Puas yog koj tab tom nrhiav NMA hmoov thiab xav paub qhov twg los nrhiav qhov chaw ntseeg tau ntawm cov khoom tseem ceeb no? Lub koob npe nrov NMA hmoov cov khoom lag luam yog qhov tseem ceeb los ua kom cov khoom zoo thiab kev ntseeg siab. Nrhiav qhov chaw txhim khu kev qha ntawm NMA hmoov yog qhov tseem ceeb los xyuas kom meej cov khoom thiab cov txheej txheem zoo thiab kev ntseeg tau. Los ntawm kev saib xyuas qhov zoo, lub koob npe nrov, tus nqi, thiab kev muaj, koj tuaj yeem nrhiav tus neeg muag khoom uas ua tau raws li koj cov kev xav tau tshwj xeeb thiab xa cov hmoov zoo NMA hmoov uas koj xav tau. Txawm hais tias koj yog tus kws tshawb fawb, lossis tus neeg muag khoom, cov lus qhia no tuaj yeem pab koj nrhiav tau lub npe nrov NMA hmoov cov neeg muag khoom thiab xyuas kom meej tias koj qhov project.
N-Methyl-DL-Aspartic Acid,tseem hu ua NMA. Nws muaj cov qauv zoo sib xws rau N-methylDL-aspartic acid (NMDA) thiab muaj cov teebmeem zoo sib xws. NMDA receptors koom nrog ntau yam txheej txheem physiological, suav nrog kev kawm, nco, thiab synaptic plasticity.
N-Methyl-DL-Aspartic Acid (NMA) kuj yog ib qho amino acid derivative uas ua raws li cov agonist tshwj xeeb ntawm NMDA receptors thiab ua lub luag haujlwm tseem ceeb hauv lub hauv paus paj hlwb. NMA ua raws li cov teebmeem ntawm glutamate, cov neurotransmitter uas ib txwm ua rau cov receptor no. Piv nrog rau glutamate, N-Methyl-DL-Aspartic Acid (NMA) txawv nyob rau hauv uas nws tsuas khi thiab modulates NMDA receptors thiab tsis xaiv rau lwm cov glutamate receptors xws li AMPA thiab kainate. lub cev) tsis muaj teebmeem.
Vim nws cov teebmeem, N-Methyl-DL-Aspartic Acid (NMA) kuj tseem siv rau hauv kev tsim kho lub cev raws li cov khoom siv hauv endocrine, raws li N-Methyl-DL-Aspartic Acid (NMA) muaj zog ntau hauv kev txhawb nqa NMDA receptors dua li DAA yog zoo dua, tab sis nws kuj tseem pheej yig dua piv rau N-Methyl-DL-Aspartic Acid (NMDA).
N-Methyl-DL-aspartate, yog cov khoom siv hluavtaws uas ua raws li lub zog agonist ntawm N-Methyl-DL-Aspartic Acid (NMDA) receptor. Qhov receptor no ua lub luag haujlwm tseem ceeb hauv kev tswj hwm ntawm synaptic plasticity thiab nco ua haujlwm hauv lub hauv nruab nrab paj hlwb. N-Methyl-DL-Aspartic Acid hmoov yog paub txog nws lub peev xwm los hloov kho qhov kev tso tawm ntau yam neurotransmitters, suav nrog dopamine thiab serotonin, uas yog qhov tseem ceeb rau kev tswj hwm kev xav thiab kev txawj ntse.
Kev tshawb fawb qhia tias N-Methyl-DL-Aspartic Acid receptor activation tuaj yeem pab tswj kev sib koom tes thiab cov leeg ua haujlwm. Los ntawm lub hom phiaj NMDA receptors, N-methyl-DL-aspartate hmoov muaj peev xwm los txhim kho cov hlab ntsha hauv lub cev, yog li txhim kho lub zog, lub zog thiab kev ua kis las tag nrho. Qhov no ua rau nws yog qhov kev xaiv txaus nyiam rau cov tib neeg tab tom nrhiav kom ua kom lawv lub cev muaj peev xwm thaum lub sijhawm ua kis las thiab qoj ib ce.
