N-Boc-O-Benzyl-D-Serine yog dab tsi thiab Vim Li Cas Nws Tseem Ceeb?

Hauv kev lag luam tshuaj thiab tshuaj, N-Boc-O-benzyl-D-serine yog ib qho tseem ceeb amino acid derivative vim nws siv nyob rau hauv lub synthesis ntawm bioactive molecules thiab tshuaj. Nws tau nyiam ntau yam rau nws daim ntawv thov dav hauv kev txhim kho. "N-Boc" hais txog tert-butoxycarbonyl (Boc) pab pawg tiv thaiv, uas feem ntau siv los tiv thaiv cov amino pawg amino acids hauv peptide synthesis. "O-Benzyl" txhais tau hais tias ib pab pawg benzyl txuas nrog hydroxyl pawg ntawm serine, yog li txhim kho nws txoj kev ruaj ntseg thiab solubility.

N-Boc-O-benzyl-D-serine Taw Qhia

N-Boc-O-benzyl-D-serine (CAS: 47173-80-8), zoo nkaus li cov hmoov dawb mus rau dawb, N- Boc-O-Benzyl-D-serine yog ib qho derivative ntawm cov amino acid D-serine. Vim nws cov yam ntxwv tshwj xeeb, nws ua lub luag haujlwm tseem ceeb hauv kev tsim tshuaj lom neeg thiab peptide chemistry. Cov hauv qab no yog cov lus piav qhia ntxaws txog nws cov khoom xyaw: qhov twg N-Boc hais txog tert-butoxycarbonyl (Boc) pab pawg tiv thaiv.

Cov pab pawg tiv thaiv yog siv hauv cov organic synthesis los tiv thaiv cov pab pawg ua haujlwm ib ntus, tso cai rau kev xaiv cov tshuaj tiv thaiv yam tsis muaj kev cuam tshuam los ntawm lwm qhov chaw tshuaj tiv thaiv. O-benzyl qhia tias pawg benzyl txuas nrog oxygen ntawm pawg hydroxyl ntawm serine. Benzyl yog ib hom tshuaj tsw qab uas tuaj yeem cuam tshuam cov solubility thiab reactivity ntawm cov tebchaw. D-serine yog ib qho ntawm ob enantiomers ntawm serine thiab belongs rau tsev neeg methionine. Serine yog ib qho tseem ceeb amino acid rau biosynthesis, zog tsim thiab intracellular txo tus neeg sawv cev ntau lawm. Cov txheej txheem no tseem ceeb heev rau kev loj hlob thiab kev loj hlob ntawm cov qog nqaij hlav cancer.

N-Boc-O-benzyl-D-serine Muaj nuj nqi Taw qhia

1. D-serine tuaj yeem txo cov tsos mob ntawm kev paub tsis meej.

Glutaminergic signaling yog paub los txhim kho kev nco qab vim tias kev ua haujlwm ntawm NMDA receptors ua rau cov calcium influx thiab mobilization ntawm calmodulin-dependent kinase (CaMK) thiab CREB-binding proteins, uas ua rau induce mus sij hawm ntev potentiation (LTP), uas yog lub hauv paus ntawm lub mechanism hu ua nco, thiab ua rau muaj kev nce hauv NMDA signaling (tshwj xeeb tshaj yog los ntawm NR2B subunit) ua rau muaj kev nce hauv kev nco thiab LTP. Qhov no kuj yog lub cim xeeb txhim kho mechanism pom nrog magnesium L-threonate. Vim tias D-serine tuaj yeem txhim kho kev taw qhia los ntawm NMDA receptors, ua ke nrog kev ua haujlwm ntawm D-serine hauv cov txheej txheem no thiab paub qhov rhiab heev ntawm hippocampal hlwb rau D-serine stimulation, nws ntseeg tau tias ntxiv D-serine tuaj yeem txhawb kev nco thiab kev kawm.

2.Kev tshawb fawb tau pom tias qhov poob ntawm Menin protein nyob rau hauv hypothalamus yog ib qho tseem ceeb ua rau kev laus, thiab ntxiv D-serine tuaj yeem txhim kho kev paub tsis meej hauv cov nas laus.

Cov kev tshawb fawb tau pom tias hypothalamus tseem ua lub luag haujlwm tseem ceeb hauv kev paub tsis meej los ntawm kev laus. Thaum lub sij hawm kev laus, Menin protein nyob rau hauv lub hypothalamus (tom qab no hu ua Menin) yuav maj mam txo nrog cov txheej txheem kev laus, cuam tshuam cov synthesis ntawm D-serine, ntxiv tsub kom cov txheej txheem kev laus thiab kev txawj ntse tsis ua hauj lwm. Tsis tas li ntawd, D-serine supplementation tuaj yeem txhim kho qhov kev laus ntawm cov phenotype thiab txo qhov kev xav tsis zoo hauv cov nas hnub nyoog.

