7,8-Dihydroxyflavone yog dab tsi thiab vim li cas koj yuav tsum tau saib xyuas?

7,8-Dihydroxyflavone (7,8-DHF)yog ib qho flavonoid uas tshwm sim ntuj, ib qho polyphenolic compound pom muaj nyob rau hauv ntau yam nroj tsuag. Flavonoids paub txog lawv cov khoom antioxidant thiab ua lub luag haujlwm tseem ceeb hauv cov txheej txheem tiv thaiv ntawm cov nroj tsuag. 7,8-Dihydroxyflavone pom tshwj xeeb hauv cov nroj tsuag xws li Godmania aesculifolia thiab Tridax procumbens.

7,8-Dihydroxyflavone txawv ntawm lwm cov flavonoids hauv nws lub peev xwm los ua raws li kev ua haujlwm ntawm lub hlwb-derived neurotrophic factor (BDNF). BDNF yog ib qho protein uas txhawb nqa kev ciaj sia, kev loj hlob, thiab kev ua haujlwm ntawm cov neurons hauv lub hlwb. Nws ua lub luag haujlwm tseem ceeb hauv neuroplasticity, lub hlwb lub peev xwm los rov kho nws tus kheej los ntawm kev tsim cov kev sib txuas neural tshiab. Cov khoom no ntawm 7,8-DHF qhib ntau txoj hauv kev tshawb fawb, tshwj xeeb tshaj yog hauv thaj chaw ntawm neuroscience.

Txoj kev ua haujlwm

Lub tshuab tseem ceeb uas 7,8-Dihydroxyflavone ua haujlwm yog kev ua kom TrkB (tropomyosin receptor kinase B) receptor ua haujlwm. TrkB yog ib qho receptor uas muaj kev sib raug zoo rau BDNF. Thaum 7,8-Dihydroxyflavone khi rau TrkB, nws ua rau muaj ntau txoj hauv kev xa xov hauv lub hlwb uas txhawb nqa kev ciaj sia, kev loj hlob, thiab kev sib txawv ntawm cov hlwb.

Cov kev tshawb fawb ua ntej tau qhia tias 7,8-dihydroxyflavone tuaj yeem ua raws li BDNF (lub hlwb-derived neurotrophic factor) thiab ua rau nws cov kev qhia tawm thiab cov theem hauv hippocampus nce ntxiv. Hauv cov qauv tsiaj, nws muaj peev xwm kho tau ntau yam kab mob neurological lossis kev mob, uas yog mob stroke, kev nyuaj siab, thiab Parkinson's kab mob. Hauv ob txoj kev tshawb fawb sib txawv, 7,8-dihydroxyflavone tau qhia txog kev noj qab haus huv tseem ceeb thiab pom tias hla lub hlwb-ntshav thaiv (BBB). Vim tias nws ua haujlwm ntawm txoj kev nitric oxide signaling thiab ua haujlwm TrkB receptor (tropomyosin receptor kinase B)

Tus yam neurotrophic BDNF feem ntau xa cov teeb liab los ntawm kev khi rau cov receptors tshwj xeeb, yog li cuam tshuam rau cov txheej txheem physiological ntawm neurons. Thaum 7,8-DHF tuaj yeem ua raws li cov nyhuv ntawm tus yam neurotrophic BDNF, qhov tseem ceeb nyob rau hauv nws cov mechanism sib cuam tshuam nrog BDNF receptor. Cov kev tshawb fawb tau qhia tias 7,8-DHF tuaj yeem khi rau BDNF receptor TrkB thiab ua kom cov downstream signaling pathways.

