Hauv lub ntiaj teb kev noj qab haus huv thiab kev nyob zoo uas tab tom loj hlob zuj zus, NAD+ tau dhau los ua ib lo lus nrov, nyiam cov kws tshawb fawb thiab cov neeg nyiam kev noj qab haus huv. Tab sis NAD+ yog dab tsi tiag? Vim li cas nws thiaj tseem ceeb rau koj txoj kev noj qab haus huv? Cia peb kawm ntxiv txog cov ntaub ntawv tseem ceeb hauv qab no!
NAD+ yog dab tsi?
Lub npe scientific ntawm NAD yog nicotinamide adenine dinucleotide. NAD+ muaj nyob hauv txhua lub cell ntawm peb lub cev. Nws yog ib qho tseem ceeb metabolite thiab coenzyme hauv ntau txoj kev metabolic. Nws yog tus neeg nruab nrab thiab koom nrog ntau yam txheej txheem biological. Ntau tshaj 300 enzymes vam khom NAD+ kom ua haujlwm.
NAD+yog lus Askiv luv ntawm Nicotinamide adenine dinucleotide. Nws lub npe tag nrho hauv Suav yog nicotinamide adenine dinucleotide, lossis Coenzyme I luv. Ua ib qho coenzyme uas xa cov hydrogen ions, NAD + ua lub luag haujlwm hauv ntau yam ntawm tib neeg lub cev metabolism, suav nrog glycolysis, Gluconeogenesis, tricarboxylic acid cycle, thiab lwm yam. Qee qhov kev tshawb fawb tau taw qhia tias qhov kev poob qis ntawm NAD + yog cuam tshuam nrog hnub nyoog, thiab cov txheej txheem physiological mediated los ntawm NAD + yog cuam tshuam nrog kev laus, cov kab mob metabolic, neuropathy thiab mob qog noj ntshav, suav nrog kev tswj hwm cell homeostasis, sirtuins hu ua "longevity genes", kho DNA, PARPs tsev neeg cov protein cuam tshuam nrog necroptosis thiab CD38 uas pab hauv calcium signaling.
NAD+ ua haujlwm zoo li lub tsheb thauj neeg, nqa cov electrons los ntawm ib lub molecule cell mus rau lwm lub. Ua ke nrog nws cov molecular counterpart NADH, nws koom nrog ntau yam kev hloov pauv metabolic los ntawm kev sib pauv electron uas tsim adenosine triphosphate (ATP), lub cev "zog" molecule.
Hais yooj yim xwb, NAD+ yog qhov tseem ceeb rau kev tswj lub cev kom noj qab haus huv thiab sib npaug. Kev ua haujlwm ntawm lub cev, kev hloov pauv redox, kev saib xyuas thiab kho DNA, kev ruaj khov ntawm cov noob caj noob ces, kev tswj hwm epigenetic, thiab lwm yam. txhua yam xav tau kev koom tes ntawm NAD+.
Yog li ntawd, peb lub cev muaj kev xav tau siab rau NAD +. NAD + raug tsim tawm tas li, rhuav tshem thiab rov ua dua tshiab hauv cov hlwb kom tswj tau cov theem NAD + ruaj khov.
NAD+ yog ib qho tseem ceeb ntawm kev ua haujlwm ntawm tes thiab koom nrog kev muab zog thiab kho DNA, ob qho tib si muaj feem cuam tshuam nrog kev laus noj qab haus huv.
1) Nws muaj ntau yam nyob rau hauv txhua lub cell ntawm tib neeg lub cev thiab koom nrog ntau txhiab qhov kev tshuaj tiv thaiv biocatalytic. Nws tuaj yeem txhawb kev ua haujlwm ntawm cov suab thaj, rog thiab amino acids, thiab koom nrog kev tsim lub zog. Nws yog ib qho coenzyme tseem ceeb uas tsim nyog rau tib neeg lub cev.
2) NAD+ yog tib lub substrate rau cov enzymes uas siv coI (tib lub substrate rau DNA kho enzyme PARP, tib lub substrate rau cov protein Sirtuins uas kav ntev, thiab tib lub substrate rau cyclic ADP ribose synthase CD38/157).
Txawm li cas los xij, thaum muaj hnub nyoog ntau zuj zus, qib NAD + hauv lub cev yuav txo qis sai sai. Nws yuav txo qis 50% txhua 20 xyoo. Thaum yuav luag muaj 40 xyoo, cov ntsiab lus NAD + hauv tib neeg lub cev tsuas yog 25% ntawm qhov nws muaj nyob rau hauv cov menyuam yaus.
