Niaj hnub no, raws li qhov nruab nrab lub neej expectancy ntawm cov neeg nyob ib ncig ntawm lub ntiaj teb no yog maj mam nce, anti-aging tau los ua ib tug tseem ceeb lub ntsiab lus. Tsis ntev los no, Urolithin A, ib lo lus uas tsis paub yav dhau los, tau maj mam tuaj rau hauv pej xeem saib. Nws yog ib yam khoom tshwj xeeb metabolized los ntawm plab hnyuv microorganisms thiab yog ze rau kev noj qab haus huv. Kab lus no yuav nthuav tawm qhov paub tsis meej ntawm qhov txuj ci tseem ceeb no - urolithin A.
Keeb kwm ntawmurolithin A (UA)tuaj yeem taug qab rov qab mus rau xyoo 2005. Nws yog ib qho metabolite ntawm cov kab mob hauv plab hnyuv thiab tsis tuaj yeem ncaj qha ntxiv los ntawm kev noj zaub mov. Txawm li cas los xij, nws cov precursor ellagitannins yog nplua nuj nyob rau hauv ntau yam txiv hmab txiv ntoo xws li pomegranates thiab strawberries.
Lub luag haujlwm ntawm urolithin A
Thaum Lub Peb Hlis 25, 2016, ib qho kev tshawb fawb loj hauv phau ntawv xov xwm "Nature Medicine" tau ua rau cov neeg tuaj saib xyuas nws txoj kev sib txuas nrog ncua kev laus ntawm tib neeg. Txij li thaum nws tau tshawb pom nyob rau hauv 2016 tias UA tuaj yeem txuas tau lub neej ntev ntawm C. elegans, UA tau siv nyob rau txhua theem (hematopoietic qia hlwb, cov ntaub so ntswg ntawm daim tawv nqaij, lub hlwb (cov kabmob), lub cev tsis muaj zog, lub neej ntev) thiab ntau hom. (C. elegans, melanogaster Cov tshuaj tiv thaiv kev laus tau pom muaj zog hauv cov txiv hmab txiv ntoo yoov, nas, thiab tib neeg.
(1) Los tiv thaiv kev laus thiab txhim kho cov leeg ua haujlwm
Ib qho kev sim tshuaj ntsuam randomized luam tawm nyob rau hauv JAMA Network Open, ib phau ntawv xov xwm hauv phau ntawv Journal of the American Medical Association, qhia tias rau cov neeg laus lossis cov neeg uas muaj teeb meem txav mus los vim muaj mob, UA tshuaj yuav pab txhim kho cov leeg nqaij thiab ua kom muaj kev tawm dag zog.
(2) Pab txhawm rau txhim kho qhov muaj peev xwm tiv thaiv qog noj ntshav ntawm kev tiv thaiv kab mob
Xyoo 2022, pab pawg tshawb fawb ntawm Florian R. Greten los ntawm Georg-Speyer-Haus lub koom haum ntawm Tumor Biology thiab Kev Tshawb Fawb Kev Kho Mob hauv Tebchaws Yelemees tau tshawb pom tias UA tuaj yeem ua rau mitophagy hauv T hlwb, txhawb kev tso tawm PGAM5, qhib Wnt signaling pathway, thiab txhawb T nco qia hlwb. tsim, yog li txhawb kev tiv thaiv qog noj ntshav.
(3) thim rov qab kev laus ntawm hematopoietic qia hlwb thiab tiv thaiv kab mob
Hauv kev tshawb fawb 2023, University of Lausanne hauv Switzerland tau kawm txog nws cov txiaj ntsig ntawm hematopoietic system los ntawm kev tso cai rau cov nas muaj hnub nyoog 18 hli noj urolithin A-nplua nuj zaub mov rau 4 lub hlis thiab saib xyuas cov kev hloov pauv hauv lawv cov ntshav txhua hli. Kev npam.
Cov txiaj ntsig tau pom tias UA noj zaub mov tau nce tus naj npawb ntawm hematopoietic qia hlwb thiab lymphoid progenitor hlwb, thiab txo cov erythroid progenitor hlwb. Qhov kev tshawb pom no qhia tias qhov kev noj haus no tuaj yeem thim rov qab qee qhov kev hloov pauv hauv hematopoietic system cuam tshuam nrog kev laus.
(4) Anti-inflammatory nyhuv
Kev tiv thaiv kev ua haujlwm ntawm UA yog muaj zog dua thiab tuaj yeem cuam tshuam ntau yam kev mob tshwm sim xws li TNF-α. Nws yog qhov tseeb rau qhov no uas UA ua lub luag haujlwm hauv ntau yam kev kho mob nrog rau lub hlwb, rog, lub plawv, plab hnyuv thiab daim siab. Nws tuaj yeem txo qhov mob ntawm ntau yam ntaub so ntswg.
