1-Methylnicotinamide Chloride CAS No.:1005-24-9
Cov Khoom Siv
| Lub npe khoom | 1-Methylnicotinamide chloride |
| Lwm lub npe | N-Methylnicotinamide chloride; NMN-Cl; 1-MNA chloride；3-carbamoyl-1-methyl-pyridinium chloride |
| CAS Nr. | 1005-24-9 |
| Cov mis molecular | C7H9N2OCl |
| Qhov hnyav ntawm cov molecule | 172.61 |
| Kev dawb huv | 98.5% |
| Qhov tsos | Dawb - dawb tawm, crystalline khoomhmoov |
| Ntim khoom | 1kg/hnab; 25kg/nruas |
| Daim Ntawv Thov | ctshuaj lom neegekev sim tshuajmcov khoom siv |
Kev taw qhia txog khoom
1-Methylnicotinamide chloride yog ib qho methylated derivative ntawm nicotinamide, uas muaj cov qauv ntsev quaternary ammonium ruaj khov. Nws ua haujlwm ua ib qho tseem ceeb hauv kev kawm txog nicotinamide metabolism. Nws cov dej solubility zoo thiab kev ruaj khov tshuaj ua rau nws tsim nyog ua cov cuab yeej sib xyaw rau kev tshawb fawb biochemical.
1-MNA yog ib yam khoom uas muaj nyob hauv tib neeg lub cev, ua haujlwm ua ib yam khoom ntawm niacin metabolism. Ua ib qho nruab nrab hauv txoj kev metabolic no, 1-MNA raug ua tiav ntxiv los ntawm aldehyde oxidase los tsim cov metabolites xws li N-methyl-2-pyridone-5-carboxamide (2PY) thiab N-methyl-4-pyridone-3-carboxamide (4PY), uas thaum kawg raug tso tawm los ntawm cov kab mob tso zis.
1-Methylnicotinamide chloride yog ib qho methylated derivative ntawm nicotinamide, uas muaj cov qauv ntsev quaternary ammonium ruaj khov. Nws ua haujlwm ua ib qho tseem ceeb hauv kev kawm txog nicotinamide metabolism. Nws cov dej solubility zoo thiab kev ruaj khov tshuaj ua rau nws tsim nyog ua cov cuab yeej sib xyaw rau kev tshawb fawb biochemical.
1-MNA yog ib yam khoom uas muaj nyob hauv tib neeg lub cev, ua haujlwm ua ib yam khoom ntawm niacin metabolism. Ua ib qho nruab nrab hauv txoj kev metabolic no, 1-MNA raug ua tiav ntxiv los ntawm aldehyde oxidase los tsim cov metabolites xws li N-methyl-2-pyridone-5-carboxamide (2PY) thiab N-methyl-4-pyridone-3-carboxamide (4PY), uas thaum kawg raug tso tawm los ntawm cov kab mob tso zis.
Feature
(1) Kev yaj dej: Yooj yim yaj hauv dej thiab cov kuab tshuaj polar organic.
(2) Kev Ruaj Ntseg: Ruaj khov nyob rau hauv chav tsev kub tab sis yuav tsum tau khaws cia rau hauv qhov chaw tsis muaj dej noo.
(3) Kev Nyab Xeeb: Lub Koom Haum European Union tau ua qhov kev ntsuam xyuas txog 1-MNA ua cov khoom xyaw tshiab hauv cov khoom noj. Raws li EU Txoj Cai (EC) No 258/97, 1-MNA suav tias muaj kev nyab xeeb rau kev noj, nrog rau kev pom zoo kom cov neeg laus noj ntau tshaj plaws txhua hnub ntawm 58 mg, feem ntau yog siv rau hauv cov khoom noj khoom haus ntxiv.
Cov ntawv thov
1-Methylnicotinamide chloride (hu ua MNC) yog ib qho methylated derivative ntawm nicotinamide. Kev kuaj pom ntawm 1-MNA tuaj yeem ua tiav los ntawm cov txheej txheem xws li high-performance liquid chromatography (HPLC) thiab enzyme-linked immunosorbent assay (ELISA). Nws qhia txog peev xwm rau kev siv hauv cov khoom noj khoom haus thiab cov khoom lag luam kev noj qab haus huv. Hauv kev lag luam khoom noj khoom haus, nws tuaj yeem ua haujlwm ua antioxidant los ncua lipid oxidation thiab khaws cia cov khoom noj khoom haus zoo. Vim nws cov yam ntxwv ntawm cov qauv, nws kuj tuaj yeem ua haujlwm ua cov khoom xyaw ua haujlwm hauv cov khoom noj khoom haus muaj txiaj ntsig zoo. Ntxiv mus, 1-MNA qhia txog kev ua ub no hauv kev tswj hwm metabolic thiab kev txhim kho ntawm cov xwm txheej physiological, qiv nws tus nqi rau kev txhim kho hauv cov khoom noj khoom haus ua haujlwm thiab cov khoom noj khoom haus tshuaj uas muaj kev thov kev noj qab haus huv.
Kev ntsuam xyuas ntawm EU tau xaus lus tias kev noj 58 mg ntawm 1-MNA txhua hnub los ntawm cov khoom noj khoom haus tsis zoo li yuav ua rau muaj kev noj qab haus huv tsis zoo rau tib neeg, thiab nws tau raug suav nrog hauv EU daim ntawv teev khoom noj tshiab.
Ua ib qho tshuaj lom neeg tseem ceeb thiab tus qauv siv, 1-methylnicotinamide chloride muaj cov kev siv dav hauv kev tshawb fawb, kev tsim tshuaj, thiab kev lag luam khoom noj khoom haus ntxiv. Nws qhov kev ntsuam xyuas kev nyab xeeb zoo thiab ntau yam kev ua ub no ntawm lub cev ua rau nws yog ib qho tseem ceeb rau kev tshawb fawb thiab ib qho khoom siv rau ntau yam kev siv.
