Chaw tsim tshuaj Agomelatine hmoov CAS No.: 138112-76-2 99% purity min. rau cov khoom xyaw ntxiv
Cov Yeeb Yaj Kiab Txog Khoom
Cov Khoom Siv
| Lub npe khoom | Agomelatine |
| Lwm lub npe | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
| CAS Nr. | 138112-76-2 |
| Cov mis molecular | C15H17NO2 |
| Qhov hnyav ntawm cov molecule | 243.3082 |
| Kev dawb huv | 99.0% |
| Qhov tsos | Hmoov dawb |
| Ntim khoom | 1kg/hnab 25kg/nruas |
| Daim Ntawv Thov | Cov khoom siv raw khoom noj qab haus huv |
Kev taw qhia txog khoom
Agomelatine tau pib tsim tawm thawj zaug hauv Tebchaws Europe xyoo 2009 thiab tam sim no tau pom zoo siv rau ntau dua 70 lub tebchaws. Tsis zoo li cov tshuaj antidepressants ib txwm muaj, agomelatine ua haujlwm los ntawm kev tsom mus rau melatonin thiab serotonin receptors hauv lub hlwb. Los ntawm kev ua haujlwm ua tus agonist ntawm melatonin receptors, agomelatine pab ua kom cov qauv pw tsaug zog tsis zoo uas feem ntau cuam tshuam nrog kev nyuaj siab. Lub tshuab no tsis yog tsuas yog pab txhim kho kev pw tsaug zog zoo xwb tab sis kuj pab rov qab kho lub sijhawm circadian ntuj. Tsis tas li ntawd, agomelatine ua haujlwm ua tus antagonist ntawm qee cov serotonin receptors (5-HT2C receptors). Qhov kev ua ob yam tshwj xeeb no ua rau muaj serotonin hauv lub hlwb, uas yog neurotransmitter uas yog lub luag haujlwm rau kev tswj hwm kev xav. Los ntawm kev tswj hwm cov theem serotonin, agomelatine tuaj yeem ua haujlwm ua tus antidepressant zoo, txo cov tsos mob xws li kev tu siab, tsis muaj kev txaus siab, kev xav txhaum lossis tsis muaj nqis. Tsis tas li ntawd, agomelatine yuav muab lwm yam txiaj ntsig. Kev tshawb fawb qhia tias nws yuav pab txhim kho kev ua haujlwm ntawm kev paub Kev tshawb fawb qhia txog nws lub peev xwm los txhim kho kev nco, kev mloog zoo, thiab kev ua haujlwm ntawm tus thawj coj, ua rau nws yog qhov chaw zoo siab rau kev tshawb fawb yav tom ntej.
Feature
(1) Kev ntshiab siab: Agomelatine tuaj yeem tau txais cov khoom ntshiab siab los ntawm kev ua kom cov txheej txheem tsim khoom. Kev ntshiab siab txhais tau tias muaj kev nyab xeeb zoo dua thiab tsawg dua cov kev tsis zoo.
(2) Kev Nyab Xeeb: Kev nyab xeeb siab, ob peb qhov kev tsis haum.
(3) Kev Ruaj Ntseg: Agomelatine muaj kev ruaj ntseg zoo thiab tuaj yeem tswj nws cov haujlwm thiab cov nyhuv hauv qab ntau qhov chaw thiab cov xwm txheej cia khoom.
Cov ntawv thov
Agomelatine yog ib yam tshuaj antidepressant thiab yog ib yam tshuaj melatonin antagonist. Nws txo cov tsos mob ntawm kev nyuaj siab los ntawm kev tswj hwm melatonin MT1 receptors (txo cov teeb liab cortical) thiab MT2 receptors (circadian sleep rhythm) thiab serotonin theem. Noj thaum hmo ntuj, nws ua raws li lub suab ntuj ntawm melatonin tso tawm thiab tuaj yeem txhim kho kev pw tsaug zog zoo heev. Nws txoj kev ua haujlwm tawg dhau los ntawm lub cev monoamine transmitter system. Nws ua kom melatonin receptors MT1 thiab MT2 ua haujlwm thiab antagonizes 5-HT2C receptors. Txhim kho kev pw tsaug zog zoo, rov qab ua kom lub suab biological, thiab muaj cov nyhuv antidepressant; ntawm lawv, los ntawm kev antagonizing 5-HT2C receptors ntawm postsynaptic membrane, nws tuaj yeem ua rau muaj kev tso tawm ntawm DA thiab NE hauv prefrontal cortex, ua rau muaj kev cuam tshuam antidepressant. Thaum MT agonism thiab 5-HT2C receptor antagonism coexist, ib qho kev cuam tshuam synergistic tshwj xeeb tuaj yeem tsim tawm, txhawb kev tso tawm ntau dua DA thiab NE hauv thaj chaw PFC hlwb, ntxiv dag zog rau cov nyhuv antidepressant. Ntxiv rau, agomelatine tuaj yeem txhawb kev tso tawm ntawm lub hlwb-derived neurotrophic factor hauv PFC thiab thaiv kev ntxhov siab ua rau muaj kev tso tawm ntawm glutamate hauv thaj chaw hlwb amygdala.
