Vim li cas Koj Yuav Tsum Yuav Spermidine Powder? Cov txiaj ntsig tseem ceeb piav qhia

Spermidine,tseem hu ua spermidine, yog ib yam khoom triamine polyamine uas dav pom nyob rau hauv cov nroj tsuag xws li nplej, soybeans, thiab qos yaj ywm, kab mob xws li lactobacilli thiab bifidobacteria, thiab ntau yam tsiaj cov ntaub so ntswg. Spermidine yog hydrocarbon nrog lub zigzag-shaped carbon skeleton tsim los ntawm 7 carbon atoms thiab amino pawg ntawm ob qho tag nrho thiab hauv nruab nrab.

Kev tshawb fawb niaj hnub no tau ua pov thawj tias spermidine koom nrog hauv cov txheej txheem tseem ceeb hauv lub neej xws li cellular DNA replication, mRNA transcription, thiab protein translation, nrog rau ntau yam pathophysiological txheej txheem xws li lub cev tiv thaiv kev ntxhov siab thiab metabolism. Nws muaj kev tiv thaiv kab mob plawv thiab neuroprotection, tiv thaiv qog nqaij hlav, thiab kev tswj kev mob, thiab lwm yam kev ua haujlwm lom neeg tseem ceeb.

Spermidine yog suav hais tias yog lub zog ua kom muaj zog ntawm autophagy, cov txheej txheem rov ua dua tshiab hauv cov cell los ntawm cov hlwb qub rov ua dua lawv tus kheej thiab rov ua haujlwm. Spermidine plays lub luag haujlwm tseem ceeb hauv kev ua haujlwm ntawm tes thiab muaj sia nyob. Nyob rau hauv lub cev, spermidine yog tsim los ntawm nws precursor putrescine, uas nyob rau hauv lem yog ib tug precursor rau lwm polyamine hu ua spermine, uas yog tseem ceeb heev rau lub cell function.

Spermidine thiab putrescine txhawb nqa autophagy, lub kaw lus uas rhuav tshem cov khib nyiab hauv cellular thiab rov ua dua cov khoom siv ntawm tes thiab yog lub tshuab tswj kom zoo rau mitochondria, lub zog ntawm lub cell. Autophagy rhuav tshem thiab pov tseg ntawm mitochondria puas lossis puas, thiab kev pov tseg mitochondrial yog txheej txheem nruj nruj. Polyamines tuaj yeem khi rau ntau hom molecules, ua rau lawv muaj ntau yam. Lawv txhawb cov txheej txheem xws li kev loj hlob ntawm tes, DNA stability, cell proliferation, thiab apoptosis. Polyamines tshwm sim ua haujlwm zoo ib yam li cov khoom loj hlob thaum lub sijhawm cell faib, uas yog vim li cas putrescine thiab spermidine tseem ceeb heev rau kev loj hlob thiab kev ua haujlwm ntawm cov ntaub so ntswg noj qab haus huv.

Cov kws tshawb fawb tau kawm seb spermidine tiv thaiv cov hlwb ntawm oxidative kev nyuaj siab, uas tuaj yeem ua rau cov hlwb puas thiab ua rau ntau yam kab mob. Lawv pom tias spermidine activates autophagy. Txoj kev tshawb no tau txheeb xyuas ntau lub noob tseem ceeb cuam tshuam los ntawm spermidine uas txo cov oxidative kev nyuaj siab thiab txhawb nqa autophagy hauv cov hlwb. Tsis tas li ntawd, lawv pom tias thaiv txoj kev mTOR, uas feem ntau koom nrog hauv inhibiting autophagy, ntxiv txhim kho spermidine cov kev tiv thaiv.

Cov zaub mov twg muaj spermidine siab?

