7,8-Dihydroxyflavone yog dab tsi thiab Vim Li Cas Koj Yuav Tsum Saib Xyuas?

Tom ntej: 7,8-Dihydroxyflavone (7,8-DHF)yog ib qho tshwm sim ntawm flavonoid, polyphenolic compound pom nyob rau hauv ntau yam nroj tsuag. Flavonoids paub txog lawv cov khoom antioxidant thiab ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv cov nroj tsuag. 7,8-Dihydroxyflavone tshwj xeeb tshaj yog nyob rau hauv cov nroj tsuag xws li Godmania aesculifolia thiab Tridax procumbens.

7,8-Dihydroxyflavone txawv ntawm lwm cov flavonoids hauv nws lub peev xwm los ua cov haujlwm ntawm lub hlwb-derived neurotrophic factor (BDNF). BDNF yog cov protein uas txhawb kev ciaj sia, kev loj hlob, thiab kev ua haujlwm ntawm cov neurons hauv lub hlwb. Nws ua lub luag haujlwm tseem ceeb hauv neuroplasticity, lub hlwb lub peev xwm los kho nws tus kheej los ntawm kev tsim cov kev sib txuas neural tshiab. Cov cuab yeej no ntawm 7,8-DHF qhib ntau txoj hauv kev ntawm kev tshawb fawb, tshwj xeeb tshaj yog nyob rau hauv thaj tsam ntawm neuroscience.

Mechanism ntawm kev ua

Lub ntsiab mechanism uas 7,8-Dihydroxyflavone exerts nws cov teebmeem yog ua kom lub TrkB (tropomyosin receptor kinase B) receptor. TrkB yog qhov muaj txiaj ntsig zoo rau BDNF. Thaum 7,8-Dihydroxyflavone khi rau TrkB, nws ua rau muaj ntau txoj hauv kev hauv lub cev uas txhawb nqa kev muaj sia nyob, kev loj hlob, thiab kev sib txawv.

Cov kev tshawb fawb ua ntej tau pom tias 7,8-dihydroxyflavone tuaj yeem ua raws li BDNF (lub hlwb tau txais txiaj ntsig neurotrophic) thiab nce nws cov lus qhia thiab qib hauv hippocampus. Hauv cov qauv tsiaj, nws muaj peev xwm kho tau rau ntau yam kab mob neurological lossis mob, xws li mob stroke, kev nyuaj siab, thiab Parkinson's disease. Hauv ob txoj kev tshawb fawb sib txawv, 7,8-dihydroxyflavone tau qhia txog qhov ncauj bioavailability tseem ceeb thiab tau pom tias hla lub hlwb-ntshav barrier (BBB). Vim tias nws ua haujlwm ntawm nitric oxide signaling pathway thiab qhib TrkB receptor (tropomyosin receptor kinase B)

Qhov tseem ceeb neurotrophic BDNF feem ntau xa cov teeb liab los ntawm kev khi rau cov receptors tshwj xeeb, yog li cuam tshuam rau cov txheej txheem physiological ntawm neurons. Thaum 7,8-DHF tuaj yeem simulate cov txiaj ntsig ntawm neurotrophic yam BDNF, qhov tseem ceeb nyob hauv nws txoj kev sib cuam tshuam nrog BDNF receptor. Cov kev tshawb fawb tau pom tias 7,8-DHF tuaj yeem khi rau BDNF receptor TrkB thiab qhib cov kev taw qhia hauv qab.

Tshwj xeeb, thaum 7,8-DHF khi rau TrkB, nws ua rau muaj cov xwm txheej ntawm cov teeb liab intracellular transduction. Qhov no suav nrog kev ua kom cov protein kinases xws li PI3K / Akt thiab MAPK / ERK txoj hauv kev. Kev ua kom txoj hauv kev no yog qhov tseem ceeb rau kev txhawb nqa kev muaj sia nyob, kev loj hlob, thiab synaptic plasticity. Los ntawm kev simulating kev ua kom cov kev no los ntawm BDNF, 7,8-DHF pab txhim kho neuronal adaptability thiab tsis kam mus rau sab nraud kev nyuaj siab.

7,8-DHF kuj tswj cov noob qhia hauv cov neurons. Nws tuaj yeem cuam tshuam rau kev hloov pauv ntawm cov noob ntsig txog kev tsim kho neurodevelopment, neuroprotection thiab synapse tsim, yog li ua raws li cov teebmeem ntawm BDNF ntawm qib molecular. Qhov kev hloov pauv ntawm cov noob qhia ntxiv txhawb nqa lub luag haujlwm ntawm 7,8-DHF hauv kev txhawb nqa kev noj qab haus huv.

7,8-Dihydroxyflavone (7,8-DHF) yog monophenolic flavonoid nrog ntau yam teebmeem. Nws ua raws li agonist rau neurotrophic tyrosine kinase receptor TrkB (Kd = 320nM) thiab tiv thaiv TrkB-expressing neurons los ntawm apoptosis. Brain-derived neurotrophic factor (BDNF) yog cov protein uas muaj cov teebmeem neurotrophic uas yog qhov tseem ceeb rau kev tsim lub hlwb, kev kawm thiab kev nco.