(5) Neuroprotection
Qee cov kws tshawb fawb tau lees paub tias UA tuaj yeem cuam tshuam txoj hauv kev mitochondria-txog apoptosis thiab tswj txoj kev p-38 MAPK, yog li inhibiting oxidative stress-induced apoptosis. Piv txwv li, UA tuaj yeem txhim kho qhov ciaj sia taus ntawm cov neurons txhawb nqa los ntawm oxidative kev nyuaj siab thiab muaj kev ua haujlwm zoo neuroprotective.
(6) Cov nyhuv ntawm cov rog
UA tuaj yeem cuam tshuam cov cellular lipid metabolism thiab lipogenesis. Cov kev tshawb fawb tau pom tias UA tuaj yeem ua rau kom muaj roj xim av thiab xim av ntawm cov rog dawb, thaum tiv thaiv cov rog los ntawm kev noj haus.
(7) Txhim kho kev rog
UA kuj tseem tuaj yeem txo cov rog hauv adipocytes thiab daim siab hlwb kab lis kev cai hauv vitro thiab nce rog oxidation. Nws tuaj yeem hloov qhov tsis tshua muaj zog T4 hauv thyroxine mus rau ntau lub zog T3, txhim kho metabolic tus nqi thiab kub ntau lawm los ntawm thyroxine signaling. , yog li ua lub luag haujlwm hauv kev tswj kev rog.
(8) Tiv thaiv qhov muag
mitophagy inducer UA tuaj yeem txo cov kev ntxhov siab oxidative hauv cov laus retina; Nws txo cov qib ntawm cytosolic cGAS thiab txo cov glial cell ua kom muaj hnub nyoog retina.
(9) Kev tu tawv nqaij
Ntawm tag nrho cov pom mammalian plab hnyuv metabolites, UA muaj zog tshaj antioxidant kev ua, thib ob tsuas yog rau proanthocyanidin oligomers, catechins, epicatechin thiab 3,4-dihydroxyphenylacetic acid. tos.
Urolithin Ib daim ntawv thov scenarios
Hauv 2018, UA tau raug xaiv los ntawm US Food and Drug Administration ua cov khoom noj "feem ntau lees paub tias muaj kev nyab xeeb" thiab tuaj yeem muab ntxiv rau cov protein shakes, noj mov hloov dej haus, instant oatmeal, cov khoom noj muaj protein ntau thiab mis nyuj haus (txog 500 mg. / pab)), Greek yogurt, high-protein yogurt thiab mis nyuj protein shakes (txog 1000 mg / pab).
UA kuj tseem tuaj yeem ntxiv rau cov khoom tu tawv nqaij, suav nrog hnub cream, hmo ntuj thiab cov tshuaj pleev xim sib xyaw ua ke, tsim los txhim kho daim tawv nqaij hydration thiab txo qis wrinkles, txhim kho daim tawv nqaij zoo nkauj ntawm sab hauv tawm, thiab tiv thaiv cov tsos mob ntawm kev laus. , pab daim tawv nqaij nyob rau hauv cov hluas.
Cov txheej txheem ntau lawm Urolithin A
(1) Cov txheej txheem fermentation
Kev ua lag luam ntawm UA yog thawj zaug ua tiav los ntawm kev siv tshuab fermentation, uas feem ntau yog fermented los ntawm pomegranate peels thiab muaj urolithin A cov ntsiab lus ntau dua 10%.
(2) Cov txheej txheem chemical synthesis
Nrog rau kev nruam ntej thiab kev loj hlob ntawm kev tshawb fawb, tshuaj synthesis yog ib qho tseem ceeb ntawm kev tsim khoom ntawm urolithin A. Suzhou Myland Pharm yog lub neej tshiab kev tshawb fawb ntxiv, kev cai synthesis thiab kev tsim cov tuam txhab uas tuaj yeem muab High-purity, loj ntim urolithin A. hmoov raw khoom.
Kev lees paub: Kab lus no yog rau cov ntaub ntawv dav dav nkaus xwb thiab yuav tsum tsis txhob raug txhais raws li cov lus qhia kho mob. Qee cov ntaub ntawv blog tshaj tawm los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, formatting thiab kho cov ntawv. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntau ntxiv tsis txhais tau hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Nco ntsoov sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Post lub sij hawm: Aug-23-2024
