Taurine yog ib qho tseem ceeb micronutrient thiab ntau aminosulfonic acid. Nws yog dav faib nyob rau hauv ntau yam ntaub so ntswg thiab kabmob hauv lub cev. Nws feem ntau muaj nyob rau hauv lub xeev dawb hauv cov kua nruab nrog cev thiab cov kua dej intracellular. Vim nws xub muaj nyob rau hauv Named tom qab nws pom nyob rau hauv ox bile. Taurine yog ntxiv rau cov dej haus uas muaj txiaj ntsig zoo los ntxiv dag zog thiab txhim kho qaug zog.
Tsis ntev los no, kev tshawb fawb txog taurine tau luam tawm nyob rau hauv peb phau ntawv sau npe Science, Cell, thiab Xwm. Cov kev tshawb fawb no tau nthuav tawm cov haujlwm tshiab ntawm taurine - tiv thaiv kev laus, txhim kho cov nyhuv ntawm kev kho mob qog noj ntshav, thiab tiv thaiv kev rog.
Thaum Lub Rau Hli 2023, cov kws tshawb fawb los ntawm National Institute of Immunology hauv Is Nrias teb, Columbia University hauv Tebchaws Meskas, thiab lwm lub tsev kawm ntawv tau tshaj tawm cov ntaub ntawv hauv cov ntawv xov xwm thoob ntiaj teb kev kawm Science. Txoj kev tshawb no qhia tias taurine tsis muaj peev xwm ua rau muaj kev laus. Supplementing taurine tuaj yeem ua rau qeeb ntawm kev laus ntawm nematodes, nas, thiab liab, thiab tuaj yeem txuas ntxiv kev noj qab haus huv ntawm cov nas hnub nyoog nruab nrab los ntawm 12%. Paub meej: Kev Tshawb Fawb: Lub zog dhau ntawm koj qhov kev xav! Taurine tseem tuaj yeem thim rov qab kev laus thiab txuas ntxiv lub neej?
Thaum lub Plaub Hlis 2024, Xib Fwb Zhao Xiaodi, Associate Professor Lu Yuanyuan, Xib Fwb Nie Yongzhan, thiab xibfwb Wang Xin los ntawm Xijing Tsev Kho Mob ntawm Lub Tsev Kawm Ntawv Qib Siab Fourth Military Medical University tau tshaj tawm cov ntaub ntawv nyob rau hauv cov ntawv xov xwm thoob ntiaj teb sab saum toj Cell. Txoj kev tshawb no pom tias cov qog hlwb sib tw nrog CD8 + T hlwb rau taurine los ntawm overexpressing taurine transporter SLC6A6, uas induces T cell tuag thiab qaug zog, ua rau cov qog tiv thaiv kab mob khiav, yog li txhawb cov qog nqaij hlav thiab rov tshwm sim, thaum ntxiv Taurine tuaj yeem rov ua kom tag CD8+ T hlwb. thiab txhim kho kev kho mob qog noj ntshav.
Thaum Lub Yim Hli 7, 2024, pab pawg ntawm Jonathan Z. Long ntawm Stanford University (Dr. Wei Wei yog thawj tus kws sau ntawv) tau luam tawm cov ntaub ntawv tshawb fawb hu ua: PTER yog N-acetyl taurine hydrolase uas tswj kev noj zaub mov thiab rog hauv cov kev kawm thoob ntiaj teb sab saum toj. phau ntawv Nature.
Txoj kev tshawb no tshawb pom thawj N-acetyl taurine hydrolase hauv cov tsiaj tsiaj, PTER, thiab tau lees paub lub luag haujlwm tseem ceeb ntawm N-acetyl taurine hauv kev txo cov zaub mov noj thiab tiv thaiv rog. Nyob rau hauv lub neej yav tom ntej, nws muaj peev xwm tsim muaj zog thiab xaiv PTER inhibitors rau kev kho mob rog.
Taurine yog dav pom nyob rau hauv cov ntaub so ntswg mammalian thiab ntau yam khoom noj thiab pom muaj nyob rau hauv tshwj xeeb yog siab concentration nyob rau hauv excitable ntaub so ntswg xws li lub plawv, qhov muag, hlwb, thiab cov leeg. Taurine tau piav qhia tias muaj pleiotropic cellular thiab lub cev muaj zog, tshwj xeeb tshaj yog nyob rau hauv cov ntsiab lus ntawm metabolic homeostasis. Kev txo caj ces hauv cov qib taurine ua rau cov leeg nqaij atrophy, txo qis kev tawm dag zog, thiab mitochondrial tsis ua haujlwm hauv ntau cov ntaub so ntswg. Taurine supplementation txo mitochondrial redox kev ntxhov siab, txhim kho kev tawm dag zog, thiab txo qis lub cev hnyav.
