Kev noj zaub mov ntxiv-Tshwj xeeb rau lub neej ntev thiab tiv thaiv kev laus: Calcium Alpha-ketoglutarate

Calcium Alpha ketoglutarate (AKG) yog ib qho nruab nrab metabolite ntawm lub voj voog tricarboxylic acid thiab koom nrog kev tsim cov amino acids, vitamins, thiab organic acids thiab lub zog metabolism. Nws tuaj yeem siv los ua kev noj zaub mov ntxiv thiab muaj kev thov dav dav. Ntxiv rau nws txoj haujlwm lom neeg hauv tib neeg lub cev, calcium alpha-ketoglutarate kuj tau siv dav hauv kev lag luam tshuaj thiab tau dhau los ua ib qho tseem ceeb ntawm ntau yam khoom noj qab haus huv thiab kev kho mob.

Calcium alpha-ketoglutarate ua haujlwm li cas

Ua ntej,cAlcium alpha-ketoglutarateplays lub luag haujlwm tseem ceeb hauv lub zog metabolism. Raws li cov khoom nruab nrab ntawm lub voj voog tricarboxylic acid (TCA lub voj voog), calcium α-ketoglutarate koom nrog hauv cov txheej txheem tsim hluav taws xob intracellular. Los ntawm TCA lub voj voog, cov khoom noj xws li carbohydrates, rog, thiab cov proteins yog oxidized thiab decomposed los tsim ATP (adenosine triphosphate) los muab lub zog rau cov hlwb. Raws li ib qho tseem ceeb nruab nrab ntawm TCA lub voj voog, calcium α-ketoglutarate tuaj yeem txhawb nqa lub zog ntawm tes metabolism, ua kom lub cev muaj zog, pab txhim kho lub cev lub zog thiab kev ua siab ntev, thiab txhim kho lub cev qaug zog.

Thib ob, calcium α-ketoglutarate plays lub luag haujlwm tseem ceeb hauv cov amino acid metabolism. Amino acids yog cov ntsiab lus ntawm cov protein, thiab calcium α-ketoglutarate koom nrog hauv kev hloov pauv thiab metabolism ntawm cov amino acids. Hauv cov txheej txheem ntawm kev hloov cov amino acids rau hauv lwm cov metabolites, calcium α-ketoglutarate transaminates nrog cov amino acids los tsim cov amino acids tshiab los yog α-keto acids, yog li tswj kev sib npaug thiab kev siv cov amino acids. Tsis tas li ntawd, calcium α-ketoglutarate kuj tseem tuaj yeem ua oxidation substrate rau cov amino acids, koom nrog oxidative metabolism ntawm amino acids, thiab tsim lub zog thiab carbon dioxide. Yog li, calcium α-ketoglutarate yog qhov tseem ceeb hauv kev tswj hwm homeostasis ntawm amino acids thiab protein metabolism hauv lub cev.

Tsis tas li ntawd, calcium alpha-ketoglutarate ua cov tshuaj antioxidant uas tshem tawm cov dawb radicals thiab tiv thaiv cov hlwb los ntawm kev puas tsuaj oxidative. Nyob rau tib lub sijhawm, calcium α-ketoglutarate tuaj yeem tswj hwm kev ua haujlwm ntawm lub cev tiv thaiv kab mob, txhawb kev ua kom lub cev tiv thaiv kab mob, thiab txhim kho lub cev tiv thaiv kab mob thiab kis kab mob. Yog li, calcium α-ketoglutarate yog qhov tseem ceeb hauv kev tswj hwm lub cev tiv thaiv kab mob thiab tiv thaiv kab mob.

Kev tshawb fawb txog cov teebmeem ntawm kev laus

Kev laus muaj feem cuam tshuam rau peb txhua tus thiab yog ib qho kev pheej hmoo rau ntau yam kab mob, thiab raws li Medicare kev lag luam cov pej xeem, qhov tshwm sim ntawm tus kab mob yuav nce ntxiv nrog rau hnub nyoog. Txhawm rau txo kev laus thiab txo qhov kev pheej hmoo ntawm tus kab mob, kev tshawb fawb tau tshawb pom muaj kev nyab xeeb thiab bioactive tshuaj uas tuaj yeem cuam tshuam kev laus - calcium alpha-ketoglutarate.

Calcium alpha-ketoglutarate yog ib qho tseem ceeb metabolite hauv peb lub cev, paub txog lub luag haujlwm ntawm tes hauv Krebs cycle, lub voj voog tseem ceeb rau oxidation ntawm fatty acids thiab amino acids, tso cai rau mitochondria tsim ATP (ATP yog lub zog ntawm cov hlwb).

Qhov no suav nrog kev thauj khoom ntawm cov txheej txheem calcium alpha-ketoglutarate, yog li calcium alpha-ketoglutarate kuj tuaj yeem hloov mus rau glutamate thiab tom qab ntawd mus rau glutamine, uas tuaj yeem pab txhawb kev sib txuas ntawm cov protein thiab collagen (collagen yog cov protein ntau uas ua rau 1/3 ntawm tag nrho cov protein nyob rau hauv lub cev thiab pab txhawb cov pob txha, tawv nqaij thiab cov leeg nqaij).

Ponce De Leon Health, Inc., lub tuam txhab tshawb fawb txog kev noj qab haus huv tau tsom mus rau kev thim rov qab cov noob caj noob ces, ua kev tshawb fawb ntau xyoo ntawm calcium alpha-ketoglutarate rau cov nas hnub nyoog nruab nrab thiab pom tias lub neej ntev ntawm cov nas hauv pawg sim tau nce los ntawm 12%. Qhov tseem ceeb tshaj, Dab tsi ntxiv, frailty raug txo los ntawm 46% thiab noj qab haus huv lifespan nce 41%. Cov ntaub ntawv pov thawj qhia tau hais tias alpha-ketoglutarate supplementation yuav tsis tau tsuas yog ncua lub neej tab sis kuj tseem txuas ntxiv kev noj qab haus huv ntau dua.

Calcium α-ketoglutarate, raws li cov khoom noj muaj txiaj ntsig zoo, muaj cov ntawv thov dav dav hauv cov khoom kho mob. Nws muaj ntau yam kev ua haujlwm lom neeg xws li antioxidant, tiv thaiv kev laus, kev tiv thaiv kab mob thiab cov amino acid metabolism ua rau nws yog ib qho cuab yeej muaj zog los txhim kho tib neeg kev noj qab haus huv. Nrog rau kev paub txog kev noj qab haus huv thiab kev sib sib zog nqus ntawm kev tshawb fawb, nws ntseeg tau tias daim ntawv thov ntawm α-ketoglutarate calcium nyob rau hauv cov khoom siv kho mob yuav tau txais kev saib xyuas thiab kev loj hlob ntxiv.