Agomelatine hmoov chaw tsim tshuaj paus CAS No.: 138112-76-2 99% purity min.rau cov khoom xyaw ntxiv
Khoom Parameters
| Khoom npe | Agomelatine |
| Lwm lub npe | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide; N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide |
| CAS Nr. | 138112-76-2 |
| Cov mis mos molecular | C15H17NO2 |
| Molecular hnyav | 243.3082 ib |
| Purity | 99.0% |
| Qhov tshwm sim | Dawb hmoov |
| Ntim | 1kg / hnab 25kg / nruas |
| Daim ntawv thov | Khoom noj khoom haus raw khoom |
Khoom taw qhia
Agomelatine yog ib hom tshuaj tiv thaiv kev nyuaj siab tshiab.Nws cov txheej txheem ntawm kev ua txhaum los ntawm cov tsoos monoamine transmitter system.Nws activates melatonin receptors, MT1 thiab MT2, thiab antagonizes 5-HT2C receptors.Nws tuaj yeem txhim kho kev pw tsaug zog zoo thiab kho cov kab mob lom neeg thaum muaj cov nyhuv antidepressant;ntawm lawv, los ntawm kev tawm tsam 5-HT2C receptor ntawm postsynaptic membrane, nws tuaj yeem ua rau kom tso tawm DA thiab NE nyob rau hauv lub prefrontal cortex thiab ua si lub luag hauj lwm antidepressant.Thaum MT agonism thiab 5-HT2C receptor antagonism tshwm sim nyob rau tib lub sijhawm, ib qho kev sib koom ua ke tshwj xeeb tuaj yeem tsim los txhawb kev tso tawm ntau dua DA thiab NE hauv thaj tsam PFC lub hlwb, ntxiv dag zog rau cov nyhuv antidepressant.Tsis tas li ntawd, agomelatine tseem tuaj yeem txhawb kev tso tawm ntawm lub hlwb-derived neurotrophic yam hauv PFC thiab thaiv kev ntxhov siab vim tso tawm glutamate hauv thaj av amygdala hlwb.
Feature
(1) Dual regulation: Nws tuaj yeem tsis tsuas yog tswj kev tso tawm ntawm melatonin, tab sis kuj tswj kev tso tawm ntawm 5-hydroxytryptamine thiab norepinephrine, yog li ua lub luag haujlwm hauv kev tswj lub siab, pw tsaug zog, mob thiab lwm yam.
(2) Txhim kho kev pw tsaug zog: Agomelatine yog qhov uas tuaj yeem txhim kho insomnia tsis ua rau tsaug zog lossis coma.
(3) Txhim kho kev txawj ntse: Agomelatine tuaj yeem txhim kho kev txawj ntse los ntawm kev txhim kho neuroplasticity hauv hippocampus.
(4) Kev nyab xeeb siab: Piv nrog rau lwm cov tshuaj tiv thaiv kev ntxhov siab, cov tshuaj muaj qhov cuam tshuam tsawg dua thaum kho kev nyuaj siab, thiab yuav tsis cuam tshuam rau kev sib deev thiab lub cev hnyav.
Daim ntawv thov
Agomelatine yog rau cov tshuaj tiv thaiv kev nyuaj siab uas kuj yog ib qho tshuaj melatonin antagonist.Nws txo cov tsos mob ntawm kev nyuaj siab los ntawm kev hloov kho qib ntawm melatonin MT1 receptors (kom txo qis cortical tswb signals) thiab MT2 receptors (rau circadian rhythms ntawm kev pw tsaug zog) thiab serotonin.Noj thaum hmo ntuj kom ua raws li lub ntuj lub suab ntawm melatonin tso tawm, nws tuaj yeem txhim kho kev pw tsaug zog zoo.