Lub biochemistry thiab enzymology ntawm taurine metabolism tau nyiam kev tshawb fawb ntau heev. Nyob rau hauv txoj kev endogenous taurine biosynthetic, cysteine yog metabolized los ntawm cysteine dioxygenase (CDO) thiab cysteine sulfinate decarboxylase (CSAD) los tsim hypotaurine, uas yog tom qab Oxidation los ntawm flavin monooxygenase 1 (FMO1) tsim taurine taurine. Tsis tas li ntawd, cysteine tuaj yeem tsim hypotaurine los ntawm lwm txoj hauv kev ntawm cysteamine thiab cysteamine dioxygenase (ADO). Hauv qab ntawm taurine nws tus kheej yog ob peb theem taurine metabolites, suav nrog taurocholate, tauramidine, thiab N-acetyl taurine. Tib lub enzyme uas paub los ua kom cov kab hauv qab no yog BAAT, uas ua ke taurine nrog cov kua tsib acyl-CoA los tsim taurocholate thiab lwm cov kua tsib ntsev. Ntxiv rau BAAT, cov cim molecular ntawm lwm cov enzymes kho cov theem nrab taurine metabolism tseem tsis tau txiav txim siab.
N-acetyltaurine (N-acetyl taurine) yog ib qho nthuav tshwj xeeb tab sis tsis tau kawm theem nrab metabolite ntawm taurine. N-acetyl taurine qib nyob rau hauv cov kua roj lom yog dynamically tswj los ntawm ntau yam physiological perturbations uas ua rau kom taurine thiab / los yog acetate flux, nrog rau endurance ce, haus cawv, thiab noj taurine supplementation. Tsis tas li ntawd, N-acetyltaurine muaj tshuaj lom neeg cov qauv zoo sib xws rau kev taw qhia cov molecules nrog rau cov neurotransmitter acetylcholine thiab cov saw ntev N-fatty acyltaurine uas tswj cov ntshav qab zib, tawm tswv yim tias nws kuj tseem ua haujlwm raws li cov teeb liab metabolite Cov khoom ua haujlwm. Txawm li cas los xij, biosynthesis, degradation, thiab muaj peev xwm ua haujlwm ntawm N-acetyl taurine tseem tsis meej.
Hauv qhov kev tshawb fawb tshiab no, pab pawg tshawb fawb tau txheeb xyuas PTER, tus menyuam ntsuag enzyme ntawm kev ua haujlwm tsis paub, raws li cov tsiaj loj loj N-acetyl taurine hydrolase. Hauv vitro, recombinant PTER nthuav tawm qhov nqaim substrate ntau yam thiab cov kev txwv loj. Hauv N-acetyl taurine, nws yog hydrolyzed rau hauv taurine thiab acetate.
Knocking tawm Pter noob hauv cov nas ua rau ua tiav ntawm N-acetyl taurine hydrolytic kev ua haujlwm hauv cov ntaub so ntswg thiab kev nce hauv cov ntsiab lus N-acetyl taurine hauv ntau cov ntaub so ntswg.
Tib neeg PTER qhov chaw yog txuam nrog lub cev qhov ntsuas (BMI). Pab pawg tshawb fawb ntxiv tau pom tias tom qab kev txhawb nqa nrog cov qib taurine ntau ntxiv, Pter knockout nas pom tau tias txo qis kev noj zaub mov thiab tiv thaiv kev noj zaub mov kom rog. thiab txhim kho glucose homeostasis. Kev ntxiv ntawm N-acetyl taurine rau cov nas rog rog kuj txo cov khoom noj thiab lub cev hnyav hauv GFRAL-raws li.
Cov ntaub ntawv no tso PTER ntawm lub hauv paus enzyme node ntawm taurine theem nrab metabolism thiab qhia txog lub luag haujlwm ntawm PTER thiab N-acetyl taurine hauv kev tswj qhov hnyav thiab lub zog sib npaug.
Zuag qhia tag nrho, txoj kev tshawb no nrhiav pom thawj acetyl taurine hydrolase hauv cov tsiaj tsiaj, PTER, thiab tau lees paub lub luag haujlwm tseem ceeb ntawm acetyl taurine hauv kev txo cov zaub mov noj thiab tiv thaiv rog. Nyob rau hauv lub neej yav tom ntej, nws cia siab tias muaj zog thiab xaiv PTER inhibitors yuav raug tsim los kho kev rog.
Kev lees paub: Kab lus no yog rau cov ntaub ntawv dav dav nkaus xwb thiab yuav tsum tsis txhob raug txhais raws li cov lus qhia kho mob. Qee cov ntaub ntawv blog tshaj tawm los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, formatting thiab kho cov ntawv. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntau ntxiv tsis txhais tau hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Nco ntsoov sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Post lub sij hawm: Aug-12-2024
