NAD+ (Beta-Nicotinamide Adenine Dinucleotide) yog ib qho coenzyme pom muaj nyob rau hauv txhua lub cell uas muaj sia nyob thiab yog qhov tseem ceeb rau ntau yam txheej txheem ntawm lub cev, suav nrog kev tsim hluav taws xob thiab kev kho DNA. Thaum peb laus zuj zus, peb cov NAD+ theem txo qis, ua rau muaj ntau yam teeb meem kev noj qab haus huv. Txhawm rau tawm tsam qhov teeb meem no, ntau tus neeg tig mus rau NAD+ cov tshuaj ntxiv hauv daim ntawv hmoov. Txawm li cas los xij, nrog ntau txoj kev xaiv muaj, kev txiav txim siab seb NAD+ hmoov twg zoo tshaj plaws rau koj tuaj yeem nyuaj. Kev xaiv NAD+ hmoov zoo tshaj plaws yuav tsum tau xav txog kev huv, kev siv tau, kev noj tshuaj, kev meej, thiab cov lus tawm tswv yim ntawm cov neeg siv khoom. Los ntawm kev txiav txim siab qhov tseem ceeb ntawm cov yam no, koj tuaj yeem txiav txim siab tau zoo thiab xaiv NAD+ hmoov zoo uas txhawb nqa koj txoj kev noj qab haus huv thiab kev nyob zoo.
NAD tshwm sim ntuj tsim nyob rau hauv peb cov hlwb,feem ntau nyob rau hauv lawv cov cytoplasm thiab mitochondria, txawm li cas los xij, cov theem ntuj ntawm NAD poob qis thaum peb laus (txhua 20 xyoo, qhov tseeb), ua rau muaj cov teebmeem ib txwm ntawm kev laus, Xws li cov zog txo qis thiab mob thiab mob ntxiv. Ntxiv mus, kev laus poob qis hauv NAD yog txuam nrog lwm yam kab mob ntsig txog hnub nyoog, xws li mob qog noj ntshav, kev poob qis ntawm kev paub, thiab kev tsis muaj zog.
NAD+ tsis yog ib yam tshuaj hormones, nws yog ib qho coenzyme. NAD+ tuaj yeem txhim kho lub peev xwm ntawm DNA los kho nws tus kheej, ntev lub neej los ntawm kev thim rov qab qhov poob qis ntawm mitochondria, thiab tiv thaiv DNA thiab mitochondrial puas tsuaj. Thiab tuaj yeem txhim kho kev ruaj khov ntawm chromosome. NAD+ kuj tseem hu ua "lub molecule txuj ci tseem ceeb" uas kho thiab tswj kev noj qab haus huv ntawm cell. Hauv kev tshawb fawb txog tsiaj, nws tau lees paub tias muaj peev xwm kho ntau yam kab mob xws li kab mob plawv, ntshav qab zib, kab mob Alzheimer, thiab kev rog dhau.
NAD+ koom nrog ntau yam kev tshuaj lom neeg hauv cov cell, xws li glycolysis, fatty acid oxidation, tricarboxylic acid cycle, respiratory chain, thiab lwm yam. Hauv cov txheej txheem no, NAD+ ua haujlwm ua lub tshuab xa hydrogen, txais cov electrons thiab hydrogen los ntawm cov substrates thiab tom qab ntawd hloov lawv mus rau lwm cov molecules, xws li NADH thiab FAD, los tswj kev sib npaug ntawm cov redox hauv cell. NAD+ ua lub luag haujlwm tseem ceeb hauv kev tsim lub zog cellular, kev tiv thaiv cov dawb radical, kev kho DNA, thiab kev xa xov.
Ntxiv rau qhov ntawd, NAD+ kuj muaj feem cuam tshuam nrog kev laus, thiab nws cov theem txo qis nrog rau hnub nyoog. Yog li ntawd, kev tswj cov theem NAD+ ua lub luag haujlwm tseem ceeb hauv kev ncua kev laus, txhim kho lub zog, txhawb kev kho cell, txhim kho kev ua haujlwm ntawm lub hlwb, thiab tswj kev ua haujlwm ntawm lub cev.
