Salidroside yog cov khoom xyaw tseem ceeb uas tau rho tawm los ntawm Rhodiola rosea thiab muaj ntau yam khoom siv biological thiab pharmacological. Salidroside muaj cov teebmeem ntawm kev tiv thaiv kev ntxhov siab oxidative, inhibiting cell apoptosis, thiab txo cov tshuaj tiv thaiv kev o.
Salidroside yog ib qho tshuaj antioxidant ntuj uas tiv thaiv cov hlwb ntawm cov hlab ntsha los ntawm kev tshem tawm ROS thiab tiv thaiv cov hlwb apoptosis.
Kev muaj calcium ntau dhau hauv cov hlwb yog ib qho ua rau cov hlwb puas tsuaj. Rhodiola rosea extract thiab salidroside tuaj yeem txo qhov nce ntawm cov calcium dawb hauv cov hlwb uas tshwm sim los ntawm kev ntxhov siab oxidative thiab tiv thaiv cov hlwb cortical tib neeg los ntawm glutamate. Salidroside tuaj yeem tiv thaiv lipopolysaccharide-induced microglial activation, tiv thaiv NO ntau lawm, tiv thaiv inducible nitric oxide synthase (iNOS) kev ua haujlwm, thiab txo TNF-α thiab IL-1β, IL-6 theem.
Salidroside inhibits NADPH oxidase 2 / ROS / mitogen-activated protein kinase (MAPK) thiab cov lus teb tswj kev loj hlob thiab DNA puas tsuaj 1 (REDD1) / mammalian lub hom phiaj ntawm rapamycin (mTOR) / p70 ribosome Cov protein S6 kinase signaling pathway ua rau AMP-dependent protein kinase / silent information regulator 1, RAS homologous gene tsev neeg tswv cuab A / MAPK thiab PI3K / Akt signaling pathways.
1. Salidroside tiv thaiv kev puas tsuaj ntawm cov dawb radical thiab tiv thaiv lub cev
Lub cev muaj peev xwm tsim tau qee yam ntawm cov dawb radicals endogenous thaum lub sijhawm ua haujlwm ntawm lub cev, thiab qee qhov koob tshuaj ntawm cov dawb radicals yog qhov tsim nyog los tswj lub cev cov haujlwm ib txwm muaj. Kuj tseem muaj lub kaw lus tshem tawm cov dawb radicals hauv lub cev kom tshem tawm cov dawb radicals uas ntau tshaj qhov koob tshuaj ntawm lub cev kom tsis txhob ua rau lub cev noj qab haus huv puas tsuaj.
Txawm li cas los xij, nyob rau hauv kev cuam tshuam ntawm qee qhov tshwj xeeb ib puag ncig yam, lub cev cov dawb radicals endogenous yuav ntau dhau thiab tshaj qhov system qhov dawb radical scavenging rate, ua rau muaj kev tsis sib npaug hauv lub cev cov pa oxygen dawb radical tsim-scavenging system, ua rau muaj kev sib sau ua ke ntawm cov pa oxygen dawb radicals hauv lub cev, yog li ua rau lub cell membrane puas tsuaj.
Kev tshawb fawb qhia tau hais tias qhov chaw hypoxic nyob rau hauv cov xwm txheej plateau tuaj yeem ua rau muaj kev tsis sib npaug ntawm cov pa oxygen-free radical metabolism, sib sau ua ke intracellular free radicals thiab ua rau cov khoom lipid peroxidation nce ntxiv. Kev tshawb fawb tau qhia tias salidroside tuaj yeem tiv thaiv cov ntaub so ntswg los ntawm kev tshem tawm cov free radicals hauv lub cev.
2. Salidroside tiv thaiv hypoxia kom tswj tau qhov ruaj khov ntawm mitochondrial kev ua haujlwm
Kwv yees li 80-90% ntawm cov pa oxygen hauv lub hlwb yog siv rau kev ua kom lub cev tsis muaj zog hauv mitochondria los tsim ATP thiab tsim cov pa oxygen reactive ROS los tswj cov haujlwm ua neej ib txwm ntawm cov hlwb. Tsuas yog 10-20% ntawm cov pa oxygen yog dawb sab nraum mitochondria rau biosynthesis, degradation, biotransformation (detoxification), thiab lwm yam. Kev ua haujlwm ntawm mitochondria ua pa tau zoo dua hauv hypoxia me me lossis thaum ntxov ntawm hypoxia, uas yog qhia ua qhov kev teb rov qab ntawm lub cev ua pa.
