Salidroside yog cov khoom xyaw tseem ceeb muab rho tawm los ntawm Rhodiola rosea thiab muaj ntau yam kev lom neeg thiab tshuaj siv tshuaj. Salidroside muaj cov teebmeem ntawm kev tawm tsam oxidative kev nyuaj siab, inhibiting cell apoptosis, thiab txo cov kev mob tshwm sim.
Salidroside yog lub ntuj antioxidant uas tiv thaiv cov paj hlwb los ntawm kev khawb ROS thiab inhibiting cell apoptosis.
Intracellular calcium overload yog ib qho ntawm cov ua rau neuronal apoptosis. Rhodiola rosea extract thiab salidroside tuaj yeem txo qhov nce ntawm cov calcium uas tsis muaj nyob hauv cov cell vim yog oxidative kev nyuaj siab thiab tiv thaiv tib neeg cortical hlwb los ntawm glutamate. Salidroside tuaj yeem inhibit lipopolysaccharide-induced microglial activation, inhibit TSIS MUAJ ntau lawm, inhibit inducible nitric oxide synthase (iNOS) kev ua, thiab txo TNF-α thiab IL-1β, IL-6 qib.
Salidroside inhibits NADPH oxidase 2 / ROS / mitogen-activated protein kinase (MAPK) thiab cov lus teb regulator ntawm kev loj hlob thiab DNA puas 1 (REDD1) / mammalian lub hom phiaj ntawm rapamycin (mTOR) / p70 ribosome Cov protein S6 kinase signaling pathway activates AMP-dependent. protein kinase/silent information regulator 1, RAS homologous gene family member A/MAPK and PI3K/Akt signaling pathways.
1. Salidroside antagonizes dawb radical puas thiab tiv thaiv lub cev
Lub cev muaj peev xwm tsim tau ib qho nyiaj ntawm endogenous dawb radicals thaum lub sij hawm ib txwm physiological dab, thiab ib tug physiological koob tshuaj ntawm dawb radicals yog tsim nyog los tswj lub cev lub cev physiological kev ua ub no. Kuj tseem muaj cov dawb radical scavenging system nyob rau hauv lub cev kom tshem tawm cov dawb radicals uas ntau tshaj physiological koob tshuaj kom tsis txhob ua mob rau lub cev.
Txawm li cas los xij, nyob rau hauv kev cuam tshuam ntawm qee qhov tshwj xeeb ib puag ncig, lub cev endogenous dawb radicals yuav ntau dhau thiab tshaj qhov system cov dawb radical scavenging tus nqi, ua rau lub cev tsis muaj oxygen dawb radical ntau lawm-scavenging system, ua rau tsub zuj zuj ntawm oxygen dawb radicals. nyob rau hauv lub cev, yog li ua rau cell membrane puas. kev puas tsuaj.
Kev tshawb fawb qhia tau hais tias qhov chaw hypoxic nyob rau hauv toj siab tej yam kev mob tuaj yeem ua rau muaj kev tsis sib haum xeeb hauv oxygen-dawb radical metabolism, accumulating intracellular dawb radicals thiab nce lipid peroxidation khoom. Cov kev tshawb fawb tau pom tias salidroside tuaj yeem tiv thaiv cov ntaub so ntswg los ntawm kev tshem tawm cov dawb radicals hauv lub cev.
2. Salidroside antagonizes hypoxia kom muaj kev ruaj ntseg ntawm mitochondrial muaj nuj nqi
Txog 80-90% ntawm cov pa oxygen intracellular yog siv rau kev lom oxidation hauv mitochondria los tsim ATP thiab tsim cov pa oxygen reactive ROS kom tswj tau lub neej ua haujlwm ntawm cov hlwb. Tsuas yog 10-20% ntawm cov pa oxygen yog dawb sab nraum lub mitochondria rau biosynthesis, degradation, biotransformation (detoxification), thiab lwm yam. Mitochondrial ua pa ua pa yog txhim kho nyob rau hauv me me hypoxia los yog nyob rau hauv thaum ntxov theem ntawm hypoxia, uas yog manifested raws li ib tug compensatory teb. lub cev ua pa system.
