Tam sim no nrhiav tau telomerase activator-cycloastraganol yog dab tsi?

Xyoo 1985, Greider et al. thawj zaug pom telomerase, thiab cov enzyme tshiab no tuaj yeem ntxiv DNA rov qab mus rau qhov kawg ntawm chromosomes kom tswj tau telomere ntev. Telomerase yog ib qho ribonucleoprotein complex uas nws catalytic core muaj xws li TERT thiab TERC, uas TERT yog tus yuam sij rau regulating telomerase kev ua. Telomere ntev txuas ntxiv luv thaum cov hlwb sib faib. Thaum nws ncav cuag tus nqi tseem ceeb, nws ua rau cov cim DNA puas tsuaj, ua rau lub voj voog luv luv ntawm tes thiab cov kab mob tsis ua haujlwm ntawm cov nqaij mos uas ua rau luv luv telomeres.

Xyoo 2010, Asmeskas tuam txhab Geron koom tes nrog Hong Kong University of Science thiab Technology ntawm kev tshawb fawb txog kev tshuaj ntsuam telomerase activators. Nws pom tiascycloastraganoltuaj yeem qhib telomerase kev ua haujlwm thiab txhawb nqa telomere txuas ntxiv. Qhov kev tshawb pom no nquag txhawb txoj kev loj hlob ntawm telomerase activators. Tshawb nrhiav kev nce qib thiab cov khoom lag luam cuam tshuam ntawm kev haus cawv astragalus. Cycloastragenol (CAG) yog tam sim no tsuas yog qhia telomerase activator ntawm cov khoom ntuj. Nws tuaj yeem tiv thaiv telomere luv luv thiab muaj kev tiv thaiv kev laus, tiv thaiv apoptosis, tiv thaiv fibrosis, kev tiv thaiv kab mob, txhawb kev loj hlob ntawm tes thiab kho qhov txhab, thiab lwm yam. Pharmacological teebmeem, yog li muaj peev xwm kho tau cov kab mob ntsig txog telomere dysfunction.

Cycloastragenol thiab kev laus

telomeres
Telomeres yog cov qauv tshwj xeeb ntawm qhov kawg ntawm chromosomes uas tiv thaiv chromosomes thiab luv nrog chromosome replication thiab cell division. Cells kuj muaj hnub nyoog li telomeres luv.

telomerase
Telomerase tuaj yeem tsim cov telomeres kom ruaj khov qhov ntev thiab cov qauv ntawm telomeres, yog li tiv thaiv chromosomes thiab ncua kev laus ntawm cellular.

Los tiv thaiv kev laus: Ib qho telomerase activator, uas ua rau muaj kev tiv thaiv kev laus los ntawm kev nce telomerase thiab yog li ncua qhov luv ntawm telomeres.

Telomeres yog lub kaus mom nyob rau ntawm qhov kawg ntawm cov chromosomes cell uas tiv thaiv lawv los ntawm kev puas tsuaj thaum lub sij hawm faib cell. Raws li cov hlwb txuas ntxiv sib faib, telomeres txuas ntxiv luv, mus txog qhov tseem ceeb uas cov hlwb yuav muaj hnub nyoog lossis tuag. Telomerase tuaj yeem txuas ntxiv qhov ntev ntawm telomeres, thiab lub neej ntev ntawm cov hlwb yuav nce ntxiv raws li.

Kev laus yog ib feem tseem ceeb ntawm lub neej; Txawm li cas los xij, cov kws tshawb fawb tab tom kawm ntau yam kev kho mob los sim zam qee qhov cuam tshuam ntawm kev laus, suav nrog kev kawm senolytics. Senolytics yog cov tebchaw uas tshem tawm cov senescent (aging) hlwb thiab tau pom tias txo cov teebmeem ntawm kev laus. Ib txoj kev tshawb fawb tshiab qhia tias cycloastraganol muaj kev tiv thaiv kev laus.

Txoj kev tshawb no, los ntawm Tuam Tshoj thiab luam tawm nyob rau hauv International Journal of Molecular Sciences, tsom rau senescent tib neeg lub hlwb thiab nas nrog hluav taws xob-induced senescence. Cycloastragenol txo cov hlwb tsis muaj kev cuam tshuam rau cov hlwb uas tsis yog senescent. Kev kho Cycloastragenol kuj tseem txo cov proteins hauv cov hlwb uas xav tau rau kev loj hlob ntawm tes thiab muaj sia nyob. Tsis tas li ntawd, nws inhibits cell txav cuam tshuam nrog lub hnub nyoog txog kev mob hlwb thiab cov txheej txheem. Cov nas muaj hnub nyoog kho nrog cycloastraganol tau pom tias muaj cov hlwb tsawg dua thiab txhim kho lub hnub nyoog ntsig txog lub cev tsis ua haujlwm.

