7,8-Dihydroxyflavone (7,8-DHF) yog ib qho flavonoid uas tshwm sim los ntawm ntuj uas qhia txog kev cog lus hauv ntau qhov chaw ntawm kev noj qab haus huv. Yog tias koj xav tau cov tshuaj ntxiv lossis cov khoom xyaw noj haus uas yuav txhawb nqa kev noj qab haus huv ntawm lub hlwb, kev xav, thiab kev noj qab haus huv tag nrho, 7,8-DHF tej zaum yuav tsim nyog tshawb nrhiav. Cov hmoov 7,8-Dihydroxyflavone uas muab los ntawm Suzhou Myland muaj tus lej CAS ntawm 38183-03-8 thiab qhov huv si txog li 98%. Cov khoom tau dhau los ntawm kev tswj hwm zoo thiab ua raws li cov qauv thoob ntiaj teb, ua kom ntseeg tau tias cov khoom ua haujlwm tau zoo thiab muaj kev nyab xeeb. , tsim nyog rau kev tshawb fawb, kev tsim tshuaj, kev tsim khoom kho mob thiab lwm yam teb, muab rau koj nrog kev xaiv txhim khu kev qha.
7,8-Dihydroxyflavone (7,8-DHF)yog ib qho flavonoid compound uas tsis tshua muaj nyob hauv xwm. Nws tau pom muaj nyob rau hauv Astragalus pumila, Primula grandifolia thiab Hubei crabapple. tau tshwm sim ua ib qho nootropic compound cog lus. Nws tau ua pov thawj ntau yam ntawm cov teebmeem neuropharmacological hauv kev tshawb fawb preclinical,
Flavonoids yog ib pawg ntawm cov tshuaj polyphenolic uas pom muaj nyob rau hauv ntau yam txiv hmab txiv ntoo, zaub, thiab lwm yam nroj tsuag. Nyob rau hauv xyoo tas los no, lawv tau txais kev saib xyuas ntau vim lawv cov antioxidant, anti-inflammatory, thiab neuroprotective zog.
Cov tshuaj no tau pom tias muaj txiaj ntsig zoo rau lub hlwb, suav nrog kev txhim kho kev ua haujlwm ntawm kev paub thiab tiv thaiv cov kab mob neurodegenerative. 7,8-DHF yog ib qho ntawm cov tshuaj polyphenolic tseem ceeb tshaj plaws uas tau txais kev saib xyuas ntau ntxiv ua ib qho nootropic. Nws tau raug kawm txog nws cov teebmeem rau kev xav, kev nco, kev kawm, kev ntxhov siab, thiab lwm yam kev ua haujlwm ntawm kev paub.
Cov teebmeem ntawm 7,8-DHF hauv lub paj hlwb tau xav tias yog los ntawm nws txoj kev sib cuam tshuam nrog cov receptors tshwj xeeb. Nws tau pom tias yog TrkA, ib qho receptor uas koom nrog kev loj hlob ntawm cov hlab ntsha thiab tseem ceeb rau kev ciaj sia thiab kev hloov pauv ntawm cov hlab ntsha.
7,8-DHF ua haujlwm los ntawm kev tswj hwm kev qhia tawm ntawm ntau yam receptors, suav nrog glutamate receptor subunits thiab BDNF. Nws kuj tseem cuam tshuam rau kev tsim synapse, kev hloov pauv zog, thiab kev tso tawm acetylcholine hauv qee thaj chaw hauv lub hlwb.
Ntxiv mus, osteoporosis yog hu ua "tus neeg tua neeg ntsiag to" ntawm tib neeg lub cev, ua rau muaj kev hem thawj rau kev noj qab haus huv ntawm cov neeg hnub nyoog nruab nrab thiab cov neeg laus, tshwj xeeb tshaj yog cov poj niam postmenopausal. Nyob rau hauv cov xwm txheej ib txwm muaj, kev kho pob txha rov qab zoo li qub; tab sis thaum muaj kev tsis sib npaug ntawm kev tsim pob txha osteoblast thiab kev puas tsuaj ntawm pob txha osteoclast, thiab qhov ntau ntawm cov pob txha tsim tsis txaus los ntxiv rau cov pob txha uas nqus tau, cov pob txha yuav txo qis. , cov qauv me me ntawm cov pob txha raug rhuav tshem, ua rau osteoporosis.
