation. Cov teebmeem no pab txhawb rau nws cov teebmeem neuroprotective los ntawm alleviating oxidative stress-induced neuronal puas thiab tsis ua haujlwm.
Anti-inflammatory effect: tswj microglial activation thiab cytokine ntau lawm
Ntxiv nrog rau nws cov khoom antioxidant, 7,8-DHF tau pom los ua kom muaj zog tiv thaiv kab mob los ntawm kev hloov kho microglial activation thiab txo qis kev tsim cov cytokines pro-inflammatory xws li TNF-α thiab IL-1β. Qhov no ntxiv txhawb rau nws cov teebmeem neuroprotective thiab nootropic los ntawm kev tiv thaiv o-mediated neuronal puas.
Thaum nrhiav ib tus neeg muag khoom ntawm7,8-Dihydroxyflavone hmoovHmoov, koj tuaj yeem xav txog cov hauv qab no:
1. Tus neeg muag khoom lub koob npe nrov
Xaiv tus xa khoom nrog lub koob npe zoo yog qhov tseem ceeb. Koj tuaj yeem tau txais kev nkag siab ntawm tus neeg muag khoom lub koob npe nrov los ntawm kev txheeb xyuas cov neeg siv khoom, cov ntawv tshaj tawm kev lag luam, thiab cov rooj sab laj kev tshaj lij. Suzhou Myland nyiam lub koob npe nrov hauv kev lag luam, nrog cov lus pom zoo rau cov neeg siv khoom thiab tau lees paub cov khoom zoo.
2. Cov khoom zoo
Xyuas kom meej tias cov khoom muab los ntawm cov neeg muag khoom ua raws li cov qauv thoob ntiaj teb thiab kev tswj xyuas kom zoo. Suzhou Myland 7,8-Dihydroxyflavone Powder tau dhau los ua kev soj ntsuam nruj nruj thiab muaj qhov purity txog li 98%, ua kom cov khoom ua tau zoo thiab kev nyab xeeb.
3. Ntawv pov thawj thiab ua raws
Xaiv ib tus neeg xa khoom nrog GMP (Kev Ua Haujlwm Zoo) thiab ISO daim ntawv pov thawj kom ntseeg tau tias nws cov txheej txheem tsim tau raws li cov qauv thoob ntiaj teb. Suzhou Myland nruj me ntsis raws li cov qauv no kom muaj kev ruaj ntseg thiab sib xws ntawm txhua pawg ntawm cov khoom.
4. Kev txhawb nqa thiab kev pabcuam
Ib tus neeg muag khoom ntseeg siab yuav tsum muab kev txhawb nqa kev tshaj lij thiab kev pabcuam rau cov neeg siv khoom. Suzhou Myland muaj ib pab neeg ua haujlwm tshaj lij uas tuaj yeem muab cov neeg siv khoom nrog cov lus qhia siv khoom siv thiab cov lus qhia ua haujlwm los pab cov neeg siv khoom ua tiav cov txiaj ntsig zoo hauv kev tshawb fawb thiab kev thov.
5. Nqe thiab lub sijhawm khoom xa tuaj
Tus nqi thiab lub sijhawm xa khoom kuj tseem ceeb rau kev txiav txim siab thaum xaiv tus neeg muag khoom. Koj tuaj yeem thov quotes los ntawm ntau tus neeg muag khoom thiab sib piv lawv cov nqi thiab lub sijhawm xa khoom kom pom qhov kev xaiv tsim nyog. Suzhou Myland
muab cov nqi sib tw thiab lub sijhawm xa khoom yooj yim thaum ua kom cov khoom zoo.
Yuav Ua Li Cas Tau Txais 7,8-Dihydroxyflavone Powder
Yog tias koj tab tom nrhiav kom zoo 7,8-Dihydroxyflavone Powder, Suzhou Myland yog koj qhov kev xaiv zoo tshaj plaws. Koj tuaj yeem tiv tauj peb ntawm:
Official lub website: Mus saib lubofficial lub website ntawm Suzhou Mylandkom paub ntau ntxiv txog cov ntaub ntawv khoom thiab kev txhawb nqa.
