Kev laus yog ib txoj kev uas txhua yam kab mob mus txog. Cov tib neeg tsis tuaj yeem tiv thaiv kev laus, tab sis lawv tuaj yeem siv qee yam kev ntsuas kom qeeb cov txheej txheem kev laus thiab qhov tshwm sim ntawm cov kab mob uas muaj hnub nyoog. Ib qho chaw tau txais kev saib xyuas ntau - nicotinamide riboside, tseem hu ua NR. Raws li NAD + precursor, nicotinamide riboside xav tias yuav muaj txiaj ntsig zoo los tiv thaiv kev laus. Los ntawm kev nce qib NAD +, nicotinamide riboside txhim kho sirtuin kev ua, txhim kho mitochondrial muaj nuj nqi, thiab ua kom muaj ntau yam cellular txoj hauv kev koom nrog kev tiv thaiv kev laus.
Nicotinamide riboside (NR) yog ib daim ntawv ntawm vitamin B3, tseem hu ua nicotinic acid los yog nicotinic acid. Nws yog ib qho tshwm sim tshwm sim nyob rau hauv me me nyob rau hauv tej yam khoom noj, xws li mis nyuj, poov xab, thiab ib co zaub.
NR yog lub hauv paus ntawm nicotinamide adenine dinucleotide (NAD +), coenzyme tam sim no hauv txhua lub hlwb. NAD + ua lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem lom neeg, suav nrog kev tsim hluav taws xob, kho DNA, thiab kev tswj hwm ntawm cellular metabolism. Raws li peb muaj hnub nyoog, peb qib NAD + yuav txo qis, uas tuaj yeem cuam tshuam cov haujlwm tseem ceeb no. NR cov tshuaj ntxiv tau raug npaj los ua ib qho kev nce qib NAD + thiab tej zaum yuav ua rau qeeb ntawm cov txheej txheem kev laus.
Ib qho txiaj ntsig tseem ceeb ntawm NR supplementation yog nws lub peev xwm los txhim kho mitochondrial muaj nuj nqi. Mitochondria yog lub zog ntawm lub xovtooj ntawm tes, lub luag haujlwm rau tsim feem ntau ntawm lub zog ntawm tes hauv daim ntawv ntawm adenosine triphosphate (ATP). NR tau pom tias txhawb ATP ntau lawm los ntawm kev nce qib NAD +, yog li txhawb kev tsim hluav taws xob zoo thiab cov cellular metabolism. Qhov kev tsim tawm lub zog no tuaj yeem muaj txiaj ntsig ntau yam ntawm cov ntaub so ntswg thiab lub cev, nrog rau lub hlwb, lub plawv, thiab cov leeg.
●Txhim kho cellular zog
Nicotinamide riboside ua lub luag haujlwm tseem ceeb hauv kev muab lub zog rau lub zog ntawm lub zog, mitochondria. Cov tshuaj no yog ib qho ua ntej ntawm nicotinamide adenine dinucleotide (NAD +), ib qho tseem ceeb coenzyme koom nrog ntau cov txheej txheem ntawm tes, tshwj xeeb tshaj yog lub zog metabolism. Kev tshawb fawb qhia tau hais tias ntxiv nrog NR tuaj yeem nce qib NAD + thiab txhawb nqa kev ua pa ntawm tes thiab lub zog tsim tawm.
NAD + qib yuav poob qis thaum peb muaj hnub nyoog, ua rau tsis muaj zog mitochondrial muaj nuj nqi thiab qis zog tag nrho. Txawm li cas los xij, los ntawm kev ntxiv nrog nicotinamide riboside, nws muaj peev xwm thim rov qab qhov kev poob qis thiab rov ua kom cov hluas zog. NR kuj tau pom los txhim kho lub cev muaj zog thiab txhim kho kev ua kis las, ua rau nws yog ib qho chaw txaus nyiam rau cov neeg ncaws pob thiab cov neeg nrhiav kev noj qab haus huv.
●Txhim kho cell kho thiab tiv thaiv kev laus
Lwm qhov ntxim nyiam ntawm nicotinamide riboside yog nws lub peev xwm los txhawb DNA kho thiab tiv thaiv kev puas tsuaj rau hnub nyoog. NAD + yog ib qho tseem ceeb hauv cov txheej txheem kho DNA. Los ntawm kev ntxiv NR kom nce qib NAD +, peb tuaj yeem txhim kho lub cell lub peev xwm los kho DNA, yog li tiv thaiv kev laus dua.
