Kev Tshawb Fawb Tom Qab Urolithin A: Yam Koj Yuav Tsum Paub

Urolithin A (UA)yog ib qho tshuaj uas tsim los ntawm kev ua haujlwm ntawm cov kab mob hauv plab hnyuv hauv cov khoom noj uas muaj ellagitannins (xws li txiv lws suav, txiv pos nphuab, thiab lwm yam). Nws suav hais tias muaj kev tiv thaiv kev o, tiv thaiv kev laus, antioxidant, induction ntawm mitophagy, thiab lwm yam, thiab tuaj yeem hla cov ntshav-lub hlwb barrier. Ntau txoj kev tshawb fawb tau lees paub tias urolithin A tuaj yeem ncua kev laus, thiab kev tshawb fawb hauv tsev kho mob kuj tau pom cov txiaj ntsig zoo.

Urolithin A yog dab tsi?

Urolithin A (Uro-A) yog ib qho metabolite ellagitannin (ET)-hom intestinal flora. Nws tau raug tshawb pom thiab muab lub npe rau xyoo 2005. Nws cov mis molecular yog C13H8O4, thiab nws qhov hnyav molecular yog 228.2. Raws li cov khoom noj ua ntej ntawm Uro-A, cov khoom noj tseem ceeb ntawm ET yog txiv lws suav, txiv pos nphuab, txiv pos nphuab, txiv ntoo walnuts thiab cawv liab. UA yog ib yam khoom ntawm ETs metabolized los ntawm cov kab mob hauv plab. UA muaj kev cia siab dav dav hauv kev tiv thaiv thiab kho ntau yam kab mob. Tib lub sijhawm, UA muaj ntau yam khoom noj.

Kev tshawb fawb txog cov teebmeem antioxidant ntawm urolithins tau ua tiav lawm. Urolithin-A tsis muaj nyob rau hauv lub xeev ntuj, tab sis yog tsim los ntawm ntau qhov kev hloov pauv ntawm ET los ntawm cov kab mob hauv plab hnyuv. UA yog ib yam khoom ntawm ETs metabolized los ntawm cov kab mob hauv plab hnyuv. Cov khoom noj nplua nuj hauv ET dhau los ntawm lub plab thiab txoj hnyuv me me hauv tib neeg lub cev, thiab thaum kawg metabolized feem ntau rau hauv Uro-A hauv txoj hnyuv loj. Ib qho me me ntawm Uro-A kuj tuaj yeem pom hauv txoj hnyuv me me qis.

Raws li cov tshuaj polyphenolic ntuj, ETs tau nyiam ntau qhov kev saib xyuas vim lawv cov haujlwm biological xws li antioxidant, anti-inflammatory, anti-allergic thiab anti-viral. Ntxiv nrog rau qhov tau los ntawm cov khoom noj xws li txiv lws suav pomegranate, txiv pos nphuab strawberries, txiv ntseej walnuts, txiv pos nphuab raspberries thiab almonds, ETs kuj pom muaj nyob rau hauv gallnuts, txiv lws suav peels, myrobalan, Dimininus, geranium, betel nut, nplooj hiav txwv buckthorn, Phyllanthus, Uncaria, Sanguisorba, Hauv cov tshuaj suav xws li Phyllanthus emblica thiab Agrimony.

Pawg hydroxyl hauv cov qauv molecular ntawm ETs yog qhov sib piv polar, uas tsis zoo rau kev nqus los ntawm phab ntsa plab hnyuv, thiab nws qhov bioavailability yog qis heev. Ntau txoj kev tshawb fawb tau pom tias tom qab ETs raug noj los ntawm tib neeg lub cev, lawv raug metabolized los ntawm cov kab mob plab hnyuv hauv plab hnyuv thiab hloov mus ua urolithin ua ntej raug nqus. ETs raug hydrolyzed rau hauv ellagic acid (EA) hauv txoj hnyuv sab saud, thiab EA dhau los ntawm txoj hnyuv. Cov kab mob bacterial ntxiv cov txheej txheem thiab poob lub nplhaib lactone thiab dhau los ntawm kev ua haujlwm dehydroxylation tas mus li los tsim urolithin. Muaj cov ntawv tshaj tawm tias urolithin tej zaum yuav yog lub hauv paus rau cov teebmeem biological ntawm ETs hauv lub cev.

