Kev Tshawb Fawb Tom Qab Urolithin A: Yam Koj Yuav Tsum Paub

Urolithin A (UA)yog ib qho chaw tsim los ntawm cov metabolism hauv plab hnyuv hauv cov khoom noj uas muaj ellagitannins (xws li pomegranates, raspberries, thiab lwm yam). Nws suav hais tias muaj cov tshuaj tiv thaiv kab mob, tiv thaiv kev laus, antioxidant, induction ntawm mitophagy, thiab lwm yam, thiab tuaj yeem hla cov ntshav-hlwb teeb meem. Ntau qhov kev tshawb fawb tau lees paub tias urolithin A tuaj yeem ncua kev laus, thiab kev tshawb fawb soj ntsuam kuj tau pom cov txiaj ntsig zoo.

urolithin A yog dab tsi?

Urolithin A (Uro-A) yog ib qho ellagitannin (ET) hom plab hnyuv metabolite. Nws tau raug tshawb pom thiab muaj npe nyob rau xyoo 2005. Nws cov mis molecular yog C13H8O4, thiab nws cov txheeb ze molecular loj yog 228.2. Raws li cov metabolic precursor ntawm Uro-A, cov khoom noj tseem ceeb ntawm ET yog pomegranates, strawberries, raspberries, walnuts thiab liab cawu cub. UA yog ib yam khoom ntawm ETs metabolized los ntawm plab hnyuv microorganisms. UA muaj kev thov dav dav hauv kev tiv thaiv thiab kho ntau yam kab mob. Tib lub sijhawm, UA muaj ntau yam khoom noj.

Kev tshawb fawb txog cov teebmeem antioxidant ntawm urolithins tau ua tiav. Urolithin-A tsis muaj nyob rau hauv lub xeev ntuj, tab sis yog tsim los ntawm ib tug series ntawm transformations ntawm ET los ntawm txoj hnyuv flora. UA yog ib yam khoom ntawm ETs metabolized los ntawm plab hnyuv microorganisms. Cov khoom noj uas nplua nuj nyob rau hauv ET kis tau los ntawm lub plab thiab cov hnyuv me hauv tib neeg lub cev, thiab nws thiaj li metabolized feem ntau rau hauv Uro-A hauv txoj hnyuv. Ib qho me me ntawm Uro-A kuj tuaj yeem kuaj pom hauv cov hnyuv me.

Raws li ntuj polyphenolic tebchaw, ETs tau nyiam ntau yam vim lawv cov kev ua ub no xws li antioxidant, tiv thaiv-inflammatory, tiv thaiv kev ua xua thiab tiv thaiv kab mob. Ntxiv rau qhov muab tau los ntawm cov khoom noj xws li pomegranates, strawberries, walnuts, raspberries thiab almonds, ETs kuj pom muaj nyob rau hauv gallnuts, pomegranate peels, myrobalan, Dimininus, geranium, betel txiv ntoo, hiav txwv buckthorn nplooj, Phyllanthus, Uncaria, Sanguisorba, Suav. Cov tshuaj xws li Phyllanthus emblica thiab Agrimony.

Cov pab pawg hydroxyl nyob rau hauv cov qauv molecular ntawm ETs yog cov polar, uas tsis haum rau kev nqus los ntawm lub plab hnyuv phab ntsa, thiab nws cov bioavailability tsawg heev. Ntau cov kev tshawb fawb tau pom tias tom qab ETs tau noj los ntawm tib neeg lub cev, lawv tau metabolized los ntawm cov hnyuv hauv cov hnyuv thiab hloov mus rau hauv urolithin ua ntej nws nqus tau. ETs yog hydrolyzed rau hauv ellagic acid (EA) nyob rau hauv lub plab hnyuv sab sauv, thiab EA yog dhau los ntawm cov hnyuv. Cov kab mob flora ntxiv cov txheej txheem thiab poob lub nplhaib lactone thiab ua rau muaj kev cuam tshuam tsis tu ncua dehydroxylation los tsim urolithin. Muaj cov ntawv ceeb toom tias urolithin yuav yog cov khoom siv rau kev lom neeg ntawm ETs hauv lub cev.

