Calcium Alpha Ketoglutarate (AKG) yog ib qho nruab nrab metabolite ntawm lub voj voog tricarboxylic acid thiab koom nrog hauv kev sib txuas ntawm amino acids, vitamins thiab organic acids thiab lub zog metabolism. Nws tuaj yeem siv los ua kev noj zaub mov ntxiv thiab muaj kev thov dav dav. Ntxiv rau nws txoj haujlwm lom neeg hauv tib neeg lub cev, calcium alpha-ketoglutarate kuj tau siv dav hauv kev lag luam tshuaj thiab tau dhau los ua ib qho tseem ceeb ntawm ntau yam khoom noj qab haus huv thiab kev kho mob.
alpha-ketoglutarate yog dab tsi?
AKG yog ib txwm tshwm sim endogenous intermediary metabolite uas yog ib feem ntawm lub voj voog Krebs, txhais tau tias peb lub cev tsim nws. Kev lag luam ntxiv kuj tsim cov khoom siv hluavtaws uas yog tshuaj zoo ib yam rau ib txwm ua AKG.
AKG ua dab tsi?
AKG yog ib qho molecule koom nrog ntau txoj hauv kev metabolic thiab cellular. Nws ua hauj lwm pab raws li lub zog pub, precursor rau amino acid ntau lawm thiab cell signaling molecule, thiab yog ib tug modulator ntawm epigenetic txheej txheem. Nws yog ib qho tseem ceeb molecule nyob rau hauv lub voj voog Krebs, tswj tag nrho cov ceev ntawm lub cev lub voj voog citric acid. Nws ua haujlwm nyob rau hauv ntau txoj hauv kev hauv lub cev los pab tsim cov leeg nqaij thiab pab kho qhov txhab, uas yog ib qho ntawm cov laj thawj nws nrov hauv ntiaj teb kev tsim lub cev.
AKG kuj tseem ua raws li cov khoom pov tseg nitrogen, tiv thaiv nitrogen ntau dhau thiab tiv thaiv kev tsim cov ammonia ntau dhau. Nws kuj yog ib qho chaw zoo ntawm glutamate thiab glutamine, uas txhawb nqa cov protein synthesis hauv cov leeg thiab inhibit protein degradation.
Tsis tas li ntawd, nws tswj hwm 10-11 translocation (TET) enzyme koom nrog hauv DNA demethylation thiab Jumonji C domain-muaj lysine demethylase, uas yog histone demethylase loj. Nyob rau hauv txoj kev no, nws yog ib qho tseem ceeb hauv kev tswj cov noob thiab kev qhia.
AKG puas tuaj yeem ncua kev laus?
Muaj pov thawj tias AKG tuaj yeem cuam tshuam kev laus, thiab ntau cov kev tshawb fawb qhia tias qhov no yog qhov teeb meem. Ib txoj kev tshawb fawb 2014 tau pom tias AKG txuas ntxiv lub neej ntawm cov neeg laus C. elegans los ntawm kwv yees li 50% los ntawm inhibiting ATP synthase thiab lub hom phiaj ntawm rapamycin (TOR).
Hauv txoj kev tshawb no, peb pom tias AKG tsis yog tsuas yog ncua lub neej xwb tab sis kuj ncua qee qhov muaj hnub nyoog ntsig txog phenotypes, xws li poob ntawm kev sib koom ua ke ntawm lub cev nrawm uas muaj nyob hauv cov laus C. elegans. Txhawm rau kom nkag siab tias AKG cuam tshuam li cas rau kev laus, peb yuav piav qhia txog cov txheej txheem uas AKG inhibits ATP synthase thiab TOR kom ncua txoj sia nyob hauv C. elegans thiab tej zaum lwm hom.
Calcium alpha-ketoglutarate ua haujlwm li cas
Ua ntej, calcium alpha-ketoglutarate plays lub luag haujlwm tseem ceeb hauv lub zog metabolism. Raws li cov khoom nruab nrab ntawm lub voj voog tricarboxylic acid (TCA lub voj voog), calcium α-ketoglutarate koom nrog hauv cov txheej txheem tsim hluav taws xob intracellular. Los ntawm TCA lub voj voog, cov khoom noj xws li carbohydrates, rog, thiab cov proteins yog oxidized thiab decomposed los tsim ATP (adenosine triphosphate) los muab lub zog rau cov hlwb. Raws li ib qho tseem ceeb nruab nrab ntawm TCA lub voj voog, calcium α-ketoglutarate tuaj yeem txhawb nqa lub zog ntawm tes metabolism, ua kom lub cev muaj zog, pab txhim kho lub cev lub zog thiab kev ua siab ntev, thiab txhim kho lub cev qaug zog.