Cov txiaj ntsig ntawm txoj kev tshawb fawb pom tau tias tom qab ntxiv D-serine, qib ntawm D-serine hauv hypothalamus thiab hippocampus ntawm peb pawg nas tau nce ntau dua piv rau tib hom nas uas tsis tau ntxiv nrog D-serine (p <0.01), thiab lawv cov xwm txheej kev txawj ntse tau txhim kho. Kev txhim kho tseem ceeb (p<0.05), qhia tias D-serine supplementation tej zaum yuav yog ib qho kev kho mob rau kev txhim kho kev laus ntawm kev txawj ntse.

N-Boc-O-Benzyl-D-Serine vs Lwm Amino Acids: Dab tsi yog qhov txawv?

1. Cov qauv sib txawv

Qhov sib txawv tshaj plaws ntawm N-Boc-O-benzyl-D-serine thiab lwm cov amino acids yog nws cov qauv. Thaum cov txheej txheem amino acids muaj cov pob txha yooj yim uas muaj cov amino pawg, carboxyl pawg thiab cov saw hlau sab, N-Boc-O-benzyl-D-serine muaj cov pab pawg ua haujlwm ntxiv uas hloov nws cov khoom.

Piv txwv li, pab pawg Boc muab kev tiv thaiv thaum lub sij hawm peptide synthesis, tso cai rau ntau cov tshuaj tiv thaiv kom ua tau yam tsis muaj kev xav sab nraud. Benzyl pab pawg txhim kho kev sib cuam tshuam hydrophobic, yog li cuam tshuam rau folding thiab stability ntawm peptides thiab proteins.

2. Cov yam ntxwv ua haujlwm

N-Boc-O-Benzyl-D-Serine nthuav tawm cov khoom ua haujlwm tshwj xeeb piv rau lwm cov amino acids. Nws txoj kev teeb tsa D tso cai rau nws cuam tshuam nrog cov kab ke lom neeg sib txawv piv rau L configuration ntau dua pom hauv cov protein ntau. Qhov no tuaj yeem ua rau muaj kev hloov pauv hauv kev ua haujlwm lom neeg, ua rau nws muaj txiaj ntsig zoo hauv kev tsim tshuaj thiab kev loj hlob.

Hauv qhov sib piv, yooj yim dua, ntau cov amino acids xws li glycine lossis alanine tsis muaj tib theem ntawm qhov nyuaj lossis qhov tshwj xeeb hauv lawv cov kev sib cuam tshuam. Qhov no ua rau N-Boc-O-Benzyl-D-Serine tshwj xeeb hauv kev tshawb fawb ntawm neuropharmacology thiab receptor kev sib cuam tshuam.

3. Kev siv hauv kev tshawb fawb thiab tshuaj

N-Boc-O-Benzyl-D-Serine tau nyiam nyob rau hauv ntau qhov chaw, tshwj xeeb tshaj yog nyob rau hauv kev kho mob chemistry thiab neurobiology. Nws lub peev xwm los hloov kho NMDA receptor kev ua haujlwm ua rau nws yog ib tus neeg sib tw tshuaj rau kev kawm txog kev puas hlwb xws li schizophrenia thiab Alzheimer's kab mob. Cov kws tshawb fawb tab tom tshawb nrhiav nws lub peev xwm los ua tus neeg sawv cev kho mob txhawm rau txhim kho kev txawj ntse lossis txo cov txheej txheem neurodegenerative.

Hauv qhov sib piv, ntau cov amino acids xws li leucine los yog valine feem ntau tau kawm txog lawv lub luag haujlwm hauv cov leeg nqaij metabolism thiab protein synthesis. Thaum lawv tseem ceeb rau kev noj qab haus huv thiab kev noj qab haus huv tag nrho, lawv cov phiaj xwm siv hauv neuropharmacology txawv ntawm N-Boc-O-Benzyl-D-Serine.

4. Synthesis thiab stability

Lub synthesis ntawm N-Boc-O-benzyl-D-serine cuam tshuam cov tshuaj lom neeg ntau dua li cov qauv amino acids. Kev taw qhia txog kev tiv thaiv pab pawg thiab kev xav tau rau cov xwm txheej tshwj xeeb tuaj yeem ua rau lawv cov synthesis nyuaj dua. Txawm li cas los xij, cov kev hloov kho no kuj txhim kho nws txoj kev ruaj ntseg, ua rau nws haum rau ntau yam kev sim.

Hauv qhov sib piv, cov qauv amino acids feem ntau tau yooj yim thiab yooj yim rau kev sib txuas, tab sis lawv yuav tsis muab tib theem ntawm kev ruaj ntseg lossis qhov tshwj xeeb uas yuav tsum tau ua rau kev tshawb fawb qib siab.