Yog tias tib neeg lub hlwb tsis muaj NAD +, mitochondrial dysfunction txo qis, DNA puas tsuaj kho tau txo qis, thiab cov protein gene tsev neeg Sirtuin kuj tsis ua haujlwm, thiab lwm yam. Cov yam tsis zoo no tuaj yeem ua rau apoptosis, kab mob tib neeg, laus thiab txawm tias tuag.
Lub Luag Haujlwm ntawm NAD + hauv Koj Txoj Kev Noj Qab Haus Huv Tag Nrho
Tiv thaiv kev laus
NAD + tswj kev sib txuas lus tshuaj ntawm lub nucleus thiab mitochondria, thiab kev sib txuas lus tsis muaj zog yog qhov tseem ceeb ua rau lub hlwb laus.
NAD + tuaj yeem tshem tawm cov lej DNA tsis raug uas nce ntxiv thaum lub sijhawm ua haujlwm ntawm lub cell, tswj kev qhia tawm ntawm cov noob caj noob ces, tswj kev ua haujlwm ib txwm ntawm cov cell, thiab qeeb qeeb kev laus ntawm tib neeg cov cell.
Kho cov DNA puas tsuaj
NAD+ yog ib qho tseem ceeb rau cov enzyme kho DNA PARP, uas muaj feem cuam tshuam loj heev rau kev kho DNA, kev qhia txog gene, kev loj hlob ntawm cell, kev ciaj sia ntawm cell, kev tsim kho chromosome, thiab kev ruaj khov ntawm gene.
Qhib cov protein kom muaj sia nyob ntev
Sirtuins feem ntau hu ua tsev neeg protein ntev thiab ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm ntawm lub hlwb, xws li kev o, kev loj hlob ntawm lub hlwb, circadian rhythm, kev hloov pauv zog, kev ua haujlwm ntawm neuronal, thiab kev tiv thaiv kev ntxhov siab, thiab NAD + yog ib qho enzyme tseem ceeb rau kev tsim cov protein ntev.
Ua kom tag nrho 7 cov protein uas ua rau lub cev ntev ntev hauv tib neeg lub cev, ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kev ntxhov siab ntawm tes, kev ua kom lub zog metabolism, tiv thaiv kev hloov pauv ntawm tes, apoptosis thiab kev laus.
Muab zog
Nws ua rau muaj zog ntau dua 95% ntawm lub zog uas xav tau rau kev ua neej. Mitochondria hauv tib neeg lub hlwb yog cov chaw tsim hluav taws xob ntawm cov hlwb. NAD + yog ib qho coenzyme tseem ceeb hauv mitochondria los tsim cov zog molecule ATP, hloov cov as-ham mus rau hauv lub zog uas tib neeg lub cev xav tau.
Txhawb kom cov hlab ntsha rov qab zoo thiab tswj cov hlab ntsha elasticity
Cov hlab ntsha yog cov nqaij uas tseem ceeb rau kev ua neej. Thaum peb laus zuj zus, cov hlab ntsha maj mam poob lawv qhov kev ywj pheej thiab ua rau tawv, tuab dua, thiab nqaim dua, ua rau "arteriosclerosis."
NAD + tuaj yeem ua rau kom muaj kev ua haujlwm ntawm elastin hauv cov hlab ntsha, yog li ntawd tswj tau qhov elasticity ntawm cov hlab ntsha thiab tswj kev noj qab haus huv ntawm cov hlab ntsha.
Txhawb kev zom zaub mov
Kev ua haujlwm ntawm lub cev yog kev sib sau ua ke ntawm ntau yam tshuaj lom neeg hauv lub cev. Lub cev yuav txuas ntxiv pauv cov khoom thiab lub zog. Thaum qhov kev sib pauv no nres, lub neej ntawm lub cev kuj yuav xaus.
Xibfwb Anthony thiab nws pab neeg tshawb fawb ntawm University of California, Tebchaws Meskas, pom tias NAD + tuaj yeem txhim kho qhov qeeb ntawm cov metabolism hauv lub hlwb uas cuam tshuam nrog kev laus, yog li txhim kho tib neeg txoj kev noj qab haus huv thiab ntev lub neej.
Tiv thaiv kev noj qab haus huv ntawm lub plawv
Lub plawv yog lub cev tseem ceeb tshaj plaws ntawm tib neeg, thiab NAD + theem hauv lub cev ua lub luag haujlwm tseem ceeb hauv kev tswj hwm kev ua haujlwm ib txwm ntawm lub plawv.
