Koj yuav tsum paub dab tsi txog nicotinamide adenine dinucleotide (NAD +)?

NAD + tseem hu ua coenzyme, thiab nws lub npe tag nrho yog nicotinamide adenine dinucleotide. Nws yog ib qho tseem ceeb coenzyme nyob rau hauv lub voj voog tricarboxylic acid. Nws txhawb cov metabolism hauv qab zib, rog, thiab amino acids, koom nrog hauv kev sib txuas ntawm lub zog, thiab koom nrog ntau txhiab qhov kev xav hauv txhua lub cell. Ntau qhov kev sim cov ntaub ntawv qhia tau hais tias NAD + tau koom nrog ntau yam kev ua haujlwm ntawm lub cev hauv lub cev, yog li cuam tshuam hauv cov haujlwm tseem ceeb hauv cellular xws li lub zog metabolism, kho DNA, hloov kho caj ces, mob, lom neeg lub cev, thiab kev ntxhov siab.

Raws li kev tshawb fawb cuam tshuam, NAD + qib hauv tib neeg lub cev yuav txo qis nrog hnub nyoog. Txo NAD + qib tuaj yeem ua rau cov hlab ntsha tsis zoo, tsis pom kev, kev rog, lub plawv tsis ua haujlwm thiab lwm yam kev ua haujlwm tsis zoo. Yog li ntawd, yuav ua li cas kom nce qib NAD + hauv tib neeg lub cev ib txwm muaj lus nug. Ib lub ntsiab lus kub tshawb fawb hauv zej zog biomedical.

Vim li cas NAD + txo qis?

Vim hais tias, raws li peb muaj hnub nyoog, DNA kev puas tsuaj nce. Thaum lub sijhawm kho DNA, qhov kev thov rau PARP1 nce, cov haujlwm ntawm SIRT raug txwv, NAD + noj nce ntxiv, thiab tus nqi ntawm NAD + ib txwm txo qis.

Yog peb ntxiv txausNAD+, peb yuav pom tias ntau lub luag haujlwm ntawm lub cev pib rov ua kom cov hluas.

Cells muaj NAD +. Peb puas tseem yuav tau ntxiv nws?

Peb lub cev yog tsim los ntawm kwv yees li 37 trillion hlwb. Cells yuav tsum ua kom tiav ntau "ua haujlwm" lossis cov tshuaj tiv thaiv cellular los tswj lawv tus kheej. Txhua ntawm koj 37 trillion hlwb nyob ntawm NAD + ua nws txoj haujlwm tsis tu ncua.

Raws li lub ntiaj teb cov pej xeem muaj hnub nyoog, cov kab mob kev laus xws li Alzheimer's disease, kab mob plawv, teeb meem sib koom ua ke, pw tsaug zog thiab teeb meem plawv tau dhau los ua cov kab mob tseem ceeb uas ua rau tib neeg noj qab haus huv.

Yog li ntawd, txij li thaum NAD tau tshawb pom los ntawm cov kws tshawb fawb Asmeskas, NAD tau nkag mus rau tib neeg lub neej, thiab NAD + thiab nws cov tshuaj ntxiv tau pom zoo rau daim ntawv thov kev cia siab hauv kev tiv thaiv kab mob kev laus.

① NAD + ua raws li coenzyme hauv mitochondria los txhawb kev sib npaug ntawm metabolic. NAD + ua lub luag haujlwm tshwj xeeb hauv cov txheej txheem metabolic xws li glycolysis, TCA voj voog (aka Krebs voj voog lossis citric acid voj voog) thiab cov saw hlau thauj hluav taws xob. Nws yog li cas cov hlwb tau txais lub zog. Kev laus thiab kev noj zaub mov muaj calorie tsawg txo NAD + qib hauv lub cev.

Cov kev tshawb fawb tau pom tias hauv cov nas laus, noj NAD + tshuaj txo qis kev noj haus- lossis hnub nyoog txog qhov hnyav nce thiab txhim kho kev tawm dag zog. Tsis tas li ntawd, cov kev tshawb fawb tseem tau thim rov qab cov txiaj ntsig ntawm ntshav qab zib hauv poj niam nas, qhia cov tswv yim tshiab los tawm tsam cov kab mob metabolic xws li rog rog.

