Calcium Alpha ketoglutarate (AKG) yog ib qho metabolite nruab nrab ntawm lub voj voog tricarboxylic acid thiab koom nrog kev tsim cov amino acids, cov vitamins thiab cov organic acids thiab lub zog metabolism. Nws tuaj yeem siv ua cov khoom noj khoom haus ntxiv thiab muaj kev cia siab dav dav. Ntxiv rau nws cov haujlwm biological hauv tib neeg lub cev, calcium alpha-ketoglutarate kuj tseem siv dav hauv kev lag luam tshuaj thiab tau dhau los ua ib qho tseem ceeb ntawm ntau cov khoom noj khoom haus thiab kev daws teeb meem kho mob.
Alpha-ketoglutarate yog dab tsi?
AKG yog ib qho metabolite endogenous uas tshwm sim hauv lub cev uas yog ib feem ntawm lub voj voog Krebs, txhais tau tias peb lub cev tsim nws. Kev lag luam tshuaj ntxiv kuj tsim cov qauv tsim uas zoo ib yam li AKG uas tsim tawm hauv ntuj.
AKG ua dab tsi?
AKG yog ib lub molecule uas koom nrog ntau txoj kev ua haujlwm ntawm lub cev thiab lub hlwb. Nws ua haujlwm ua tus pub zog, tus ua ntej rau kev tsim cov amino acid thiab cov molecule signaling ntawm lub hlwb, thiab yog tus modulator ntawm cov txheej txheem epigenetic. Nws yog ib lub molecule tseem ceeb hauv lub voj voog Krebs, tswj hwm qhov ceev ntawm lub voj voog citric acid ntawm lub cev. Nws ua haujlwm hauv ntau txoj hauv kev hauv lub cev los pab tsim cov leeg thiab pab kho qhov txhab, uas yog ib qho laj thawj uas nws nrov hauv ntiaj teb kev ua kom lub cev muaj zog.
AKG kuj ua haujlwm ua tus neeg khaws nitrogen, tiv thaiv nitrogen ntau dhau thiab tiv thaiv kev tsim cov ammonia ntau dhau. Nws kuj yog qhov chaw zoo ntawm glutamate thiab glutamine, uas txhawb nqa kev tsim cov protein hauv cov leeg thiab tiv thaiv kev puas tsuaj ntawm cov protein.
Ntxiv rau, nws tswj hwm 10-11 translocation (TET) enzyme koom nrog DNA demethylation thiab Jumonji C domain-muaj lysine demethylase, uas yog qhov tseem ceeb histone demethylase. Ua li no, nws yog ib tus neeg ua si tseem ceeb hauv kev tswj hwm gene thiab kev qhia tawm.
AKG puas tuaj yeem ncua kev laus?
Muaj pov thawj tias AKG tuaj yeem cuam tshuam rau kev laus, thiab ntau txoj kev tshawb fawb qhia tias qhov no yog qhov tseeb. Ib txoj kev tshawb fawb xyoo 2014 tau qhia tias AKG ua rau lub neej ntawm cov neeg laus C. elegans ntev li ntawm 50% los ntawm kev txwv ATP synthase thiab lub hom phiaj ntawm rapamycin (TOR).
Hauv kev tshawb fawb no, peb pom tias AKG tsis yog tsuas yog ua rau lub neej ntev xwb tab sis kuj ncua qee yam phenotypes uas cuam tshuam nrog hnub nyoog, xws li kev poob ntawm kev txav mus los sai sai uas feem ntau pom muaj nyob rau hauv cov neeg laus C. elegans. Txhawm rau kom nkag siab tias AKG cuam tshuam li cas rau kev laus, peb yuav piav qhia txog cov txheej txheem uas AKG inhibits ATP synthase thiab TOR kom ntev lub neej hauv C. elegans thiab tej zaum lwm hom tsiaj.
Yuav ua li cas calcium alpha-ketoglutarate ua haujlwm
Ua ntej, calcium alpha-ketoglutarate ua lub luag haujlwm tseem ceeb hauv kev hloov pauv lub zog. Raws li cov khoom nruab nrab ntawm lub voj voog tricarboxylic acid (TCA voj voog), calcium α-ketoglutarate koom nrog hauv cov txheej txheem tsim lub zog hauv lub hlwb. Los ntawm lub voj voog TCA, cov as-ham xws li carbohydrates, rog, thiab cov protein raug oxidized thiab decomposed los tsim ATP (adenosine triphosphate) los muab lub zog rau cov hlwb. Raws li ib qho tseem ceeb nruab nrab hauv lub voj voog TCA, calcium α-ketoglutarate tuaj yeem txhawb kev hloov pauv lub zog ntawm lub hlwb, ua rau lub cev muaj zog ntau dua, pab txhim kho lub zog thiab kev ua siab ntev, thiab txhim kho kev qaug zog ntawm lub cev.