Tsis tas li ntawd, N-Methyl-DL-Aspartic Acid hmoov tau kawm txog nws lub luag haujlwm tseem ceeb hauv kev txhawb nqa hormonal tshuav. Nws ntseeg tau tias muaj kev cuam tshuam rau kev tso tawm cov tshuaj hormones xws li testosterone thiab kev loj hlob hormone, uas yog ib qho tseem ceeb rau kev loj hlob ntawm cov leeg thiab rov qab. Los ntawm kev tswj hwm qib hormone, N-Methyl-DL-Aspartic Acid hmoov txhawb cov txheej txheem anabolic hauv lub cev, yog li txhim kho cov leeg nqaij protein synthesis thiab tag nrho cov leeg nqaij loj hlob.
NMA, los yog N-methyl-D-aspartate,yog ib hom tshwj xeeb ntawm receptor uas ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm ntawm lub hauv nruab nrab paj hlwb. Nws yog ib qho subtype ntawm glutamate receptor uas yog qhov tseem ceeb rau kev kawm thiab kev nco. NMDA receptors paub txog lawv txoj kev koom tes hauv synaptic plasticity, txheej txheem tseem ceeb rau kev kawm thiab kev tsim kev nco. Cov receptors no kuj tau cuam tshuam rau ntau yam kab mob neurological, suav nrog Alzheimer's disease, Parkinson's disease, thiab lwm yam.
Ntawm qhov tod tes, NMDA (los yog N-Methyl-DL-Aspartic Acid) yog cov khoom siv hluavtaws uas ua rau muaj zog agonist ntawm NMDA receptor. Nws nquag siv los kawm txog kev ua haujlwm ntawm NMDA receptors thiab lawv lub luag haujlwm hauv cov kab mob neurological. NMDA tau raug kev tshawb fawb dav dav rau nws cov kev siv tshuaj kho mob hauv cov xwm txheej xws li kev nyuaj siab, kev ntxhov siab, thiab mob ntev.
Ib qho ntawm qhov sib txawv loj ntawm NMA thiab NMDA yog lawv lub luag haujlwm hauv lub hlwb. NMA yog ib qho tshwm sim receptor nyob rau hauv lub hauv nruab nrab lub paj hlwb uas ua lub luag haujlwm tseem ceeb hauv synaptic plasticity thiab kev kawm, thaum NMDA yog cov khoom siv hluavtaws uas ua raws li agonist ntawm NMDA receptors. Qhov sib txawv tseem ceeb no qhia txog cov haujlwm tshwj xeeb thiab keeb kwm ntawm ob lub koom haum no.
Tsis tas li ntawd, NMA thiab NMDA muaj kev cuam tshuam loj heev rau lub hlwb kev noj qab haus huv thiab kev paub txog kev ua haujlwm. NMA receptors koom nrog cov txheej txheem xws li kev muaj peev xwm mus sij hawm ntev, ib qho kev kawm hauv qab thiab kev nco. NMA receptor dysfunction yog txuam nrog ntau cov hlab ntsha, qhia txog lawv qhov tseem ceeb hauv kev tswj lub hlwb. NMDA, ntawm qhov tod tes, yog cov khoom siv hluavtaws uas tau kawm txog nws qhov muaj peev xwm cuam tshuam rau kev nyuaj siab thiab mob ntev, thiab lwm yam. Nws lub luag haujlwm ua NMDA receptor agonist ua rau nws yog ib qho kev txaus siab rau kev tsim kho tshiab.
NMA thiab NMDA kuj sib txawv thaum nws los txog rau kev tshawb fawb thiab kev siv tshuaj kho mob. NMA receptors tau ua qhov kev tshawb fawb dav dav txhawm rau nkag siab lawv lub luag haujlwm hauv synaptic plasticity thiab kev paub txog kev ua haujlwm. Qhov kev tshawb fawb no ua rau txoj hauv kev rau kev txhim kho cov tshuaj tsom NMA receptors, uas muaj peev xwm hloov kho synaptic plasticity thiab txhim kho kev txawj ntse. Ntawm qhov tod tes, NMDA, raws li cov khoom siv hluavtaws, feem ntau tau kawm rau nws cov kev siv paj hlwb.