NAD + khi rau enzymes thiab hloov electrons ntawm molecules. Electrons yog lub hauv paus ntawm cellular zog. NAD + ua rau cov hlwb zoo li rov them lub roj teeb. Thaum siv cov electrons, lub roj teeb tuag. Hauv cov hlwb, NAD + tuaj yeem txhawb kev hloov pauv hluav taws xob thiab muab lub zog rau cov hlwb. Nyob rau hauv txoj kev no, NAD + tuaj yeem txo lossis nce kev ua haujlwm enzyme, txhawb kev qhia cov noob thiab kev qhia ntawm tes.

② NAD + pab tswj DNA puas

Raws li cov kab mob muaj hnub nyoog, qhov tsis zoo ntawm ib puag ncig xws li hluav taws xob, kev ua qias tuaj, thiab kev hloov pauv DNA tsis zoo tuaj yeem ua rau DNA puas. Qhov no yog ib qho ntawm cov kev xav ntawm kev laus. Yuav luag txhua lub hlwb muaj "molecular machinery" los kho qhov kev puas tsuaj no.

Qhov kev kho no yuav tsum muaj NAD + thiab lub zog, yog li kev puas tsuaj DNA ntau dhau siv cov khoom siv cellular zoo. Kev ua haujlwm ntawm PARP, qhov tseem ceeb DNA kho cov protein, kuj nyob ntawm NAD +. Kev laus ib txwm ua rau DNA puas tsuaj rau hauv lub cev, RARP nce, thiab yog li ntawd NAD + concentrations txo. Mitochondrial DNA puas ntawm txhua kauj ruam yuav ua rau qhov kev puas tsuaj loj.

③ NAD+cuam ​​tshuam rau kev ua haujlwm ntawm cov noob neej ntev Sirtuins thiab inhibits kev laus

Cov noob caj noob ces uas tau tshawb pom ntev ntev sirtuins, tseem hu ua "cov neeg saib xyuas ntawm cov noob," ua lub luag haujlwm tseem ceeb hauv kev saib xyuas kev noj qab haus huv ntawm tes. Sirtuins yog ib tsev neeg ntawm cov enzymes koom nrog hauv cellular stress teb thiab kho puas. Lawv kuj koom nrog hauv kev tso cov tshuaj insulin, cov txheej txheem kev laus, thiab kev laus txog kev noj qab haus huv xws li cov kab mob neurodegenerative thiab ntshav qab zib.

NAD + yog cov roj uas pab sirtuins tswj genome kev ncaj ncees thiab txhawb nqa DNA kho. Ib yam li lub tsheb tsis tuaj yeem nyob tsis muaj roj, Sirtuins xav tau NAD + rau kev ua haujlwm. Cov txiaj ntsig los ntawm kev tshawb fawb tsiaj pom tau tias nce qib NAD + hauv lub cev ua kom cov proteins sirtuin thiab txuas ntxiv lub neej ntawm cov poov xab thiab nas.

④ Lub plawv muaj nuj nqi

Kev nce qib NAD + tiv thaiv lub plawv thiab txhim kho lub plawv ua haujlwm. Ntshav siab tuaj yeem ua rau lub plawv loj thiab cov hlab ntsha txhaws, uas tuaj yeem ua rau mob stroke. Tom qab ntxiv NAD + qib hauv lub plawv los ntawm NAD + tshuaj ntxiv, kev puas tsuaj rau lub plawv los ntawm kev rov ua dua yog inhibited. Lwm cov kev tshawb fawb tau pom tias NAD + cov tshuaj ntxiv kuj tiv thaiv cov nas los ntawm lub plawv tsis zoo.

⑤ Neurodegeneration

Hauv cov nas nrog Alzheimer's kab mob, nce NAD + qib txhim kho kev txawj ntse los ntawm kev txo qis cov proteins uas cuam tshuam kev sib txuas lus hauv hlwb. Kev nce qib NAD + kuj tseem tiv thaiv cov hlwb hauv hlwb los ntawm kev tuag thaum tsis muaj ntshav txaus rau lub hlwb. NAD + zoo li muaj cov lus cog tseg tshiab hauv kev tiv thaiv neurodegeneration thiab txhim kho kev nco.

⑥ Kev tiv thaiv kab mob

Thaum peb muaj hnub nyoog, peb lub cev tiv thaiv kab mob poob qis thiab peb raug mob ntau dua. Kev tshawb fawb tsis ntev los no qhia tias NAD + qib ua lub luag haujlwm tseem ceeb hauv kev tswj hwm lub cev tiv thaiv kab mob thiab o thiab cell ciaj sia taus thaum laus. Txoj kev tshawb no qhia txog cov peev xwm kho mob ntawm NAD + rau kev tiv thaiv kab mob.