Qhov thib ob, calcium α-ketoglutarate ua lub luag haujlwm tseem ceeb hauv kev hloov pauv amino acid. Amino acids yog cov khoom tseem ceeb ntawm cov protein, thiab calcium α-ketoglutarate koom nrog kev hloov pauv thiab kev hloov pauv ntawm amino acids. Hauv cov txheej txheem ntawm kev hloov pauv amino acids mus rau lwm cov metabolites, calcium α-ketoglutarate transaminates nrog amino acids los tsim cov amino acids tshiab lossis α-keto acids, yog li tswj kev sib npaug thiab kev siv cov amino acids. Tsis tas li ntawd, calcium α-ketoglutarate kuj tseem tuaj yeem ua haujlwm ua lub substrate oxidation rau amino acids, koom nrog hauv kev hloov pauv oxidative ntawm amino acids, thiab tsim lub zog thiab carbon dioxide. Yog li ntawd, calcium α-ketoglutarate yog qhov tseem ceeb heev hauv kev tswj hwm homeostasis ntawm amino acids thiab protein metabolism hauv lub cev.
Ntxiv rau, calcium alpha-ketoglutarate ua haujlwm ua cov tshuaj antioxidant uas tshem tawm cov free radicals thiab tiv thaiv cov cell ntawm kev puas tsuaj oxidative. Tib lub sijhawm, calcium α-ketoglutarate kuj tseem tuaj yeem tswj hwm kev ua haujlwm ntawm lub cev tiv thaiv kab mob, txhawb kev ua haujlwm thiab kev loj hlob ntawm cov cell tiv thaiv kab mob, thiab txhim kho lub cev tiv thaiv kab mob thiab kev kis kab mob. Yog li ntawd, calcium α-ketoglutarate yog qhov tseem ceeb heev hauv kev tswj lub cev tiv thaiv kab mob thiab tiv thaiv kab mob.
Kev tshawb fawb txog cov teebmeem ntawm calcium α-ketoglutarate rau kev laus
Kev laus zuj zus cuam tshuam rau peb txhua tus thiab yog ib qho kev pheej hmoo rau ntau yam kab mob, thiab raws li cov ntaub ntawv hais txog kev lag luam Medicare, qhov muaj feem yuav mob nce ntxiv nrog hnub nyoog.
Calcium alpha-ketoglutarate yog ib qho tseem ceeb metabolite hauv peb lub cev, paub txog lub luag haujlwm ntawm lub cell hauv lub voj voog Krebs, lub voj voog tseem ceeb rau kev oxidation ntawm fatty acids thiab amino acids, tso cai rau mitochondria tsim ATP (ATP yog lub zog ntawm cov cell).
Uas cuam tshuam txog kev thauj cov txheej txheem calcium alpha-ketoglutarate, yog li calcium alpha-ketoglutarate kuj tseem tuaj yeem hloov mus ua glutamate thiab tom qab ntawd mus ua glutamine, uas tuaj yeem pab txhawb kev tsim cov protein thiab collagen (collagen yog ib qho protein fibrous uas ua rau 1/3 ntawm tag nrho cov protein hauv lub cev thiab pab txhawb kev noj qab haus huv ntawm pob txha, tawv nqaij thiab cov leeg nqaij).
Calcium α-ketoglutarate, ua ib yam khoom noj khoom haus ntau yam, muaj kev siv dav hauv cov khoom kho mob. Nws muaj ntau yam haujlwm xws li antioxidant, tiv thaiv kev laus, tswj kev tiv thaiv kab mob thiab amino acid metabolism ua rau nws yog ib qho cuab yeej muaj zog los txhim kho tib neeg kev noj qab haus huv. Nrog rau kev paub ntau ntxiv txog kev kho mob thiab kev tshawb fawb tob zuj zus, nws ntseeg tias kev siv α-ketoglutarate calcium hauv kev kho mob yuav tau txais kev saib xyuas thiab kev txhim kho ntau dua.
Lus Ceeb Toom: Tsab xov xwm no tsuas yog rau cov ntaub ntawv dav dav xwb thiab yuav tsum tsis txhob txhais hais tias yog cov lus qhia kho mob. Qee cov ntaub ntawv hauv blog los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, tsim hom ntawv thiab kho cov ntawv xwb. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntxiv tsis tau txhais hais tias koj pom zoo nrog nws cov kev xav lossis lees paub qhov tseeb ntawm nws cov ntsiab lus. Ib txwm sab laj nrog tus kws kho mob ua ntej siv cov tshuaj ntxiv lossis hloov pauv koj txoj kev kho mob.
Lub sijhawm tshaj tawm: Lub Kaum Hli-15-2024