Qhov bioavailability ntawm urolithin muaj feem cuam tshuam li cas?

Pom qhov no, yog tias koj ntse, tej zaum koj twb paub lawm tias qhov bioavailability ntawm UA muaj feem cuam tshuam li cas.

Qhov tseem ceeb tshaj plaws yog cov khoom sib xyaw ntawm cov microbiome, vim tias tsis yog txhua hom kab mob me me tuaj yeem tsim tau. Cov khoom siv raw ntawm UA yog ellagitannins tau los ntawm cov khoom noj. Cov precursor no yooj yim nrhiav tau thiab yuav luag txhua qhov chaw hauv xwm.

Ellagitannins raug hydrolyzed hauv txoj hnyuv kom tso tawm ellagic acid, uas cov kab mob hauv plab hnyuv ua tiav ntxiv rau hauv urolithin A.

Raws li kev tshawb fawb hauv phau ntawv xov xwm Cell, tsuas yog 40% ntawm cov neeg tuaj yeem hloov urolithin A los ntawm nws cov khoom ua ntej mus rau hauv urolithin A uas siv tau.

Cov haujlwm ntawm urolithin A yog dab tsi?

Tiv thaiv kev laus

Lub tswv yim dawb radical ntawm kev laus ntseeg tias cov tshuaj reactive oxygen tsim nyob rau hauv mitochondrial metabolism ua rau oxidative kev ntxhov siab hauv lub cev thiab ua rau kev laus, thiab mitophagy ua lub luag haujlwm tseem ceeb hauv kev tswj hwm kev noj qab haus huv thiab kev ncaj ncees ntawm mitochondrial. Nws tau tshaj tawm tias UA tuaj yeem tswj hwm mitophagy thiab yog li qhia txog lub peev xwm los ncua kev laus. Ryu et al. pom tias UA txo qhov tsis ua haujlwm mitochondrial thiab ntev lub neej hauv Caenorhabditis elegans los ntawm kev ua rau mitophagy; hauv cov nas, UA tuaj yeem thim rov qab kev ua haujlwm ntawm cov leeg nqaij uas muaj hnub nyoog, qhia tias UA txhim kho kev ua haujlwm mitochondrial los ntawm kev txhim kho cov leeg nqaij thiab ntev lub neej ntawm lub cev. Liu et al. siv UA los cuam tshuam rau kev laus ntawm daim tawv nqaij fibroblasts. Cov txiaj ntsig tau qhia tias UA ua rau muaj kev qhia tawm ntawm hom I collagen thiab txo qhov kev qhia tawm ntawm matrix metalloproteinase-1 (MMP-1). Nws kuj tseem ua rau nuclear Factor E2-related factor 2 (nuclear factor erythroid 2-related factor 2, Nrf2)-mediated antioxidant teb txo cov intracellular ROS, yog li qhia txog lub zog tiv thaiv kev laus.

Cov nyhuv tiv thaiv kab mob

Tam sim no, muaj ntau txoj kev tshawb fawb tau ua tiav rau cov nyhuv antioxidant ntawm urolithin. Ntawm tag nrho cov metabolites urolithin, Uro-A muaj cov antioxidant muaj zog tshaj plaws, thib ob tsuas yog proanthocyanidin oligomers, catechins, epicatechin thiab 3,4-dihydroxyphenylacetic acid. Kev ntsuas oxygen radical absorbance capacity (ORAC) ntawm cov plasma ntawm cov neeg pab dawb noj qab haus huv pom tias cov antioxidant muaj peev xwm nce 32% tom qab 0.5 teev ntawm kev noj cov kua txiv pomegranate, tab sis qib ntawm cov reactive oxygen hom tsis hloov pauv ntau, thaum nyob rau hauv Neuro- In vitro kev sim ntawm 2a hlwb pom tias Uro-A tuaj yeem txo qib ntawm cov reactive oxygen hom hauv hlwb. Cov txiaj ntsig no qhia tau tias Uro-A muaj cov teebmeem antioxidant muaj zog.