Spermidine yog ib qho tseem ceeb polyamine. Ntxiv nrog rau kev tsim los ntawm tib neeg lub cev nws tus kheej, nws cov khoom noj ntau thiab cov kab mob hauv plab hnyuv kuj yog txoj hauv kev tseem ceeb. Tus nqi ntawm cov spermidine nyob rau hauv ntau yam zaub mov txawv heev, nrog rau cov hom qoob mog yog cov nroj tsuag paub zoo. Lwm qhov chaw noj zaub mov muaj xws li txiv kab ntxwv qaub, kua txiv hmab txiv ntoo, taum, pob kws, cov nplej tag nrho, chickpeas, peas, ntsuab peppers, broccoli, txiv kab ntxwv, tshuaj yej ntsuab, nplej bran thiab tshiab kua txob ntsuab. Tsis tas li ntawd, cov khoom noj xws li nceb shiitake, noob amaranth, zaub qhwv, cheese paub tab thiab durian kuj muaj spermidine.

Nws tsim nyog sau cia tias Mediterranean noj zaub mov muaj ntau cov khoom noj spermidine-nplua nuj, uas tuaj yeem pab piav qhia txog qhov tshwm sim "xiav cheeb tsam" uas tib neeg nyob ntev dua hauv qee thaj chaw. Txawm li cas los xij, rau cov neeg uas tsis tuaj yeem noj cov spermidine txaus los ntawm kev noj zaub mov, cov tshuaj spermidine yog ib qho kev xaiv zoo. Cov spermidine hauv cov tshuaj no yog tib yam tshwm sim molecule, ua rau nws muaj txiaj ntsig zoo.

Putrescine yog dab tsi?

Kev tsim cov putrescine suav nrog ob txoj hauv kev, ob qho tib si pib nrog cov amino acid arginine. Hauv thawj txoj kev, arginine yog thawj zaug hloov mus rau agmatine catalyzed los ntawm arginine decarboxylase. Tom qab ntawd, agmatine tau hloov dua siab tshiab rau hauv N-carbamoylputrescine los ntawm kev ua ntawm agmatine iminohydroxylase. Thaum kawg, N-carbamoylputrescine hloov mus rau hauv putrescine, ua tiav cov txheej txheem hloov pauv. Txoj kev thib ob yog qhov yooj yim, nws ncaj qha hloov arginine rau hauv ornithine, thiab tom qab ntawd hloov ornithine rau hauv putrescine los ntawm kev ua ntawm ornithine decarboxylase. Txawm hais tias ob txoj hauv kev no muaj cov kauj ruam sib txawv, lawv ob qho tib si thaum kawg ua tiav kev hloov pauv ntawm arginine mus rau putrescine.

Putrescine yog ib qho diamine uas muaj nyob rau hauv ntau yam kabmob xws li pancreas, thymus, tawv nqaij, hlwb, uterus thiab zes qe menyuam. Putrescine kuj pom muaj nyob rau hauv cov khoom noj xws li hom qoob mog, kua txob ntsuab, taum pauv, pistachios, thiab txiv kab ntxwv. Cov kev tshawb fawb tsis ntev los no tau pom tias putrescine yog ib qho tseem ceeb hauv kev tswj hwm cov tshuaj metabolic uas tuaj yeem cuam tshuam nrog cov macromolecules lom neeg xws li cov tsis zoo DNA, RNA, ntau yam ligands (xws li β1 thiab β2 adrenergic receptors), thiab cov proteins membranes. , ua rau ib tug series ntawm physiological los yog pathological hloov nyob rau hauv lub cev.

Spermidine nyhuv

Antioxidant kev ua si: Spermidine muaj zog antioxidant kev ua si thiab tuaj yeem hnov ​​​​mob dawb radicals los txo oxidative kev puas tsuaj rau cov hlwb los ntawm cov dawb radicals. Hauv lub cev, spermidine tuaj yeem txhawb kev nthuav tawm ntawm cov enzymes antioxidant thiab txhim kho antioxidant muaj peev xwm.

