5-Amino-1-methylquinolinium iodide (NNMTi) CAS No.:42464-96-0 98.0% kev huv huv tsawg kawg nkaus | chaw tsim khoom xyaw ntxiv
Cov Khoom Siv
| Lub npe khoom | 5-Amino-1-methylquinolinium iodide (NNMTi) |
| Lwm lub npe | NNMTi5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE 5-amino-1-methylquinolinium iodide 5-Amino-1-methylquinolin-1-iumiodide 1-methylquinolin-1-ium-5-amine;iodide 5-Amino-1-methyl-1-quinolinium Iodide 5-Amino-1-mq iodide |
| CAS Nr. | 42464-96-0 |
| Cov mis molecular | C10H11IN2 |
| Qhov hnyav ntawm cov molecule | 286.11 |
| Kev dawb huv | 98.0% |
| Qhov tsos | Xim av rau xim av liab dawb khov kho |
| Ntim khoom | 1kg/hnab, 25kg/phaj |
| Daim Ntawv Thov | Khoom Noj Khoom Haus Ntxiv Raw Khoom |
Kev taw qhia txog khoom
Tus cytosolic enzyme nicotinamide N-methyltransferase (NNMT) tau raug tshawb pom tshiab los tswj cov theem ntawm nicotinamide precursors uas xav tau rau NAD + biosynthesis thiab yog li ntawd ua lub luag haujlwm tseem ceeb hauv kev tswj hwm NAD + salvage pathway thiab cellular metabolism. NNMT yog qhia nyob rau hauv cov leeg pob txha, thiab nws qhov kev qhia maj mam nce nrog kev laus ntawm cov leeg nqaij. Qhov tseem ceeb, NNMT yog ib qho tseem ceeb ntawm cov cim qhia sarcopenic gene, thiab nws qhov kev qhia ntau dhau yuav ua rau muaj kev txo qis hauv NAD + thiab kev poob qis hauv cov leeg nqaij, lub zog, thiab kev ua haujlwm uas nrog kev laus. Kev kho cov nas laus nrog cov tshuaj me me NNMT inhibitor (NNMTi) txhim kho kev loj hlob, kev sib xyaw, thiab kev rov ua dua tshiab ntawm muSCs, yog li txhim kho kev ua haujlwm ntawm cov leeg pob txha. Cov txiaj ntsig zoo sib xws tau txais hauv vitro siv C2C12 hlwb, uas zoo ib yam li muSCs, qhov twg NNMTi kev kho mob txhawb nqa myoblast sib txawv thiab txhawb nqa kev hloov pauv metabolic hauv cellular metabolites cuam tshuam nrog NAD + salvage pathway.
NNMTi yog ib qho enzyme uas overexpressed thaum lub sij hawm cov leeg nqaij laus thiab cuam tshuam nrog kev puas tsuaj rau txoj kev NAD+, kev ua haujlwm ntawm sirtuin1 tsis zoo, thiab kev laus ntawm cov leeg nqaij. NNMT yog ib qho enzyme metabolic uas catalyzes qhov methylation ntawm nicotinamide (NAM) siv cov methyl donor S-adenosylmethionine (SAM), txuas lub xeev metabolic ntawm lub cell rau qhov sib npaug ntawm methylation thiab cov theem NAD+ hauv lub hlwb. NNMT tau qhia ntau heev hauv daim siab thiab cov nqaij adipose, nrog rau hauv cov mob pathological uas muaj kev xav tau metabolic ntau ntxiv, xws li qee yam kab mob siab rog thiab ntshav qab zib. NNMT koom nrog ntau yam txheej txheem sib txawv, suav nrog kev hloov pauv ntawm cov hlwb ntawm tib neeg mus rau cov neeg laus, myogenesis, thiab kev hloov pauv epithelial thiab neuromesenchymal hauv ntau yam mob qog noj ntshav. NNMT kev qhia tawm yog tswj hwm hauv cov nqaij thiab cov ntsiab lus tshwj xeeb es tsis yog los ntawm tus qauv tswj hwm uas muaj nyob thoob plaws.
Feature
(1) Kev ntshiab siab: NNMTi tuaj yeem tau txais cov khoom ntshiab siab los ntawm cov txheej txheem tsim khoom zoo. Kev ntshiab siab txhais tau tias muaj kev noj qab haus huv zoo dua.
(2) Kev Taw Qhia: NNMTi tsom mus rau NNMT enzyme thiab tuaj yeem tiv thaiv nws txoj haujlwm, yog li cuam tshuam rau txoj kev zom zaub mov ntawm nicotinamide.
(3) Kev Ruaj Ntseg: NNMTi muaj kev ruaj ntseg zoo thiab tuaj yeem tswj nws cov haujlwm thiab cov txiaj ntsig nyob rau hauv ntau qhov chaw ib puag ncig thiab cov xwm txheej khaws cia.
(4) Kev cia siab rau kev loj hlob: Vim muaj ntau yam ntxwv ntawm NNMTi, nws txoj kev loj hlob tau txais kev saib xyuas dav dav thiab muaj kev tshawb fawb dav dav thiab kev cia siab rau daim ntawv thov.
Cov ntawv thov
NNMTi (CAS 42464-96-0) yog ib qho nicotinamide N-methyltransferase (NNMT) inhibitor, ib qho muaj zog inhibitor (IC50 = 1.2 μM) ntawm nicotinamide N-methyltransferase (NNMT) uas txhawb nqa myoblast differentiation. NNMTi xaiv khi rau NNMT substrate binding site residues. NNMTi txhawb nqa myoblast differentiation hauv vitro thiab txhim kho cov leeg nqaij stem cell fusion thiab regeneration hauv nas laus. NNMT yog ib qho cytosolic biotransformation enzyme tseem ceeb uas catalyzes N-methylation ntawm endogenous thiab exogenous xenobiotics. Piv nrog rau kev hloov zaub mov lean ib leeg, kev kho mob NNMTi ua ke nrog kev hloov zaub mov lean ua kom nrawm dua kev txhim kho hauv lub cev poob rog, nce tag nrho lub cev lean pawg rau qhov hnyav ntawm lub cev, txo qis lub siab epididymal dawb adipose nqaij hnyav, txo qis lub siab rog deposition, thiab txhim kho lub siab steatosis. Tsis tas li ntawd, NNMTi tuaj yeem ua rau muaj zog thiab txhawb nqa lub peev xwm rov ua dua ntawm cov leeg laus, uas yuav pab tau rau kev kho mob sarcopenia.