Kev sib tham hauv online: Sib txuas lus ncaj qha nrog peb pab neeg muab kev pabcuam los ntawm kev sib tham hauv online uas muab los ntawm lub vev xaib kom tau txais cov ntaub ntawv khoom thiab cov lus hais uas koj xav tau.
Kev sib cuag hauv xov tooj: Hu rau peb tus lej xov tooj kom sib txuas lus nrog cov neeg ua haujlwm muag khoom thiab tau txais cov ncauj lus kom ntxaws txog cov khoom lag luam thiab cov lus qhia yuav khoom.
Email nug: Koj tuaj yeem nug peb cov ntaub ntawv khoom ntawm email, thiab peb yuav teb koj sai li sai tau.
Nrhiav kev txhim khu kev qha 7,8-Dihydroxyflavone Powder lwm tus neeg tsis yog yooj yim, tab sis los ntawm kev ua tib zoo saib xyuas tus neeg muag khoom lub koob npe nrov, cov khoom zoo, ntawv pov thawj thiab kev ua raws, kev txhawb nqa thiab kev pabcuam, nrog rau cov nqi thiab lub sijhawm khoom xa tuaj, koj tuaj yeem txiav txim siab zoo. xaiv. Suzhou Myland yog koj tus khub zoo tshaj plaws nrog nws cov purity 7,8-Dihydroxyflavone Powder thiab cov neeg siv khoom zoo heev. Peb tos ntsoov yuav ua haujlwm nrog koj los tshawb nrhiav ntau daim ntawv thov muaj peev xwm ntawm 7,8-Dihydroxyflavone.
Q: Proflavin puas tuaj yeem txhim kho kev kawm tau?
A: Yog lawm, proflavin tau pom tias yuav txhim khu kev kawm hauv kev tshawb fawb tsiaj los ntawm kev txhawb nqa neurogenesis thiab synaptic kev sib txuas. Nws tswj cov neurotransmitter systems uas tseem ceeb rau txoj kev kawm, tshwj xeeb tshaj yog nyob rau hauv hippocampus, ib cheeb tsam tseem ceeb ntawm lub hlwb rau kev kawm.
Q: Puas yog 7,8-DHF pab kev paub zoo tom qab raug mob?
A: Yog lawm, kev tshawb fawb preclinical qhia tias 7,8-DHF tuaj yeem pab kev paub txog kev rov qab los ntawm lub hlwb raug mob los ntawm kev txhawb nqa neuroprotection thiab neuroregeneration. Nws txo qis kev tuag neuronal thiab txhawb kev loj hlob ntawm cov neurons tshiab, muaj peev xwm txhim kho kev paub txog kev ua haujlwm tsis zoo los ntawm kev raug mob lossis kev raug mob ischemic.
Q: Lub luag haujlwm dab tsi ua 7,8-dihydroxyflavone ua si hauv kev laus txog kev paub txog kev poob qis?
A: Kev tshawb fawb tam sim no qhia tias 7,8-DHF tuaj yeem ua rau lub hlwb qeeb qeeb cuam tshuam nrog kev laus los ntawm kev tiv thaiv oxidative kev nyuaj siab thiab o, feem ntau ntawm cov hnub nyoog ntsig txog kab mob.
Los ntawm kev txhim kho BDNF qib thiab TrkB receptor activation, nws pab tswj kev paub txog kev txawj ntse, txawm tias xav tau kev tshawb fawb ntau ntxiv rau tib neeg los tshawb xyuas cov teebmeem no.
Q: 7,8-DHF puas tuaj yeem txhim kho kev mloog thiab kev ua haujlwm?
A: Kev tshawb fawb txog tsiaj ua ntej qhia tias 7,8-DHF tuaj yeem txhim kho kev mloog zoo thiab kev ua haujlwm los ntawm kev txhim kho cov kev tswj hwm neurotransmitter thiab kev sib txuas ntawm neural hauv cheeb tsam paj hlwb koom nrog cov txheej txheem no.
Kev lees paub: Kab lus no yog rau cov ntaub ntawv dav dav nkaus xwb thiab yuav tsum tsis txhob raug txhais raws li cov lus qhia kho mob. Qee cov ntaub ntawv blog tshaj tawm los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, formatting thiab kho cov ntawv. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntau ntxiv tsis txhais tau hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Nco ntsoov sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Post lub sij hawm: Oct-16-2024