Qhov tseem ceeb, kev laus yog nrog los ntawm kev poob qis hauv cov ntaub so ntswg thiab cov cellular NAD + theem hauv ntau yam qauv kab mob, suav nrog cov nas thiab tib neeg.
Yog li ntawd, kev ntxiv cov NAD+ hauv lub cev raws sijhawm tuaj yeem ncua kev laus thiab ua kom muaj kev noj qab haus huv. Yog tias koj xav kom hnub nyoog tsuas yog tus lej xwb, noj NAD+ ntxiv sai li sai tau kom koj zoo li hluas dua los ntawm sab hauv mus rau sab nraud.
Cov theem NAD + poob qis nrog hnub nyoog, feem ntau vim tias nws cov nqi tsim khoom tsis tuaj yeem ua raws li nws cov nqi siv.
Muaj ntau txoj kev tshawb fawb tau qhia tias qhov kev poob qis hauv NAD + yog qhov ua rau muaj ntau yam kab mob ntsig txog kev laus, suav nrog kev poob qis ntawm kev paub, kev o, mob qog noj ntshav, kab mob metabolic, sarcopenia, kab mob neurodegenerative, thiab lwm yam.
Qhov no yog vim li cas peb thiaj xav tau cov tshuaj NAD+. Ib yam li peb cov collagen hom 3, nws pheej ploj mus tas li.
NAD+ muaj peev xwm tiv taus kev laus. Lub hauv paus ntsiab lus tom qab nws yog dab tsi?
nad+ ua kom cov enzyme kho parp1 gene
Pab kho DNA Ib qho ntawm cov ua rau laus yog DNA puas tsuaj. Koj cov plaub hau dawb, zes qe menyuam thiab lwm yam kab mob poob qis, txhua yam muaj feem cuam tshuam nrog DNA puas tsuaj. Nyob lig thiab ntxhov siab yuav ua rau DNA puas tsuaj ntxiv.
Cov kev tshawb fawb tau pom tias NAD + pab ua kom lub noob PARP1 ua haujlwm (uas ua haujlwm ua tus thawj teb los ntes DNA puas tsuaj thiab tom qab ntawd txhawb kev xaiv ntawm txoj kev kho. PARP1 ua rau decompression ntawm cov qauv chromatin los ntawm ADP ribosylation ntawm histones, thiab koom nrog ntau yam kev kho DNA (Cov yam ntxwv sib cuam tshuam thiab hloov kho lawv, yog li txhim kho kev kho kom zoo), yog li kho DNA puas tsuaj thiab txhawb kev ua rau muaj kev hloov pauv ntawm cov metabolism.
Hauv kev xaus lus, NAD + tuaj yeem cuam tshuam ncaj qha thiab tsis ncaj qha rau ntau lub luag haujlwm tseem ceeb ntawm lub cev, suav nrog txoj hauv kev metabolic, kho DNA, chromatin remodeling, cellular senescence, kev ua haujlwm ntawm lub cev tiv thaiv kab mob, thiab lwm yam, yog li ua rau qeeb qeeb ntawm tib neeg txoj kev laus.
NAD+ yog lus Askiv luv ntawm Nicotinamide adenine dinucleotide. Nws lub npe tag nrho hauv Suav yog nicotinamide adenine dinucleotide, lossis Coenzyme I luv. Ua ib qho coenzyme uas xa cov hydrogen ions, NAD + ua lub luag haujlwm hauv ntau yam ntawm tib neeg lub cev metabolism, suav nrog glycolysis, Gluconeogenesis, tricarboxylic acid cycle, thiab lwm yam. Qee qhov kev tshawb fawb tau taw qhia tias qhov kev poob qis ntawm NAD + yog cuam tshuam nrog hnub nyoog, thiab cov txheej txheem physiological mediated los ntawm NAD + yog cuam tshuam nrog kev laus, cov kab mob metabolic, neuropathy thiab mob qog noj ntshav, suav nrog kev tswj hwm cell homeostasis, sirtuins hu ua "longevity genes", kho DNA, PARPs tsev neeg cov protein cuam tshuam nrog necroptosis thiab CD38 uas pab hauv calcium signaling.