Tsis tas li ntawd, NR tau cuam tshuam txog kev tswj hwm txoj kev ua neej nyob ntev, xws li sirtuins, uas ua lub luag haujlwm tseem ceeb hauv kev tswj hwm kev noj qab haus huv ntawm tes. Cov noob ntev ntev no pab txhim kho cellular tiv thaiv mechanisms tiv thaiv kev ntxhov siab thiab txhawb nqa tag nrho lub neej ntev. Los ntawm kev ua kom sirtuins, nicotinamide riboside tuaj yeem pab ncua cov kab mob uas muaj hnub nyoog thiab muaj feem cuam tshuam rau peb txoj kev noj qab haus huv.
●Tiv thaiv cov kab mob neurodegenerative
Cov kab mob neurodegenerative xws li Alzheimer's thiab Parkinson's tau dhau los ua ntau dua hauv peb lub neej. Kev tshawb fawb qhia tias nicotinamide riboside tej zaum yuav muaj kev cog lus hauv kev tiv thaiv cov kab mob debilitating. Cov kev tshawb fawb tau pom tias NR cov thawj coj txhim kho mitochondrial muaj nuj nqi, txo oxidative kev nyuaj siab, thiab txhim kho neuroplasticity, tag nrho cov uas ua rau lub hlwb noj qab haus huv.
Tsis tas li ntawd, NR supplementation tau txuas nrog txhim kho kev paub txog kev ua haujlwm, nco khaws cia, thiab txhim kho kev ua kom pom tseeb thiab mloog zoo dua. Thaum xav tau kev tshawb fawb ntxiv, cov kev tshawb pom ua ntej no qhia tias nicotinamide riboside tuaj yeem ua pov thawj los ua qhov kev tiv thaiv kev tiv thaiv lossis kev txhawb nqa rau cov tib neeg uas muaj kev pheej hmoo ntawm neurodegeneration.
●Txhim kho qhov rhiab heev ntawm insulin
Ntau qhov kev tshawb fawb tau pom tias NR muaj peev xwm txhim kho kev noj qab haus huv tag nrho. Nws tau pom tias yuav txhim kho cov tshuaj insulin, yog qhov tseem ceeb hauv kev tswj cov ntshav qab zib kom noj qab haus huv thiab tiv thaiv kev txhim kho ntawm hom 2 mob ntshav qab zib. Cov kev tshawb fawb tseem pom tau tias NR ntxiv tuaj yeem txhim kho lipid metabolism, yog li txo qis cov roj cholesterol thiab triglyceride. Cov teebmeem no tseem ceeb tshwj xeeb rau cov neeg uas muaj teeb meem metabolic lossis cov neeg rog rog lossis rog.
●Nws muaj peev xwm antioxidant
Tsis tas li ntawd, NR tau pom tias yuav txhim kho cellular tiv thaiv oxidative kev nyuaj siab. Kev ntxhov siab Oxidative tshwm sim thaum muaj qhov tsis sib xws ntawm kev tsim cov pa oxygen reactive (ROS) thiab lub cev muaj peev xwm ua kom tsis muaj zog nrog cov tshuaj antioxidants. Cov qib siab ntawm oxidative kev nyuaj siab tuaj yeem ua rau cov hlwb puas tsuaj thiab ua rau muaj kev loj hlob ntawm ntau yam kab mob, suav nrog mob qog noj ntshav, kab mob plawv, thiab kab mob neurodegenerative. Cov kev tshawb fawb tau pom tias ntxiv NR tuaj yeem txhim kho lub peev xwm antioxidant ntawm cov hlwb thiab txo qhov cuam tshuam ntawm oxidative kev nyuaj siab ntawm lub cev.
Kev tshawb fawb qhia tau hais tias nicotinamide riboside muaj peev xwm ua rau kev laus qeeb los ntawm kev nce qib ntawm nicotinamide adenine dinucleotide (NAD +) molecule. NAD + yog ib qho tseem ceeb molecule uas ua lub luag haujlwm tseem ceeb hauv cellular metabolism.
NAD + qib ib txwm poob qis thaum peb muaj hnub nyoog. Qhov kev poob qis no suav tias yog qhov ua rau muaj kev laus zuj zus. Los ntawm kev nce qib NAD +, nicotinamide riboside tuaj yeem pab cuam tshuam qhov kev poob qis thiab qeeb cov teebmeem ntawm kev laus.
