Spermidine yog dab tsi? Ib phau ntawv qhia yooj yim txog spermidine

Spermidineyog ib hom polyamine. Polyamines yog cov me me, rog, polycationic (-NH3 +) biomolecules. Muaj plaub lub polyamines tseem ceeb hauv cov tsiaj txhu: spermine, spermidine, putrescine thiab cadaverine. Spermine yog cov tetramines, spermidine yog cov triamines, putrescine thiab cadaverine yog cov diamines. Cov lej sib txawv ntawm cov amino pawg muab rau lawv cov khoom sib txawv ntawm lub cev.

Spermidine hauv tib neeg

Spermidine tsis yog tsuas muaj nyob hauv cov phev xwb, tab sis kuj tseem muaj ntau nyob rau hauv lwm cov nqaij thiab cov qe ntawm tib neeg lub cev. Qhov concentration ntawm cov spermidine hauv cov qe feem ntau nyob ntawm plaub yam tseem ceeb:

① Kev tsim cov hlwb hauv lub cev:

Arginine → putrescine → spermidine ← spermine. Arginine yog cov khoom siv tseem ceeb rau kev tsim cov spermidine hauv cov hlwb. Nws yog catalyzed los ntawm arginase los tsim ornithine thiab urea. Ornithine ces siv los tsim putrescine nyob rau hauv qhov kev ua ntawm ornithine decarboxylase (ODC1). Qhov no yog cov kauj ruam txwv tus nqi), putrescine tsim spermidine nyob rau hauv qhov kev ua ntawm spermidine synthase (SPDS). Spermidine kuj tseem tuaj yeem tsim los ntawm kev puas tsuaj ntawm spermine.

② Kev nqus ntawm cov hlwb sab nraud:

Muab faib ua cov khoom noj thiab cov kab mob hauv plab hnyuv. Cov khoom noj uas muaj spermidine suav nrog cov noob nplej, natto, taum pauv, nceb, thiab lwm yam. Spermine thiab spermidine uas noj los ntawm cov khoom noj tau nqus sai sai los ntawm cov hnyuv thiab faib tawm yam tsis muaj kev puas tsuaj, yog li qhov concentration ntawm spermidine hauv cov ntshav yog qhov sib txawv heev. Cov kab mob probiotic hauv cov kab mob hauv plab hnyuv xws li Bifidobacterium kuj tuaj yeem tsim cov spermidine.

③Kev ua kom lub cev zom zaub mov qeeb:

Cov phev hauv lub cev maj mam decomposed mus ua spermidine thiab putrescine los ntawm N1-acetyltransferase (SSAT), polyamine oxidase (PAO) thiab lwm yam amine oxidases, thaum putrescine raug hloov mus ua aminobutyric acid los ntawm oxidases. Thaum kawg, amine ions thiab carbon dioxide raug tsim thiab tso tawm ntawm lub cev.

④Hnub Nyoog:

Qhov kev sib sau ua ke ntawm cov spermidine hloov pauv raws li hnub nyoog. Cov kws tshawb fawb ntsuas qhov kev sib sau ua ke ntawm cov polyamines hauv ntau cov nqaij thiab cov kab mob ntawm cov nas uas muaj 3 lub lis piam, 10 lub lis piam thiab 26 lub lis piam thiab pom tias nws tau khaws cia rau hauv lub txiav, lub hlwb thiab lub tsev menyuam. Kev hloov pauv hauv txoj hnyuv txo qis me ntsis raws li hnub nyoog, thiab txo qis ntau hauv thymus, spleen, ovary, siab, plab, ntsws, raum, plawv thiab cov leeg. Nws tsis nyuaj rau peb xav tias cov laj thawj rau qhov kev hloov pauv no suav nrog kev hloov pauv zaub mov, kev hloov pauv hauv cov qauv ntawm cov kab mob hauv plab, kev ua haujlwm txo qis ntawm polyamine synthase, thiab lwm yam.

Lub hom phiaj ntuj ntawm spermidine

Vim li cas ib lub molecule me me yooj yim no thiaj li yog ib yam khoom tseem ceeb rau tib neeg lub cev? Qhov zais cia tiag tiag yog nyob rau hauv nws cov qauv: Spermidine yog ib lub polycationic (-NH3+) fatty amine me me uas muaj nyob rau hauv daim ntawv multi-protonated nyob rau hauv physiological pH mob, nrog rau cov positive ions faib thoob plaws hauv cov saw hlau carbon. Fais fab them, muaj zog physiological kev ua ub no.

