Thaum peb muaj hnub nyoog, kev tswj hwm peb txoj kev noj qab haus huv tag nrho yog qhov tseem ceeb zuj zus. Cov kev tshawb fawb ntsig txog qhia tau hais tias nicotinamide riboside, ib daim ntawv ntawm vitamin B3, tuaj yeem tiv thaiv cellular aging thiab txhawb kev laus noj qab haus huv. Nicotinamide Riboside Ntxiv rau qhov rov ua kom cov laus laus, nicotinamide riboside kuj qhia tau hais tias kev cog lus hauv kev txhim kho tag nrho kev noj qab haus huv thiab kev ua neej ntev. Cov kev tshawb fawb tsiaj pom tau hais tias NR cov tshuaj ntxiv tuaj yeem ua rau lub neej ntev thiab txhim kho kev noj qab haus huv hauv ntau hom hnub nyoog, suav nrog kev rog, kab mob plawv, thiab kab mob neurodegenerative.
Kev laus yog txheej txheem ntuj tsim uas txhua yam muaj sia nyob tau raug. Raws li tib neeg, peb lub cev thiab lub siab tau hloov pauv ntau thaum peb muaj hnub nyoog.
Qhov pom tseeb tshaj plaws yog qhov hloov ntawm daim tawv nqaij, nrog wrinkles, hnub nyoog me ntsis, thiab lwm yam tshwm sim. Tsis tas li ntawd, cov leeg yuav tsis muaj zog, cov pob txha poob qis, cov pob qij txha ua nruj, thiab ib tus neeg txoj kev txav mus los yog txwv.
Lwm qhov tseem ceeb ntawm kev laus yog qhov kev pheej hmoo ntawm cov kab mob ntev xws li kab mob plawv, ntshav qab zib, thiab qee yam mob qog noj ntshav. Tsis tas li ntawd, kev txawj ntse poob yog lwm qhov teeb meem. Tsis nco qab, nyuaj rau kev xav, thiab txo qis kev puas siab puas ntsws tuaj yeem cuam tshuam rau peb lub neej txhua hnub.
Ntau tus neeg laus kuj muaj kev kho siab, kev nyuaj siab, lossis kev ntxhov siab, tshwj xeeb tshaj yog tias lawv ntsib teeb meem kev noj qab haus huv lossis tau ploj tus neeg hlub. Hauv qhov xwm txheej no, nws yog ib qho tseem ceeb kom nrhiav kev txhawb siab los ntawm tsev neeg, phooj ywg, thiab txawm tias cov kws tshaj lij.
Thaum peb tsis tuaj yeem tso tseg txoj kev laus, muaj ntau txoj hauv kev uas peb tuaj yeem ua kom nws qeeb thiab tuav lub ntsej muag hluas kom ntev. Cov tshuaj tiv thaiv kev laus yog ib qho kev xaiv zoo.
NAD + yog ib qho tseem ceeb coenzyme pom nyob rau hauv tag nrho cov nyob cell. Nws lub luag haujlwm tseem ceeb yog los txhawb cov cellular metabolism los ntawm kev pab hloov hluav taws xob hauv ntau cov txheej txheem lom neeg xws li kev tsim hluav taws xob. Txawm li cas los xij, thaum peb muaj hnub nyoog, NAD + qib hauv peb lub cev poob qis. Qee qhov kev tshawb fawb qhia tias kev txo qis NAD + qib tuaj yeem ua rau muaj txiaj ntsig zoo rau kev laus.
Ib qho ntawm qhov tseem ceeb tshaj plaws hauv NAD + kev tshawb fawb yog qhov kev tshawb pom ntawm NAD + precursor molecule hu ua nicotinamide riboside (NR). NR yog ib daim ntawv ntawm cov vitamin B3 uas hloov mus rau hauv NAD + hauv peb lub hlwb. Ntau qhov kev tshawb fawb tsiaj tau pom cov txiaj ntsig tau zoo, qhia tias NR ntxiv tuaj yeem nce qib NAD + thiab muaj feem cuam tshuam txog hnub nyoog poob qis.