7,8-Dihydroxyflavone (7,8-DHF) yog ib qho flavonoid uas tau los ntawm cov nroj tsuag uas tuaj yeem ua raws li kev ua haujlwm ntawm lub hlwb-derived neurotrophic factor (BDNF), ua rau dimerization ntawm TrkB receptors thiab ua kom nws cov downstream signaling molecules ua haujlwm. Cov kev tshawb fawb tau qhia tias BDNF tuaj yeem txhawb kev sib txawv ntawm osteoblast thiab kev tsiv teb tsaws chaw thiab ua kom cov pob txha kho sai dua.
7,8-DHF tuaj yeem txhawb kev loj hlob thiab kev sib txawv ntawm osteoblasts los ntawm kev sib cuam tshuam nrog TrkB thiab ua kom Wnt / β-catenin signaling pathway, thiab tuaj yeem tiv thaiv kev tsim cov osteoclasts los ntawm kev txo qis cov transcription factor c-fos; ntxiv rau, 7,8-DHF tuaj yeem txhim kho cov tsos mob osteoporosis hauv cov nas ovariectomized.
Cov qauv tshuaj lom neeg thiab cov khoom ntawm 7,8-dihydroxyflavone
Nws muaj ob pawg hydroxyl ntawm lub nplhaib benzene thiab ib pawg hydroxyl ntawm lub nplhaib pyrrolone. Cia peb saib ze dua ntawm cov qauv tshuaj ntawm 7,8-dihydroxyflavone:
Cov mis molecular ntawm 7,8-DHF yog C15H10O5, qhia tias nws muaj 15 carbon atoms, 10 hydrogen atoms, thiab 5 oxygen atoms.
7,8-Dihydroxyflavone yog ib qho khoom daj crystalline nrog lub molecular hnyav ntawm 286.24 g / mol. Nws yog me ntsis soluble hauv dej vim muaj ntau pawg hydroxyl uas tuaj yeem khi hydrogen rau cov dej molecules.
7,8-DHF Txoj kev ua haujlwm: kev tswj hwm BDNF thiab kev ua haujlwm ntawm Trkb receptor
Hais txog txoj kev ua haujlwm, 7,8-DHF paub tias txhawb kev tsim cov BDNF (lub hlwb-derived neurotrophic factor) los ntawm kev khi rau thiab ua kom nws lub receptor TrkB ua haujlwm. Tsis tas yuav ua kom yooj yim dhau, qhov no ua rau muaj ntau yam kev ua ub no hauv lub hlwb uas pab txhawb kev ua haujlwm ntawm lub paj hlwb thiab txhawb kev tsim cov hlwb.
Cia peb los saib ze dua ntawm 7,8-DHF txoj kev ua haujlwm tseem ceeb hauv qab no.
Lub hlwb-derived neurotrophic factor (BDNF) thiab nws lub luag haujlwm hauv neuroplasticity
Nrog rau kev tshawb pom tias qhov kev qhia tawm ntawm lub hlwb los ntawm neurotrophic factor (BDNF) raug txo qis hauv cov kab mob neurodegenerative, tshwj xeeb tshaj yog Alzheimer's tus kab mob (AD), nws qhov tseem ceeb hauv kev tswj hwm thiab txhim kho kev noj qab haus huv ntawm lub hlwb tau pom tseeb zuj zus.
BDNF tseem ceeb heev rau ntau yam kev ua haujlwm ntawm cov hlab ntsha vim nws txhawb nqa kev sib kis synaptic, synaptogenesis, thiab synaptic plasticity los ntawm kev xa xov nrog TrkB receptors. Qhov no ua rau BDNF-TrkB signaling pathway ua lub hom phiaj zoo rau kev txhim kho kev kho mob uas tsom mus rau kev tawm tsam cov kab mob neurodegenerative.
Cov kev tshawb fawb tsis ntev los no tau tshawb nrhiav txog cov txiaj ntsig ntawm cov tshuaj me me TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) hauv kev txo cov teebmeem thaum ntxov ntawm AD-cuam tshuam. Hauv kev tshawb fawb ntawm tus qauv nas 5xFAD ntawm AD, cov nas tau kho nrog 7,8-DHF rau ob lub hlis pib thaum muaj ib hlis.