Dab tsi yog bioavailability ntawm urolithin ntsig txog?

Pom qhov no, yog tias koj ntse, koj twb paub tias bioavailability ntawm UA yog dab tsi.

Qhov tseem ceeb tshaj plaws yog qhov muaj pes tsawg leeg ntawm microbiome, vim tias tsis yog txhua hom kab mob microbial tuaj yeem tsim tau. Cov khoom siv raw ntawm UA yog ellagitannins tau los ntawm cov khoom noj. Qhov precursor no yooj yim muaj thiab yuav luag txhua qhov chaw.

Ellagitannins yog hydrolyzed nyob rau hauv txoj hnyuv kom tso tawm ellagic acid, uas yog ntxiv ua tiav los ntawm plab hnyuv flora rau hauv urolithin A.

Raws li kev tshawb fawb hauv phau ntawv xov xwm Cell, tsuas yog 40% ntawm cov tib neeg tuaj yeem hloov pauv urolithin A los ntawm nws cov precursor mus rau usable urolithin A.

Lub luag haujlwm ntawm urolithin A yog dab tsi?

Anti-aging

Cov dawb radical txoj kev xav ntawm kev laus ntseeg hais tias reactive oxygen hom tsim nyob rau hauv mitochondrial metabolism ua rau oxidative kev nyuaj siab nyob rau hauv lub cev thiab ua rau kev laus, thiab mitophagy plays lub luag hauj lwm tseem ceeb hauv kev tswj mitochondrial kev noj qab haus huv thiab kev ncaj ncees. Nws tau raug tshaj tawm tias UA tuaj yeem tswj hwm mitophagy thiab yog li nthuav tawm lub peev xwm los ncua kev laus. Ryu et al. pom tias UA alleviated mitochondrial dysfunction thiab ncua lifespan nyob rau hauv Caenorhabditis elegans los ntawm inducing mitophagy; Hauv cov nas tsuag, UA tuaj yeem thim rov qab hnub nyoog txog cov leeg nqaij ua haujlwm poob qis, qhia tias UA txhim kho mitochondrial kev ua haujlwm los ntawm kev txhim kho Cov leeg nqaij thiab ua kom lub cev ntev. Liu et al. siv UA los cuam tshuam rau kev laus ntawm daim tawv nqaij fibroblasts. Cov txiaj ntsig tau pom tias UA tau nce qhov kev qhia ntawm hom I collagen thiab txo qhov kev qhia ntawm matrix metalloproteinase-1 (MMP-1). Nws kuj tau qhib cov khoom siv hluav taws xob nuclear E2-txog yam 2 (nuclear factor erythroid 2-related factor 2, Nrf2)-mediated antioxidant teb txo intracellular ROS, yog li qhia muaj zog tiv thaiv kev laus.

Antioxidant nyhuv

Tam sim no, ntau cov kev tshawb fawb tau ua tiav ntawm cov nyhuv antioxidant ntawm urolithin. Ntawm tag nrho cov urolithin metabolites, Uro-A muaj qhov muaj zog antioxidant kev ua haujlwm, thib ob tsuas yog proanthocyanidin oligomers, catechins, epicatechin thiab 3,4-dihydroxyphenylacetic acid. Kev ntsuas oxygen radical absorbance peev (ORAC) ntawm cov ntshav ntshav ntawm cov neeg ua haujlwm noj qab haus huv pom tias muaj peev xwm antioxidant tau nce 32% tom qab 0.5 teev ntawm kev noj cov kua txiv pomegranate, tab sis qib ntawm cov pa oxygen reactive tsis hloov pauv, thaum nyob hauv Neuro-In. Kev sim tshuaj vitro ntawm 2a hlwb pom tias Uro-A tuaj yeem txo qis qib ntawm cov pa oxygen reactive hauv hlwb. Cov txiaj ntsig no qhia tau tias Uro-A muaj cov tshuaj tiv thaiv antioxidant.

