4 Cov Tshuaj Pab Tiv Thaiv Kev Laus Zoo Tshaj Plaws rau Kev Txhim Kho Kev Noj Qab Haus Huv Mitochondrial: Qhov Twg Muaj Zog Dua?

Cov kws tshawb fawb tau pom tias thaum peb laus zuj zus, peb cov mitochondria maj mam poob qis thiab tsim cov zog tsawg dua. Qhov no tuaj yeem ua rau muaj cov kab mob ntsig txog hnub nyoog xws li cov kab mob neurodegenerative, kab mob plawv, thiab ntau ntxiv.

Urolithin A

Urolithin A yog ib yam khoom ntuj tsim uas muaj cov tshuaj antioxidant thiab antiproliferative effects. Cov kws tshawb fawb txog kev noj haus ntawm Nova Southeastern University hauv Tebchaws Meskas tau pom tias kev siv urolithin A ua kev cuam tshuam kev noj haus tuaj yeem ncua kev laus thiab tiv thaiv kev loj hlob ntawm cov kab mob ntsig txog hnub nyoog.
Urolithin A (UA) yog tsim los ntawm peb cov kab mob hauv plab tom qab noj cov polyphenols pom muaj nyob rau hauv cov khoom noj xws li txiv lws suav, txiv pos nphuab, thiab txiv ntoo walnuts. Kev noj UA ntxiv rau cov nas hnub nyoog nruab nrab ua rau sirtuins ua haujlwm thiab ua rau NAD + thiab cov qib zog ntawm tes nce ntxiv. Qhov tseem ceeb, UA tau pom tias tshem tawm cov mitochondria puas tsuaj ntawm cov leeg nqaij tib neeg, yog li txhim kho lub zog, tiv taus kev nkees, thiab kev ua kis las. Yog li ntawd, kev noj UA ntxiv tuaj yeem ua rau lub neej ntev dua los ntawm kev tiv thaiv kev laus ntawm cov leeg nqaij.
Urolithin A tsis yog los ntawm kev noj zaub mov ncaj qha, tab sis cov tshuaj xws li ellagic acid thiab ellagitannins uas muaj nyob rau hauv cov txiv ntoo, txiv lws suav, txiv hmab thiab lwm yam txiv hmab yuav tsim cov urolithin A tom qab raug metabolized los ntawm cov kab mob hauv plab hnyuv.

Spermidine

Spermidine yog ib hom tshuaj polyamine uas tau txais kev saib xyuas nyob rau xyoo tas los no rau nws lub peev xwm los txuas lub neej ntev thiab ua kom lub neej noj qab haus huv ntev dua. Ib yam li NAD + thiab CoQ10, spermidine yog ib qho molecule uas tshwm sim ntuj uas txo qis nrog hnub nyoog. Zoo ib yam li UA, spermidine yog tsim los ntawm peb cov kab mob hauv plab thiab ua rau mitophagy - kev tshem tawm cov mitochondria tsis zoo thiab puas tsuaj. Kev tshawb fawb nas qhia tau hais tias kev noj tshuaj spermidine tuaj yeem tiv thaiv kab mob plawv thiab kev laus ntawm poj niam. Tsis tas li ntawd, kev noj zaub mov spermidine (pom muaj nyob rau hauv ntau yam khoom noj suav nrog taum pauv thiab nplej) txhim kho kev nco hauv nas. Xav tau kev tshawb fawb ntxiv kom txiav txim siab seb cov kev tshawb pom no puas tuaj yeem rov ua dua hauv tib neeg.
Raws li kev tshawb fawb luam tawm hauv Scientific Reports los ntawm cov kws tshawb fawb ntawm Kyoto Prefectural University of Medicine hauv Nyiv, cov txheej txheem laus ib txwm txo qhov kev sib sau ua ke ntawm cov qauv ntuj ntawm spermidine hauv lub cev. Txawm li cas los xij, qhov xwm txheej no tsis tau pom nyob rau hauv cov neeg muaj hnub nyoog centenarians;
Spermidine tuaj yeem txhawb nqa autophagy.
Cov khoom noj uas muaj cov spermidine ntau suav nrog: cov khoom noj ua los ntawm cov nplej tag nrho, kelp, nceb shiitake, txiv ntoo qhuav, bracken, purslane, thiab lwm yam.

curcumin
Curcumin yog cov khoom xyaw nquag hauv turmeric uas muaj cov khoom tiv thaiv kev o thiab antioxidant.
Cov kws tshawb fawb txog kev tshawb fawb los ntawm Polish Academy of Sciences tau tshawb pom tias curcumin tuaj yeem txo cov tsos mob ntawm kev laus thiab ncua qhov kev nce qib ntawm cov kab mob ntsig txog hnub nyoog uas cov hlwb laus koom nrog ncaj qha, yog li ua rau lub neej ntev dua.
Ntxiv rau turmeric, cov khoom noj uas muaj curcumin ntau suav nrog: qhiav, qej, dos, kua txob dub, mustard thiab curry.

NAD+ cov tshuaj ntxiv
Qhov twg muaj mitochondria, muaj NAD+ (nicotinamide adenine dinucleotide), ib qho molecule tsim nyog rau kev tsim hluav taws xob ntau tshaj plaws. NAD+ ntuj tsim yuav poob qis thaum muaj hnub nyoog, uas zoo li sib xws nrog kev poob qis ntawm kev ua haujlwm ntawm mitochondrial uas cuam tshuam nrog hnub nyoog. Qhov no yog ib qho laj thawj vim li cas NAD+ boosters xws li NR (Nicotinamide Ribose) tau tsim los kho cov theem NAD+.
Kev tshawb fawb qhia tau hais tias los ntawm kev txhawb nqa NAD +, NR tuaj yeem txhim kho kev tsim hluav taws xob mitochondrial thiab tiv thaiv kev ntxhov siab ntsig txog hnub nyoog. NAD + cov tshuaj ntxiv tuaj yeem txhim kho kev ua haujlwm ntawm cov leeg nqaij, kev noj qab haus huv ntawm lub hlwb, thiab kev ua haujlwm ntawm lub cev thaum muaj peev xwm tawm tsam cov kab mob neurodegenerative. Tsis tas li ntawd, lawv txo qhov hnyav nce, txhim kho kev nkag siab ntawm insulin, thiab ua kom cov roj lipid zoo li qub, xws li txo qis LDL cholesterol.