Tiv Thaiv Kev Laus
Kev laus yog hais txog cov txheej txheem uas cov cell tsis rov qab faib dua li qub. Kev puas tsuaj ntawm DNA uas tsis kho lossis kev ntxhov siab ntawm cell tuaj yeem ua rau laus. Kev laus feem ntau txhais tias yog cov txheej txheem ntawm kev puas tsuaj ntawm cov haujlwm ntawm lub cev nrog hnub nyoog; cov tsos mob sab nraud yog kev hloov pauv ntawm lub cev uas tshwm sim los ntawm kev poob ntawm cov leeg thiab pob txha, thiab cov tsos mob sab hauv yog kev txo qis ntawm cov metabolism hauv paus thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob.
Cov kws tshawb fawb tau kawm txog cov neeg uas muaj sia nyob ntev, thiab cov txiaj ntsig tshawb fawb qhia tau tias muaj ib hom noob caj noob ces uas cuam tshuam txog kev muaj sia nyob ntev - lub noob caj noob ces "Sirtuins". Lub noob caj noob ces no yuav koom nrog hauv cov txheej txheem kho lub cev lub zog thiab kev tsim cov DNA kom tswj tau qhov kev ua tiav thiab kev ruaj khov ntawm cov noob caj noob ces, tshem tawm cov hlwb laus, txhim kho lub cev tiv thaiv kab mob los ntawm kev tiv thaiv kev o thiab cov tshuaj antioxidant, thiab ncua kev laus ntawm cov hlwb ib txwm muaj.
Tsuas yog lub hom phiaj ua kom cov noob caj noob ces "Sirtuins" ua haujlwm ntev xwb -NAD+
NAD+ yog qhov tseem ceeb rau kev tswj lub cev kom noj qab haus huv thiab sib npaug. Kev ua haujlwm ntawm lub cev, kev hloov pauv redox, kev saib xyuas thiab kho DNA, kev ruaj khov ntawm cov noob caj noob ces, kev tswj hwm epigenetic, thiab lwm yam. txhua yam yuav tsum muaj kev koom tes ntawm NAD+.
NAD + tswj kev sib txuas lus tshuaj ntawm lub nucleus thiab mitochondria, thiab kev sib txuas lus tsis muaj zog yog qhov tseem ceeb ua rau lub hlwb laus.
NAD + tuaj yeem tshem tawm cov lej DNA tsis raug uas nce ntxiv thaum lub sijhawm ua haujlwm ntawm lub cell, tswj kev qhia tawm ntawm cov noob caj noob ces, tswj kev ua haujlwm ib txwm ntawm cov cell, thiab qeeb qeeb kev laus ntawm tib neeg cov cell.
Kho cov DNA puas tsuaj
NAD+ yog ib qho tseem ceeb rau cov enzyme kho DNA PARP, uas muaj feem cuam tshuam loj heev rau kev kho DNA, kev qhia txog gene, kev loj hlob ntawm cell, kev ciaj sia ntawm cell, kev tsim kho chromosome, thiab kev ruaj khov ntawm gene.
Qhib cov protein kom muaj sia nyob ntev
Sirtuins feem ntau hu ua tsev neeg cov protein ntev thiab ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm ntawm lub hlwb, xws li kev o, kev loj hlob ntawm lub hlwb, circadian rhythm, kev hloov pauv zog, kev ua haujlwm ntawm neuronal, thiab kev tiv thaiv kev ntxhov siab, thiab NAD + yog ib qho enzyme tseem ceeb rau kev tsim cov protein ntev. Ua kom tag nrho 7 cov protein ntev hauv tib neeg lub cev, ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kev ntxhov siab ntawm lub hlwb, kev hloov pauv zog, tiv thaiv kev hloov pauv ntawm lub hlwb, apoptosis thiab kev laus.