Cov txiaj ntsig ntawm kev tshawb nrhiav no qhia tau tias 7,8-DHF muaj peev xwm kho tau cov kev hloov pauv ntawm cov tshuaj neurochemical thiab cov cim qhia txog AD. Qhov tseem ceeb, kev kho mob 7,8-DHF ua rau muaj kev txo qis ntawm cov plaque Aβ hauv cortical, uas yog ib qho cim tseem ceeb ntawm AD.
Ntxiv mus, nws tiv thaiv cov cortical neurons los ntawm kev txo qis hauv dendritic arbor complexity, pab tswj hwm tag nrho cov qauv neuronal. Txawm li cas los xij, nws tsis cuam tshuam rau qhov ceev ntawm dendritic spine.
Raws li Aytan, Nurgul thiab lwm tus, kev kho mob kuj tau qhia txog cov teebmeem neuroprotective hauv hippocampus, tiv thaiv cov qib siab ntawm cov tshuaj choline thiab txo qhov poob glutamate.
Txoj kev xa xov ntawm Tropomyosin receptor kinase B (Trkb) receptor
Xyoo 2010, pawg neeg ntawm Xibfwb Ye Keqiang ntawm Emory University tau tshaj tawm thawj zaug hauv Cov Txheej Txheem ntawm Lub Tsev Kawm Ntawv Qib Siab Hauv Tebchaws (PNAS) tias 7,8-DHF tuaj yeem siv ua tus agonist me me ntawm tropomyosin receptor kinase B (TrkB), uas tuaj yeem ua piv txwv txog kev ua haujlwm ntawm lub hlwb-derived neurotrophic factor (BDNF) ntxiv ua rau cov kev taw qhia signaling downstream ntawm TrkB, xws li MAPK/ERK, PI3K/Akt thiab PKC. Ntxiv mus, cov kev tshawb fawb tom qab ntawd pom tias 7,8-DHF tuaj yeem txo qhov kev rog rog ntau hauv cov nas poj niam los ntawm kev ua kom cov leeg nqaij pob txha TrkB ua haujlwm, qhia txog qhov sib txawv ntawm poj niam txiv neej.
Cov yam ntxwv neurotrophic uas los ntawm lub hlwb (BDNF) tuaj yeem txhawb kev sib txawv ntawm osteoblast, kev tsiv teb tsaws chaw thiab kev kho pob txha tawg. BDNF yog ib tug tswv cuab ntawm tsev neeg neurotrophic factor thiab tswj hwm ntau yam txheej txheem ntawm lub cev feem ntau los ntawm kev khi rau lub transmembrane receptor tyrosine kinase B (TrkB). Txawm li cas los xij, lub teeb liab TrkB uas BDNF ua rau muaj yog transient ntawm 10 feeb thiab nce mus txog qhov siab tshaj plaws ntawm 60 feeb. Txawm li cas los xij, BDNF muaj lub sijhawm luv luv thiab tsis tuaj yeem hla dhau cov ntshav-lub hlwb thaiv.
7,8-dihydroxyflavone (7,8-DHF) yog ib qho flavonoid uas tau los ntawm cov nroj tsuag uas muaj peev xwm kov yeej cov kev txwv saum toj no ntawm BDNF thiab tau txheeb xyuas tias yog ib qho BDNF mimetic ua haujlwm thiab tam sim no siv rau hauv ntau yam biochemical thiab cellular systems Nws tau txheeb xyuas tias nws tuaj yeem ua rau TrkB dimerization thiab ua kom nws cov downstream signaling molecules.
Tus tropomyosin receptor kinase B (TrkB) receptor ua lub luag haujlwm tseem ceeb hauv kev cuam tshuam cov teebmeem ntawm BDNF rau cov neurons. Ua tus transmembrane tyrosine kinase receptor, TrkB yog tus thawj receptor rau BDNF thiab pib ua ib qho cascade ntawm cov xwm txheej signaling intracellular thaum khi rau cov neurotrophic factors.
BDNF ua kom TrkB ua haujlwm los ua kom muaj ntau txoj hauv kev tseem ceeb hauv lub hlwb, suav nrog phosphatidylinositol 3-kinase (PI3K)-Akt, mitogen-activated protein kinase (MAPK)-extracellular signal-regulated kinase (ERK), thiab phospholipase Cγ (PLCγ)-protein kinase C (PKC) txoj hauv kev. Txhua txoj hauv kev no pab txhawb rau ib qho sib txawv ntawm kev ua haujlwm ntawm lub hlwb thiab kev noj qab haus huv.