NAD + koom nrog ntau cov txheej txheem cellular tseem ceeb, suav nrog kev tsim hluav taws xob, kho DNA, thiab kev qhia cov noob. Los ntawm kev nce qib NAD +, nicotinamide riboside tuaj yeem txhim kho cov txheej txheem no thiab txhim kho kev ua haujlwm ntawm cellular tag nrho.
Ntau qhov kev tshawb fawb tau pom tias muaj txiaj ntsig zoo hauv cov tsiaj thiab tib neeg lub hlwb. Hauv ib txoj kev tshawb fawb, cov kws tshawb fawb pom tias nicotinamide riboside supplementation nce NAD + qib hauv cov leeg nqaij, yog li txhim kho mitochondrial muaj nuj nqi thiab kev tawm dag zog hauv cov nas.
Lwm txoj kev tshawb nrhiav pom tias nicotinamide riboside supplementation txhim kho insulin rhiab heev thiab qabzib kam rau cov nas rog rog, prediabetic nas. Qhov no qhia tias nicotinamide riboside kuj tseem tuaj yeem muaj txiaj ntsig zoo rau kev noj qab haus huv metabolic.
Hauv ib qho kev tshawb fawb me me ntawm cov neeg laus thiab cov laus laus, nicotinamide riboside supplementation nce NAD + ntau ntau thiab txhim kho cov ntshav siab thiab cov hlab ntsha, ob qho tseem ceeb ntawm kev noj qab haus huv ntawm cov hlab plawv.
Hauv lwm txoj kev tshawb fawb, cov kws tshawb fawb pom tias nicotinamide riboside supplementation txhim kho cov leeg nqaij thiab tiv thaiv cov leeg nqaij hauv cov laus. Qhov no qhia tau hais tias nicotinamide riboside tuaj yeem muaj txiaj ntsig zoo tiv thaiv hnub nyoog txog cov leeg nqaij.
Nws yog ib nqi sau cia hais tias kev laus yog ib tug complex txheej txheem cuam tshuam los ntawm ntau yam, nrog rau cov noob caj noob ces, txoj kev ua neej thiab ib puag ncig. Nicotinamide riboside yuav tsum tau saib raws li ib qho ntxiv uas yuav pab tau qeeb aging thiab txhawb kev noj qab haus huv laus dua li cov mos txwv khawv koob.
Ob pebNAD+ Precursors tau raug txheeb xyuas, suav nrog nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), thiab nicotinic acid (NA). Cov precursors no tau hloov dua siab tshiab rau hauv NAD + ib zaug hauv lub cell.
Ntawm cov precursors no, nicotinamide riboside tau txais kev saib xyuas thoob plaws vim nws txoj kev ruaj ntseg, bioavailability, thiab muaj peev xwm ua tau zoo nce qib NAD +. NR yog daim ntawv tshwm sim ntawm cov vitamin B3 thiab pom nyob rau hauv cov kab hauv cov kua mis thiab lwm yam khoom noj. Nws tau pom tias txhim kho NAD + synthesis thiab txhawb kev ua haujlwm ntawm sirtuins, ib pawg ntawm cov proteins cuam tshuam nrog kev ua neej ntev.
Ib qho ntawm qhov zoo ntawm nicotinamide riboside yog nws lub peev xwm los hla cov kauj ruam nruab nrab uas yuav tsum tau ua rau NAD + synthesis. Nws tuaj yeem hloov pauv ncaj qha rau NAD + yam tsis tas yuav muaj cov enzymes ntxiv. Hauv qhov sib piv, lwm cov precursors xws li nicotinamide mononucleotide xav tau cov kauj ruam enzymatic ntxiv nrog rau nicotinamide phosphoribosyltransferase (NAMPT) kom hloov mus rau NAD +.
Ntau qhov kev tshawb fawb tau muab piv rau qhov ua tau zoo ntawm nicotinamide riboside rau lwm cov NAD + precursors, thiab NR tsis tu ncua los ntawm sab saum toj. Hauv kev tshawb fawb ua ntej hauv cov nas laus, nicotinamide riboside supplementation tau pom tias nce qib NAD +, txhim kho mitochondrial muaj nuj nqi, thiab txhim kho cov leeg nqaij.
Kev tshawb fawb randomized, ob-dig muag, tshuaj placebo-tswj nyob rau hauv cov neeg laus noj qab haus huv kuj tau pom cov txiaj ntsig tau zoo. NAD + qib tau nce ntxiv hauv cov neeg koom nrog noj nicotinamide riboside piv nrog cov pab pawg placebo. Tsis tas li ntawd, lawv tau tshaj tawm txog kev paub txog kev ua haujlwm zoo dua qub thiab txo qis kev qaug zog.
