Oleoylethanolamide (OEA) hmoov chaw tsim tshuaj CAS No.: 111-58-0 98%, 85% purity min. rau cov khoom xyaw ntxiv
Cov Khoom Siv
| Lub npe khoom | Oleoyl ethanolamide |
| Lwm lub npe | N-oleoyl ethanolamine; N-(2-hydroxyethyl)-,(Z)-9-Octadecenamide |
| CAS Nr. | 111-58-0 |
| Cov mis molecular | C20H39NO2 |
| Qhov hnyav ntawm cov molecule | 325.53 |
| Kev dawb huv | 98.0% ，85.0% |
| Qhov tsos | Hmoov siv lead ua dawb zoo |
| Ntim khoom | 1kg/hnab, 25kg/nruas |
| Daim Ntawv Thov | Kev txo qhov mob, tiv thaiv kev o |
Kev taw qhia txog khoom
Oleoylethanolamide yog ib qho tshuaj amide thib ob uas muaj lipophilic oleic acid thiab hydrophilic ethanolamine. Oleoylethanolamide kuj yog ib qho lipid molecule uas tshwm sim hauv lwm cov tsiaj txhu thiab cov nroj tsuag. Nws muaj ntau nyob rau hauv cov tsiaj txhu thiab cov nroj tsuag xws li cocoa hmoov, taum pauv, thiab txiv ntoo, tab sis nws cov ntsiab lus tsawg heev. Tsuas yog thaum ib puag ncig sab nraud hloov pauv lossis zaub mov raug txhawb nqa, lub cev cov ntaub so ntswg cell Tsuas yog tom qab ntawd yuav ntau dua ntawm cov tshuaj no raug tsim tawm.
Thaum sov li chav tsev, Oleoylethanolamide yog cov khoom dawb nrog lub ntsiab lus yaj ntawm kwv yees li 50 ° C. Nws yooj yim yaj hauv cov kuab tshuaj cawv xws li methanol thiab ethanol, yooj yim yaj hauv cov kuab tshuaj tsis-polar xws li n-hexane thiab ether, thiab tsis yaj hauv dej. OEA yog ib qho molecule amphiphilic uas ib txwm siv ua surfactant thiab detergent hauv kev lag luam tshuaj lom neeg. Txawm li cas los xij, kev tshawb fawb ntxiv pom tias OEA tuaj yeem ua haujlwm ua lub lipid signaling molecule hauv lub plab-lub hlwb axis thiab tso saib ntau yam kev ua ub no hauv lub cev, suav nrog: tswj kev ntshaw, txhim kho lipid metabolism, txhim kho kev nco thiab kev paub thiab lwm yam haujlwm. Ntawm lawv, Oleoylethanolamide lub luag haujlwm ntawm kev tswj kev ntshaw thiab txhim kho lipid metabolism tau txais kev saib xyuas ntau tshaj plaws.
Oleoylethanolamide tuaj yeem tswj kev noj zaub mov thiab lub zog homeostasis los ntawm kev ua kom peroxisome proliferator-activated receptor-α. Tsis tas li ntawd, Oleoylethanolamide ua rau pom lwm yam kev ua ub no ntsig txog kev noj qab haus huv, suav nrog kev hloov pauv kev ua haujlwm hauv lysosomal-rau-nuclear signaling txoj kev cuam tshuam nrog kev tswj hwm lub neej ntev thiab tiv thaiv cov hlab ntsha uas tswj kev coj cwj pwm nyuaj siab. Kev tshawb fawb kuj qhia tias Oleoylethanolamide yuav muaj cov teebmeem neuroprotective. Hauv cov qauv tsiaj, nws tau pom tias txo qhov kev puas tsuaj los ntawm mob stroke thiab raug mob hlwb. Cov nyhuv tswj hwm ntawm Oleoylethanolamide yog vim nws khi rau PPARα, uas dimerizes nrog retinoid X receptor (RXR) thiab ua kom nws ua lub zog transcription factor koom nrog kev sib xyaw ua ke ntawm lub zog homeostasis, lipid metabolism, autophagy, thiab o. downstream targets.
Feature
(1) Kev huv siab: OEA tuaj yeem tau txais cov khoom lag luam huv siab los ntawm kev ua kom huv cov txheej txheem tsim khoom. Kev huv siab txhais tau tias muaj kev nyab xeeb zoo dua thiab tsawg dua cov kev tsis zoo.
(2) Kev Nyab Xeeb: OEA tau raug pov thawj tias muaj kev nyab xeeb rau tib neeg lub cev.
(3) Kev Ruaj Ntseg: OEA muaj kev ruaj khov zoo thiab tuaj yeem tswj nws cov haujlwm thiab cov txiaj ntsig nyob rau hauv ntau qhov chaw sib txawv thiab cov xwm txheej khaws cia.
(4) Yooj yim rau nqus: OEA tuaj yeem nqus tau sai los ntawm lub cev tib neeg thiab faib rau ntau cov ntaub so ntswg thiab cov kabmob sib txawv.
Cov ntawv thov
Oleoylethanolamide yog ib hom lipid ethanolamide ntuj siv los ua kev npaj zaub mov thiab tswj qhov hnyav ntawm ntau hom tsiaj vertebrate. Nws yog ib qho metabolite ntawm oleic acid tsim nyob rau hauv tib neeg lub plab me. Oleylethanolamide (OEA) yog ib qho molecule uas tswj cov metabolism lipid thiab lub zog homeostasis. Nws lo rau PPAR Alpha receptors thiab pab tswj plaub yam tseem ceeb: kev tshaib kev nqhis, rog hauv lub cev, roj cholesterol thiab qhov hnyav. PPAR Alpha sawv cev rau peroxide proliferator-activated receptor alpha, thiab cov bioactive lipid amide oleoylethanolamide (OEA) muaj ntau yam khoom tshwj xeeb, suav nrog kev ua haujlwm tiv thaiv kev o, kev tiv thaiv kab mob, thiab cov teebmeem antioxidant.