Txawm hais tias NMA thiab NMDA suab zoo sib xws, lawv yog cov chaw sib txawv nrog cov teebmeem sib txawv thiab cuam tshuam rau lub hlwb kev noj qab haus huv thiab kev txawj ntse. NMA, raws li ib txwm tshwm sim receptor nyob rau hauv lub hauv paus paj hlwb, plays lub luag hauj lwm tseem ceeb nyob rau hauv synaptic plasticity thiab kev kawm, thaum NMDA, raws li ib tug hluavtaws compound, tau kawm rau nws muaj peev xwm siv nyob rau hauv neurological thiab puas siab puas ntsws kab mob.
N-Methyl-DL-aspartic acid plays lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem physiological hauv lub cev. Cov amino acid derivative no ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm ntawm lub paj hlwb thiab tau txais kev saib xyuas rau nws cov txiaj ntsig zoo ntawm kev txawj ntse, kev nco, thiab tag nrho lub hlwb kev noj qab haus huv.
NMDA yog ib tug neurotransmitter uas ua raws li ib tug signaling molecule nyob rau hauv lub hlwb. Nws koom nrog hauv cov teeb liab kis ntawm cov paj hlwb thiab yog qhov tseem ceeb rau kev ua haujlwm ntawm lub hauv nruab nrab paj hlwb. Ib lub luag haujlwm tseem ceeb ntawm N-methyl-DL-aspartate yog nyob rau hauv cov kev cai ntawm synaptic plasticity, uas yog lub hlwb lub peev xwm los hloov thiab hloov hauv cov lus teb rau kev paub thiab kev kawm. Cov txheej txheem no tseem ceeb heev rau kev tsim kev nco thiab kev loj hlob ntawm kev txawj ntse.
Tsis tas li ntawd, NMDA receptors tau qhib los ntawm N-methyl-DL-aspartate ua lub luag haujlwm tseem ceeb hauv kev tswj hwm kev sib kis ntawm synaptic thiab kev sib koom ua ke ntawm cov teeb liab excitatory hauv lub hlwb. Cov receptors no koom nrog cov txheej txheem xws li kev kawm thiab kev nco, nrog rau kev tswj hwm ntawm kev xav thiab kev xav. NMDA receptor dysfunction yog txuam nrog ntau yam kev puas siab puas ntsws thiab puas siab puas ntsws, qhia txog qhov tseem ceeb ntawm N-methyl-DL-aspartate hauv kev tswj lub hlwb.
Ntxiv nrog rau nws lub luag haujlwm hauv lub paj hlwb, N-methyl-DL-aspartate koom nrog lwm yam kev ua haujlwm ntawm lub cev. Nws tau pom tias muaj kev koom tes hauv kev tswj hwm cov tshuaj hormone secretion, tshwj xeeb tshaj yog tso tawm cov tshuaj hormones loj hlob thiab gonadotropin-tso cov tshuaj hormones. Qhov no qhia tias NMDA tuaj yeem muaj kev cuam tshuam rau kev tswj hwm kev loj hlob, kev loj hlob, thiab kev ua me nyuam ua haujlwm.
Tsis tas li ntawd, N-methyl-DL-aspartate tau kawm txog nws lub luag haujlwm tseem ceeb hauv kev txhawb nqa tag nrho kev paub txog kev ua haujlwm thiab lub hlwb acuity. Kev tshawb fawb qhia tias NMDA yuav muaj cov teebmeem neuroprotective, pab tiv thaiv lub hlwb los ntawm kev puas tsuaj thiab degeneration. Qhov no tau ua rau muaj kev txaus siab rau N-methyl-DL-aspartate raws li lub hom phiaj kho mob rau cov kab mob xws li Alzheimer's disease, Parkinson's disease thiab lwm yam kab mob neurodegenerative.
Tsis tas li ntawd, NMDA tau koom nrog hauv kev tswj xyuas qhov mob ntawm kev nkag siab thiab rhiab heev. Nws muaj kev koom tes hauv kev sib kis ntawm cov cim mob hauv qaum qaum thiab lub hlwb, thiab nws cov kev hloov kho yuav muaj feem cuam tshuam rau kev kho mob ntev. Qhov no tau ua rau muaj kev txaus siab rau kev tsim NMDA receptor modulators raws li cov tshuaj muaj peev xwm.