Thaum lwm cov NAD + precursors, xws li nicotinamide mononucleotide thiab niacin, tau pom cov txiaj ntsig zoo ntawm NAD + qib hauv qee qhov kev tshawb fawb, lawv tseem tsis tau pom tib theem ntawm kev ua tau zoo li nicotinamide riboside.
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias txawm hais tias nicotinamide riboside zoo li ua tau zoo dua ntawm kev nce qib NAD +, cov lus teb ntawm tus kheej yuav txawv. Qee tus neeg yuav pom tias lwm cov tshuaj ua ntej, xws li nicotinamide mononucleotide lossis niacin, yog qhov tsim nyog rau lawv cov kev xav tau tshwj xeeb.
Nicotinamide riboside tshuaj muaj nyob rau hauv cov ntsiav tshuaj, tshuaj ntsiav, thiab hmoov cov ntaub ntawv. Nrhiav kom tau qhov NR noj npaum li cas yog nyob ntawm ntau yam, suav nrog hnub nyoog, kev noj qab haus huv, thiab cov txiaj ntsig xav tau. Yog li ntawd, nws yog ib qho tsim nyog los sab laj tus kws kho mob ua ntej pib cov txheej txheem ntxiv tshiab, vim lawv tuaj yeem muab cov lus qhia tus kheej raws li koj cov kev xav tau tshwj xeeb.
Ntxiv rau, nrog NR qhov kev muaj koob meej nce siab thiab suav tsis txheeb cov npe dej nyab rau hauv kev ua lag luam, nws yog ib qho tseem ceeb uas yuav tau xaiv qhov muaj txiaj ntsig zoo thiab muaj npe nrov. Nov yog qee yam tseem ceeb los xav txog thaum xaiv NR ntxiv:
1. Purity thiab Quality: Nrhiav cov khoom uas yog cov neeg thib peb kuaj thiab ntawv pov thawj los xyuas kom meej tias lawv ua tau raws li cov qauv nruj. Tshawb nrhiav cov tshuaj uas tsis muaj cov tshuaj ntxiv, cov tshuaj ntxiv uas tsim kev puas tsuaj, thiab cov kab mob muaj peev xwm.
2. Kev Ua Haujlwm Zoo: Xaiv cov tshuaj uas tsim nyob rau hauv FDA-sau npe cov chaw thiab ua raws li Kev Tswj Xyuas Zoo (GMP) cov lus qhia. Qhov no ua kom cov khoom sib xws, kev nyab xeeb thiab ua haujlwm tau zoo.
4. Kev Ruaj Ntseg thiab Kev Ntsuam Xyuas Cov Neeg Siv Khoom: Tshawb xyuas cov neeg siv khoom tshuaj xyuas thiab kev ntaus nqi kom tau txais kev nkag siab txog kev ua tau zoo ntxiv thiab tag nrho cov neeg siv khoom txaus siab.
Q: Nicotinamide Riboside (NR) ua haujlwm li cas?
A: Nicotinamide Riboside (NR) ua haujlwm los ntawm kev nce qib ntawm NAD + hauv lub cev. NAD + koom nrog hauv cellular zog tsim, kho DNA, thiab tswj kev noj qab haus huv thiab kev ua haujlwm ntawm mitochondria.
Q: Puas muaj peev xwm tiv thaiv kev laus ntawm Nicotinamide Riboside (NR)?
A: Nicotinamide Riboside (NR) tau pom tias muaj txiaj ntsig los tiv thaiv kev laus los ntawm nws lub luag haujlwm hauv kev txhawb nqa NAD + qib. Kev nce qib NAD + tuaj yeem txhim kho mitochondrial muaj nuj nqi, txhim kho cellular zog tsim, thiab txhawb kev kho DNA, tag nrho cov no tuaj yeem pab txhawb rau kev tiv thaiv hnub nyoog poob qis thiab txhim kho kev noj qab haus huv tag nrho.
Kev lees paub: Kab lus no yog rau cov ntaub ntawv dav dav nkaus xwb thiab yuav tsum tsis txhob raug txhais raws li cov lus qhia kho mob. Qee cov ntaub ntawv blog tshaj tawm los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, formatting thiab kho cov ntawv. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntau ntxiv tsis txhais tau hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Nco ntsoov sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Post lub sij hawm: Nov-10-2023