Kev sib raug zoo ntawm lub luag haujlwm ntawm NAD + thiab kev laus

Coenzymes koom nrog hauv cov metabolism hauv cov khoom tseem ceeb xws li qab zib, rog, thiab cov protein hauv tib neeg lub cev, thiab ua lub luag haujlwm tseem ceeb hauv kev tswj hwm lub cev cov khoom thiab lub zog metabolism thiab tswj kev ua haujlwm ntawm lub cev. NAD yog cov coenzyme tseem ceeb tshaj plaws hauv tib neeg lub cev, tseem hu ua coenzyme I. Nws koom nrog ntau txhiab tus redox enzymatic cov tshuaj tiv thaiv hauv tib neeg lub cev. Nws yog ib qho tseem ceeb ntawm cov metabolism hauv txhua lub cell. Nws muaj ntau yam haujlwm, lub luag haujlwm tseem ceeb yog:

1. Txhawb kev tsim khoom ntawm bioenergy

NAD + tsim ATP los ntawm kev ua pa ntawm tes, ncaj qha ntxiv lub zog ntawm tes thiab txhim kho kev ua haujlwm ntawm tes;

2. Kho cov noob

NAD + yog tib lub substrate rau DNA kho enzyme PARP. Hom enzyme no koom nrog hauv kev kho DNA, pab kho DNA puas thiab hlwb, txo txoj kev hloov ntawm tes, thiab tiv thaiv qhov tshwm sim ntawm qog noj ntshav;

3. Ua kom tag nrho cov proteins uas nyob ntev

NAD + tuaj yeem qhib tau tag nrho 7 cov proteins uas muaj sia nyob ntev, yog li NAD + muaj kev cuam tshuam tseem ceeb dua rau kev tiv thaiv kev laus thiab kev ua neej ntev;

4. Txhim kho lub cev tiv thaiv kab mob

NAD + ntxiv dag zog rau lub cev tiv thaiv kab mob thiab txhim kho kev tiv thaiv kab mob ntawm tes los ntawm kev xaiv cuam tshuam rau kev ciaj sia thiab kev ua haujlwm ntawm kev tswj T hlwb.

5. Txhawb cov plaub hau kev loj hlob

Qhov laj thawj tseem ceeb ntawm cov plaub hau poob yog qhov poob ntawm cov plaub hau niam cell vitality, thiab poob ntawm cov plaub hau niam cell vitality yog vim NAD + qib hauv tib neeg lub cev txo. Cov plaub hau niam hlwb tsis muaj ATP txaus los ua cov plaub hau protein synthesis, yog li poob lawv qhov tseem ceeb thiab ua rau cov plaub hau poob.

6. Kev tswj qhov hnyav, txhawb cov metabolism

Hauv xyoo 2017, xibfwb David Sinclair ntawm Harvard Medical School thiab ib pab neeg los ntawm Australian Medical College tau ua qhov kev sim sib piv ntawm cov poj niam rog rog ua haujlwm ntawm lub treadmill rau 9 lub lis piam thiab noj NMN txhua hnub rau 18 hnub. Txoj kev tshawb nrhiav pom tias NMN cuam tshuam rau daim siab rog metabolism. Thiab cov nyhuv ntawm synthesis yog pom tseeb ntau dua li ntawm kev tawm dag zog.

Qhov tseem ceeb, kev laus yog nrog los ntawm kev poob qis hauv cov ntaub so ntswg thiab cellular NAD + qib hauv ntau hom kab mob, nrog rau cov nas thiab tib neeg. Kev txo qis NAD + qib yog cuam tshuam rau ntau yam kab mob cuam tshuam nrog kev laus, suav nrog kev paub tsis meej, mob qog noj ntshav, kab mob metabolic, sarcopenia, thiab frailty.

Kuv tuaj yeem ntxiv NAD + txhua hnub li cas?

Tsis muaj qhov kawg ntawm NAD + hauv peb lub cev. Cov ntsiab lus thiab kev ua ntawm NAD + hauv tib neeg lub cev yuav txo qis nrog lub hnub nyoog, thiab nws yuav txo qis sai tom qab hnub nyoog 30 xyoo, ua rau kev laus ntawm tes, apoptosis thiab tsis muaj peev xwm rov tsim dua tshiab. .