03. Urolithin A thiab kab mob plawv thiab cerebrovascular

Lub ntiaj teb no tshwm sim ntawm kab mob plawv (CVD) yog nce xyoo los ntawm lub xyoo, thiab cov neeg tuag nyob rau hauv siab. Nws tsis tsuas yog ua kom lub nra ntawm kev noj qab haus huv thiab nyiaj txiag, tab sis tseem cuam tshuam rau tib neeg lub neej zoo. CVD yog ib tug kab mob multifactorial. Kev mob tshwm sim tuaj yeem ua rau muaj kev pheej hmoo ntawm CVD. Kev ntxhov siab oxidative cuam tshuam nrog cov kab mob ntawm CVD. Muaj cov lus ceeb toom tias cov metabolites tau los ntawm cov kab mob hauv plab hnyuv muaj feem cuam tshuam nrog kev pheej hmoo ntawm CVD.

UA tau tshaj tawm tias muaj cov tshuaj tiv thaiv kab mob thiab cov tshuaj tiv thaiv antioxidant, thiab cov kev tshawb fawb cuam tshuam tau lees paub tias UA tuaj yeem ua lub luag haujlwm muaj txiaj ntsig hauv CVD. Sav et al. siv tus qauv nas mob ntshav qab zib los ua hauv vivo kev tshawb fawb txog ntshav qab zib cardiomyopathy thiab pom tias UA tuaj yeem txo cov lus teb thawj zaug ntawm cov ntaub so ntswg myocardial rau hyperglycemia, txhim kho myocardial microenvironment, thiab txhawb kev rov qab los ntawm cardiomyocyte contractility thiab calcium dynamics, qhia tias UA tuaj yeem ua tau. tuaj yeem siv los ua cov tshuaj pab tswj ntshav qab zib cardiomyopathy thiab tiv thaiv nws cov teeb meem.

UA tuaj yeem txhim kho mitochondrial muaj nuj nqi thiab cov leeg nqaij ua haujlwm los ntawm inducing mitophagy. Lub plawv mitochondria yog cov organelles tseem ceeb ua lub luag haujlwm tsim lub zog-nplua nuj ATP. Mitochondrial dysfunction yog lub hauv paus ua rau lub plawv tsis ua haujlwm. Mitochondrial dysfunction yog tam sim no suav tias yog lub hom phiaj kho mob. Yog li ntawd, UA kuj tau dhau los ua cov tshuaj tshiab rau kev kho mob CVD.

Urolithin A thiab cov kab mob neurological

Neuroinflammation yog ib qho tseem ceeb hauv kev tshwm sim thiab kev loj hlob ntawm tus kab mob neurodegenerative (ND). Apoptosis tshwm sim los ntawm oxidative kev nyuaj siab thiab txawv txav protein aggregation feem ntau ua rau neuroinflammation, thiab cov pro-inflammatory cytokines tso tawm los ntawm neuroinflammation ces cuam tshuam rau neurodegeneration.

Cov kev tshawb fawb tau pom tias UA mediates los tiv thaiv kev ua haujlwm los ntawm inducing autophagy thiab activating lub suab ntsiag to teeb liab regulator 1 (SIRT-1) deacetylation mechanism, inhibiting neuroinflammation thiab neurotoxicity, thiab tiv thaiv neurodegeneration, qhia tias UA yog ib tug zoo Neuroprotective tus neeg saib xyuas. Nyob rau tib lub sijhawm, qee qhov kev tshawb fawb tau pom tias UA tuaj yeem tsim cov teebmeem neuroprotective los ntawm kev tshem tawm cov dawb radicals ncaj qha thiab inhibiting oxidases.

Cov kev tshawb fawb tau pom tias cov kua txiv pomegranate ua lub luag haujlwm tiv thaiv neuroprotective los ntawm kev ua kom mitochondrial aldehyde dehydrogenase kev ua haujlwm, tswj qib ntawm cov tshuaj tiv thaiv apoptotic protein Bcl-xL, txo α-synuclein aggregation thiab oxidative puas tsuaj, thiab cuam tshuam rau kev ua haujlwm neuronal thiab kev ruaj ntseg. Urolithin tebchaw yog cov metabolites thiab cov nyhuv ntawm ellagitannins hauv lub cev thiab muaj cov haujlwm lom xws li tshuaj tiv thaiv kab mob, tiv thaiv oxidative kev nyuaj siab, thiab tiv thaiv apoptosis. Urolithin tuaj yeem ua rau muaj kev tiv thaiv neuroprotective los ntawm cov ntshav-hlwb barrier thiab yog ib qho muaj peev xwm ua haujlwm me me rau kev cuam tshuam hauv cov kab mob neurodegenerative.