Txoj kev PI3K-Akt yog qhov tseem ceeb rau kev txhawb nqa kev ciaj sia ntawm cov hlwb thiab tiv thaiv kev tuag ntawm cov hlwb. BDNF-TrkB signaling ua kom txoj kev no ua kom cov hlwb muaj sia nyob ntau ntxiv los ntawm kev txwv tsis pub cov yam ntxwv pro-apoptotic thiab txhawb cov yam ntxwv anti-apoptotic, yog li ua kom ntseeg tau tias cov hlwb noj qab haus huv zoo.
Ntawm qhov tod tes, txoj kev MAPK-ERK ua lub luag haujlwm tseem ceeb hauv kev sib txawv ntawm cov neuronal thiab kev loj hlob. BDNF-TrkB signaling txhawb kev ua haujlwm ntawm txoj kev MAPK-ERK, uas ua rau txhawb nqa kev loj hlob ntawm cov neuronal thiab kev sib txawv thiab lawv kev koom ua ke rau hauv cov tes hauj lwm neuronal uas twb muaj lawm.
Txoj kev PLCγ-PKC yog qhov tseem ceeb rau kev tswj hwm qhov synaptic plasticity, uas yog ib qho txheej txheem tseem ceeb ntawm kev kawm thiab kev nco. BDNF-TrkB signaling hloov kho qhov kev ua haujlwm ntawm txoj kev no, thaum kawg ua rau muaj kev hloov pauv hauv lub zog synaptic thiab kev sib txuas.
Qhov kev hloov kho no txhawb nqa kev hloov kho thiab kev rov tsim kho dua tshiab ntawm cov kab ke neural los teb rau cov kev paub tshiab thiab cov kev txhawb nqa ib puag ncig.
Cov khoom tiv thaiv hlwb
Kev tshawb fawb qhia tau hais tias cov flavonoid no tiv thaiv cov neurons ntawm kev ntxhov siab oxidative thiab apoptosis (programmed cell death). Kev ntxhov siab oxidative yog ib qho tseem ceeb hauv cov kab mob neurodegenerative xws li Alzheimer's thiab Parkinson's kab mob. Los ntawm kev tshem tawm cov free radicals thiab txo cov kev puas tsuaj oxidative, 7,8-DHF yuav pab tiv thaiv kev ncaj ncees thiab kev ua haujlwm ntawm neuronal.
Hauv kev tshawb nrhiav txog tsiaj txhu, 7,8-DHF tau pom tias ua rau lub hlwb ua haujlwm zoo dua thiab nco qab zoo dua. Piv txwv li, hauv cov qauv ntawm tus kab mob Alzheimer, 7,8-DHF tau pom tias ua rau lub hlwb ua haujlwm zoo dua, uas yog qhov tseem ceeb rau kev kawm thiab kev nco qab.
Cov nyhuv tiv thaiv kev o
Ntxiv rau nws cov khoom tiv thaiv neuroprotective, 7,8-dihydroxyflavone kuj muaj cov teebmeem tiv thaiv kev o. Kev o ntev yog ib qho ntawm ntau yam kab mob, suav nrog cov kab mob neurodegenerative. Los ntawm kev hloov kho txoj kev o, 7,8-DHF yuav pab txo qhov neuroinflammation, uas feem ntau cuam tshuam nrog kev poob qis ntawm kev paub.
Cov khoom tiv thaiv kab mob antioxidant: ROS scavenging thiab lipid peroxidation
7,8-DHF muaj cov khoom antioxidant raws li pov thawj los ntawm nws lub peev xwm los scavenge reactive oxygen species (ROS) thiab txo cov lipid peroxidation. Cov teebmeem no pab txhawb rau nws cov teebmeem neuroprotective los ntawm kev txo cov kev ntxhov siab oxidative ua rau neuronal puas tsuaj thiab ua haujlwm tsis zoo.
Cov kev tshawb fawb tau qhia tias 7,8-DHF tiv thaiv kev tsim cov cytokines pro-inflammatory thiab txo qhov ua haujlwm ntawm microglia, cov hlwb tiv thaiv kab mob hauv lub paj hlwb hauv nruab nrab. Cov nyhuv tiv thaiv kev o no tsis yog tsuas yog tiv thaiv cov neurons xwb tab sis kuj tsim kom muaj ib puag ncig zoo dua rau kev ua haujlwm ntawm lub hlwb.
