spermidine yog dab tsi? Ib qho yooj yim qhia rau spermidine

Spermidineyog ib hom polyamine. Polyamines yog me me, fatty, polycationic (-NH3 +) biomolecules. Muaj plaub lub ntsiab polyamines hauv cov tsiaj txhu: spermine, spermidine, putrescine thiab cadaverine. Spermine belongs rau tetramines, spermidine belongs rau triamines, putrescine thiab cadaverine belongs rau diamines. Cov lej sib txawv ntawm cov amino pawg muab lawv sib txawv physiological zog.

Spermidine hauv tib neeg

Spermidine tsis tsuas yog muaj nyob rau hauv cov phev, tab sis kuj dav faib nyob rau hauv lwm cov ntaub so ntswg thiab hlwb ntawm tib neeg lub cev. Intracellular spermidine concentration feem ntau yog nyob ntawm plaub yam:

①Intracellular synthesis:

Arginine → putrescine → spermidine ← spermine. Arginine yog cov khoom siv tseem ceeb rau kev tsim cov spermidine hauv cov hlwb. Nws yog catalyzed los ntawm arginase los tsim ornithine thiab urea. Ornithine yog siv los tsim putrescine nyob rau hauv qhov kev txiav txim ntawm ornithine decarboxylase (ODC1). Qhov no yog cov kauj ruam txwv tus nqi), putrescine generates spermidine nyob rau hauv qhov kev txiav txim ntawm spermidine synthase (SPDS). Spermidine kuj tuaj yeem tsim los ntawm kev degradation ntawm spermine.

② Extracellular uptake:

Muab faib ua zaub mov noj thiab plab hnyuv microbial synthesis. Cov zaub mov uas muaj cov spermidine muaj xws li cov noob nplej, natto, taum pauv, nceb, thiab lwm yam. Spermine thiab spermidine noj los ntawm cov khoom noj tau sai sai absorbed los ntawm cov hnyuv thiab faib tsis muaj degradation, yog li cov concentration ntawm spermidine nyob rau hauv cov ntshav yog Concentrations muaj ntau haiv neeg. Cov kab mob probiotic nyob rau hauv plab hnyuv microbiota xws li Bifidobacterium tuaj yeem tsim cov spermidine.

③Catabolism:

Spermine hauv lub cev yog maj mam decomposed rau hauv spermidine thiab putrescine los ntawm N1-acetyltransferase (SSAT), polyamine oxidase (PAO) thiab lwm yam amine oxidases, thaum putrescine yog ntxiv hloov mus rau hauv aminobutyric acid los ntawm oxidases. Thaum kawg, amine ions thiab carbon dioxide raug tsim tawm thiab tawm ntawm lub cev.

④ Hnub nyoog:

Qhov concentration ntawm spermidine hloov nrog lub hnub nyoog. Cov kws tshawb fawb tau ntsuas qhov concentration ntawm polyamines nyob rau hauv ntau yam ntaub so ntswg thiab kabmob ntawm 3-lub lis piam-hnub, 10-lub lim tiam-hnub thiab 26-lub lim tiam nas thiab pom tias nws yog ib qho tseem ceeb tswj nyob rau hauv lub pancreas, hlwb thiab lub tsev menyuam. Cov kev hloov hauv txoj hnyuv txo qis me ntsis nrog lub hnub nyoog, thiab txo qis hauv thymus, spleen, zes qe menyuam, siab, plab, ntsws, lub raum, lub plawv thiab cov leeg. Nws tsis yog qhov nyuaj rau peb xav tias vim li cas rau qhov kev hloov pauv no suav nrog kev hloov pauv kev noj haus, kev hloov hauv plab hnyuv cov qauv, txo cov haujlwm ntawm polyamine synthase, thiab lwm yam.

Lub hom phiaj ntawm spermidine

Vim li cas thiaj li yooj yim me me molecule yog ib yam tseem ceeb ntawm tib neeg lub cev? Qhov zais cia tiag tiag nyob hauv nws cov qauv: Spermidine yog polycationic (-NH3 +) fatty amine me me molecule uas muaj nyob rau hauv ntau daim ntawv protonated nyob rau hauv lub cev pH, nrog zoo ions faib thoob plaws hauv cov saw hlau. Hluav taws xob nqi, muaj zog physiological kev ua si.