D-Real-Life Daim ntawv thov ntawm N-Boc-O-Benzyl-D-Serine

Serine plays lub luag haujlwm tseem ceeb hauv lub cev hauv tib neeg lub cev, tshwj xeeb tshaj yog kev tswj hwm thiab kev tiv thaiv ntawm lub paj hlwb. N-Boc-O-benzyl-D-serine raws li serine derivative yog ib chav kawm tseem ceeb ntawm bioactive molecules uas nquag siv nyob rau hauv peptide synthesis thiab lwm yam organic chemistry daim ntaub ntawv, tshwj xeeb tshaj yog nyob rau hauv kev loj hlob ntawm cov tshuaj thiab bioactive compounds. Cov pab pawg tiv thaiv tuaj yeem raug tshem tawm raws li cov xwm txheej tshwj xeeb kom tau txais cov amino acids dawb lossis lwm yam khoom siv rau kev tshawb fawb ntxiv lossis kev thov. Dav siv nyob rau hauv kev kho mob thiab kev tshawb fawb lom.

1. Tshuaj synthesis thiab peptide chemistry

N-Boc-O-benzyl-D-serine yog siv los ua ib lub tsev thaiv nyob rau hauv cov tshuaj synthesis ntawm ntau lub tebchaw thiab tseem yog ib feem tseem ceeb ntawm peptide chemistry. Nws siv nyob rau hauv daim teb no yog vim nws muaj peev xwm muab tso rau hauv cov qauv molecular loj, pab txoj kev loj hlob ntawm cov tshuaj tshiab thiab bioactive molecules.

2. Kev lag luam kws tshuaj

N-Boc-O-benzyl-D-serine tau siv los ua tus thawj coj rau kev npaj hloov pauv naphthodiazolidinones. Cov tebchaw no ua raws li cov protein tyrosine phosphatase degraders thiab muaj peev xwm siv tshuaj kho mob cancer thiab kab mob metabolic. Kev degradation ntawm cov phosphatase no pab tswj cov kev taw qhia ntawm tes, yog li muab txoj hauv kev kho mob los tiv thaiv cov kab mob no.

3. Kev tshawb fawb thiab kev tsim kho

Hauv kev tshawb fawb thiab kev tsim kho, N-Boc-O-benzyl-D-serine yog siv los ua ke cov molecules tshiab nrog rau kev ua haujlwm lom neeg. Nws cov qauv tshwj xeeb tso cai rau cov kws tshawb fawb tshawb nrhiav nws cov khoom thiab cov ntawv thov los tsim cov tshuaj tshiab thiab kev kho mob rau ntau yam mob.

Qhov twg yuav N-Boc-O-benzyl-D-serine?

Raws li cov chaw tsim khoom ntawm N-Boc-O-benzyl-D-serine hmoov, Suzhou Myland tau yeej kev ntseeg siab ntawm ntau tus neeg siv khoom nrog nws cov khoom siv siab huv thiab kev tswj xyuas nruj. Lub tuam txhab tau cog lus los muab cov neeg siv khoom nrog cov khoom zoo raw khoom thiab pab lawv ua tiav hauv lawv cov kev lag luam.

1. Kev ntseeg tau cov khoom zoo

Suzhou Myland's N-Boc-O-benzyl-D-serine hmoov tau dhau ntau qhov kev ntsuam xyuas kom ntseeg tau tias nws cov purity thiab zoo raws li cov qauv kev lag luam. Lub tuam txhab muaj ib pab neeg soj ntsuam zoo uas ua random soj ntsuam ntawm cov khoom tsis tu ncua los xyuas kom meej ruaj khov zoo ntawm txhua batch ntawm cov khoom.

2. Muaj peev xwm muab tau yooj yim

Txawm hais tias nws yog ib pawg me me lossis kev txiav txim loj, Suzhou Mailun Biotechnology tuaj yeem teb tau yooj yim los xyuas kom meej tias cov neeg siv khoom xav tau. Lub tuam txhab tau tsim kom tiav logistics system kom xa khoom sai sai rau cov neeg siv khoom.

3. Kev txhawb nqa kev tshaj lij

Suzhou Myland pab pawg R & D yog tsim los ntawm ntau tus kws tshaj lij kev lag luam thiab tuaj yeem muab cov neeg siv khoom nrog kev sib tham thiab kev txhawb nqa los pab cov neeg siv khoom nkag siab zoo dua thiab siv N-Boc-O-benzyl-D-serine.

4. Tus nqi sib tw

Ntawm qhov chaw ntawm kev ua kom cov khoom zoo, Suzhou Myland muab cov nqi sib tw los pab cov neeg siv khoom txo nqi thiab txhim kho kev lag luam kev sib tw.

Xaiv txoj cai N-Boc-O-benzyl-D-serine tus neeg muag khoom yog qhov tseem ceeb los ua kom cov khoom zoo thiab kev nyab xeeb. Suzhou Myland tau dhau los ua kev ntseeg siab hauv kev lag luam nrog nws cov khoom siv siab huv, kev tswj xyuas nruj thiab kev pabcuam tshaj lij. Txawm hais tias koj yog ib lub tuam txhab tshuaj lossis ib lub chaw tshawb fawb tshawb fawb, Suzhou Myland tuaj yeem muab cov hmoov zoo N-Boc-O-benzyl-D-serine rau koj los pab koj tshawb nrhiav thiab txhim kho. Yog xav paub ntxiv, thov mus saib Suzhou Myland lub vev xaib official.