Txawm hais tias N-methyl-DL-aspartate ua lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem ntawm lub cev, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias nws cov qib thiab kev ua si yuav tsum tau ua tib zoo tswj.
1. Paub qhov chaw thiab purity
Thaum muas Oleoylethanolamide (OEA) hmoov, koj yuav tsum xav txog qhov chaw thiab purity ntawm cov khoom. Nrhiav cov neeg muag khoom muaj npe nrov uas siv cov khoom xyaw zoo thiab ua raws li cov qauv tsim khoom nruj. Qhov zoo tshaj plaws, OEA hmoov yuav tsum tau muab los ntawm cov khoom siv ntuj tsim thiab muaj purity siab los xyuas kom meej nws cov txiaj ntsig thiab kev nyab xeeb.
2. Tshawb xyuas qhov kev xeem thib peb
Txhawm rau kom ntseeg tau tias qhov zoo thiab purity ntawm Oleoylethanolamide (OEA) hmoov, nws yog ib qho tseem ceeb uas yuav tau xaiv cov khoom uas tau raug kuaj los ntawm peb lub chaw soj nstuam. Kev ntsuam xyuas thib peb kom ntseeg tau tias OEA cov hmoov tsis muaj cov kab mob thiab ua tau raws li qhov muaj peev xwm thiab qib purity. Saib rau cov khoom uas muab cov txiaj ntsig kev sim pob tshab thiab pov thawj, muab kev thaj yeeb rau koj lub siab txog qhov zoo ntawm OEA hmoov koj yuav.
3. Xav txog daim ntawv qhia
Oleoylethanolamide (OEA) hmoov muaj nyob rau hauv ntau yam formulations, nrog rau cov tshuaj ntsiav thiab hmoov. Thaum xaiv cov qauv uas haum rau koj, xav txog koj qhov kev nyiam thiab kev ua neej. Capsules muab kev siv yooj yim thiab meej, thaum hmoov thiab kua tuaj yeem sib xyaw yooj yim rau hauv dej qab zib lossis zaub mov.
4. Ntsuas cov khoom lag luam lub koob npe nrov
Thaum yuav OEA hmoov, nws yog ib qho tseem ceeb uas yuav tsum tau yuav los ntawm ib tus neeg muag khoom muaj npe nrov thiab muaj kev ntseeg siab. Tshawb nrhiav tus neeg muag khoom lub koob npe nrov, kev tshuaj xyuas cov neeg siv khoom, thiab cov ntawv pov thawj kom ntseeg tau tias koj tau txais cov khoom lag luam txhim khu kev qha thiab zoo. Tus neeg muag khoom muaj npe nrov yuav ua pob tshab txog lawv cov khoom siv, kev tsim khoom, thiab cov khoom zoo, muab kev ntseeg siab rau koj qhov kev yuav khoom.
5. Ntsuas tus nqi thiab tus nqi
Thaum tus nqi yuav tsum tsis yog qhov kev txiav txim siab nkaus xwb, nws tseem ceeb heev uas yuav tsum xav txog tus nqi ntawm OEA hmoov koj tab tom yuav. Sib piv cov nqi los ntawm cov neeg muag khoom sib txawv, suav nrog cov khoom lag luam hauv paus, purity, formulation thiab lub koob npe nrov. Nco ntsoov tias cov hmoov zoo OEA tej zaum yuav kim dua, tab sis tus nqi nws muab raws li kev ua tau zoo thiab kev nyab xeeb yog tsim nyog rau kev nqis peev.
6. Tham nrog ib tug kws kho mob
Ua ntej ntxiv OEA hmoov rau koj cov txheej txheem ntxiv, nws raug nquahu kom sab laj nrog kws kho mob, tshwj xeeb tshaj yog tias koj muaj mob hauv qab lossis noj tshuaj. Tus kws kho mob tuaj yeem muab kev taw qhia tus kheej thiab xyuas kom OEA tsim nyog rau koj txoj kev noj qab haus huv txhua hnub.