Muab zog
Nws ua rau muaj zog ntau dua 95% ntawm lub zog uas xav tau rau kev ua neej. Mitochondria hauv tib neeg lub hlwb yog cov chaw tsim hluav taws xob ntawm cov hlwb. NAD + yog ib qho coenzyme tseem ceeb hauv mitochondria los tsim cov zog molecule ATP, hloov cov as-ham mus rau hauv lub zog uas tib neeg lub cev xav tau.
Txhawb kom cov hlab ntsha rov qab zoo thiab tswj cov hlab ntsha elasticity
Cov hlab ntsha yog cov nqaij tseem ceeb rau kev ua neej. Thaum peb laus zuj zus, cov hlab ntsha maj mam poob lawv qhov kev ywj pheej thiab ua rau tawv, tuab dua, thiab nqaim dua, ua rau "arteriosclerosis." NAD+ tuaj yeem ua rau cov hlab ntsha ua haujlwm ntau dua, yog li ntawd tswj tau qhov ywj pheej ntawm cov hlab ntsha thiab tswj kev noj qab haus huv ntawm cov hlab ntsha.
Txhawb kev zom zaub mov
Kev ua haujlwm ntawm lub cev yog kev sib sau ua ke ntawm ntau yam tshuaj lom neeg hauv lub cev. Lub cev yuav txuas ntxiv pauv cov khoom thiab lub zog. Thaum qhov kev sib pauv no nres, lub neej ntawm lub cev kuj yuav xaus.
Xibfwb Anthony thiab nws pab neeg tshawb fawb ntawm University of California, Tebchaws Meskas, pom tias NAD + tuaj yeem txhim kho qhov qeeb ntawm cov metabolism hauv lub hlwb uas cuam tshuam nrog kev laus, yog li txhim kho tib neeg txoj kev noj qab haus huv thiab ntev lub neej.
Tiv thaiv kev noj qab haus huv ntawm lub plawv
Lub plawv yog lub cev tseem ceeb tshaj plaws ntawm tib neeg, thiab NAD + theem hauv lub cev ua lub luag haujlwm tseem ceeb hauv kev tswj hwm kev ua haujlwm ib txwm ntawm lub plawv. Kev txo qis ntawm NAD + tej zaum yuav cuam tshuam nrog pathogenesis ntawm ntau yam kab mob plawv, thiab ntau qhov kev tshawb fawb yooj yim kuj tau lees paub qhov cuam tshuam ntawm kev ntxiv NAD + rau cov kab mob plawv.
Tiv thaiv cov kab mob plawv thiab cov kab mob cerebrovascular
Cov kev tshawb fawb tau qhia tias yuav luag txhua xya hom subtypes ntawm sirtuins (SIRT1-SIRT7) muaj feem cuam tshuam nrog kev tshwm sim ntawm cov kab mob plawv. Sirtuins raug suav hais tias yog cov hom phiaj agonistic rau kev kho cov kab mob plawv, tshwj xeeb tshaj yog SIRT1.
NAD+ yog tib lub substrate rau Sirtuins. Kev ntxiv NAD+ rau lub cev tib neeg raws sijhawm tuaj yeem ua kom txhua hom Sirtuins ua haujlwm tau zoo, yog li tiv thaiv kev noj qab haus huv ntawm lub plawv thiab tiv thaiv cov kab mob plawv.
Txhawb kev loj hlob ntawm cov plaub hau
Qhov ua rau plaub hau poob yog qhov poob ntawm cov plaub hau niam lub zog, thiab qhov poob ntawm cov plaub hau niam lub zog yog vim NAD + theem hauv tib neeg lub cev txo qis. Cov plaub hau niam lub zog tsis muaj ATP txaus los ua cov protein plaub hau synthesis, yog li poob lawv lub zog thiab ua rau plaub hau poob. Yog li ntawd, kev ntxiv NAD + tuaj yeem ua kom lub voj voog acid thiab tsim ATP, yog li cov plaub hau niam lub zog muaj peev xwm txaus los tsim cov protein plaub hau, yog li txhim kho cov plaub hau poob.
