Agomelatine hmoov chaw tsim tshuaj paus CAS No.: 138112-76-2 99% purity min. rau cov khoom xyaw ntxiv
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Khoom Parameters
| Khoom npe | Agomelatine |
| Lwm lub npe | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide; N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide |
| CAS Nr. | 138112-76-2 |
| Cov mis mos molecular | C15H17NO2 |
| Molecular hnyav | 243.3082 ib |
| Purity | 99.0% |
| Qhov tshwm sim | Dawb hmoov |
| Ntim | 1kg / hnab 25kg / nruas |
| Daim ntawv thov | Khoom noj khoom haus raw khoom |
Khoom taw qhia
Agomelatine tau tsim thawj zaug hauv Tebchaws Europe hauv xyoo 2009 thiab tam sim no tau pom zoo siv hauv ntau dua 70 lub tebchaws. Tsis zoo li cov tshuaj tiv thaiv kev nyuaj siab, agomelatin ua haujlwm los ntawm kev tsom melatonin thiab serotonin receptors hauv lub hlwb. Los ntawm kev ua tus agonist ntawm melatonin receptors, agomelatine pab normalize cov kev pw tsaug zog cuam tshuam feem ntau cuam tshuam nrog kev nyuaj siab. Cov txheej txheem no tsis yog tsuas yog pab txhim kho kev pw tsaug zog zoo xwb tab sis kuj tseem pab kho lub cev circadian rhythms. Tsis tas li ntawd, agomelatine ua ib qho antagonist ntawm qee yam serotonin receptors (5-HT2C receptors). Qhov tshwj xeeb ob qhov kev txiav txim tsis ncaj ncees ua rau muaj cov serotonin nyob rau hauv lub hlwb, ib tug neurotransmitter lub luag hauj lwm rau regulating mus ob peb vas. Los ntawm kev tswj hwm qib serotonin, agomelatine tuaj yeem ua tau zoo los tiv thaiv kev ntxhov siab, txo cov tsos mob xws li kev tu siab, tsis txaus siab, kev xav txhaum lossis tsis muaj nqis. Tsis tas li ntawd, agomelatin tuaj yeem muab lwm cov txiaj ntsig. Kev tshawb fawb qhia tias nws tuaj yeem pab txhim kho kev txawj ntse Kev Tshawb Fawb qhia nws lub peev xwm los txhim kho kev nco, kev saib xyuas, thiab kev ua haujlwm, ua rau nws yog ib qho chaw zoo siab rau kev tshawb fawb yav tom ntej.
Feature
(1) High purity: Agomelatine tuaj yeem tau txais cov khoom siv purity siab los ntawm cov txheej txheem ntau lawm. High purity txhais tau hais tias bioavailability zoo dua thiab tsawg dua qhov tsis zoo.
(2) Kev Nyab Xeeb: Kev nyab xeeb siab, tsis tshua muaj tshwm sim.
(3) Kev ruaj ntseg: Agomelatine muaj kev ruaj ntseg zoo thiab tuaj yeem tswj hwm nws cov haujlwm thiab cov txiaj ntsig hauv qhov chaw sib txawv thiab chaw cia khoom.
Daim ntawv thov
Agomelatine yog ib qho tshuaj tiv thaiv kev nyuaj siab thiab ua rau melatonin antagonist. Nws txo cov tsos mob ntawm kev nyuaj siab los ntawm kev tswj hwm melatonin MT1 receptors (txo qis cortical tswb signals) thiab MT2 receptors (circadian pw tsaug zog atherosclerosis) thiab qib serotonin. Noj thaum hmo ntuj, nws ua raws li lub ntuj lub suab ntawm melatonin tso tawm thiab tuaj yeem txhim kho kev pw tsaug zog zoo. Nws cov txheej txheem ntawm kev ua txhaum los ntawm cov tsoos monoamine transmitter system. Nws activates melatonin receptors MT1 thiab MT2 thiab antagonizes 5-HT2C receptors. Txhim kho kev pw tsaug zog zoo, kho cov kab mob lom neeg, thiab muaj cov nyhuv antidepressant; ntawm lawv, los ntawm antagonizing 5-HT2C receptors ntawm postsynaptic daim nyias nyias, nws tuaj yeem ua rau kom tso tawm DA thiab NE nyob rau hauv lub prefrontal cortex, exerting ib tug antidepressant nyhuv. Thaum MT agonism thiab 5-HT2C receptor antagonism coexist, ib qho kev sib koom ua ke tshwj xeeb tuaj yeem tsim tau, txhawb kev tso tawm ntau dua DA thiab NE hauv thaj tsam PFC lub hlwb, ntxiv dag zog rau cov nyhuv antidepressant. Tsis tas li ntawd, agomelatine tuaj yeem txhawb kev tso tawm ntawm lub hlwb-derived neurotrophic yam hauv PFC thiab thaiv kev ntxhov siab vim tso tawm glutamate hauv amygdala hlwb.