Kev mob hnyav hypoxia yuav ua ntej cuam tshuam rau sab nraud oxygenation ntawm mitochondria thiab kev ua haujlwm metabolic ntawm lub cev, txo qis kev tsim cov neurotransmitters, thiab tsis muaj peev xwm biotransformation tsis muaj zog, yog li cuam tshuam rau kev ua haujlwm ntawm cov ntaub so ntswg thiab kabmob. Cov kev tshawb fawb tau pom tias salidroside tuaj yeem tiv thaiv kev saib xyuas ntawm mitochondrial muaj nuj nqi los ntawm kev txo ROS cov ntsiab lus hauv cell mitochondria, nce SOD kev ua haujlwm, thiab nce cov mitochondria.
3. Myocardial tiv thaiv cov nyhuv ntawm salidroside
Cov kev tshawb fawb tau pom tias cov kab mob plawv yog cov kab ke tseem ceeb uas hloov ib puag ncig hypoxic. Ib puag ncig hypoxic yuav ua rau lub cev aerobic metabolism tsis muaj zog thiab tsis muaj zog txaus, ua rau cov tsos mob xws li hypoxia, ischemia, thiab apoptosis ntawm myocardial cells. Cov kev tshawb fawb tau pom tias salidroside tuaj yeem txhim kho kev ua haujlwm ntawm lub plawv thiab txhim kho microcirculation los ntawm dilating arterial thiab venous cov hlab ntsha, txhim kho myocardial blood perfusion, hloov cov hemodynamics ntawm lub plawv, txo cov plawv load, thiab attenuating myocardial ischemic puas.
Hauv luv luv, salidroside tuaj yeem ua rau cov hlab plawv los ntawm ntau lub tshuab, txoj hauv kev, thiab lub hom phiaj, tiv thaiv myocardial cell apoptosis los ntawm ntau yam ua rau, thiab txhim kho lub cev ischemia thiab hypoxia. Nyob rau hauv ib puag ncig hypoxic, Rhodiola rosea txoj kev cuam tshuam yog qhov tseem ceeb hauv kev tiv thaiv lub cev cov ntaub so ntswg thiab cov kab mob hauv nruab nrog cev thiab tswj kev ruaj ntseg ntawm tes ua haujlwm. Nws ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv thiab txo qhov mob siab.
Tam sim no cov xwm txheej ntawm salidroside ntau lawm
1) Feem ntau cia siab rau cov nroj tsuag rho tawm
Rhodiola rosea yog cov khoom siv raw ntawmsalidroside.Raws li ib yam ntawm cov nroj tsuag perennial, Rhodiola rosea tsuas yog loj hlob hauv thaj chaw uas muaj qhov txias txias, anoxia, dryness, thiab kub sib txawv ntawm nruab hnub thiab hmo ntuj ntawm qhov siab ntawm 1600-4000 meters. Nws yog ib qho ntawm cov tsiaj qus toj siab nroj tsuag. Tuam Tshoj yog ib qho ntawm cov chaw tsim khoom tseem ceeb ntawm Rhodiola rosea hauv ntiaj teb, tab sis kev ua neej nyob ntawm Rhodiola rosea yog qhov tshwj xeeb heev. Tsis tsuas yog nws nyuaj rau cultivate artificially, tab sis tawm los ntawm qus ntau yam yog tsis tshua muaj heev. Qhov kev thov txhua xyoo rau Rhodiola rosea yog siab li 2,200 tons.
2) Tshuaj synthesis thiab lom fermentation
Vim muaj cov ntsiab lus tsis tshua muaj nqi thiab cov nqi ntau lawm hauv cov nroj tsuag, ntxiv rau txoj kev extraction ntuj, salidroside ntau lawm txoj kev kuj muaj xws li tshuaj synthesis txoj kev, biological fermentation txoj kev, thiab lwm yam. txoj hauv kev rau kev tshawb nrhiav kev txhim kho thiab tsim cov salidroside. Tam sim no, Suzhou Mailun tau ua tiav kev tshawb fawb thiab kev txhim kho thiab tau ua tiav kev lag luam.
Kev lees paub: Kab lus no yog rau cov ntaub ntawv dav dav nkaus xwb thiab yuav tsum tsis txhob raug txhais raws li cov lus qhia kho mob. Qee cov ntaub ntawv blog tshaj tawm los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, formatting thiab kho cov ntawv. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntau ntxiv tsis txhais tau hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Nco ntsoov sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Post lub sij hawm: Aug-15-2024