Kev tsis muaj pa oxygen ntau dhau yuav ua rau lub mitochondria thiab cov teeb meem ntawm lub cev ua haujlwm tsis zoo, txo cov neurotransmitters, thiab ua rau lub cev tsis muaj zog, ua rau cov nqaij thiab cov kabmob ua haujlwm tsis zoo. Cov kev tshawb fawb tau qhia tias salidroside tuaj yeem tiv thaiv kev ua haujlwm ntawm mitochondrial los ntawm kev txo cov ntsiab lus ROS hauv cell mitochondria, ua rau SOD ua haujlwm ntau ntxiv, thiab ua rau mitochondria ntau ntxiv.
3. Cov nyhuv tiv thaiv myocardial ntawm salidroside
Cov kev tshawb fawb tau qhia tias lub plawv thiab cov hlab ntsha yog lub cev tseem ceeb uas hloov pauv qhov chaw tsis muaj pa oxygen. Qhov chaw tsis muaj pa oxygen yuav ua rau lub cev ua haujlwm aerobic tsis muaj zog thiab tsis muaj zog txaus, ua rau muaj cov tsos mob xws li hypoxia, ischemia, thiab apoptosis ntawm cov hlwb myocardial. Cov kev tshawb fawb tau qhia tias salidroside tuaj yeem txhim kho kev ua haujlwm ntawm lub plawv thiab txhim kho microcirculation los ntawm kev nthuav cov hlab ntsha arterial thiab venous, txhim kho myocardial ntshav perfusion, hloov pauv hemodynamics ntawm lub plawv, txo cov nra hnyav ntawm lub plawv, thiab txo qhov kev puas tsuaj ntawm myocardial ischemic.
Hauv ntej, salidroside tuaj yeem ua haujlwm rau lub plawv los ntawm ntau txoj hauv kev, txoj kev, thiab lub hom phiaj, tiv thaiv myocardial cell apoptosis los ntawm ntau yam ua rau, thiab txhim kho lub cev ischemia thiab hypoxia mob. Hauv ib puag ncig hypoxic, Rhodiola rosea kev cuam tshuam yog qhov tseem ceeb heev rau kev tiv thaiv lub cev cov nqaij thiab cov kab mob thiab tswj kev ruaj khov ntawm cov haujlwm ntawm lub hlwb. Nws ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv thiab txo qhov mob siab.
Cov xwm txheej tam sim no ntawm kev tsim cov salidroside
1) Feem ntau vam khom cov nroj tsuag rho tawm
Rhodiola rosea yog cov khoom siv raw ntawm cov khoom nosalidroside.Ua ib hom nroj tsuag uas muaj hnub nyoog ntev, Rhodiola rosea feem ntau loj hlob hauv thaj chaw uas muaj huab cua txias heev, tsis muaj pa oxygen, qhuav, thiab qhov kub thiab txias sib txawv ntawm nruab hnub thiab hmo ntuj ntawm qhov siab ntawm 1600-4000 meters. Nws yog ib qho ntawm cov nroj tsuag qus hauv toj siab. Tuam Tshoj yog ib qho ntawm cov chaw tsim khoom tseem ceeb ntawm Rhodiola rosea hauv ntiaj teb, tab sis cov cwj pwm nyob ntawm Rhodiola rosea yog qhov tshwj xeeb heev. Tsis yog nws nyuaj rau cog qoob loo xwb, tab sis cov qoob loo ntawm cov tsiaj qus qis heev. Qhov sib txawv txhua xyoo rau Rhodiola rosea yog siab txog 2,200 tons.
2) Kev tsim tshuaj lom neeg thiab kev ua kom lub cev muaj sia
Vim tias cov ntsiab lus tsawg thiab tus nqi tsim khoom siab hauv cov nroj tsuag, ntxiv rau cov txheej txheem rho tawm ntuj, cov txheej txheem tsim khoom salidroside kuj suav nrog cov txheej txheem tsim tshuaj lom neeg, cov txheej txheem fermentation biological, thiab lwm yam. Ntawm lawv, thaum cov thev naus laus zis txuas ntxiv mus, kev fermentation biological tau dhau los ua txoj hauv kev tseem ceeb rau kev tshawb fawb kev txhim kho thiab kev tsim khoom ntawm salidroside. Tam sim no, Suzhou Mailun tau ua tiav cov txiaj ntsig kev tshawb fawb thiab kev txhim kho thiab tau ua tiav kev lag luam.
Lus Ceeb Toom: Tsab xov xwm no tsuas yog rau cov ntaub ntawv dav dav xwb thiab yuav tsum tsis txhob txhais hais tias yog cov lus qhia kho mob. Qee cov ntaub ntawv hauv blog los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, tsim hom ntawv thiab kho cov ntawv xwb. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntxiv tsis tau txhais hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Ib txwm sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Lub sijhawm tshaj tawm: Lub Yim Hli-15-2024