Kev kho mob NAD+ cell molecule
Thaum muaj hnub nyoog ntau zuj zus, qib ntawm NAD+ (Coenzyme I) hauv lub cev yuav poob qis heev, uas ua rau lub cev ua haujlwm thiab lub hlwb laus zuj zus! Tom qab hnub nyoog nruab nrab, qib ntawm NAD+ hauv tib neeg lub cev txo qis txhua xyoo. Thaum muaj hnub nyoog 50 xyoo, qib NAD+ hauv lub cev tsuas yog ib nrab ntawm qhov ntawd thaum muaj hnub nyoog 20 xyoo. Thaum muaj hnub nyoog 80 xyoo, qib NAD+ tsuas yog li 1% ntawm qhov lawv muaj thaum muaj hnub nyoog 20 xyoo.
Yog li, NAD + hmoov txawv li cas ntawm lwm cov tshuaj ntxiv hauv khw? Cia peb saib ze dua ntawm qee cov ntsiab lus tseem ceeb uas yuav tsum xav txog:
1. Kev siv tau zoo:
Ib qho ntawm qhov sib txawv tseem ceeb ntawm NAD+ hmoov thiab lwm yam tshuaj ntxiv yog nws qhov bioavailability. NAD+ hmoov yooj yim nqus los ntawm lub cev thiab siv cov coenzymes zoo. Ntawm qhov tod tes, qee cov tshuaj ntxiv yuav muaj bioavailability qis dua, txhais tau tias lub cev yuav tsis tuaj yeem nqus thiab siv cov khoom xyaw nquag tau zoo.
2. Lub tshuab ua haujlwm:
Hmoov NAD+ ua haujlwm los ntawm kev rov ua kom NAD+ ntau ntxiv hauv lub cev, yog li txhawb nqa ntau yam haujlwm ntawm tes. Lwm cov tshuaj ntxiv yuav muaj cov txheej txheem sib txawv ntawm kev ua haujlwm, tsom mus rau txoj hauv kev lossis cov kab ke hauv lub cev. Kev nkag siab txog cov txheej txheem tshwj xeeb ntawm kev ua haujlwm ntawm cov tshuaj ntxiv sib txawv tuaj yeem pab koj txiav txim siab seb cov twg zoo tshaj plaws rau koj tus kheej cov kev xav tau.
3. Kev tshawb fawb thiab pov thawj:
Thaum xav txog cov tshuaj ntxiv, nws yog ib qho tseem ceeb uas yuav tsum tau saib xyuas cov kev tshawb fawb thiab cov pov thawj uas twb muaj lawm uas txhawb nqa nws cov txiaj ntsig thiab kev nyab xeeb. NAD + hmoov tau yog lub ntsiab lus ntawm ntau txoj kev tshawb fawb, qhia txog nws cov txiaj ntsig zoo rau kev noj qab haus huv ntawm tes thiab lub neej ntev. Ntawm qhov tod tes, qee cov tshuaj ntxiv yuav muaj kev tshawb fawb tsawg los txhawb lawv cov lus thov. Kev nkag siab txog cov pov thawj tshawb fawb tom qab cov tshuaj ntxiv tuaj yeem pab koj txiav txim siab ntau ntxiv txog nws siv.
