Mitochondria feem ntau hu ua "chaw nres tsheb fais fab" ntawm lub cell, ib lo lus uas qhia txog lawv lub luag haujlwm tseem ceeb hauv kev tsim hluav taws xob. Cov organelles me me no yog qhov tseem ceeb rau suav tsis txheeb cov txheej txheem ntawm tes, thiab lawv qhov tseem ceeb txuas mus deb tshaj qhov tsim hluav taws xob. Muaj ntau ntau cov tshuaj uas tuaj yeem txhim kho mitochondrial noj qab haus huv. Cia peb saib!
Cov qauv ntawm mitochondria
Mitochondria yog qhov tshwj xeeb ntawm cov cellular organelles vim lawv cov qauv ob-membrane. Lub txheej membrane yog du thiab ua raws li ib tug barrier ntawm lub cytoplasm thiab lub internal ib puag ncig ntawm lub mitochondria. Txawm li cas los xij, lub intima yog curled heev, tsim folds hu ua cristae. Cov cristae no nce qhov chaw saum npoo av muaj rau cov tshuaj tiv thaiv, uas yog qhov tseem ceeb rau kev ua haujlwm ntawm lub cev.
Nyob rau hauv lub puab daim nyias nyias yog mitochondrial matrix, ib tug gel zoo li cov khoom uas muaj enzymes, mitochondrial DNA (mtDNA), thiab ribosomes. Tsis zoo li feem ntau lwm cov organelles, mitochondria muaj lawv tus kheej cov khoom siv caj ces, uas tau txais los ntawm cov niam txiv. Qhov tshwj xeeb no ua rau cov kws tshawb fawb ntseeg tias mitochondria yog los ntawm cov kab mob symbiotic thaum ub.
Mitochondrial muaj nuj nqi
1. Kev tsim hluav taws xob
Lub luag haujlwm tseem ceeb ntawm mitochondria yog tsim cov adenosine triphosphate (ATP), lub xov tooj ntawm lub zog thawj txiaj txiaj. Cov txheej txheem no, hu ua oxidative phosphorylation, tshwm sim nyob rau hauv daim nyias nyias thiab muaj ib tug complex series ntawm biochemical tshuaj. Cov saw hlau thauj hluav taws xob (ETC) thiab ATP synthase yog cov tseem ceeb hauv cov txheej txheem no.
(1) Electron thauj saw (ETC): ETC yog ib qho ntawm cov protein complexes thiab lwm yam molecules embedded rau hauv daim nyias nyias. Cov hluav taws xob raug xa mus los ntawm cov complexes, tso tawm lub zog uas siv los tso cov protons (H +) los ntawm cov matrix mus rau qhov chaw nruab nrab. Qhov no tsim ib qho electrochemical gradient, tseem hu ua proton motive force.
(2) ATP synthase: ATP synthase yog ib qho enzyme uas siv lub zog khaws cia hauv proton motive quab yuam los ua ke ATP los ntawm adenosine diphosphate (ADP) thiab inorganic phosphate (Pi). Raws li protons ntws rov qab mus rau lub matrix los ntawm ATP synthase, lub enzyme catalyzes tsim ntawm ATP.
2. Metabolic txoj kev
Ntxiv rau ATP ntau lawm, mitochondria tau koom nrog ntau txoj hauv kev metabolic, suav nrog lub voj voog citric acid (Krebs cycle) thiab fatty acid oxidation. Cov txheej txheem no tsim cov nruab nrab molecules uas tseem ceeb rau lwm cov txheej txheem ntawm tes, xws li kev sib txuas ntawm cov amino acids, nucleotides, thiab lipids.
3. Apoptosis
Mitochondria kuj tseem ua lub luag haujlwm tseem ceeb hauv kev tuag ntawm tes, lossis apoptosis. Thaum lub sij hawm apoptosis, mitochondria tso tawm cytochrome c thiab lwm yam pro-apoptotic yam rau hauv cytoplasm, ua rau muaj ntau yam xwm txheej ua rau kev tuag ntawm tes. Cov txheej txheem no tseem ceeb heev rau kev tswj hwm cellular homeostasis thiab tshem tawm cov hlwb puas lossis kab mob.