Tshwj xeeb, thaum 7,8-DHF khi rau TrkB, nws ua rau muaj ntau yam kev hloov pauv ntawm lub hlwb. Qhov no suav nrog kev ua kom cov protein kinases xws li PI3K/Akt thiab MAPK/ERK txoj kev. Kev ua kom cov txoj kev no tseem ceeb heev rau kev txhawb nqa kev ciaj sia ntawm cov hlwb, kev loj hlob, thiab kev hloov pauv ntawm cov hlwb. Los ntawm kev ua kom cov txoj kev no ua haujlwm los ntawm BDNF, 7,8-DHF pab txhim kho kev hloov pauv ntawm cov hlwb thiab kev tiv thaiv kev ntxhov siab sab nraud.

7,8-DHF kuj tswj kev qhia tawm cov noob caj noob ces hauv cov neurons. Nws tuaj yeem cuam tshuam rau kev sau cov noob caj noob ces uas cuam tshuam nrog kev loj hlob ntawm lub hlwb, kev tiv thaiv ntawm lub hlwb thiab kev tsim cov synapse, yog li ua raws li cov teebmeem ntawm BDNF ntawm theem molecular. Qhov kev hloov pauv ntawm kev qhia tawm cov noob caj noob ces no txhawb nqa lub luag haujlwm ntawm 7,8-DHF hauv kev txhawb nqa kev noj qab haus huv ntawm lub hlwb.

7,8-Dihydroxyflavone (7,8-DHF) yog ib qho monophenolic flavonoid uas muaj ntau yam teebmeem. Nws ua haujlwm ua tus agonist rau lub neurotrophic tyrosine kinase receptor TrkB (Kd = 320nM) thiab tiv thaiv TrkB-expressing neurons los ntawm apoptosis. Lub hlwb-derived neurotrophic factor (BDNF) yog ib qho protein nrog neurotrophic teebmeem uas tseem ceeb rau kev tsim lub hlwb, kev kawm thiab kev nco.

• Kev tiv thaiv lub hlwb: 7,8-DHF yog neuroprotective hauv cov qauv tsiaj ntawm Parkinson tus kab mob, txhawb kev kawm ntawm kev xav hauv nas thiab thim rov qab qhov tsis nco qab hauv cov qauv nas ntawm Alzheimer tus kab mob, thiab tseem tuaj yeem txhim kho kev ua haujlwm ntawm lub cev thiab ua kom lub sijhawm ciaj sia ntawm cov qauv tsiaj uas muaj mob ntev dua. BDNF tuaj yeem txhim kho neuroplasticity thiab neuron ciaj sia, pab lub hlwb tsim cov kev sib txuas neural tshiab, kho cov hlwb hlwb uas tsis ua haujlwm, thiab tiv thaiv cov hlwb hlwb noj qab haus huv. Nws yog qhov tseem ceeb rau kev tsim lub hlwb, kev kawm thiab kev nco qab, thiab tuaj yeem tiv thaiv lub hlwb ntawm kev puas tsuaj ntawm kev paub txog hnub nyoog. Txo qis hauv kev muaj peev xwm paub thiab tiv thaiv cov kab mob neurodegenerative xws li Alzheimer tus kab mob thiab Parkinson tus kab mob.

• Tswj kev ciaj sia ntawm cov hlab ntsha hauv lub hlwb: 7,8-DHF tuaj yeem khi rau TrkB thiab ua kom cov kev taw qhia downstream, xws li PI3K/Akt thiab MAPK/ERK txoj kev. Kev ua kom cov kev taw qhia no yog qhov tseem ceeb rau kev txhawb nqa kev ciaj sia ntawm cov hlab ntsha hauv lub hlwb, kev loj hlob thiab kev hloov pauv ntawm cov hlwb. Qhov tseem ceeb. BDNF kuj yog ib qho neurotrophic factor uas tuaj yeem ua kom cov kev taw qhia intracellular los ntawm kev khi rau TrkB receptors thiab txhawb kev ciaj sia thiab kev loj hlob ntawm cov hlab ntsha.