1. Cov neeg muab khoom tshawb fawb
Thaum tab tom nrhiav NMA, kev tshawb fawb tus neeg muag khoom lossis cov chaw tsim khoom yog qhov tseem ceeb. Nrhiav ib lub tuam txhab uas muaj lub koob npe zoo thiab taug qab cov ntaub ntawv ntawm kev tsim cov tshuaj zoo. Tshawb xyuas cov ntawv pov thawj, xws li Kev Ua Haujlwm Zoo (GMP) lossis NSF International, uas qhia tau tias tus neeg muag khoom ua raws li cov qauv zoo.
2. Purity thiab Potency
NMA zoo yuav tsum muaj siab purity thiab potency. Nrhiav cov khoom uas tau raug sim los ntawm cov neeg thib peb lub chaw kuaj mob rau purity thiab potency. Cov neeg muag khoom muaj npe nrov yuav muab Daim Ntawv Pov Thawj Kev Ntsuam Xyuas (COA) los txheeb xyuas cov khoom purity thiab potency theem. Tsis txhob yuav cov khoom uas tsis muab cov ntaub ntawv no vim lawv yuav tsis ua raws li cov qauv tsim nyog.
3. Nyeem cov qhua tuaj noj mov
Ua ntej kev yuav khoom, thov siv sijhawm los nyeem cov neeg siv khoom tshuaj xyuas ntawm NMA cov khoom koj xav txog. Nrhiav cov lus tawm tswv yim txog cov khoom siv tau zoo, purity, thiab tag nrho qhov zoo. Saib xyuas cov chij liab, xws li cov lus ceeb toom ntawm impurities lossis tsis muaj txiaj ntsig. Kev tshuaj xyuas cov neeg siv khoom tuaj yeem muab kev nkag siab zoo rau cov khoom lag luam zoo thiab tus neeg muag khoom lub koob npe nrov.
4. Xav txog tus nqi thiab zoo
Thaum nws tseem ceeb heev los xav txog NMA tus nqi, nws tseem ceeb sib npaug rau qhov tseem ceeb ntawm qhov zoo. Cov khoom pheej yig dua tej zaum yuav ntxias, tab sis lawv yuav yog cov khoom qis dua thiab tuaj yeem muaj cov impurities. Kev nqis peev hauv NMA cov khoom lag luam zoo dua yuav raug nqi ntau dua, tab sis nws tuaj yeem muab cov txiaj ntsig zoo dua thiab muab kev thaj yeeb rau koj txog nws txoj kev huv thiab muaj zog.
5. Nrhiav cov ntawv pob tshab
Tus neeg muag khoom uas ntseeg siab NMA yuav muab cov ntawv pob tshab uas qhia meej cov khoom xyaw thiab lawv cov koob tshuaj. Zam cov khoom uas tsis meej lossis cov khoom sib xyaw ua ke vim tias lawv yuav tsis nthuav tawm cov ntsiab lus tseeb ntawm NMA thiab lwm yam khoom xyaw. Cov ntawv pob tshab tso cai rau koj los txiav txim siab paub txog cov khoom zoo thiab seb nws ua tau raws li koj xav tau.
6. Nrhiav kev tshaj lij
Yog tias koj tsis paub meej yam khoom NMA xaiv, xav txog kev nrhiav tswv yim los ntawm tus kws kho mob lossis tus kws paub txog zaub mov tsim nyog. Lawv tuaj yeem muab cov lus pom zoo rau tus kheej raws li koj lub hom phiaj kev noj qab haus huv tshwj xeeb thiab xav tau. Tsis tas li ntawd, lawv tuaj yeem pab koj taug qab qhov nyuaj ntawm NMA cov tshuaj ntxiv thiab xyuas kom koj xaiv cov khoom zoo.
Suzhou Myland Pharm & Nutrition Inc. tau koom nrog kev lag luam khoom noj khoom haus ntxiv txij li xyoo 1992. Nws yog thawj lub tuam txhab hauv Suav teb los tsim thiab ua lag luam txiv hmab txiv ntoo extract.