03. Urolithin A thiab cov kab mob plawv thiab cov kab mob cerebrovascular

Cov kab mob plawv thoob ntiaj teb (CVD) nce ntxiv txhua xyoo, thiab tus nqi tuag tseem siab. Nws tsis yog tsuas yog ua rau lub nra hnyav ntawm kev sib raug zoo thiab kev lag luam xwb, tab sis kuj cuam tshuam rau tib neeg lub neej zoo. CVD yog ib yam kab mob ntau yam. Kev o tuaj yeem ua rau muaj kev pheej hmoo ntawm CVD. Kev ntxhov siab oxidative muaj feem cuam tshuam nrog pathogenesis ntawm CVD. Muaj cov ntawv tshaj tawm tias cov metabolites los ntawm cov kab mob hauv plab hnyuv muaj feem cuam tshuam nrog kev pheej hmoo ntawm CVD.

Tau tshaj tawm tias UA muaj cov teebmeem tiv thaiv kev o thiab antioxidant muaj zog, thiab cov kev tshawb fawb tseem ceeb tau lees paub tias UA tuaj yeem ua lub luag haujlwm zoo hauv CVD. Savi et al. siv tus qauv nas ntshav qab zib los ua kev tshawb fawb hauv vivo ntawm tus kab mob plawv dhia tsis xwm yeem thiab pom tias UA tuaj yeem txo qhov kev teb thawj zaug ntawm cov nqaij myocardial rau hyperglycemia, txhim kho myocardial microenvironment, thiab txhawb kev rov qab los ntawm cardiomyocyte contractility thiab calcium dynamics, qhia tias UA tuaj yeem siv ua tshuaj pabcuam los tswj tus kab mob plawv dhia tsis xwm yeem thiab tiv thaiv nws cov teeb meem.

UA tuaj yeem txhim kho kev ua haujlwm ntawm mitochondrial thiab cov leeg nqaij los ntawm kev ua kom mitophagy. Lub plawv mitochondria yog cov organelles tseem ceeb uas muaj lub luag haujlwm tsim cov zog ATP. Kev ua haujlwm tsis zoo ntawm mitochondrial yog lub hauv paus ua rau lub plawv tsis ua haujlwm. Kev ua haujlwm tsis zoo ntawm mitochondrial tam sim no suav hais tias yog lub hom phiaj kho mob. Yog li ntawd, UA kuj tau dhau los ua cov tshuaj tshiab rau kev kho mob CVD.

Urolithin A thiab cov kab mob neurological

Kev mob hlwb yog ib qho txheej txheem tseem ceeb hauv kev tshwm sim thiab kev loj hlob ntawm tus kab mob neurodegenerative (ND). Apoptosis tshwm sim los ntawm kev ntxhov siab oxidative thiab kev sib sau ua ke ntawm cov protein tsis zoo feem ntau ua rau neuroinflammation, thiab cov cytokines pro-inflammatory uas tso tawm los ntawm neuroinflammation ces cuam tshuam rau neurodegeneration.

Cov kev tshawb fawb tau pom tias UA ua rau muaj kev tiv thaiv kev o los ntawm kev ua kom autophagy thiab ua kom lub tshuab tswj lub teeb liab ntsiag to 1 (SIRT-1) deacetylation mechanism, tiv thaiv kev mob hlwb thiab kev lom hlwb, thiab tiv thaiv kev puas hlwb, qhia tias UA yog tus neeg sawv cev Neuroprotective zoo. Tib lub sijhawm, qee qhov kev tshawb fawb tau pom tias UA tuaj yeem ua rau muaj kev cuam tshuam rau kev tiv thaiv hlwb los ntawm kev tshem tawm cov dawb radicals thiab tiv thaiv cov oxidases.

Cov kev tshawb fawb tau qhia tias kua txiv lws suav ua lub luag haujlwm tiv thaiv lub hlwb los ntawm kev ua kom mitochondrial aldehyde dehydrogenase ua haujlwm ntau ntxiv, tswj qib ntawm cov protein tiv thaiv apoptotic Bcl-xL, txo α-synuclein sib sau ua ke thiab kev puas tsuaj oxidative, thiab cuam tshuam rau kev ua haujlwm ntawm neuronal thiab kev ruaj khov. Cov tshuaj Urolithin yog cov metabolites thiab cov khoom cuam tshuam ntawm ellagitannins hauv lub cev thiab muaj cov haujlwm biological xws li tiv thaiv kev o, tiv thaiv kev ntxhov siab oxidative, thiab tiv thaiv apoptosis. Urolithin tuaj yeem ua haujlwm tiv thaiv lub hlwb los ntawm cov ntshav-lub hlwb thaiv thiab yog ib qho molecule me me uas muaj peev xwm ua haujlwm rau kev cuam tshuam rau cov kab mob neurodegenerative.

