CMS121 hmoov chaw tsim tshuaj CAS No.: 1353224-53-9 98.0% purity min. rau cov khoom xyaw ntxiv
Cov Khoom Siv
| Lub npe khoom | CMS121 |
| Lwm lub npe | CMS-121; 1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-; 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121); ACC, AcetylCoenzymeACarboxylase, kab mob, neuroprotective, inhibit, anti-inflammatory, mitochondrial, Alzheimer's, antioxidative, acetylation, Inhibitor, H3K9, Acetyl-CoACarboxylase, CMS121, dementia, ACC1, CMS-121 |
| CAS Nr. | 1353224-53-9 |
| Cov mis molecular | C20H19NO3 |
| Qhov hnyav ntawm cov molecule | 321.37 |
| Kev dawb huv | 98.0% |
| Qhov tsos | Hmoov daj daj |
| Daim Ntawv Thov | Khoom Noj Khoom Haus Ntxiv Raw Khoom |
Kev taw qhia txog khoom
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol yog ib qho tshuaj uas hu ua CMS121. Qhov nyuaj ntawm cov tshuaj no qhia tau tias nws yuav muaj cov khoom tshwj xeeb thiab kev siv tau zoo. Yuav kom nkag siab txog nws qhov tseem ceeb, nws pab txheeb xyuas cov pab pawg ua haujlwm uas muaj thiab tshuaj xyuas lawv qhov cuam tshuam. Qhov muaj lub nplhaib quinoline qhia tau tias cov tshuaj no yuav muaj txiaj ntsig zoo rau lub cev. Cov tshuaj quinoline uas tau los ntawm cov tshuaj no paub txog lawv cov khoom siv ntau yam, suav nrog cov tshuaj tua kab mob thiab tiv thaiv kev o. Kev txuas ntawm pawg cyclopentyloxy yuav pab txhawb rau kev yaj ntawm cov tshuaj lossis txhim kho nws cov haujlwm ua haujlwm los ntawm cov teebmeem steric. Hauv kev tshawb fawb txog HT22 hlwb, CMS-121 tau ua pov thawj tias muaj txiaj ntsig zoo rau kev tiv thaiv lub hlwb, tiv thaiv cov hlwb no los ntawm ischemia thiab kev puas tsuaj oxidative. Ntxiv mus, CMS-121 muaj cov khoom tiv thaiv kev o, qhia tau tias nws muaj peev xwm hloov kho cov lus teb o. Los ntawm kev ua li ntawd, CMS-121 muaj peev xwm txo qhov o hauv ntau cov ntaub so ntswg thiab cov kabmob. CMS-121 muaj kev ua haujlwm pharmacological muaj zog ua tus inhibitor ntawm acetyl-CoA carboxylase 1 (ACC1). Nws cov nyhuv inhibitory muaj zog ntawm ACC1 ua rau nws yog ib qho tshuaj cog lus.
Feature
(1) Kev ntshiab siab: CMS-121 tuaj yeem tau txais cov khoom ntshiab siab los ntawm cov txheej txheem tsim khoom zoo. Kev ntshiab siab txhais tau tias muaj kev nyab xeeb zoo dua thiab muaj tsawg dua cov kev tsis zoo.
(2) Kev Nyab Xeeb: Kev nyab xeeb siab, ob peb qhov kev tsis haum.
(3) Kev Ruaj Ntseg: CMS-121 muaj kev ruaj ntseg zoo thiab tuaj yeem tswj nws cov haujlwm thiab cov txiaj ntsig nyob rau hauv ntau qhov chaw sib txawv thiab cov xwm txheej khaws cia.
Cov ntawv thov
CMS-121 yog ib qho quinolone derivative thiab acetyl-CoA carboxylase 1 (ACC1) inhibitor uas noj nrog cov khoom cog lus pharmacological. Kev tshawb fawb dav dav tau ua los tshawb nrhiav cov txiaj ntsig ntawm CMS-121 hauv ntau qhov chaw, suav nrog kev tiv thaiv neuroprotection, cov teebmeem tiv thaiv kev o, kev ua haujlwm antioxidant, thiab nws cov teebmeem rau cov cim qhia txog kev laus noj qab haus huv.