Ntau yam kab mob uas muaj hnub nyoog, xws li cov kab mob neurodegenerative thiab metabolic dysfunction, yog txuam nrog impaired mitochondrial function. Mitochondria yog lub zog ntawm peb lub hlwb, lub luag haujlwm tsim lub zog. NAD + ua lub luag haujlwm tseem ceeb hauv kev tswj kom pom kev ua haujlwm mitochondrial. Los ntawm kev tiv thaiv mitochondrial kev noj qab haus huv, NAD + muaj peev xwm txo tau qhov kev pheej hmoo ntawm cov kab mob uas muaj hnub nyoog thiab ua rau lub neej ntev.
Tsis tas li ntawd, NAD + koom nrog hauv cov haujlwm ntawm sirtuins, tsev neeg ntawm cov proteins cuam tshuam nrog kev ua neej ntev. Sirtuins tswj ntau yam txheej txheem lom neeg, suav nrog kev kho DNA, kev ntxhov siab ntawm tes, thiab kev mob. NAD + yog qhov tseem ceeb rau Sirtuin muaj nuj nqi, ua haujlwm ua ib coenzyme uas ua rau nws txoj haujlwm enzymatic. Los ntawm kev ntxiv NAD + thiab txhim kho Sirtuin muaj nuj nqi, peb tuaj yeem ncua kev laus thiab txhawb kev noj qab haus huv thiab kev ua neej ntev.
Ntau cov kev tshawb fawb tau pom tias NAD + supplementation muaj txiaj ntsig zoo hauv cov qauv tsiaj. Piv txwv li, ib txoj kev tshawb fawb hauv nas tau pom tias ntxiv nrog NR txhim kho cov leeg nqaij thiab kev ua siab ntev. Lwm cov kev tshawb fawb tau pom tias NR ntxiv tuaj yeem txhim kho cov metabolism hauv cov nas muaj hnub nyoog, ua rau nws zoo ib yam li cov nas hluas. Cov kev tshawb pom no qhia tias NAD + supplementation yuav muaj kev cuam tshuam zoo sib xws rau tib neeg, txawm tias xav tau kev tshawb fawb ntxiv.
Nicotinamide riboside(tseem hu ua niagen) yog lwm hom niacin (tseem hu ua vitamin B3) thiab pom muaj nyob hauv me me hauv mis nyuj thiab lwm yam khoom noj. Nws tuaj yeem hloov mus rau hauvNAD+ hauv cov hlwb. Raws li ib tug precursor, NR yog yooj yim absorbed thiab thauj mus rau hauv lub hlwb, qhov twg nws yog hloov dua siab tshiab rau hauv NAD + los ntawm ib tug series ntawm enzymatic tshuaj.
NR supplementation kev tshawb fawb nyob rau hauv ob qho tib si tsiaj thiab tib neeg kev tshawb fawb tau pom tau hais tias muaj kev vam meej. Hauv cov nas, NR supplementation tau pom tias nce NAD + ntau ntau hauv ntau cov ntaub so ntswg thiab txhim kho metabolic thiab mitochondrial muaj nuj nqi.
NAD + koom nrog ntau yam txheej txheem ntawm tes uas poob qis nrog lub hnub nyoog, suav nrog kev kho DNA, kev tsim hluav taws xob, thiab kev tswj hwm ntawm noob caj noob ces. Nws yog hypothesized tias ntxiv NAD + qib nrog NR tuaj yeem rov qab ua haujlwm ntawm tes, yog li txhim kho kev noj qab haus huv thiab txuas ntxiv lub neej.
Tsis tas li ntawd, hauv kev tshawb fawb ntawm cov txiv neej rog rog thiab rog rog, NR supplementation nce NAD + qib, yog li txhim kho insulin rhiab heev thiab mitochondrial muaj nuj nqi. Cov kev tshawb pom no qhia tias NR supplementation yuav muaj peev xwm siv tau los daws cov kab mob metabolic xws li hom 2 mob ntshav qab zib thiab rog rog.