Vim nws cov txiaj ntsig zoo rau kev noj qab haus huv ntawm lub hlwb, 7,8-dihydroxyflavone muaj peev xwm siv tau rau ntau qhov chaw ntawm kev noj qab haus huv thiab tshuaj. Qee qhov kev siv nto moo tshaj plaws suav nrog:
Kev sib sau ua ke thiab kev rov qab tau lub cim xeeb
7,8-DHF tau pom tias ua rau lub cim xeeb ruaj khov thiab rov qab tau ntau yam kev kawm thiab kev nco qab hauv cov qauv nas uas nyob ntawm hippocampus. Cov kev tshawb pom no qhia tias 7,8-DHF tej zaum yuav yog ib qho nootropic zoo rau kev txhim kho kev ua haujlwm nco qab hauv cov tib neeg noj qab haus huv thiab cov neeg uas muaj kev tsis nco qab.
Synaptic plasticity: lub zog mus sij hawm ntev thiab kev nyuaj siab
Raws li tau hais ua ntej lawm, 7,8-DHF tau pom tias yuav hloov kho qhov synaptic plasticity los ntawm kev txhawb nqa LTP thiab txo LTD hauv hippocampus. Cov teebmeem no tau xav tias yog los ntawm nws lub peev xwm los ua kom TrkB receptors qhib thiab tom qab ntawd txhim kho txoj kev BDNF signaling.
Qhov kev hloov pauv ntawm synaptic plasticity no pab txhawb rau kev txhim kho hauv kev ua haujlwm ntawm lub hlwb uas pom tom qab kev siv 7,8-DHF.
Kev txhim kho kev paub
Raws li tau hais ua ntej lawm, 7,8-DHF qhia tau tias muaj peev xwm txhim kho kev ua haujlwm ntawm lub hlwb thiab kev nco. Qhov no ua rau nws yog ib qho khoom noj khoom haus uas siv los txhim kho kev ua haujlwm ntawm lub hlwb, tshwj xeeb tshaj yog rau cov neeg laus lossis cov tib neeg uas muaj kev poob qis ntawm kev paub.
Kev Nqus Tau, Kev Faib Tawm, Kev Ua Haujlwm Hloov Pauv, thiab Kev Tso Tawm (ADME): 7,8-DHF muaj cov yam ntxwv zoo ntawm kev siv tshuaj, suav nrog kev nqus tau sai, kev faib tawm dav dav, thiab kev nkag mus rau hauv lub hlwb tau zoo. Nws feem ntau yog metabolized los ntawm lub siab, nrog rau feem ntau ntawm cov tshuaj raug tso tawm hauv cov quav thiab me me raug tso tawm hauv cov zis.
Kev nkag mus rau hauv cov ntshav thiab lub hlwb cov ntaub so ntswg thiab kev nkag mus rau hauv cov ntaub so ntswg ntawm lub hlwb. Ib qho ntawm cov yam ntxwv tseem ceeb ntawm 7,8-DHFyog nws lub peev xwm hla cov ntshav-lub hlwb thaiv (BBB) thiab nkag mus rau hauv lub hlwb cov ntaub so ntswg, uas yog qhov tseem ceeb rau nws cov txiaj ntsig zoo li nootropic.
Cov Ntaub Ntawv Kev Nyab Xeeb Ua Ntej Kev Kho Mob - Kev Tshawb Fawb Txog Kev Lom Zem Mob Hnyav thiab Mob Ntev: Kev tshawb fawb txog kev nyab xeeb ua ntej kev kho mob tau qhia tias 7,8-DHF muaj cov ntaub ntawv kev nyab xeeb zoo, tsis muaj cov teebmeem tsis zoo uas pom muaj nyob rau hauv kev tshawb fawb txog kev lom zem mob hnyav thiab mob ntev hauv cov nas. Txawm li cas los xij, yuav tsum tau soj ntsuam kev nyab xeeb ntxiv, suav nrog kev tshawb fawb hauv cov tsiaj txhu thiab cov neeg mob, kom txiav txim siab nws txoj kev nyab xeeb rau kev siv hauv kev kho mob.
Txawm hais tias kev tshawb fawb ua ntej kuaj mob tau qhia tias 7,8-DHF muaj kev nyab xeeb zoo, tab sis cov teeb meem tshwm sim rau tib neeg tseem tsis tau paub meej. Ib yam li lwm yam tshuaj tshiab, yuav tsum ceev faj thiab yuav tsum saib xyuas cov teeb meem tshwm sim thaum soj ntsuam nws siv rau tib neeg.