Yog li ntawd, txawm tias nws yog nucleic acids, phospholipids, acidic proteins uas muaj acidic residues, pectic polysaccharides uas muaj carboxyl pawg thiab sulfates, los yog neurotransmitters thiab cov tshuaj hormones (dopamine, epinephrine, serotonin, thyroid hormone, thiab lwm yam) nrog cov qauv zoo sib xws, muaj peev xwm ua tau lub hom phiaj rau spermidine. kev khi. Qhov tseem ceeb tshaj yog:

① Nucleic acid:

Cov kev tshawb fawb tau pom tias feem ntau cov polyamines muaj nyob rau hauv daim ntawv ntawm polyamine-RNA complexes nyob rau hauv lub hlwb, nrog 1-4 sib npaug ntawm polyamine khi rau 100 qhov sib npaug ntawm phosphate tebchaw. Yog li, lub luag haujlwm tseem ceeb ntawm spermidine muaj feem xyuam rau cov qauv kev hloov pauv thiab kev txhais lus ntawm RNA, xws li cuam tshuam rau ntau theem ntawm cov protein synthesis los ntawm kev cuam tshuam cov qauv theem nrab ntawm mRNA, tRNA thiab rRNA. Spermidine tseem tuaj yeem tsim "txhim kho" ntawm ob-helical DNA strands, txo cov kev nkag mus tau ntawm cov dawb radicals lossis lwm yam DNA ua kom puas, thiab tiv thaiv DNA los ntawm thermal denaturation thiab X-ray hluav taws xob.

② Protein:

Spermidine tuaj yeem khi rau cov protein uas nqa cov nqi tsis zoo thiab hloov pauv qhov sib txawv ntawm cov protein, yog li cuam tshuam rau nws txoj haujlwm physiological. Piv txwv suav nrog cov protein kinases / phosphatase (ib qho tseem ceeb txuas hauv ntau txoj hauv kev xa cov teeb liab), enzymes koom nrog hauv histone methylation thiab acetylation ( cuam tshuam cov noob qhia los ntawm kev hloov cov epigenetics), acetylcholinesterase (ib qho tseem ceeb ntawm cov kab mob neurodegenerative). ib qho ntawm cov tshuaj kho mob), ion channel receptors (xws li AMPA, AMDA receptors), thiab lwm yam.

Suzhou Myland yog FDA sau npe chaw tsim tshuaj paus muab cov khoom zoo thiab siab purity Spermidine hmoov.

Ntawm Suzhou Myland, peb tau cog lus los muab cov khoom zoo tshaj plaws ntawm tus nqi zoo tshaj. Peb cov Spermidine hmoov yog nruj me ntsis soj ntsuam rau purity thiab potency, kom ntseeg tau tias koj tau txais cov khoom zoo uas koj tuaj yeem ntseeg tau. Txawm hais tias koj xav txhawb kev noj qab haus huv ntawm tes, txhawb koj lub cev tiv thaiv kab mob lossis txhim kho kev noj qab haus huv tag nrho, peb cov hmoov Spermidine yog qhov kev xaiv zoo tshaj.

Nrog 30 xyoo ntawm kev paub thiab tsav los ntawm cov cuab yeej siv siab thiab lub tswv yim zoo R&D, Spermidine tau tsim ntau yam khoom sib tw los ua ib qho kev tshawb fawb txog lub neej tshiab, kev cai synthesis thiab kev tsim cov tuam txhab.

Tsis tas li ntawd, Suzhou Myland kuj yog ib lub chaw tsim tshuaj paus FDA. Lub tuam txhab R & D cov peev txheej, cov chaw tsim khoom, thiab cov cuab yeej tshuaj ntsuam xyuas yog niaj hnub thiab muaj ntau yam, thiab muaj peev xwm tsim tau cov tshuaj los ntawm milligrams mus rau tons hauv nplai, thiab ua raws li ISO 9001 cov qauv thiab cov khoom specifications GMP.