4. Cov kev xav tau thiab lub hom phiaj ntawm tus kheej:
Thaum kawg, qhov kev txiav txim siab siv NAD + hmoov lossis lwm yam tshuaj ntxiv yuav tsum yog raws li koj tus kheej xav tau thiab lub hom phiaj kev noj qab haus huv. Xav txog kev sab laj nrog tus kws kho mob lossis tus kws noj zaub mov tsim nyog kom txiav txim siab seb cov tshuaj ntxiv twg yuav muaj txiaj ntsig zoo tshaj plaws rau koj. Cov yam ntxwv xws li hnub nyoog, kev ua neej, thiab cov mob kev noj qab haus huv uas twb muaj lawm tuaj yeem ua lub luag haujlwm hauv kev txiav txim siab txog kev noj tshuaj ntxiv uas tsim nyog tshaj plaws.
NAD+, cov kws tshawb fawb tau kawm txog nws tau 100 xyoo. NAD+ tsis yog ib qho kev tshawb pom tshiab, tab sis yog ib yam khoom uas tau kawm txog ntau tshaj 100 xyoo.
NAD+ tau pom thawj zaug hauv xyoo 1904 los ntawm tus kws tshuaj lom neeg Askiv Sir Arthur Harden, uas tom qab ntawd yeej qhov khoom plig Nobel hauv Chemistry hauv xyoo 1929.
Xyoo 1920, Hans von Euler-Chelpin tau cais thiab ntxuav NAD+ thawj zaug thiab nrhiav pom nws cov qauv dinucleotide, thiab tom qab ntawd yeej qhov khoom plig Nobel hauv Chemistry xyoo 1929.
Xyoo 1930, Otto Warburg thawj zaug pom lub luag haujlwm tseem ceeb ntawm NAD + ua ib qho coenzyme hauv kev hloov pauv khoom siv thiab lub zog, thiab tom qab ntawd yeej qhov khoom plig Nobel hauv kev kho mob xyoo 1931.
Xyoo 1980, George Birkmayer, ib tug xibfwb ntawm Department of Medical Chemistry ntawm University of Graz hauv Austria, thawj zaug siv NAD + txo qis rau kev kho mob.
Xyoo 2012, pawg tshawb fawb ntawm Leonard Guarente, pawg tshawb fawb ntawm tus kws tshuaj lom neeg nto moo thoob ntiaj teb Stephen L. Helfand, thiab pawg tshawb fawb ntawm Haim Y. Cohen tau tshawb pom tias NAD + tuaj yeem ua kom cov pas nrig ntawm Caenorhabditis elegans ntev dua. Lub neej ntawm nematodes yog ze li ntawm 50%, nws tuaj yeem ua kom lub neej ntawm cov yoov txiv hmab txiv ntoo ntev dua li 10% -20%, thiab nws tuaj yeem ua kom lub neej ntawm cov nas txiv neej ntev dua 10%.
Cov kws tshawb fawb txoj kev tshawb nrhiav thiab kev tshawb fawb txog lub neej tau raug hloov kho tshiab tas li. Thaum Lub Kaum Ob Hlis 2013, David Sinclair, tus xibfwb qhia txog noob caj noob ces ntawm Harvard University, tau luam tawm "Supplementing NAD nrog NAD" hauv phau ntawv xov xwm kev kawm zoo tshaj plaws hauv ntiaj teb "Cell". "Tom qab ib lub lim tiam ntawm kev nce NAD nrog tus neeg sawv cev, lub neej ntawm nas tau ntev dua 30%. Cov txiaj ntsig kev tshawb fawb tau qhia thawj zaug tias NAD + cov tshuaj ntxiv tuaj yeem thim rov qab kev laus thiab ntev lub neej. Kev tshawb fawb no ua rau lub ntiaj teb xav tsis thoob thiab qhib txoj hauv kev kom muaj koob meej rau NAD cov tshuaj ntxiv ua cov tshuaj tiv thaiv kev laus.
Nrog qhov kev tshawb pom zoo kawg no, NAD + tau tsim kom muaj kev sib txuas tsis sib xws nrog kev tiv thaiv kev laus. Nyob rau hauv xyoo tas los no, kev tshawb fawb txog NAD + tau yuav luag tswj hwm cov ntawv xov xwm SCI kev kawm zoo tshaj plaws xws li Science, Nature, thiab Cell, dhau los ua qhov kev tshawb pom zoo tshaj plaws hauv zej zog kho mob. Nws tau hais tias qhov no Nws yog ib kauj ruam keeb kwm uas tib neeg tau ua hauv kev taug kev los tawm tsam kev laus thiab txuas lub neej ntev.