Qhov kev txo qis ntawm NAD + tej zaum yuav muaj feem cuam tshuam nrog pathogenesis ntawm ntau yam kab mob plawv, thiab ntau qhov kev tshawb fawb yooj yim kuj tau lees paub qhov cuam tshuam ntawm kev ntxiv NAD + rau cov kab mob plawv.
Tiv thaiv cov kab mob plawv thiab cov kab mob cerebrovascular
Cov kev tshawb fawb tau qhia tias yuav luag txhua xya hom subtypes ntawm sirtuins (SIRT1-SIRT7) muaj feem cuam tshuam nrog kev tshwm sim ntawm cov kab mob plawv. Sirtuins raug suav hais tias yog cov hom phiaj agonistic rau kev kho cov kab mob plawv, tshwj xeeb tshaj yog SIRT1.
NAD+ yog tib lub substrate rau Sirtuins. Kev ntxiv NAD+ rau lub cev tib neeg raws sijhawm tuaj yeem ua kom txhua hom Sirtuins ua haujlwm tau zoo, yog li tiv thaiv kev noj qab haus huv ntawm lub plawv thiab tiv thaiv cov kab mob plawv.
Txhawb kev loj hlob ntawm cov plaub hau
Qhov ua rau plaub hau poob yog qhov poob ntawm lub zog ntawm cov hlwb niam ntawm cov plaub hau, thiab qhov poob ntawm lub zog ntawm cov hlwb niam ntawm cov plaub hau yog vim tias NAD + theem hauv tib neeg lub cev txo qis. Cov hlwb niam ntawm cov plaub hau tsis muaj ATP txaus los ua cov protein tsim rau plaub hau, yog li ntawd poob lawv lub zog thiab ua rau plaub hau poob.
Yog li ntawd, kev ntxiv NAD + tuaj yeem ua kom lub voj voog acid thiab tsim ATP, yog li cov plaub hau niam muaj peev xwm txaus los tsim cov protein plaub hau, yog li txhim kho kev poob plaub hau.
Yuav Tau Beta-NAD+ Tshuaj Ntxiv Qhov Twg Kom Muaj Kev Nyab Xeeb Hauv Online
Suzhou Myland Pharm & Nutrition Inc. yog ib lub chaw tsim khoom uas tau sau npe los ntawm FDA uas muab cov hmoov NAD+ Supplement zoo thiab huv si.
Ntawm Suzhou Myland Pharm peb cog lus tias yuav muab cov khoom zoo tshaj plaws rau tus nqi zoo tshaj plaws. Peb cov hmoov NAD+ Supplement tau raug kuaj xyuas kom huv si thiab muaj zog, kom ntseeg tau tias koj tau txais cov tshuaj zoo uas koj ntseeg siab tau. Txawm koj xav txhawb kev noj qab haus huv ntawm tes, txhawb koj lub cev tiv thaiv kab mob lossis txhim kho kev noj qab haus huv tag nrho, peb cov hmoov NAD+ Supplement yog qhov kev xaiv zoo tshaj plaws.
Nrog 30 xyoo ntawm kev paub dhau los thiab tsav los ntawm cov thev naus laus zis siab thiab cov tswv yim R&D zoo tshaj plaws, Suzhou Myland Pharm tau tsim ntau yam khoom sib tw thiab dhau los ua lub tuam txhab tsim khoom noj khoom haus tshiab, kev tsim khoom tshwj xeeb thiab kev tsim khoom.
Ntxiv rau qhov ntawd, Suzhou Myland Pharm kuj yog ib lub chaw tsim khoom uas tau sau npe los ntawm FDA. Lub tuam txhab cov peev txheej R&D, cov chaw tsim khoom, thiab cov cuab yeej siv tshuaj ntsuam xyuas yog niaj hnub thiab muaj ntau yam, thiab tuaj yeem tsim cov tshuaj los ntawm milligrams mus rau tons hauv qhov ntsuas, thiab ua raws li ISO 9001 cov qauv thiab cov lus qhia tsim khoom GMP.
Lus Ceeb Toom: Tsab xov xwm no tsuas yog rau cov ntaub ntawv dav dav xwb thiab yuav tsum tsis txhob txhais hais tias yog cov lus qhia kho mob. Qee cov ntaub ntawv hauv blog los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, tsim hom ntawv thiab kho cov ntawv xwb. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntxiv tsis tau txhais hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Ib txwm sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Lub sijhawm tshaj tawm: Cuaj hlis-19-2024