Kev tswj hwm ntawm lub zog metabolism: Spermidine koom nrog hauv kev tswj hwm lub zog metabolism ntawm cov kab mob, tuaj yeem txhawb kev nqus thiab siv cov piam thaj tom qab noj zaub mov, thiab cuam tshuam rau qhov sib piv ntawm aerobic metabolism thiab anaerobic metabolism los ntawm kev tswj cov txiaj ntsig ntawm mitochondrial zog tsim.

anti-inflammatory nyhuv

Spermidine muaj cov tshuaj tiv thaiv kab mob thiab tuaj yeem tswj cov kev qhia ntawm cov kab mob inflammatory thiab txo qhov tshwm sim ntawm qhov mob ntev. Feem ntau cuam tshuam rau txoj hauv kev nuclear-κB (NF-κB).

Kev loj hlob, kev loj hlob thiab kev tiv thaiv kab mob: Spermidine kuj ua lub luag haujlwm tseem ceeb hauv kev loj hlob, kev loj hlob thiab kev tiv thaiv kab mob. Nws tuaj yeem txhawb kev tso tawm ntawm cov tshuaj hormones loj hlob hauv tib neeg lub cev thiab pab txhim kho kev txhim kho ntawm ntau yam ntaub so ntswg thiab kabmob ntawm lub cev. Nyob rau tib lub sijhawm, hauv kev tswj hwm kev tiv thaiv kab mob, spermidine txhim kho lub cev tiv thaiv kab mob thiab kab mob los ntawm kev tswj cov qe ntshav dawb thiab txhawb kev tshem tawm cov pa oxygen reactive.

ncua kev laus: Spermidine tuaj yeem txhawb nqa autophagy, txheej txheem ntxuav hauv cov hlwb uas pab tshem tawm cov kab mob thiab cov protein uas puas lawm, yog li ncua kev laus.

Glial cell regulation: Spermidine plays lub luag haujlwm tseem ceeb hauv glial hlwb. Nws tuaj yeem koom nrog hauv xov tooj ntawm tes taw qhia cov tshuab thiab kev sib txuas ua haujlwm ntawm cov paj hlwb, thiab ua lub luag haujlwm tseem ceeb hauv kev txhim kho neuron, kev sib txuas lus sib txuas, thiab tiv thaiv neuropathy.

Kev tiv thaiv kab mob plawv: Hauv plawv plawv, spermidine tuaj yeem txo cov lipid tsub zuj zuj hauv atherosclerotic plaques, txo qis plawv hypertrophy, thiab txhim kho diastolic muaj nuj nqi, yog li ua tiav kev tiv thaiv plawv. Tsis tas li ntawd, kev noj zaub mov noj spermidine txhim kho ntshav siab thiab txo cov hlab plawv thiab kev tuag.

Hauv xyoo 2016, kev tshawb fawb luam tawm hauv Atherosclerosis tau lees paub tias spermidine tuaj yeem txo cov lipid tsub zuj zuj hauv atherosclerotic plaques. Nyob rau hauv tib lub xyoo, ib txoj kev tshawb fawb luam tawm nyob rau hauv Nature Medicine tau lees paub tias spermidine tuaj yeem txo qis plawv hypertrophy thiab txhim kho diastolic muaj nuj nqi, yog li tiv thaiv lub plawv thiab txuas ntxiv lub neej ntawm nas.

Txhim kho Alzheimer's disease

Spermidine tau txais txiaj ntsig zoo rau tib neeg lub cim xeeb. Pab neeg ntawm xibfwb Reinhart los ntawm Australia tau pom tias kev kho spermidine tuaj yeem txhim kho kev txawj ntse ntawm cov neeg laus. Txoj kev tshawb no tau txais ntau qhov chaw ob qhov muag tsis pom kev tsim thiab tso npe rau 85 tus neeg laus hauv 6 lub tsev laus, uas tau muab faib ua ob pawg thiab siv cov tshuaj spermidine sib txawv. Lawv txoj kev paub txog kev paub tau raug soj ntsuam los ntawm kev ntsuam xyuas kev nco thiab muab faib ua plaub pawg: tsis muaj dementia, me me dementia, nruab nrab dementia thiab loj dementia. Cov ntshav tau sau los ntsuas qhov concentration ntawm spermidine hauv lawv cov ntshav. Cov txiaj ntsig tau pom tias spermidine concentration tau cuam tshuam nrog kev paub txog kev ua haujlwm hauv pawg neeg tsis yog dementia, thiab kev paub txog cov neeg laus uas muaj mob me mus rau nruab nrab dementia tau txhim kho zoo tom qab noj cov tshuaj spermidine ntau.

