5-amino-1-methylquinolinium iodide CAS No.: 42464-96-0 98.0% purity min. | ntxiv cov khoom xyaw manufacturers
Khoom Parameters
| Khoom npe | 5-amino-1-methylquinolinium iodide |
| Lwm lub npe | NNMTi5-Amino-1-mq iodide 5-amino-1-methylquinolinium iodide 5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE 5-Amino-1-methylquinolin-1-iumiodide 1-methylquinolin-1-ium-5-amine; iodide 5-Amino-1-methyl-1-quinolinium Iodide |
| CAS Nr. | 42464-96-0 |
| Cov mis mos molecular | C10H11IN2 |
| Molecular hnyav | 286.11 Nws |
| Purity | 98% |
| Qhov tshwm sim | Xim av rau reddish xim av khoom |
| Ntim | 1kg / hnab, 25kg / chim |
| Daim ntawv thov | Khoom noj khoom haus ntxiv Raw Khoom |
Khoom taw qhia
NNMTi yog ib qho enzyme overexpressed thaum lub sij hawm skeletal nqaij laus thiab yog txuam nrog kev kho ntawm NAD + txoj kev puas tsuaj, dysregulated sirtuin1 kev ua si, thiab ua kom cov nqaij ntshiv cell senescence. NNMTi txhawb nqa kev sib txawv ntawm myoblast nyob rau hauv vitro thiab txhim kho fusion thiab rov tsim dua tshiab ntawm cov leeg qia hlwb hauv cov nas hnub nyoog. NNMTi kuj yog ib qho muaj zog inhibitor ntawm nicotinamide N-methyltransferase (NNMT) (IC50 = 1.2 μM), xaiv khi rau NNMT substrate binding site residues. NNMTi txhawb nqa kev sib txawv ntawm myoblast nyob rau hauv vitro thiab txhim kho fusion thiab rov tsim dua tshiab ntawm cov leeg qia hlwb hauv cov nas hnub nyoog. Ntawm lawv, cytosolic enzyme nicotinamide N-methyltransferase (NNMT) tau raug tshawb pom tshiab los tswj cov qib ntawm nicotinamide precursors xav tau rau NAD + biosynthesis, thiab yog li ua lub luag haujlwm tseem ceeb hauv kev tswj NAD + txoj kev khaws cia thiab cellular metabolism.
Feature
(1) High purity: NNMTi tuaj yeem tau txais cov khoom siv purity siab los ntawm cov txheej txheem ntau lawm. High purity txhais tau tias zoo dua bioavailability.
(2) Lub Hom Phiaj: NNMTi tshwj xeeb yog tsom rau NNMT enzyme thiab tuaj yeem cuam tshuam nws cov haujlwm, yog li cuam tshuam rau txoj kev metabolic ntawm nicotinamide.
(3) Kev ruaj ntseg: NNMTi muaj kev ruaj ntseg zoo thiab tuaj yeem tswj hwm nws cov haujlwm thiab cov txiaj ntsig hauv qhov chaw sib txawv thiab kev cia khoom.
(4) Kev cia siab rau kev txhim kho: Vim muaj ntau yam yam ntxwv ntawm NNMT, nws txoj kev loj hlob tau txais kev saib xyuas dav thiab muaj kev tshawb fawb dav dav thiab kev cia siab rau daim ntawv thov.
Daim ntawv thov
NNMTi yog ib qho nicotinamide N-methyltransferase (NNMT) inhibitor uas txhawb kev sib txawv ntawm myoblast. NNMTi kuj tseem siv tau los ua ib qho ntxiv los pab txo qhov hnyav thiab rog thiab txhim kho daim siab rog.