1. Tshawb nrhiav lub koob npe nrov thiab kev pom tseeb ntawm lub hom lag luam
Thaum xav txog ib hom hmoov NAD+ tshwj xeeb, nws tsim nyog tshawb nrhiav txog lub koob npe nrov thiab kev pom tseeb ntawm lub tuam txhab. Nrhiav cov hom uas muab qhov tseem ceeb rau kev pom tseeb hauv lawv cov txheej txheem nrhiav thiab tsim khoom. Cov hom muaj koob npe yuav muab cov ntaub ntawv qhia txog lawv cov hmoov NAD+, suav nrog qhov zoo ntawm cov khoom siv raw thiab cov qauv tsim khoom uas lawv ua raws. Tsis tas li ntawd, nrhiav cov kev tshuaj xyuas thiab cov lus pov thawj ntawm cov neeg siv khoom los ntsuas qhov kev txaus siab thiab kev paub ntawm lwm tus neeg siv khoom nrog cov khoom lag luam.
2. Soj ntsuam qhov huv ntawm NAD + hmoov
Kev huv si yog qhov tseem ceeb thaum xaiv hom hmoov NAD+. Cov hmoov NAD+ zoo yuav tsum tsis muaj cov khoom tsis huv thiab cov khoom ntxiv, kom ntseeg tau tias koj tau txais cov khoom huv si thiab zoo. Nrhiav cov hom lag luam uas ua qhov kev sim sab nraud los xyuas kom meej tias lawv cov hmoov NAD+ huv si. Kev sim sab nraud muab kev ntseeg siab ntxiv tias cov khoom ua tau raws li cov qauv huv si siab tshaj plaws thiab tsis muaj cov tshuaj lom.
3. Xav txog cov txheej txheem tsim khoom thiab cov qauv zoo
Cov txheej txheem tsim khoom ua lub luag haujlwm tseem ceeb hauv qhov zoo ntawm NAD + hmoov. Xaiv cov hom lag luam uas ua raws li cov kev tswj hwm zoo thiab ua raws li Cov Kev Cai Tsim Khoom Zoo (GMP). Daim ntawv pov thawj GMP ua kom cov khoom tsim tawm hauv ib puag ncig huv si thiab tswj tau, txo qhov kev pheej hmoo ntawm kev ua qias tuaj thiab ua kom muaj qhov zoo sib xws. Tsis tas li ntawd, nug txog lub hom lag luam txoj kev cog lus rau kev ruaj khov thiab kev coj ua zoo, vim tias cov yam no kuj tuaj yeem cuam tshuam rau qhov zoo ntawm cov khoom.
4. Soj ntsuam qhov bioavailability thiab kev nqus ntawm NAD + hmoov
Kev Siv Tau Txhua Yam (Bioavailability) txhais tau hais tias lub cev muaj peev xwm nqus thiab siv cov khoom xyaw nquag hauv cov tshuaj ntxiv. Thaum xaiv hom NAD+ hmoov, xav txog qhov bioavailability ntawm cov khoom. Nrhiav cov hom uas siv cov txheej txheem xa khoom siab heev lossis cov thev naus laus zis los ua kom NAD+ bioavailability ntau ntxiv. Qhov no tuaj yeem suav nrog cov yam ntxwv xws li micronization lossis encapsulation, uas tuaj yeem txhim kho kev nqus ntawm NAD+ hauv lub cev, thaum kawg ua kom nws muaj txiaj ntsig zoo tshaj plaws.