Urolithin A thiab cov kab mob sib koom tes thiab txha caj qaum degenerative

Cov kab mob degenerative yog tshwm sim los ntawm ntau yam xws li kev laus, kev mob, thiab kev raug mob. Feem ntau cov kab mob degenerative ntawm cov pob qij txha yog osteoarthritis (OA) thiab degenerative spinal disease intervertebral disc degeneration (IDD). Qhov tshwm sim tuaj yeem ua rau mob thiab tsis ua haujlwm, ua rau poob ntawm kev ua haujlwm thiab ua rau muaj kev phom sij rau pej xeem kev noj qab haus huv. Lub tswv yim ntawm UA hauv kev kho tus kab mob txha caj qaum IDD tuaj yeem cuam tshuam txog kev ncua sijhawm nucleus pulposus (NP) cell apoptosis. NP yog ib qho tseem ceeb ntawm cov intervertebral disc. Nws tswj cov kev ua haujlwm lom neeg ntawm intervertebral disc los ntawm kev faib cov siab thiab tswj cov matrix homeostasis. Kev tshawb fawb tau pom tias UA induces mitophagy los ntawm activating AMPK signaling txoj kev, yog li inhibiting tert-butyl hydroperoxide (t-BHP)-induced apoptosis ntawm tib neeg osteosarcoma cell NP hlwb thiab txo intervertebral disc degeneration.

Urolithin A thiab cov kab mob metabolic

Qhov tshwm sim ntawm cov kab mob metabolic xws li kev rog rog thiab ntshav qab zib yog nce zuj zus txhua xyoo, thiab cov txiaj ntsig zoo ntawm kev noj zaub mov polyphenols rau tib neeg noj qab haus huv tau lees paub los ntawm ntau tog thiab tau pom muaj peev xwm tiv thaiv thiab kho cov kab mob metabolic. Pomegranate polyphenols thiab nws cov hnyuv metabolite UA tuaj yeem txhim kho cov kev ntsuas ntsuas cuam tshuam nrog cov kab mob metabolic, xws li lipase, α-glucosidase (α-glucosidase) thiab dipeptidyl peptidase-4 (dipeptidyl peptidase-4) koom nrog hauv cov piam thaj thiab fatty acid metabolism. 4), nrog rau cov noob muaj feem xyuam xws li adiponectin, PPARγ, GLUT4 thiab FABP4 uas cuam tshuam rau adipocyte txawv thiab triglyceride (TG) tsub zuj zuj.

Tsis tas li ntawd, qee qhov kev tshawb fawb kuj pom tias UA muaj peev xwm txo qis cov tsos mob ntawm kev rog. UA yog ib yam khoom ntawm plab hnyuv metabolism ntawm polyphenols. Cov metabolites no muaj peev xwm txo tau TG tsub zuj zuj hauv daim siab hlwb thiab adipocytes. Abdulrasheed et al. noj cov zaub mov muaj roj ntau rau Wistar nas kom ua rau rog rog. UA kev kho mob tsis yog tsuas yog nce cov rog tawm hauv cov quav, tab sis kuj txo cov visceral adipose cov ntaub so ntswg thiab lub cev hnyav los ntawm kev tswj cov noob ntsig txog lipogenesis thiab fatty acid oxidation. Txo cov rog hauv daim siab thiab nws cov oxidative kev nyuaj siab. Nyob rau tib lub sijhawm, UA tuaj yeem ua kom lub zog siv zog los ntawm kev txhim kho cov thermogenesis ntawm cov ntaub so ntswg adipose xim av thiab ua rau browning ntawm cov rog dawb. Lub tshuab yog txhawm rau nce qib triiodothyronine (T3) hauv cov rog xim av thiab cov roj inguinal. Ua kom kub ntau lawm thiab yog li antagonizes rog.

