Taurine yog ib qho tseem ceeb micronutrient thiab muaj ntau aminosulfonic acid. Nws muaj ntau nyob rau hauv ntau yam nqaij thiab cov kab mob hauv lub cev. Nws feem ntau muaj nyob rau hauv ib lub xeev dawb hauv interstitial kua thiab intracellular kua. Vim tias nws thawj zaug muaj nyob rau hauv tis npe tom qab nws pom nyob rau hauv ox bile. Taurine yog ntxiv rau cov dej haus ua haujlwm kom rov ua kom muaj zog thiab txhim kho kev qaug zog.
Tsis ntev los no, kev tshawb fawb txog taurine tau luam tawm hauv peb phau ntawv xov xwm tseem ceeb Science, Cell, thiab Nature. Cov kev tshawb fawb no tau qhia txog cov haujlwm tshiab ntawm taurine - tiv thaiv kev laus, txhim kho cov txiaj ntsig ntawm kev kho mob qog noj ntshav, thiab tiv thaiv kev rog dhau.
Thaum Lub Rau Hli 2023, cov kws tshawb fawb los ntawm Lub Koom Haum National Institute of Immunology hauv Is Nrias teb, Columbia University hauv Tebchaws Meskas, thiab lwm lub koom haum tau luam tawm cov ntawv sau hauv phau ntawv xov xwm thoob ntiaj teb Science. Kev tshawb fawb qhia tias qhov tsis txaus taurine yog tus tsav tsheb ntawm kev laus. Kev ntxiv taurine tuaj yeem ua rau qeeb qeeb ntawm kev laus ntawm nematodes, nas, thiab liab, thiab tuaj yeem txuas lub neej noj qab haus huv ntawm cov nas hnub nyoog nruab nrab los ntawm 12%. Cov ntsiab lus: Kev Tshawb Fawb: Lub zog dhau koj lub tswv yim! Taurine kuj tseem tuaj yeem thim rov qab kev laus thiab txuas lub neej?
Thaum Lub Plaub Hlis Ntuj xyoo 2024, Xib Fwb Zhao Xiaodi, Xib Fwb Pab Lu Yuanyuan, Xib Fwb Nie Yongzhan, thiab Xib Fwb Wang Xin los ntawm Tsev Kho Mob Xijing ntawm Lub Tsev Kawm Ntawv Kho Mob Tub Rog Plaub tau luam tawm cov ntawv sau hauv phau ntawv xov xwm thoob ntiaj teb Cell. Kev tshawb fawb no pom tias cov hlwb qog sib tw nrog CD8 + T hlwb rau taurine los ntawm kev ua rau lub cev thauj taurine SLC6A6 ntau dhau, uas ua rau T hlwb tuag thiab qaug zog, ua rau lub cev tiv thaiv kab mob tawm ntawm lub cev, yog li ntawd txhawb kev loj hlob ntawm lub qog thiab rov tshwm sim, thaum kev ntxiv Taurine tuaj yeem ua rau cov hlwb CD8 + T hlwb uas qaug zog rov qab ua haujlwm thiab txhim kho kev kho mob qog noj ntshav zoo.
Thaum Lub Yim Hli 7, 2024, pab neeg ntawm Jonathan Z. Long ntawm Stanford University (Dr. Wei Wei yog tus sau thawj zaug) tau luam tawm ib daim ntawv tshawb fawb hu ua: PTER yog N-acetyl taurine hydrolase uas tswj kev noj zaub mov thiab kev rog dhau hauv phau ntawv xov xwm thoob ntiaj teb Nature.
Txoj kev tshawb fawb no tau tshawb pom thawj N-acetyl taurine hydrolase hauv cov tsiaj txhu, PTER, thiab lees paub lub luag haujlwm tseem ceeb ntawm N-acetyl taurine hauv kev txo cov khoom noj thiab tiv thaiv kev rog dhau. Yav tom ntej, nws muaj peev xwm tsim cov tshuaj PTER inhibitors muaj zog thiab xaiv tau rau kev kho mob rog dhau.
Taurine pom dav hauv cov nqaij ntawm cov tsiaj txhu thiab ntau yam khoom noj thiab pom muaj ntau hauv cov nqaij uas ua rau lub cev zoo li lub plawv, qhov muag, lub hlwb, thiab cov leeg nqaij. Taurine tau piav qhia tias muaj cov haujlwm ntawm lub cev thiab lub cev, tshwj xeeb tshaj yog nyob rau hauv cov ntsiab lus ntawm kev ua haujlwm ntawm lub cev. Kev txo qis ntawm cov tshuaj taurine hauv cov noob caj noob ces ua rau cov leeg nqaij qaug zog, txo qis kev ua haujlwm, thiab kev ua haujlwm tsis zoo ntawm mitochondrial hauv ntau cov nqaij. Kev noj tshuaj Taurine txo qis kev ntxhov siab redox ntawm mitochondrial, txhim kho kev ua haujlwm, thiab txo qhov hnyav ntawm lub cev.