1. Tej yam khoom noj uas muaj nicotinamide riboside
Ib qho peev txheej ntawm NR yog cov khoom siv mis nyuj. Qee cov kev tshawb fawb tau pom tias cov khoom noj siv mis muaj cov kab mob NR, tshwj xeeb tshaj yog cov mis nyuj uas muaj zog nrog NR. Txawm li cas los xij, NR cov ntsiab lus hauv cov khoom no kuj tsawg thiab tau txais cov nyiaj txaus los ntawm kev noj haus ib leeg yuav nyuaj.
Ntxiv nrog rau cov khoom noj khoom haus, NR cov tshuaj ntxiv muaj nyob rau hauv cov tshuaj ntsiav lossis hmoov. Cov tshuaj no feem ntau muab tau los ntawm tej yam ntuj tso xws li poov xab los yog kab mob fermentation. Cov poov xab-derived NR feem ntau suav hais tias yog ib qho kev ntseeg siab thiab ruaj khov vim nws tuaj yeem tsim tau ntau yam tsis muaj kev cia siab rau tsiaj txhu. Cov kab mob ua rau NR yog lwm qhov kev xaiv, feem ntau tau los ntawm cov kab mob tshwj xeeb uas tsim tawm NR.
2. Ntxiv nicotinamide riboside
Qhov feem ntau thiab txhim khu kev qha ntawm nicotinamide riboside yog los ntawm kev noj zaub mov. NR cov tshuaj ntxiv muab txoj hauv kev yooj yim thiab siv tau los ua kom pom kev noj qab haus huv ntawm cov khoom tseem ceeb no. Thaum xaiv qhov zoo tshaj plaws NR ntxiv, nws yog ib qho tseem ceeb uas yuav tau xav txog cov hauv qab no:
a) Quality Assurance: Nrhiav cov tshuaj uas tsim los ntawm cov tuam txhab muaj koob npe thiab ua raws li cov qauv kev tswj xyuas nruj. Qhov no yuav ua kom koj tau txais cov khoom lag luam zoo tsis muaj impurities lossis kab mob.
b) Bioavailability: NR cov tshuaj siv cov khoom xa tuaj zoo xws li encapsulation lossis liposome thev naus laus zis los txhim kho bioavailability ntawm NR kom nws tuaj yeem nqus tau zoo dua thiab siv los ntawm lub cev. Xaiv hom tshuaj ntxiv no kom ua kom cov txiaj ntsig zoo tshaj plaws uas koj tau txais los ntawm NR.
c) Purity: Xyuas kom tseeb tias NR ntxiv uas koj xaiv yog dawb huv thiab tsis muaj additives, fillers los yog preservatives. Nyeem ntawv thiab nkag siab txog cov khoom xyaw tuaj yeem pab koj txiav txim siab paub.
1. Txhim kho cellular zog ntau lawm
NR ua lub luag haujlwm tseem ceeb hauv kev tsim cov molecule nicotinamide adenine dinucleotide (NAD +). NAD + koom nrog ntau yam txheej txheem ntawm tes, suav nrog lub zog metabolism. Raws li peb muaj hnub nyoog, NAD + qib hauv peb lub cev txo qis, ua rau txo qis zog. Los ntawm kev txhawb nqa cov synthesis ntawm NAD +, NR pab txhawb lub hlwb thiab ua kom muaj zog ntau lawm. Qhov kev txhim kho cellular zog no ua rau kom muaj zog, txhim kho lub cev kev ua haujlwm, thiab txo qhov qaug zog.
2. Kev tiv thaiv kev laus thiab kho DNA
Kev txo qis NAD + qib cuam tshuam nrog kev laus thiab cov kab mob muaj hnub nyoog. NR tuaj yeem nce qib NAD + hauv lub cev, ua rau nws muaj peev xwm tiv thaiv kev laus. NAD + koom nrog hauv DNA kho cov txheej txheem, ua kom muaj kev ncaj ncees ntawm peb cov khoom siv caj ces. Los ntawm kev txhawb nqa kev kho DNA, NR tuaj yeem pab tiv thaiv hnub nyoog DNA puas tsuaj thiab txhawb kev laus noj qab haus huv. Tsis tas li ntawd, NR lub luag haujlwm hauv kev ua kom sirtuins, ib chav kawm ntawm cov proteins paub los tswj cov cellular noj qab haus huv thiab lifespan, ntxiv dag zog rau nws txoj kev tiv thaiv kev laus.