Urolithin A thiab cov kab mob sib koom ua ke thiab cov kab mob ntawm tus txha caj qaum

Cov kab mob degenerative yog tshwm sim los ntawm ntau yam xws li kev laus, kev ntxhov siab, thiab kev raug mob. Cov kab mob degenerative feem ntau ntawm cov pob qij txha yog osteoarthritis (OA) thiab cov kab mob degenerative spinal intervertebral disc degeneration (IDD). Qhov tshwm sim tuaj yeem ua rau mob thiab ua haujlwm tsawg, ua rau poob haujlwm thiab ua rau muaj kev phom sij rau kev noj qab haus huv pej xeem. Lub tshuab ntawm UA hauv kev kho mob kab mob degenerative IDD ntawm tus txha caj qaum tej zaum yuav cuam tshuam nrog kev ncua nucleus pulposus (NP) cell apoptosis. NP yog ib qho tseem ceeb ntawm intervertebral disc. Nws tswj hwm lub luag haujlwm ntawm intervertebral disc los ntawm kev faib cov siab thiab tswj hwm matrix homeostasis. Cov kev tshawb fawb tau pom tias UA ua rau mitophagy los ntawm kev ua kom AMPK signaling pathway, yog li ntawd inhibiting tert-butyl hydroperoxide (t-BHP)-induced apoptosis ntawm tib neeg osteosarcoma cell NP cell thiab txo cov intervertebral disc degeneration.

Urolithin A thiab cov kab mob metabolic

Qhov tshwm sim ntawm cov kab mob metabolic xws li kev rog dhau thiab ntshav qab zib nce ntxiv txhua xyoo, thiab cov txiaj ntsig zoo ntawm kev noj zaub mov polyphenols rau tib neeg kev noj qab haus huv tau lees paub los ntawm ntau tog thiab tau pom tias muaj peev xwm hauv kev tiv thaiv thiab kho cov kab mob metabolic. Pomegranate polyphenols thiab nws cov metabolite hauv plab hnyuv UA tuaj yeem txhim kho cov cim qhia txog kev kho mob ntsig txog cov kab mob metabolic, xws li lipase, α-glucosidase (α-glucosidase) thiab dipeptidyl peptidase-4 (dipeptidyl peptidase-4) koom nrog hauv kev hloov pauv glucose thiab fatty acid. 4), nrog rau cov noob caj noob ces xws li adiponectin, PPARγ, GLUT4 thiab FABP4 uas cuam tshuam rau adipocyte sib txawv thiab triglyceride (TG) kev sib sau ua ke.

Ntxiv rau, qee qhov kev tshawb fawb kuj pom tias UA muaj peev xwm txo cov tsos mob ntawm kev rog dhau. UA yog ib yam khoom ntawm cov metabolism hauv plab hnyuv ntawm polyphenols. Cov metabolites no muaj peev xwm txo cov TG sib sau ua ke hauv cov hlwb siab thiab adipocytes. Abdulrasheed et al. pub cov zaub mov muaj roj ntau rau Wistar nas kom ua rau rog dhau. Kev kho mob UA tsis yog tsuas yog ua rau cov rog tawm hauv cov quav ntau ntxiv xwb, tab sis kuj txo cov ntaub so ntswg adipose visceral thiab qhov hnyav ntawm lub cev los ntawm kev tswj cov noob caj noob ces cuam tshuam nrog lipogenesis thiab fatty acid oxidation. Txo cov rog hauv siab thiab nws qhov kev ntxhov siab oxidative. Tib lub sijhawm, UA tuaj yeem ua rau kev siv zog ntau ntxiv los ntawm kev txhim kho thermogenesis ntawm cov ntaub so ntswg adipose xim av thiab ua rau cov rog dawb xim av. Lub tshuab yog kom nce triiodothyronine (T3) theem hauv cov rog xim av thiab cov roj inguinal depots. Ua rau muaj cua sov ntau ntxiv thiab yog li ntawd tiv thaiv kev rog dhau.