Nrog 30 xyoo ntawm kev paub thiab tsav los ntawm cov cuab yeej siv siab thiab lub tswv yim zoo R & D, lub tuam txhab tau tsim ntau yam khoom sib tw thiab dhau los ua lub neej tshiab kev tshawb fawb ntxiv, kev cai synthesis thiab tsim cov tuam txhab.
Tsis tas li ntawd, Suzhou Myland Pharm & Nutrition Inc. kuj yog ib lub chaw tsim tshuaj paus FDA. Lub tuam txhab R&D cov peev txheej, cov chaw tsim khoom, thiab cov cuab yeej tshuaj ntsuam xyuas yog niaj hnub thiab muaj ntau yam thiab tuaj yeem tsim cov tshuaj los ntawm milligrams mus rau tons hauv nplai, thiab ua raws li ISO 9001 cov qauv thiab cov khoom siv tshwj xeeb GMP.
Q. Kuv tuaj yeem yuav N-Methyl-DL-Aspartic Acid (NMA) hmoov nyob qhov twg?
A: Koj tuaj yeem yuav NMA hmoov los ntawm ntau lub chaw muag tshuaj thiab cov xa khoom. Nws yog ib qho tseem ceeb los xyuas kom meej tias koj tab tom yuav los ntawm ib lub npe nrov thiab txhim khu kev qha los lav qhov zoo ntawm cov khoom.
Q: Kuv yuav nrhiav tau zoo N-Methyl-DL-Aspartic Acid (NMA) hmoov li cas?
A: Yuav kom nrhiav tau cov hmoov zoo NMA, nws yog ib qho tseem ceeb rau kev tshawb fawb thiab sib piv cov khoom sib txawv. Nrhiav cov neeg muag khoom nrog lub koob npe zoo, ntawv pov thawj, thiab cov neeg siv khoom zoo. Tsis tas li ntawd, kev thov cov qauv los yog kev kuaj xyuas tuaj yeem pab ua kom cov khoom zoo.
Q: Kuv yuav xav li cas thaum yuav N-Methyl-DL-Aspartic Acid (NMA) hmoov?
A: Thaum muas NMA hmoov, xav txog yam xws li tus neeg muag khoom lub koob npe nrov, cov khoom zoo, tus nqi, kev xaiv shipping, thiab cov neeg siv khoom txhawb nqa. Nws yog ib qho tseem ceeb uas yuav tau xaiv tus neeg muag khoom uas ua tau raws li koj cov kev xav tau tshwj xeeb thiab muab cov khoom lag luam thiab cov kev pabcuam txhim khu kev qha.
Q: Puas muaj cov lus qhia rau kev yuav N-Methyl-DL-Aspartic Acid (NMA) hmoov?
A: Qee cov lus qhia rau kev yuav NMA hmoov suav nrog kev tshawb fawb zoo ntawm cov neeg muag khoom, thov cov qauv khoom, sib piv cov nqi thiab kev ua tau zoo, thiab tshawb xyuas tus neeg muag khoom cov ntaub ntawv pov thawj thiab ntawv pov thawj. Tsis tas li ntawd, kev nyeem cov neeg siv khoom tawm tswv yim thiab kev tshuaj xyuas tuaj yeem muab kev nkag siab zoo.
Q: Kuv puas tuaj yeem yuav N-Methyl-DL-Aspartic Acid (NMA) hmoov hauv online?
A: Yog lawm, ntau tus neeg muab tshuaj muaj kev xaiv los yuav NMA hmoov hauv online. Txawm li cas los xij, nws yog ib qho tseem ceeb los xyuas kom meej tias tus neeg muag khoom hauv online muaj npe nrov thiab muaj kev ntseeg siab. Tshawb xyuas tus neeg muag khoom cov ntaub ntawv pov thawj, cov khoom zoo, thiab kev txhawb nqa cov neeg siv khoom ua ntej kev yuav khoom.
Kev lees paub: Kab lus no yog rau cov ntaub ntawv dav dav nkaus xwb thiab yuav tsum tsis txhob raug txhais raws li cov lus qhia kho mob. Qee cov ntaub ntawv blog tshaj tawm los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, formatting thiab kho cov ntawv. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntau ntxiv tsis txhais tau hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Nco ntsoov sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Post lub sij hawm: Aug-26-2024