Nyob ntawm seb 7,8-DHF lub tshuab ua haujlwm thiab cov teebmeem rau TrkB receptors, qee qhov kev phiv uas yuav cuam tshuam nrog 7,8-DHF suav nrog:
Mob taub hau: Kev ua haujlwm ntawm BDNF thiab TrkB receptor tswj hwm kev ua haujlwm ntawm cov hlab ntsha thiab kev ua kom zoo siab; kev siv 7,8-DHF yuav ua rau mob taub hau rau qee tus neeg.
Kev pw tsaug zog tsis taus: Kev ua haujlwm ntawm cov neuronal thiab synaptic plasticity yuav cuam tshuam rau cov qauv pw tsaug zog, uas ua rau pw tsaug zog tsis taus lossis cuam tshuam kev pw tsaug zog.
Teeb Meem Kev Mob Plab: Zoo li ntau yam tshuaj bioactive, 7,8-DHF yuav ua rau muaj kev phiv tshuaj ntawm kev mob plab, xws li xeev siab, ntuav, lossis raws plab rau qee tus neeg.
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias cov kev mob tshwm sim no yuav tsum tau kawm ntxiv hauv kev sim tshuaj. Vim nws muaj peev xwm hloov kho BDNF signaling thiab TrkB receptor activation, yuav tsum ceev faj thaum muab 7,8-DHF nrog lwm cov tshuaj uas tsom mus rau cov kev no lossis muaj cov txheej txheem ua haujlwm zoo sib xws.
Raws li ib qho tshuaj tseem ceeb, 7,8-Dihydroxyflavone tau nyiam ntau qhov kev saib xyuas vim nws cov haujlwm tshwj xeeb hauv lub cev. Rau cov kws tshawb fawb thiab cov lag luam, nws yog qhov tseem ceeb kom nrhiav tau cov hmoov zoo 7,8-Dihydroxyflavone. Cov hmoov 7,8-Dihydroxyflavone uas muab los ntawm Suzhou Myland muaj tus lej CAS ntawm 38183-03-8 thiab qhov huv si txog li 98%. Cov khoom tau dhau los ntawm kev tswj hwm zoo thiab ua raws li cov qauv thoob ntiaj teb, ua kom ntseeg tau tias cov khoom ua haujlwm zoo thiab kev nyab xeeb. , tsim nyog rau kev tshawb fawb, kev tsim tshuaj, kev tsim khoom kho mob thiab lwm yam teb, muab rau koj nrog kev xaiv txhim khu kev qha.
Kev ruaj ntseg zoo
Peb paub tias qhov zoo ntawm peb cov khoom cuam tshuam ncaj qha rau peb cov neeg siv khoom txoj kev tshawb fawb thiab cov txiaj ntsig ntawm daim ntawv thov. Yog li ntawd, Suzhou Myland ua raws li GMP (Kev Ua Haujlwm Zoo) thiab ISO cov qauv ntawv pov thawj thaum lub sijhawm tsim khoom kom ntseeg tau tias muaj kev ruaj khov thiab sib xws ntawm txhua pawg khoom. Tsis tas li ntawd, peb pab neeg R & D txuas ntxiv ua cov thev naus laus zis tshiab thiab siv zog los txhim kho cov khoom zoo thiab kev ua tau zoo.
Kev pabcuam rau cov neeg siv khoom
Suzhou Myland tsis yog tsuas yog muab cov khoom zoo xwb, tab sis kuj ua tib zoo saib xyuas cov kev xav tau ntawm cov neeg siv khoom. Peb muaj pab pawg kws tshaj lij uas tuaj yeem muab cov lus qhia siv khoom thiab cov lus qhia txog kev siv khoom rau cov neeg siv khoom los pab cov neeg siv khoom ua tiav cov txiaj ntsig zoo dua hauv kev tshawb fawb thiab kev siv. Txawm hais tias nws yog kev sim me me lossis kev tsim khoom loj, peb tuaj yeem muab cov kev daws teeb meem yooj yim kom tau raws li cov kev xav tau ntawm cov neeg siv khoom sib txawv.