Autophagy

Spermidine tuaj yeem txhawb nqa autophagy, xws li mTOR (lub hom phiaj ntawm rapamycin) inhibitory txoj hauv kev. Los ntawm kev txhawb nqa autophagy, nws pab tshem tawm cov kab mob puas thiab cov proteins hauv cov hlwb thiab tswj kev noj qab haus huv ntawm tes.

Spermidine hydrochloride yog siv nyob rau hauv ntau yam teb

Hauv kev lag luam tshuaj, spermidine hydrochloride yog siv los ua tshuaj hepatoprotective uas tuaj yeem txhim kho daim siab ua haujlwm thiab txo lub siab puas tsuaj. Tsis tas li ntawd, spermidine hydrochloride tuaj yeem siv los kho cov mob xws li cov roj cholesterol siab, hypertriglyceridemia, thiab kab mob plawv.

Spermidine hydrochloride ua haujlwm los ntawm kev txo cov ntshav plasma homocysteine ​​​​(Hcy) qib, yog li txo qhov kev pheej hmoo ntawm cov kab mob plawv. Cov kev tshawb fawb tau pom tias spermidine hydrochloride tuaj yeem txhawb nqa cov metabolism hauv Hcy thiab txo qhov kev pheej hmoo ntawm cov kab mob plawv los ntawm kev txo cov ntshav Hcy qib.

Kev tshawb fawb txog qhov cuam tshuam ntawm spermidine hydrochloride ntawm kev pheej hmoo ntawm cov kab mob plawv tau pom tias spermidine hydrochloride tuaj yeem txo qis Hcy plasma, yog li txo qhov kev pheej hmoo ntawm cov kab mob plawv. Hauv txoj kev tshawb no, cov kws tshawb fawb tau faib cov neeg koom ua ob pawg, nrog rau ib qho tau txais spermidine hydrochloride supplementation thiab lwm tus tau txais cov placebo.

Cov txiaj ntsig ntawm kev tshawb fawb tau pom tias cov neeg koom nrog uas tau txais cov tshuaj spermidine hydrochloride supplementation tau txo qis Hcy plasma ntau ntau thiab txo qis kev pheej hmoo ntawm cov kab mob plawv. Tsis tas li ntawd, muaj lwm cov kev tshawb fawb txhawb nqa spermidine hydrochloride lub luag haujlwm hauv kev txo qis kev pheej hmoo ntawm cov kab mob plawv.

Hauv cov khoom noj khoom haus, spermidine hydrochloride yog siv los ua cov tshuaj tsw qab thiab humectant los txhim kho cov saj ntawm cov zaub mov thiab tswj cov dej noo ntawm cov zaub mov. Tsis tas li ntawd, spermidine hydrochloride kuj tseem siv tau los ua cov khoom noj ntxiv los txhim kho tus nqi loj hlob thiab cov leeg nqaij zoo.

Hauv cov tshuaj pleev ib ce, spermidine hydrochloride yog siv los ua cov tshuaj humectant thiab antioxidant los tswj cov tawv nqaij noo thiab txo cov dawb radical puas. Tsis tas li ntawd, spermidine hydrochloride kuj tseem siv tau rau hauv cov tshuaj pleev thaiv hnub kom txo tau qhov kev puas tsuaj ntawm ultraviolet rays rau ntawm daim tawv nqaij.

Hauv kev ua liaj ua teb, spermidine hydrochloride yog siv los ua tus tswj kev loj hlob ntawm cov nroj tsuag los txhawb cov qoob loo loj hlob thiab nce yields.