Tsis tas li ntawd, kev txo qis ntawm NAD + tseem yuav ua rau muaj teeb meem kev noj qab haus huv, yog li yog tias NAD + tsis tuaj yeem rov qab tau raws sijhawm, qhov tshwm sim tuaj yeem xav txog.

1.Ntxiv los ntawm cov khoom noj

Cov zaub mov xws li zaub qhwv, zaub qhwv, avocado, steak, nceb, thiab edamame muaj NAD + precursors, uas tuaj yeem hloov mus ua haujlwm NAD * hauv lub cev tom qab nqus tau.

2. Txwv tsis pub noj zaub mov thiab calories

Kev txwv caloric tsawg tuaj yeem ua kom muaj zog-sensing txoj hauv kev hauv cov hlwb thiab ua rau tsis ncaj nce NAD * qib. Tab sis nco ntsoov tias koj noj cov zaub mov muaj txiaj ntsig kom tau raws li koj lub cev xav tau kev noj haus

3. Nyob twj ywm thiab tawm dag zog

Kev tawm dag zog aerobic xws li khiav thiab ua luam dej tuaj yeem ua rau nce qib hauv cellular NAD +, pab txhawb cov pa oxygen hauv lub cev thiab txhim kho cov metabolism hauv lub zog.

4. Ua raws li kev pw tsaug zog zoo

Thaum pw tsaug zog, tib neeg lub cev ua ntau yam tseem ceeb hauv metabolic thiab kho cov txheej txheem, suav nrog cov synthesis ntawm NAD *. Kev pw tsaug zog txaus pab tswj cov qib NAD ib txwm muaj

5. Ntxiv NAD + cov khoom ua ntej

Nicotinic acid (NA) thiab nicotinamide (NAM) yog ob qho tib si precursors ntawm NAD +. Lawv tuaj yeem ua ke thiab hloov mus rau NAD hauv tib neeg lub cev, yog li nce nws cov ntsiab lus. Txawm li cas los xij, vim muaj kev txwv ntawm txoj kev sib xyaw ua ke thiab tus nqi txwv enzymes, bioavailability tsawg. .

6 Ncaj qha ntxiv NAD +

Exogenous supplementation ntawm NAD + tuaj yeem kho NAD + qib hauv lub cev sai sai, tso cai rau cov kabmob tseem ceeb xws li lub plawv thiab lub hlwb kom tau txais txiaj ntsig zoo NAD + ntxiv.

Suzhou Myland Pharm & Khoom noj khoom haus Inc. yog ib lub chaw tsim tshuaj paus FDA uas muab cov khoom zoo thiab siab dawb huv NAD + ntxiv hmoov.

Ntawm Suzhou Myland Pharm peb tau cog lus los muab cov khoom lag luam zoo tshaj plaws ntawm tus nqi zoo tshaj. Peb cov NAD + cov hmoov ntxiv yog nruj me ntsis kuaj rau purity thiab potency, xyuas kom koj tau txais cov khoom zoo uas koj tuaj yeem ntseeg tau. Txawm hais tias koj xav txhawb kev noj qab haus huv ntawm tes, txhawb koj lub cev tiv thaiv kab mob lossis txhim kho kev noj qab haus huv tag nrho, peb cov NAD + ntxiv hmoov yog qhov kev xaiv zoo tshaj.

Nrog 30 xyoo ntawm kev paub thiab tsav los ntawm high technology thiab optimized R & D cov tswv yim, Suzhou Myland Pharm tau tsim ib tug ntau yam ntawm kev sib tw cov khoom thiab ua ib tug tshiab lub neej science ntxiv, kev cai synthesis thiab manufacturing kev pab cuam lub tuam txhab.

Tsis tas li ntawd, Suzhou Myland Pharm kuj yog ib lub chaw tsim tshuaj paus FDA. Lub tuam txhab R&D cov peev txheej, cov chaw tsim khoom, thiab cov cuab yeej tshuaj ntsuam xyuas yog niaj hnub thiab muaj ntau yam, thiab tuaj yeem tsim cov tshuaj los ntawm milligrams mus rau tons hauv nplai, thiab ua raws li ISO 9001 cov qauv thiab cov khoom tshwj xeeb GMP.