Ntxiv rau, UA kuj muaj cov nyhuv ntawm kev txwv tsis pub tsim melanin. Cov kev tshawb fawb tau pom tias UA tuaj yeem ua rau melanin tsim tsis muaj zog hauv B16 melanoma hlwb. Lub hauv paus tseem ceeb yog tias UA cuam tshuam rau kev ua haujlwm catalytic ntawm tyrosinase los ntawm kev sib tw inhibition ntawm cell tyrosinase, yog li txo cov pigmentation. Yog li ntawd, UA muaj peev xwm thiab ua tau zoo los ua kom dawb thiab sib dua cov pob. Thiab kev tshawb fawb qhia tau hais tias urolithin A muaj cov nyhuv ntawm kev thim rov qab kev laus ntawm lub cev tiv thaiv kab mob. Cov kev tshawb fawb tshiab pom tias thaum urolithin A ntxiv rau hauv kev noj haus ntxiv, nws tsis tsuas yog ua kom lub zog ntawm thaj chaw lymphatic ntawm nas lub cev tiv thaiv kab mob, tab sis kuj txhim kho kev ua haujlwm ntawm cov hlwb hematopoietic. Kev ua tau zoo tag nrho qhia tau hais tias urolithin A muaj peev xwm los tawm tsam kev laus ntawm lub cev tiv thaiv kab mob.

Hauv kev xaus lus, UA, ua ib qho metabolite ntawm cov phytochemicals ETs hauv plab hnyuv, tau nyiam ntau qhov kev saib xyuas hauv xyoo tas los no. Nrog rau kev tshawb fawb txog cov teebmeem pharmacological thiab cov txheej txheem ntawm UA ua ntau dua thiab ntau dua thiab tob dua, UA tsis yog tsuas yog ua tau zoo hauv mob qog noj ntshav thiab CVD (kab mob plawv). Nws muaj cov txiaj ntsig zoo rau kev tiv thaiv thiab kho mob ntawm ntau yam kab mob xws li ND (kab mob neurodegenerative) thiab kab mob metabolic. Nws kuj qhia txog kev siv tau zoo hauv kev kho mob zoo nkauj thiab kev saib xyuas kev noj qab haus huv xws li ncua kev laus ntawm daim tawv nqaij, txo qhov hnyav ntawm lub cev thiab tiv thaiv melanin ntau lawm.

Suzhou Myland Pharm & Nutrition Inc. yog ib lub chaw tsim khoom uas tau sau npe los ntawm FDA uas muab cov hmoov Urolithin A zoo thiab huv si.

Ntawm Suzhou Myland Pharm peb cog lus tias yuav muab cov khoom zoo tshaj plaws rau tus nqi zoo tshaj plaws. Peb cov hmoov Urolithin A tau raug kuaj xyuas kom huv si thiab muaj zog, kom ntseeg tau tias koj tau txais cov tshuaj zoo uas koj ntseeg siab tau. Txawm koj xav txhawb kev noj qab haus huv ntawm tes, txhawb koj lub cev tiv thaiv kab mob lossis txhim kho kev noj qab haus huv tag nrho, peb cov hmoov Urolithin A yog qhov kev xaiv zoo tshaj plaws.

Nrog 30 xyoo ntawm kev paub dhau los thiab tsav los ntawm cov thev naus laus zis siab thiab cov tswv yim R&D zoo tshaj plaws, Suzhou Myland Pharm tau tsim ntau yam khoom sib tw thiab dhau los ua lub tuam txhab tsim khoom noj khoom haus tshiab, kev tsim khoom tshwj xeeb thiab kev tsim khoom.

Ntxiv rau qhov ntawd, Suzhou Myland Pharm kuj yog ib lub chaw tsim khoom uas tau sau npe los ntawm FDA. Lub tuam txhab cov peev txheej R&D, cov chaw tsim khoom, thiab cov cuab yeej siv tshuaj ntsuam xyuas yog niaj hnub thiab muaj ntau yam, thiab tuaj yeem tsim cov tshuaj los ntawm milligrams mus rau tons hauv qhov ntsuas, thiab ua raws li ISO 9001 cov qauv thiab cov lus qhia tsim khoom GMP.