Thib ob, calcium α-ketoglutarate plays lub luag haujlwm tseem ceeb hauv cov amino acid metabolism. Amino acids yog cov ntsiab lus ntawm cov protein, thiab calcium α-ketoglutarate koom nrog hauv kev hloov pauv thiab metabolism ntawm cov amino acids. Hauv cov txheej txheem ntawm kev hloov cov amino acids rau hauv lwm cov metabolites, calcium α-ketoglutarate transaminates nrog cov amino acids los tsim cov amino acids tshiab los yog α-keto acids, yog li tswj kev sib npaug thiab kev siv cov amino acids. Tsis tas li ntawd, calcium α-ketoglutarate kuj tseem tuaj yeem ua oxidation substrate rau cov amino acids, koom nrog oxidative metabolism ntawm amino acids, thiab tsim lub zog thiab carbon dioxide. Yog li, calcium α-ketoglutarate yog qhov tseem ceeb hauv kev tswj hwm homeostasis ntawm amino acids thiab protein metabolism hauv lub cev.
Tsis tas li ntawd, calcium alpha-ketoglutarate ua cov tshuaj antioxidant uas tshem tawm cov dawb radicals thiab tiv thaiv cov hlwb los ntawm kev puas tsuaj oxidative. Nyob rau tib lub sijhawm, calcium α-ketoglutarate tuaj yeem tswj hwm kev ua haujlwm ntawm lub cev tiv thaiv kab mob, txhawb kev ua kom lub cev tiv thaiv kab mob, thiab txhim kho lub cev tiv thaiv kab mob thiab kis kab mob. Yog li, calcium α-ketoglutarate yog qhov tseem ceeb hauv kev tswj hwm lub cev tiv thaiv kab mob thiab tiv thaiv kab mob.
Kev tshawb fawb txog cov teebmeem ntawm calcium α-ketoglutarate rau kev laus
Kev laus cuam tshuam rau peb txhua tus thiab yog qhov muaj feem pheej hmoo rau ntau yam kab mob, thiab raws li Medicare kev lag luam cov pej xeem, qhov tshwm sim ntawm kev muaj mob nce ntxiv nrog lub hnub nyoog.
Calcium alpha-ketoglutarate yog ib qho tseem ceeb metabolite hauv peb lub cev, paub txog lub luag haujlwm ntawm tes hauv Krebs cycle, lub voj voog tseem ceeb rau oxidation ntawm fatty acids thiab amino acids, tso cai rau mitochondria tsim ATP (ATP yog lub zog ntawm cov hlwb).
Uas suav nrog kev thauj khoom ntawm calcium alpha-ketoglutarate txheej txheem, yog li calcium alpha-ketoglutarate kuj tuaj yeem hloov mus rau glutamate thiab tom qab ntawd mus rau hauv glutamine, uas tuaj yeem pab txhawb kev sib txuas ntawm cov protein thiab collagen (collagen yog ib qho protein ntau uas ua rau 1/3. ntawm tag nrho cov protein nyob rau hauv lub cev thiab pab txhawb cov pob txha, tawv nqaij thiab cov leeg kev noj qab haus huv).
Calcium α-ketoglutarate, raws li cov khoom noj muaj txiaj ntsig zoo, muaj cov ntawv thov dav dav hauv cov khoom kho mob. Nws muaj ntau yam kev ua haujlwm lom neeg xws li antioxidant, tiv thaiv kev laus, kev tiv thaiv kab mob thiab cov amino acid metabolism ua rau nws yog ib qho cuab yeej muaj zog los txhim kho tib neeg kev noj qab haus huv. Nrog rau kev paub txog kev noj qab haus huv thiab kev sib sib zog nqus ntawm kev tshawb fawb, nws ntseeg tau tias daim ntawv thov ntawm α-ketoglutarate calcium nyob rau hauv cov khoom siv kho mob yuav tau txais kev saib xyuas thiab kev loj hlob ntxiv.
Kev lees paub: Kab lus no yog rau cov ntaub ntawv dav dav nkaus xwb thiab yuav tsum tsis txhob raug txhais raws li cov lus qhia kho mob. Qee cov ntaub ntawv blog tshaj tawm los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, formatting thiab kho cov ntawv. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntau ntxiv tsis txhais tau hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Nco ntsoov sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Post lub sij hawm: Oct-15-2024