4. Mitochondria thiab kev noj qab haus huv
Muab lub luag haujlwm tseem ceeb ntawm mitochondria hauv kev tsim hluav taws xob thiab cellular metabolism, nws tsis yog qhov xav tsis thoob tias mitochondrial ua haujlwm tsis zoo cuam tshuam nrog ntau yam teeb meem kev noj qab haus huv. Nov yog qee qhov chaw tseem ceeb uas mitochondria cuam tshuam rau peb txoj kev noj qab haus huv:
5. Kev laus
Mitochondria tau xav tias ua lub luag haujlwm tseem ceeb hauv kev laus. Thaum lub sij hawm, mitochondrial DNA accumulates kev hloov pauv thiab cov saw hlau thauj hluav taws xob ua haujlwm tsawg. Qhov no ua rau muaj kev tsim cov pa oxygen ntau ntxiv (ROS), uas ua rau cov khoom siv cellular puas thiab ua rau cov txheej txheem kev laus. Cov tswv yim los txhim kho mitochondrial muaj nuj nqi thiab txo oxidative kev nyuaj siab yog raug tshawb nrhiav raws li kev tiv thaiv kev laus.
6. Cov kab mob metabolic
Mitochondrial dysfunction tseem cuam tshuam nrog ntau yam kab mob metabolic, suav nrog kev rog, ntshav qab zib, thiab kab mob plawv. Kev ua haujlwm tsis zoo ntawm mitochondrial ua rau txo qis zog, nce rog cia, thiab tiv thaiv insulin. Kev txhim kho mitochondrial muaj nuj nqi los ntawm kev cuam tshuam hauv kev ua neej xws li kev tawm dag zog thiab noj zaub mov zoo tuaj yeem pab txo cov mob no.
NADH, resveratrol, astaxanthin, coenzyme Q10, urolithin A, thiab spermidine yog txhua yam tshuaj uas tau txais kev saib xyuas ntau thaum nws los txhim kho mitochondrial noj qab haus huv thiab tiv thaiv kev laus. Txawm li cas los xij, txhua qhov ntxiv muaj nws tus kheej cov txheej txheem thiab cov txiaj ntsig.
1. NADH
Lub luag haujlwm tseem ceeb: NADH tuaj yeem tsim NAD + hauv lub cev zoo, thiab NAD + yog lub luag haujlwm tseem ceeb hauv cov txheej txheem ntawm cov khoom siv cellular metabolism thiab mitochondrial zog tsim.
Los tiv thaiv kev laus: Los ntawm kev nce qib NAD +, NADH tuaj yeem qhib lub neej ntev protein SIRT1, kho lub moos lom neeg, qhib cov tshuaj neurotransmitters, thiab tswj cov txheej txheem pw tsaug zog. Tsis tas li ntawd, NADH tuaj yeem kho DNA puas, tiv thaiv oxidation, thiab txhim kho tib neeg cov metabolism, yog li ua tiav cov txiaj ntsig zoo ntawm kev ncua kev laus.
Qhov zoo: NASA lees paub thiab pom zoo rau NADH rau cov neeg caij nkoj los tswj lawv cov moos lom neeg, qhia nws cov txiaj ntsig hauv kev siv tswv yim.
2. Astaxanthin
Lub luag haujlwm tseem ceeb: Astaxanthin yog liab beta-ionone nplhaib carotenoid nrog cov tshuaj tua kab mob siab heev.
Anti-aging mechanism: Astaxanthin tuaj yeem tua cov pa oxygen, tshem tawm cov dawb radicals, thiab tswj kev ua haujlwm mitochondrial los ntawm kev tiv thaiv mitochondrial redox tshuav nyiaj li cas. Tsis tas li ntawd, nws nce kev ua haujlwm ntawm superoxide dismutase thiab glutathione peroxidase.
Qhov zoo: Lub peev xwm antioxidant ntawm astaxanthin yog 6,000 npaug ntawm cov vitamin C thiab 550 npaug ntawm cov vitamin E, qhia nws cov peev xwm muaj zog antioxidant.
3. Coenzyme Q10 (CoQ10)
Lub luag haujlwm tseem ceeb: Coenzyme Q10 yog lub zog hloov pauv tus neeg sawv cev rau mitochondria ntawm tes thiab tseem yog cov khoom noj khoom haus qub qub uas feem ntau lees paub los ntawm cov zej zog kev tshawb fawb.