Tsis tas li ntawd, UA kuj muaj cov nyhuv inhibiting melanin ntau lawm. Cov kev tshawb fawb tau pom tias UA tuaj yeem ua rau melanin tsis muaj zog hauv B16 melanoma hlwb. Lub ntsiab mechanism yog tias UA cuam tshuam rau catalytic activation ntawm tyrosinase los ntawm kev sib tw inhibition ntawm cell tyrosinase, yog li txo pigmentation. Yog li ntawd, UA muaj peev xwm thiab ua tau zoo rau whiten thiab lighten me ntsis. Thiab kev tshawb fawb qhia tau hais tias urolithin A muaj cov txiaj ntsig ntawm thim rov qab kev laus ntawm lub cev tiv thaiv kab mob. Cov kev tshawb fawb tshiab tau pom tias thaum urolithin A ntxiv rau hauv kev noj zaub mov ntxiv, nws tsis tsuas yog ua kom lub zog ntawm lymphatic cheeb tsam ntawm lub cev tiv thaiv kab mob, tab sis kuj txhim kho cov haujlwm ntawm hematopoietic qia hlwb. Tag nrho cov kev ua tau zoo qhia tau hais tias muaj peev xwm ntawm urolithin A los tiv thaiv hnub nyoog ntsig txog lub cev tsis muaj zog.

Raws li cov ntsiab lus, UA, raws li cov hnyuv metabolite ntawm ntuj phytochemicals ETs, tau nyiam ntau yam nyob rau xyoo tas los no. Nrog rau kev tshawb fawb txog cov tshuaj pharmacological thiab cov txheej txheem ntawm UA tau dhau los ua ntau thiab ntau dua thiab qhov tob, UA tsis yog tsuas yog siv tau rau mob qog noj ntshav thiab CVD (cov kab mob plawv). Nws muaj kev tiv thaiv zoo thiab kho mob rau ntau yam kab mob xws li ND (neurodegenerative kab mob) thiab kab mob metabolic. Nws kuj qhia tau hais tias muaj peev xwm siv tau zoo hauv kev zoo nkauj thiab kev kho mob xws li ncua kev laus ntawm daim tawv nqaij, txo lub cev hnyav thiab inhibiting melanin ntau lawm.

Suzhou Myland Pharm & Nutrition Inc. yog lub chaw tsim khoom lag luam FDA sau npe uas muab cov khoom zoo thiab siab huv Urolithin A hmoov.

Ntawm Suzhou Myland Pharm peb tau cog lus los muab cov khoom lag luam zoo tshaj plaws ntawm tus nqi zoo tshaj. Peb Urolithin A hmoov yog nruj me ntsis soj ntsuam rau purity thiab potency, kom ntseeg tau tias koj tau txais cov khoom zoo uas koj tuaj yeem ntseeg tau. Txawm hais tias koj xav txhawb nqa kev noj qab haus huv ntawm tes, txhawb koj lub cev tiv thaiv kab mob lossis txhim kho kev noj qab haus huv tag nrho, peb Urolithin A hmoov yog qhov kev xaiv zoo tshaj.

Nrog 30 xyoo ntawm kev paub thiab tsav los ntawm cov cuab yeej siv siab thiab cov tswv yim zoo R & D, Suzhou Myland Pharm tau tsim ntau yam khoom sib tw thiab dhau los ua lub neej tshiab kev tshawb fawb ntxiv, kev cai synthesis thiab kev tsim cov tuam txhab.

Tsis tas li ntawd, Suzhou Myland Pharm kuj yog ib lub chaw tsim tshuaj paus FDA. Lub tuam txhab R&D cov peev txheej, cov chaw tsim khoom, thiab cov cuab yeej tshuaj ntsuam xyuas yog niaj hnub thiab muaj ntau yam, thiab tuaj yeem tsim cov tshuaj los ntawm milligrams mus rau tons hauv nplai, thiab ua raws li ISO 9001 cov qauv thiab cov khoom tshwj xeeb GMP.