YDL223C (HBT1) hmoov chaw tsim tshuaj paus CAS No.: 489408-02-8 99% purity min. rau cov khoom xyaw ntxiv

HBT1 khi rau ligand-binding domain ntawm α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) nyob rau hauv glutamate-dependent yam. Qhov no txhais tau hais tias HBT1 yog ib qho molecule uas tsuas yog khi rau ib qho chaw tshwj xeeb ntawm AMPA-R protein thaum muaj glutamate, thiab qhov kev khi no pab tswj cov haujlwm ntawm cov protein. AMPA receptors tau nthuav tawm thoob plaws hauv lub hauv nruab nrab lub paj hlwb thiab ua lub luag haujlwm tseem ceeb hauv kev sib txuas lus neuronal, kev hnov ​​​​lus, kev kawm, nco, thiab synaptic plasticity. AMPA receptors yog cov neeg txhawb nqa loj rau excitatory neurotransmission, kho kom haum xeeb sai, sai desensitizing excitation ntawm ntau synapses, thiab koom nrog cov lus teb ntxov rau glutamate hauv thaj tsam synaptic. AMPA receptors feem ntau qhia nrog NMDA receptors ntawm synapses, thiab ua ke lawv txhawb cov txheej txheem synaptic plasticity koom nrog hauv kev kawm, nco, excitotoxicity, thiab neuroprotection. Brain-derived neurotrophic factor (BDNF) yog ib qho tseem ceeb ntawm neurotrophic uas ua lub luag haujlwm tseem ceeb hauv kev saib xyuas thiab nthuav dav ntawm cov neurons thiab muaj zog thiab ntau yam cuam tshuam rau kev loj hlob, sib txawv, ciaj sia taus thiab tuag ntawm cov hlwb thiab tsis yog neuronal. , ib tug neurotransmitter modulator uas txhawb nqa neuronal plasticity hauv kev kawm thiab kev nco. Yog li ntawd, nws yog ib qho tseem ceeb rau kev noj qab haus huv thiab kev noj qab haus huv ntawm lub paj hlwb.