Cov txheej txheem tiv thaiv kev laus: Coenzyme Q10 muaj peev xwm ua kom muaj zog antioxidant, uas tuaj yeem tshem tawm cov dawb radicals thiab pab rov qab ua haujlwm antioxidant ntawm vitamin C thiab vitamin E uas tau oxidized. Tsis tas li ntawd, nws tuaj yeem muab cov pa oxygen txaus thiab lub zog rau cov leeg hlwb thiab hlwb hlwb.
Qhov zoo: Coenzyme Q10 yog qhov tseem ceeb tshwj xeeb hauv kev noj qab haus huv hauv plawv thiab muaj txiaj ntsig zoo rau kev txhim kho cov tsos mob plawv tsis ua hauj lwm thiab txo qis kev tuag thiab kev mus pw hauv tsev kho mob hauv cov neeg mob plawv.
Lub luag haujlwm tseem ceeb: Urolithin A yog cov metabolite thib ob uas tsim los ntawm cov kab mob hauv plab hnyuv metabolizing polyphenols.
Anti-aging mechanism: Urolithin A tuaj yeem qhib sirtuins, nce NAD + thiab cellular zog, thiab tshem tawm cov mitochondria puas hauv tib neeg cov leeg. Tsis tas li ntawd, nws kuj muaj anti-inflammatory thiab anti-proliferative teebmeem.
Qhov zoo: Urolithin A tuaj yeem hla cov hlab ntsha-hlwb thiab muaj peev xwm txhim kho cov kab mob metabolic thiab tiv thaiv kev laus.
5. Spermidine
Cov txiaj ntsig tseem ceeb: Spermidine yog ib qho tshwm sim tshwm sim los ntawm cov kab mob hauv plab hnyuv.
Anti-aging mechanism: Spermidine tuaj yeem ua rau mitophagy thiab tshem tawm cov mitochondria tsis zoo thiab puas. Tsis tas li ntawd, nws muaj peev xwm tiv thaiv kab mob plawv thiab poj niam kev laus laus.
Qhov zoo: Kev noj zaub mov spermidine muaj nyob rau hauv ntau yam khoom noj, xws li kua txiv hmab txiv ntoo thiab cov nplej, thiab yooj yim muaj.
Suzhou Myland Pharm & Khoom noj khoom haus Inc. yog ib lub chaw tsim tshuaj paus FDA uas muab cov khoom zoo thiab siab dawb huv los tiv thaiv kev laus ntxiv hmoov.
Ntawm Suzhou Myland Pharm peb tau cog lus los muab cov khoom lag luam zoo tshaj plaws ntawm tus nqi zoo tshaj. Peb cov hmoov ntxiv los tiv thaiv kev laus yog nruj me ntsis kuaj rau purity thiab potency, ua rau lawv xaiv zoo tshaj plaws seb koj puas xav txhawb kev noj qab haus huv ntawm tes, txhawb koj lub cev tiv thaiv kab mob lossis txhim kho kev noj qab haus huv tag nrho.
Nrog 30 xyoo ntawm kev paub thiab tsav los ntawm cov cuab yeej siv siab thiab cov tswv yim zoo R & D, Suzhou Myland Pharm tau tsim ntau yam khoom sib tw thiab dhau los ua lub neej tshiab kev tshawb fawb ntxiv, kev cai synthesis thiab kev tsim cov tuam txhab.
Tsis tas li ntawd, Suzhou Myland Pharm kuj yog ib lub chaw tsim tshuaj paus FDA. Lub tuam txhab R&D cov peev txheej, cov chaw tsim khoom, thiab cov cuab yeej tshuaj ntsuam xyuas yog niaj hnub thiab muaj ntau yam kev ua haujlwm, thiab tuaj yeem tsim cov tshuaj los ntawm milligrams mus rau tons hauv nplai, thiab ua raws li ISO 9001 cov qauv thiab cov khoom specifications GMP.
Kev lees paub: Kab lus no yog rau cov ntaub ntawv dav dav nkaus xwb thiab yuav tsum tsis txhob raug txhais raws li cov lus qhia kho mob. Qee cov ntaub ntawv blog tshaj tawm los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, formatting thiab kho cov ntawv. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntau ntxiv tsis txhais tau hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Nco ntsoov sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Post lub sij hawm: Oct-01-2024