Cov biochemistry thiab enzymology ntawm taurine metabolism tau nyiam ntau qhov kev tshawb fawb txaus siab. Hauv txoj kev endogenous taurine biosynthetic, cysteine yog metabolized los ntawm cysteine dioxygenase (CDO) thiab cysteine sulfinate decarboxylase (CSAD) los tsim hypotaurine, uas yog tom qab Oxidation los ntawm flavin monooxygenase 1 (FMO1) tsim taurine. Tsis tas li ntawd, cysteine tuaj yeem tsim hypotaurine ntawm lwm txoj hauv kev ntawm cysteamine thiab cysteamine dioxygenase (ADO). Downstream ntawm taurine nws tus kheej yog ntau yam theem nrab taurine metabolites, suav nrog taurocholate, tauramidine, thiab N-acetyl taurine. Tsuas yog enzyme paub tias catalyze cov downstream pathways yog BAAT, uas sib xyaw taurine nrog bile acyl-CoA los tsim taurocholate thiab lwm yam bile ntsev. Ntxiv rau BAAT, cov cim molecular ntawm lwm cov enzymes mediating theem nrab taurine metabolism tseem tsis tau txiav txim siab.
N-acetyltaurine (N-acetyl taurine) yog ib qho metabolite thib ob ntawm taurine uas nthuav tshwj xeeb tab sis tsis tau kawm txog. Cov theem N-acetyl taurine hauv cov kua dej hauv lub cev raug tswj hwm los ntawm ntau yam kev cuam tshuam ntawm lub cev uas ua rau muaj taurine thiab / lossis acetate flux, suav nrog kev tawm dag zog, kev haus dej cawv, thiab kev noj zaub mov taurine ntxiv. Tsis tas li ntawd, N-acetyltaurine muaj cov qauv tshuaj zoo sib xws rau cov tshuaj signaling suav nrog cov neurotransmitter acetylcholine thiab cov saw ntev N-fatty acyltaurine uas tswj cov ntshav qab zib, qhia tias nws kuj tseem yuav ua haujlwm ua lub cim metabolite. Cov khoom ua haujlwm. Txawm li cas los xij, biosynthesis, degradation, thiab cov haujlwm ntawm N-acetyl taurine tseem tsis meej.
Hauv kev tshawb fawb tshiab no, pab pawg tshawb fawb tau txheeb xyuas PTER, ib qho enzyme menyuam ntsuag uas tsis paub ua haujlwm, ua tus tsiaj txhu loj N-acetyl taurine hydrolase. Hauv vitro, recombinant PTER tau qhia txog ntau yam substrate nqaim thiab cov kev txwv loj. Hauv N-acetyl taurine, nws tau hydrolyzed rau hauv taurine thiab acetate.
Kev tshem tawm cov noob caj noob ces Pter hauv cov nas ua rau poob tag nrho ntawm N-acetyl taurine hydrolytic kev ua haujlwm hauv cov ntaub so ntswg thiab kev nce ntxiv ntawm N-acetyl taurine cov ntsiab lus hauv ntau cov ntaub so ntswg.
Qhov chaw PTER ntawm tib neeg muaj feem cuam tshuam nrog qhov hnyav ntawm lub cev (BMI). Pab pawg tshawb fawb ntxiv pom tias tom qab kev txhawb nqa nrog cov qib taurine nce ntxiv, cov nas Pter knockout tau qhia tias kev noj zaub mov tsawg dua thiab tiv taus kev rog dhau los ntawm kev noj zaub mov. thiab txhim kho glucose homeostasis. Kev ntxiv N-acetyl taurine rau cov nas qus rog kuj txo cov zaub mov noj thiab qhov hnyav ntawm lub cev raws li GFRAL.
Cov ntaub ntawv no tso PTER rau ntawm lub hauv paus enzyme ntawm taurine theem nrab metabolism thiab qhia txog lub luag haujlwm ntawm PTER thiab N-acetyl taurine hauv kev tswj qhov hnyav thiab lub zog sib npaug.
Zuag qhia tag nrho, txoj kev tshawb fawb no tau tshawb pom thawj acetyl taurine hydrolase hauv cov tsiaj txhu, PTER, thiab lees paub lub luag haujlwm tseem ceeb ntawm acetyl taurine hauv kev txo cov khoom noj thiab tiv thaiv kev rog dhau. Yav tom ntej, nws xav tias yuav muaj cov tshuaj PTER inhibitors muaj zog thiab xaiv tau rau kev kho mob rog dhau.
Lus Ceeb Toom: Tsab xov xwm no tsuas yog rau cov ntaub ntawv dav dav xwb thiab yuav tsum tsis txhob txhais hais tias yog cov lus qhia kho mob. Qee cov ntaub ntawv hauv blog los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, tsim hom ntawv thiab kho cov ntawv xwb. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntxiv tsis tau txhais hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Ib txwm sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Lub sijhawm tshaj tawm: Lub Yim Hli-12-2024