Yuav Ua Li Cas Thiaj Tau Txais 7,8-Dihydroxyflavone Hmoov
Yog tias koj tab tom nrhiav cov hmoov zoo 7,8-Dihydroxyflavone, Suzhou Myland yog koj qhov kev xaiv zoo tshaj plaws. Koj tuaj yeem tiv tauj peb los ntawm:
Lub vas sab hauv internet: Mus saib lub vas sab hauv internet ntawm Suzhou Myland kom paub ntau ntxiv txog cov ntaub ntawv khoom thiab kev txhawb nqa kev siv tshuab.
Kev sab laj online: Sib txuas lus ncaj qha nrog peb pab neeg kev pabcuam rau cov neeg siv khoom los ntawm kev ua haujlwm sab laj online uas muab los ntawm lub vev xaib kom tau txais cov ntaub ntawv khoom thiab cov lus hais uas koj xav tau.
Kev Tiv Tauj Hauv Xov Tooj: Hu rau peb tus xov tooj kom sib txuas lus nrog cov neeg ua haujlwm muag khoom thiab tau txais cov ntaub ntawv ntxaws ntxaws txog cov khoom thiab cov lus qhia txog kev yuav khoom.
Kev nug email: Koj tuaj yeem nug peb txog cov ntaub ntawv khoom ntawm email, thiab peb yuav teb koj sai li sai tau.
Xaus lus
Ua ib qho tshuaj tseem ceeb uas muaj ntau yam kev ua haujlwm ntawm lub cev, 7,8-Dihydroxyflavone maj mam dhau los ua ib qho tseem ceeb hauv kev tshawb fawb thiab kev siv hauv kev lag luam. Cov hmoov 7,8-Dihydroxyflavone uas muaj qhov huv siab los ntawm Suzhou Myland yuav muab kev txhawb nqa zoo rau koj txoj kev tshawb fawb thiab kev tsim khoom nrog nws cov khoom zoo heev thiab kev pabcuam txhim khu kev qha. Peb tos ntsoov yuav ua haujlwm nrog koj los tshawb nrhiav ntau yam kev siv ntawm 7,8-Dihydroxyflavone.
Q: 7,8-dihydroxyflavone yog dab tsi?
A: 7,8-Dihydroxyflavone yog ib qho flavonoid uas tshwm sim ntuj tsim uas paub txog nws cov khoom muaj peev xwm tiv thaiv neuroprotective thiab tab tom kawm txog nws cov teebmeem rau kev ua haujlwm ntawm kev paub thiab kev txhim kho lub siab.
Q: Cov txiaj ntsig ntawm 7,8-dihydroxyflavone yog dab tsi?
A: Kev tshawb fawb qhia tau hais tias 7,8-dihydroxyflavone yuav pab txhim kho kev nco, txo kev ntxhov siab, thiab tiv thaiv cov kab mob neurodegenerative. Nws cov khoom antioxidant kuj tseem yuav txhawb nqa kev noj qab haus huv tag nrho los ntawm kev tawm tsam kev ntxhov siab oxidative.
Q: Lub bioavailability ntawm 7,8-DHF yog dab tsi?
A: Qhov bioavailability ntawm 7,8-dihydroxyflavone (7,8-DHF) hauv kev tshawb fawb tsiaj yog kwv yees li 5% (hauv nas) vim nws cov solubility tsis zoo thiab metabolism sai. Txawm hais tias nws cov bioavailability qis, 7,8-DHF tseem tuaj yeem hla cov ntshav-lub hlwb barrier thiab cuam tshuam rau lub hlwb. Yuav tsum muaj kev tshawb fawb ntxiv kom txiav txim siab nws cov bioavailability hauv tib neeg thiab tshawb nrhiav txoj hauv kev los txhim kho nws.
Q: 7,8-DHF ua rau koj xav li cas?
A: Ua ib qho nootropic, 7,8-dihydroxyflavone (7,8-DHF) muaj cov txiaj ntsig zoo rau kev ua haujlwm ntawm lub hlwb thiab lub siab. Cov tib neeg muaj kev nco qab zoo dua, muaj kev tsom mus rau ntau dua, thiab muaj peev xwm kawm tau zoo dua.
Lus Ceeb Toom: Tsab xov xwm no tsuas yog rau cov ntaub ntawv dav dav xwb thiab yuav tsum tsis txhob txhais hais tias yog cov lus qhia kho mob. Qee cov ntaub ntawv hauv blog los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, tsim hom ntawv thiab kho cov ntawv xwb. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntxiv tsis tau txhais hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Ib txwm sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Lub sijhawm tshaj tawm: Lub Kaum Hli-14-2024