3. Kev mob plawv
Kev tswj hwm lub plawv kom noj qab haus huv yog qhov tseem ceeb rau kev noj qab haus huv tag nrho. Nicotinamide riboside tau pom tias muaj txiaj ntsig zoo rau kev mob plawv. Nws txhawb kev ua haujlwm ntawm vascular endothelial hlwb, txhawb cov ntshav khiav thiab txo qhov mob. NR kuj txhim kho mitochondrial muaj nuj nqi hauv lub plawv hlwb, tiv thaiv oxidative kev nyuaj siab thiab optimizing zog ntau lawm. Cov teebmeem no tuaj yeem pab txo qis kev pheej hmoo ntawm cov kab mob plawv xws li atherosclerosis thiab plawv tsis ua haujlwm.
4. Neuroprotection thiab kev txawj ntse muaj nuj nqi
NR tau pom tias muaj cov khoom tiv thaiv neuroprotective, ua rau nws muaj peev xwm ua phooj ywg hauv kev tswj lub hlwb. Nws tuaj yeem muaj txiaj ntsig zoo rau kev ua haujlwm neuronal thiab tiv thaiv lub hnub nyoog txog kev paub txog kev poob qis. Los ntawm kev nce qib NAD +, NR txhawb nqa kev ua haujlwm mitochondrial hauv hlwb hlwb, txhim kho kev tsim hluav taws xob thiab txhawb kev kho cellular. Kev txhim kho mitochondrial muaj nuj nqi tuaj yeem txhim kho kev txawj ntse xws li kev nco, kev xav, thiab tag nrho lub hlwb kom meej meej.
5. Kev tswj qhov hnyav thiab kev noj qab haus huv metabolic
Kev tswj hwm qhov hnyav thiab qhov sib npaug ntawm cov metabolism yog qhov tseem ceeb rau peb txoj kev noj qab haus huv tag nrho. NR tau txuas nrog rau cov txiaj ntsig zoo ntawm cov metabolism, ua rau nws muaj peev xwm pab tswj qhov hnyav. NR qhib cov protein hu ua Sirtuin 1 (SIRT1), uas tswj cov txheej txheem metabolic xws li qabzib metabolism thiab khaws cia rog. Los ntawm kev ua kom SIRT1, NR tuaj yeem pab kom poob phaus thiab txhim kho kev noj qab haus huv hauv metabolic, yog li txo qhov kev pheej hmoo ntawm cov kab mob xws li rog rog thiab ntshav qab zib hom 2.
Q: Nicotinamide Riboside (NR) yog dab tsi?
A: Nicotinamide Riboside (NR) yog ib qho ua ntej rau Nicotinamide Adenine Dinucleotide (NAD+), coenzyme uas ua lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem lom neeg, suav nrog kev tsim hluav taws xob thiab kev tswj hwm kev ua haujlwm ntawm cov metabolism thiab cellular.
Q: Nicotinamide Riboside (NR) puas tuaj yeem pab cov metabolism?
A: Yog, Nicotinamide Riboside (NR) tau pom tias muaj txiaj ntsig zoo rau cov metabolism. Los ntawm kev nce qib NAD +, NR tuaj yeem qhib qee cov enzymes koom nrog hauv cov metabolism, xws li sirtuins. Qhov kev ua kom zoo no tuaj yeem txhim kho cov metabolism hauv kev ua haujlwm, txhim kho insulin rhiab heev, thiab txhawb kev tswj qhov hnyav.
Kev lees paub: Kab lus no yog rau cov ntaub ntawv dav dav nkaus xwb thiab yuav tsum tsis txhob raug txhais raws li cov lus qhia kho mob. Qee cov ntaub ntawv blog tshaj tawm los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, formatting thiab kho cov ntawv. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntau ntxiv tsis txhais tau hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Nco ntsoov sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Post lub sij hawm: Nov-13-2023