Cycloastragenol txo cov hlwb senescent

Senescence yog ib qho kev paub txog kev laus, tab sis cov kws tshawb fawb tau pom tias tshem tawm cov hlwb senescent thiab lawv cov pro-inflammatory signaling molecules tuaj yeem pab tiv thaiv cov kab mob uas muaj hnub nyoog thiab tseem thim rov qab rau qee kis. Ntawm no, cov kws tshawb fawb tau kho tib neeg cov hlwb nrog cycloastraganol thiab pom tias nws tshem tawm cov hlwb tsis muaj zog tsis cuam tshuam rau cov hlwb uas tsis yog senescent. Tsis tas li ntawd, cov cim cellular ntawm senescent hlwb tau txo qis tom qab kev kho cycloastraganol.

Kev tshawb fawb yav dhau los tau pom tias txoj hauv kev PI3K / AKT / mTOR - ib txoj hauv kev qhia txog kev loj hlob ntawm tes thiab kev ciaj sia - yog koom nrog cov txheej txheem inflammatory pib los ntawm cov hlwb senescent, pab txhawb kev loj hlob ntawm cov hlwb nyob ib puag ncig. Cov kws tshawb fawb pom tias cycloastragenol pab txo cov proteins hauv txoj hauv kev no, qhia tias qhov sib xyaw ua haujlwm tuaj yeem ua haujlwm los ntawm kev thaiv PI3K / AKT / mTOR txoj hauv kev los pab tiv thaiv kev laus. Tsis tas li ntawd, cycloastragenol tau pom tias txo qis lub peev xwm ntawm cov hlwb los txhawb kev laus los ntawm kev tso tawm cov inflammatory molecules, loj hlob yam, thiab immunomodulators, raws li cov lus qhia uas txo PI3K, AKT, thiab mTOR signaling yuav txo tau senescence-txhawb cov teebmeem ntawm ib puag ncig hlwb. .

Cycloastragenol belongs rau triterpene saponins thiab tsuas yog tau los ntawm hydrolysis ntawm astragaloside IV. Nws muaj qhov hnyav molecular me me thiab muaj zog lipophilicity, uas muaj txiaj ntsig zoo rau kev nkag mus rau biofilm thiab plab hnyuv nqus kom ua tiav bioavailability zoo dua. Kev ua tau zoo ntawm cycloastragalinol
1. Kev kho mob hlwb
2. Txhim kho daim siab fibrosis
3. Kev kho mob pob txha
4. Anti-aging nyhuv
5. ncua kev laus ntawm tes

Vim li cas nws thiaj li tsim nyog los ua ke cycloastraganol?

① Cycloastraganol muaj ntau yam teebmeem tshuaj xws li inhibiting hlwb cell apoptosis thiab neuroinflammation thaum lub sij hawm cerebral ischemia thiab tswj cov ntshav-hlwb barrier.
② Cycloastragenol yog tib lub me me molecule terpenoid compound nrog telomerase kev ua kom pom deb thiab tuaj yeem kho cov kab mob neurodegenerative.
③ Nws muaj cov teebmeem ntawm inhibiting myocardial fibrosis thiab pab txhawb kev tiv thaiv qog nqaij hlav. Nws yog ib tug nrov molecule nyob rau hauv kev tshawb fawb thiab kev loj hlob ntawm anti-aging tshuaj.

Cov teeb meem uas twb muaj lawm

Cov ntsiab lus ntawm cycloastraganol hauv Astragalus membranaceus yog tsawg heev thiab nws nyuaj rau tau txais nws ncaj qha. Lub tswv yim tsim tawm cycloastraganol uas twb muaj lawm vam khom cov tshuaj suav tshuaj rho tawm, uas feem ntau tau txais los ntawm kev hloov pauv astragaloside IV hauv Astragalus membranaceus. Ntawd yog, astragaloside IV yog tau los ntawm kev cog qoob loo astragalus thiab cov ntaub so ntswg kab lis kev cai, thiab tom qab ntawd astragaloside IV tau hloov mus rau hauv cycloastragaloside siv acidolysis, Smith degradation, enzyme thiab microbial hydrolysis. Txawm li cas los xij, cov txheej txheem kev npaj no yog kim, yooj yim ua rau ib puag ncig muaj kuab paug, nyuaj rau kev sib cais thiab ua kom huv, thiab tsis tsim nyog rau kev thov thiab kev txhawb nqa. Yog li ntawd, tib neeg tau tig lawv lub siab rau cov khoom siv dag zog ntawm cycloastraganol.

Yuav ua li cas siv hluavtaws biology los ua ke? --- Synthetic Biology

Synthetic Biology hais txog lub hom phiaj tsim, hloov pauv, thiab txawm tias tsim "lub neej cuav" nrog cov haujlwm tsis zoo raws li kev coj ua ntawm cov tswv yim engineering, uas yog, engineering ntawm biology. Feem ntau hais lus, nws yog tsim los ntawm kev siv tshuaj lom neeg.