• Txhawb kom muaj kev hloov pauv ntawm cov synaptic: 7,8-DHF tuaj yeem txhawb kev tsim thiab kev txhawb zog ntawm cov synapses los ntawm kev ua kom TrkB receptors ua haujlwm, yog li txhim kho kev ua haujlwm ntawm kev sib kis synaptic. BDNF kuj tseem xav tias txhawb kev tsim thiab kev txhawb zog ntawm cov synapses, yog li ua kom muaj kev ua haujlwm ntawm kev sib kis synaptic thiab yog li txhim kho kev kawm thiab kev nco qab.

• Cov teebmeem rau kev kawm thiab kev nco qab: 7,8-DHF tuaj yeem txhim kho kev kawm thiab kev nco qab hauv nas, uas tej zaum yuav muaj feem cuam tshuam nrog nws cov teebmeem rau kev ciaj sia ntawm cov neuronal thiab kev hloov pauv ntawm synaptic. BDNF kuj tseem ua lub luag haujlwm tseem ceeb hauv kev kawm thiab kev nco qab los ntawm kev txhawb nqa kev ciaj sia ntawm cov neurons thiab kev tsim cov synapses, yog li txhim kho kev kawm thiab kev nco qab.

• Hloov kho tus cwj pwm: 7,8-DHF muaj cov teebmeem hloov kho tus cwj pwm, uas tej zaum yuav muaj feem cuam tshuam nrog nws cov teebmeem rau kev ciaj sia ntawm cov neurons thiab kev hloov pauv ntawm synaptic. BDNF kuj tseem xav tias ua lub luag haujlwm hauv kev tswj hwm kev xav los ntawm kev tswj hwm kev ciaj sia ntawm cov neurons thiab kev tsim cov synapses, yog li cuam tshuam rau kev qhia tawm ntawm kev xav.

Hauv kev xaus lus, 7,8-DHF thiab BDNF muaj cov txheej txheem ua haujlwm zoo sib xws hauv kev tiv thaiv neuroprotection, tswj kev ciaj sia ntawm neuronal, txhawb kev hloov pauv synaptic, cuam tshuam rau kev kawm thiab kev nco, thiab tswj kev xav.

Suzhou Myland Pharm & Nutrition Inc. yog ib lub chaw tsim khoom uas tau sau npe los ntawm FDA uas muab cov khoom zoo thiab ntshiab 7,8-Dihydroxyflavone.

Ntawm Suzhou Myland Pharm peb cog lus tias yuav muab cov khoom zoo tshaj plaws rau tus nqi zoo tshaj plaws. Peb 7,8-Dihydroxyflavone raug kuaj xyuas kom huv si thiab muaj zog, kom ntseeg tau tias koj tau txais cov tshuaj zoo uas koj ntseeg siab tau. Txawm koj xav txhawb kev noj qab haus huv ntawm tes, txhawb koj lub cev tiv thaiv kab mob lossis txhim kho kev noj qab haus huv tag nrho, peb 7,8-Dihydroxyflavone yog qhov kev xaiv zoo tshaj plaws.

Nrog 30 xyoo ntawm kev paub dhau los thiab tsav los ntawm cov thev naus laus zis siab thiab cov tswv yim R&D zoo tshaj plaws, Suzhou Myland Pharm tau tsim ntau yam khoom sib tw thiab dhau los ua lub tuam txhab tsim khoom noj khoom haus tshiab, kev tsim khoom tshwj xeeb thiab kev tsim khoom.

Ntxiv rau qhov ntawd, Suzhou Myland Pharm kuj yog ib lub chaw tsim khoom uas tau sau npe los ntawm FDA. Lub tuam txhab cov peev txheej R&D, cov chaw tsim khoom, thiab cov cuab yeej siv tshuaj ntsuam xyuas yog niaj hnub thiab muaj ntau yam, thiab tuaj yeem tsim cov tshuaj los ntawm milligrams mus rau tons hauv qhov ntsuas, thiab ua raws li ISO 9001 cov qauv thiab cov lus qhia tsim khoom GMP.