5. Nrhiav kev tshawb fawb txog kev tshawb fawb thiab kev tshawb fawb hauv tsev kho mob
Cov hom hmoov NAD+ uas muaj koob npe feem ntau muab kev tshawb fawb thiab kev kho mob los txhawb nqa qhov ua tau zoo thiab kev nyab xeeb ntawm lawv cov khoom. Nrhiav cov hom uas nqis peev rau kev tshawb fawb thiab kev txhim kho, vim qhov no qhia txog kev cog lus los tsim cov khoom zoo thiab muaj pov thawj. Kev lees paub txog kev tshawb fawb ua kom ntseeg tau tias hmoov NAD+ tau dhau los ntawm kev sim thiab kev soj ntsuam zoo, ntxiv kev lees paub nws qhov zoo thiab kev dawb huv.
Suzhou Myland Pharm & Nutrition Inc. tau koom nrog kev lag luam khoom noj khoom haus txij li xyoo 1992. Nws yog thawj lub tuam txhab hauv Suav teb uas tsim thiab muag cov noob txiv hmab.
Nrog 30 xyoo ntawm kev paub dhau los thiab tsav los ntawm cov thev naus laus zis siab thiab kev tshawb fawb thiab kev txhim kho zoo tshaj plaws, lub tuam txhab tau tsim ntau yam khoom sib tw thiab dhau los ua lub tuam txhab tsim khoom tshiab, kev tsim khoom tshwj xeeb thiab kev pabcuam tsim khoom.
Ntxiv rau qhov ntawd, Suzhou Myland Pharm & Nutrition Inc. kuj yog ib lub tuam txhab tsim khoom uas tau sau npe rau FDA. Lub tuam txhab cov peev txheej R&D, cov chaw tsim khoom, thiab cov cuab yeej siv tshuaj ntsuam xyuas yog niaj hnub thiab muaj ntau yam thiab tuaj yeem tsim cov tshuaj los ntawm milligrams mus rau tons hauv qhov ntsuas, thiab ua raws li ISO 9001 cov qauv thiab cov lus qhia tsim khoom GMP.
Q: Cov tshuaj NAD+ siv rau dab tsi?
A: NAD+ ntxiv yog cov khoom noj khoom haus ntxiv uas ntxiv rau coenzyme NAD+ (nicotinamide adenine dinucleotide). NAD+ ua lub luag haujlwm tseem ceeb hauv kev ua kom lub zog thiab kho cov hlwb hauv cov hlwb.
Q: Cov tshuaj NAD+ puas ua haujlwm tiag?
A: Qee qhov kev tshawb fawb qhia tias NAD + cov tshuaj ntxiv yuav pab txhim kho kev ua haujlwm ntawm lub hlwb thiab qeeb qeeb cov txheej txheem laus.
Q: Cov khoom noj dab tsi yog cov khoom noj uas muaj NAD +?
A: Cov khoom noj uas muaj NAD+ suav nrog nqaij, ntses, khoom noj mis nyuj, taum, txiv ntoo qhuav thiab zaub. Cov khoom noj no muaj ntau niacinamide thiab niacin, uas tuaj yeem hloov mus ua NAD+ hauv lub cev.
Q: Kuv yuav xaiv cov tshuaj NAD+ li cas?
A: Thaum xaiv cov tshuaj NAD+, nws raug nquahu kom nrhiav kev qhia los ntawm kws kho mob lossis tus kws noj zaub mov kom nkag siab txog koj cov kev xav tau kev noj haus thiab kev noj qab haus huv. Tsis tas li ntawd, xaiv lub npe nrov, xyuas cov khoom xyaw thiab cov koob tshuaj, thiab ua raws li cov lus qhia ntawm cov koob tshuaj.
Lus Ceeb Toom: Tsab xov xwm no tsuas yog rau cov ntaub ntawv dav dav xwb thiab yuav tsum tsis txhob txhais hais tias yog cov lus qhia kho mob. Qee cov ntaub ntawv hauv blog los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, tsim hom ntawv thiab kho cov ntawv xwb. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntxiv tsis tau txhais hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Ib txwm sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Lub sijhawm tshaj tawm: Lub Yim Hli-05-2024