• Neuroprotection: 7,8-DHF yog neuroprotective nyob rau hauv cov tsiaj qauv ntawm Parkinson tus kab mob, txhawb kev xav ntawm nas thiab reverses nco deficits nyob rau hauv nas qauv ntawm Alzheimer's tus kab mob, thiab kuj yuav txhim kho lub cev muaj zog muaj nuj nqi thiab ntev mus yos hav zoov ciaj sia taus lub sij hawm ntawm cov tsiaj cov kab mob. BDNF tuaj yeem txhim kho neuroplasticity thiab neuron ciaj sia, pab lub hlwb tsim cov kev sib txuas neural tshiab, kho lub hlwb tsis ua haujlwm, thiab tiv thaiv cov hlwb hlwb. Nws yog ib qho tseem ceeb rau kev tsim lub hlwb, kev kawm thiab kev nco, thiab tuaj yeem tiv thaiv lub hlwb los ntawm hnub nyoog txog kev paub tsis meej. Kev poob qis hauv kev txawj ntse thiab tiv thaiv cov kab mob neurodegenerative xws li Alzheimer's disease thiab Parkinson's disease.

• Tswj kev ciaj sia nyob rau hauv neuronal: 7,8-DHF tuaj yeem khi rau TrkB thiab qhib cov kev taw qhia hauv qab, xws li PI3K/Akt thiab MAPK/ERK txoj hauv kev. Kev ua kom cov kab ke no yog qhov tseem ceeb rau kev txhawb nqa neuronal ciaj sia, kev loj hlob thiab synaptic plasticity. tseem ceeb. BDNF kuj yog ib qho tseem ceeb neurotrophic uas tuaj yeem ua rau cov kab mob hauv lub cev los ntawm kev khi rau TrkB receptors thiab txhawb kev ciaj sia thiab kev loj hlob ntawm neurons.

• Txhawb synaptic plasticity: 7,8-DHF tuaj yeem txhawb kev tsim thiab ntxiv dag zog ntawm cov synapses los ntawm kev ua kom TrkB receptors, yog li txhim kho kev ua haujlwm ntawm synaptic kis tau tus mob. BDNF tseem xav tias yuav txhawb kev tsim thiab ntxiv dag zog ntawm synapses, yog li ua kom muaj txiaj ntsig ntawm kev sib kis ntawm synaptic thiab yog li txhim kho kev kawm thiab kev nco muaj peev xwm.

• Qhov cuam tshuam rau kev kawm thiab kev nco: 7,8-DHF tuaj yeem txhim kho kev kawm thiab kev nco muaj peev xwm hauv cov nas, uas yuav cuam tshuam rau nws cov teebmeem ntawm neuronal ciaj sia taus thiab synaptic plasticity. BDNF tseem ua lub luag haujlwm tseem ceeb hauv kev kawm thiab kev nco qab los ntawm kev txhawb nqa kev muaj sia nyob ntawm cov neurons thiab tsim cov synapses, yog li txhim kho kev kawm thiab kev nco muaj peev xwm.

• Modulates mus ob peb vas: 7,8-DHF muaj mus ob peb vas-modulating teebmeem, uas tej zaum yuav muaj feem xyuam rau nws cov teebmeem ntawm neuronal ciaj sia taus thiab synaptic plasticity. BDNF tseem xav tias yuav ua lub luag haujlwm hauv kev tswj hwm kev xav los ntawm kev tswj hwm txoj sia nyob ntawm cov neurons thiab tsim cov synapses, yog li cuam tshuam rau kev qhia ntawm kev xav.

Hauv cov ntsiab lus, 7,8-DHF thiab BDNF muaj cov txheej txheem zoo sib xws ntawm kev ua haujlwm hauv neuroprotection, tswj hwm kev muaj sia nyob ntawm cov hlab ntsha, txhawb cov synaptic plasticity, cuam tshuam rau kev kawm thiab kev nco, thiab tswj kev xav.

Suzhou Myland Pharm & Nutrition Inc. yog ib lub chaw tsim tshuaj paus FDA uas muab cov khoom zoo thiab siab dawb huv 7,8-Dihydroxyflavone.

Ntawm Suzhou Myland Pharm peb tau cog lus los muab cov khoom lag luam zoo tshaj plaws ntawm tus nqi zoo tshaj. Peb 7,8-Dihydroxyflavone yog nruj me ntsis soj ntsuam rau purity thiab potency, kom ntseeg tau tias koj tau txais cov khoom zoo uas koj tuaj yeem ntseeg tau. Txawm hais tias koj xav txhawb kev noj qab haus huv ntawm tes, txhawb koj lub cev tiv thaiv kab mob lossis txhim kho kev noj qab haus huv tag nrho, peb 7,8-Dihydroxyflavone yog qhov kev xaiv zoo tshaj.

Nrog 30 xyoo ntawm kev paub thiab tsav los ntawm cov cuab yeej siv siab thiab cov tswv yim zoo R & D, Suzhou Myland Pharm tau tsim ntau yam khoom sib tw thiab dhau los ua lub neej tshiab kev tshawb fawb ntxiv, kev cai synthesis thiab kev tsim cov tuam txhab.

Tsis tas li ntawd, Suzhou Myland Pharm kuj yog ib lub chaw tsim tshuaj paus FDA. Lub tuam txhab R&D cov peev txheej, cov chaw tsim khoom, thiab cov cuab yeej tshuaj ntsuam xyuas yog niaj hnub thiab muaj ntau yam, thiab tuaj yeem tsim cov tshuaj los ntawm milligrams mus rau tons hauv nplai, thiab ua raws li ISO 9001 cov qauv thiab cov khoom tshwj xeeb GMP.