Yog li ntawd, txawm tias nws yog nucleic acids, phospholipids, acidic proteins uas muaj acidic residues, pectic polysaccharides uas muaj carboxyl pawg thiab sulfates, lossis neurotransmitters thiab cov tshuaj hormones (dopamine, epinephrine, serotonin, thyroid hormone, thiab lwm yam) nrog cov qauv zoo sib xws, Tej zaum yuav yog lub hom phiaj rau spermidine khi. Cov tseem ceeb dua yog:

① Cov kua qaub nucleic:

Cov kev tshawb fawb tau pom tias feem ntau cov polyamines muaj nyob rau hauv daim ntawv ntawm polyamine-RNA complexes hauv cov hlwb, nrog 1-4 sib npaug ntawm polyamine khi rau txhua 100 sib npaug ntawm cov phosphate compounds. Yog li ntawd, lub luag haujlwm tseem ceeb ntawm spermidine yog cuam tshuam nrog kev hloov pauv ntawm cov qauv thiab kev txhais lus ntawm RNA, xws li cuam tshuam rau ntau theem ntawm kev tsim cov protein los ntawm kev cuam tshuam rau cov qauv theem nrab ntawm mRNA, tRNA thiab rRNA. Spermidine kuj tseem tuaj yeem tsim cov "choj" ruaj khov ntawm ob-helical DNA strands, txo qhov nkag mus ntawm cov dawb radicals lossis lwm yam DNA-ua puas tsuaj, thiab tiv thaiv DNA los ntawm thermal denaturation thiab X-ray hluav taws xob.

②Cov protein:

Spermidine tuaj yeem khi rau cov protein uas muaj cov nqi tsis zoo loj thiab hloov pauv qhov chaw ntawm cov protein, yog li ntawd cuam tshuam rau nws txoj haujlwm ntawm lub cev. Piv txwv li suav nrog protein kinases / phosphatases (ib qho txuas tseem ceeb hauv ntau txoj kev xa xov), cov enzymes koom nrog histone methylation thiab acetylation (cuam tshuam rau kev qhia gene los ntawm kev hloov epigenetics), acetylcholinesterase (ib qho tseem ceeb ntawm cov kab mob neurodegenerative). ib qho ntawm cov tshuaj kho mob), ion channel receptors (xws li AMPA, AMDA receptors), thiab lwm yam.

Suzhou Myland yog lub chaw tsim khoom uas tau sau npe los ntawm FDA uas muab cov hmoov Spermidine zoo thiab huv si.

Ntawm Suzhou Myland, peb cog lus tias yuav muab cov khoom zoo tshaj plaws rau tus nqi zoo tshaj plaws. Peb cov hmoov Spermidine tau raug kuaj xyuas kom huv si thiab muaj zog, kom ntseeg tau tias koj tau txais cov tshuaj zoo uas koj ntseeg siab tau. Txawm koj xav txhawb kev noj qab haus huv ntawm tes, txhawb koj lub cev tiv thaiv kab mob lossis txhim kho kev noj qab haus huv tag nrho, peb cov hmoov Spermidine yog qhov kev xaiv zoo tshaj plaws.

Nrog 30 xyoo ntawm kev paub dhau los thiab tsav los ntawm cov thev naus laus zis siab thiab kev tshawb fawb thiab kev txhim kho zoo tshaj plaws, Spermidine tau tsim ntau yam khoom sib tw kom dhau los ua lub tuam txhab tsim khoom noj khoom haus tshiab, kev tsim khoom tshwj xeeb thiab kev tsim khoom.

Ntxiv mus, Suzhou Myland kuj yog ib lub chaw tsim khoom uas tau sau npe los ntawm FDA. Lub tuam txhab cov peev txheej R&D, cov chaw tsim khoom, thiab cov cuab yeej siv tshuaj ntsuam xyuas yog niaj hnub thiab muaj ntau yam, thiab muaj peev xwm tsim cov tshuaj los ntawm milligrams mus rau tons hauv qhov ntsuas, thiab ua raws li ISO 9001 cov qauv thiab cov lus qhia tsim khoom GMP.