5-Amino-1-methylquinolinium chloride CAS No.:42464-96-0 98.0% kev huv huv tsawg kawg nkaus | chaw tsim khoom xyaw ntxiv
Cov Khoom Siv
| Lub npe khoom | 5-Amino-1-methylquinolinium chloride (5-amino-1MQ) |
| Lwm lub npe | 5-amino-1MQ5-Amino-1-mq chloride 5-Amino-1-methylquinolinium chloride 5-Amino-1-methylquinolin-1-ium chloride 5-AMINO-1-METHYLQUINOLIN-1-IUM CHLOEIDE 5-Amino-1-methyl-1-quinolinium chloride |
| CAS Nr. | 42464-96-0 |
| Cov mis molecular | C₁₀H₁₁ClN₂ |
| Qhov hnyav ntawm cov molecule | 194.6 |
| Kev dawb huv | 98% |
| Qhov tsos | Xim av rau xim av liab dawb khov kho |
| Ntim khoom | 1kg/hnab, 25kg/phaj |
| Daim Ntawv Thov | Khoom Noj Khoom Haus Ntxiv Raw Khoom |
Kev taw qhia txog khoom
5-Amino-1-methylquinolinium chloride yog ib qho enzyme uas overexpressed thaum lub sij hawm cov leeg nqaij laus thiab nws cuam tshuam nrog kev kho qhov puas tsuaj ntawm NAD+ txoj kev, kev ua haujlwm ntawm sirtuin1 tsis zoo, thiab kev laus ntawm cov leeg nqaij. 5-Amino-1-methylquinolinium chloride txhawb nqa kev sib txawv ntawm myoblast hauv vitro thiab txhim kho kev sib xyaw thiab kev rov ua dua ntawm cov leeg nqaij hauv cov nas laus. 5-Amino-1-methylquinolinium chloride kuj yog ib qho tshuaj inhibitor muaj zog ntawm nicotinamide N-methyltransferase (NNMT), xaiv cov khoom sib txuas ntawm NNMT substrate. 5-Amino-1-methylquinolinium chloride txhawb nqa kev sib txawv ntawm myoblast hauv vitro thiab txhim kho kev sib xyaw thiab kev rov ua dua ntawm cov leeg nqaij hauv cov nas laus. Ntawm lawv, cov cytosolic enzyme nicotinamide N-methyltransferase (NNMT) tau raug tshawb pom tshiab los tswj cov qib ntawm nicotinamide precursors uas xav tau rau NAD+ biosynthesis, thiab yog li ntawd ua lub luag haujlwm tseem ceeb hauv kev tswj hwm NAD+ salvage pathway thiab cellular metabolism.
5-Amino-1-Methylquinolinium Chloride ua haujlwm hauv koj lub microbiome kom txo cov nqaij adipose (rog) thiab pab koj poob phaus. Thaum cov roj ntau dhau sib sau ua ke, koj lub cev tsim cov enzyme hu ua NNMT (nicotinamide N-methyltransferase). NNMT ntau npaum li cas, koj lub cev ua rau muaj kev o thiab khaws cov rog ntau npaum li ntawd. 5-Amino-1-Methylquinolinium Chloride tiv thaiv NNMT, ua rau koj lub cev poob phaus ntau dhau.
Feature
(1) Kev ntshiab siab: 5-Amino-1-methylquinolinium chloride tuaj yeem tau txais cov khoom ntshiab siab los ntawm cov txheej txheem tsim khoom zoo. Kev ntshiab siab txhais tau tias muaj kev nyab xeeb zoo dua.
(2) Kev Taw Qhia: 5-Amino-1-methylquinolinium chloride tsom mus rau NNMT enzyme thiab tuaj yeem tiv thaiv nws txoj haujlwm, yog li cuam tshuam rau txoj kev zom zaub mov ntawm nicotinamide.
(3) Kev Ruaj Ntseg: 5-Amino-1-methylquinolinium chloride muaj kev ruaj khov zoo thiab tuaj yeem tswj nws cov haujlwm thiab cov txiaj ntsig nyob rau hauv ntau qhov chaw sib txawv thiab cov xwm txheej khaws cia.
(4) Kev cia siab rau kev loj hlob: Vim muaj ntau yam ntxwv ntawm 5-Amino-1-methylquinolinium chloride, nws txoj kev loj hlob tau txais kev saib xyuas dav dav thiab muaj kev tshawb fawb dav dav thiab kev cia siab rau daim ntawv thov.
Cov ntawv thov
5-Amino-1-methylquinolinium chloride yog ib qho tshuaj nicotinamide N-methyltransferase (NNMT) inhibitor uas txhawb nqa myoblast differentiation. 5-Amino-1-methylquinolinium chloride kuj tseem siv tau ua ib qho tshuaj ntxiv los pab txo qhov hnyav thiab rog thiab txhim kho cov rog hauv siab.
